Q20765
PR
Gene name |
nhr-7 (F54D1.4) |
Protein name |
Nuclear hormone receptor family member nhr-7 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F54D1.4 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q20765
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q20765-F1 | Predicted | AlphaFoldDB |
No variants for Q20765
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q20765 | |||||
No associated diseases with Q20765
7 regional properties for Q20765
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 246 - 254 | IPR000629 |
| domain | Helicase, C-terminal | 327 - 475 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 118 - 288 | IPR011545 |
| repeat | RNA helicase p68 repeat | 498 - 532 | IPR012587-1 |
| repeat | RNA helicase p68 repeat | 551 - 583 | IPR012587-2 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 113 - 316 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 94 - 122 | IPR014014 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| nuclear receptor activity | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| zinc ion binding | Binding to a zinc ion (Zn). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| hormone-mediated signaling pathway | The series of molecular signals mediated by the detection of a hormone. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
31 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9TTR7 | NR2F2 | COUP transcription factor 2 | Bos taurus (Bovine) | PR |
| O18971 | PPARG | Peroxisome proliferator-activated receptor gamma | Bos taurus (Bovine) | PR |
| Q90733 | NR2F2 | COUP transcription factor 2 | Gallus gallus (Chicken) | PR |
| P68306 | THRB | Thyroid hormone receptor beta | Gallus gallus (Chicken) | PR |
| A7X8B3 | PGR | Progesterone receptor | Pan troglodytes (Chimpanzee) | SS |
| Q0ZAQ8 | PPARD | Peroxisome proliferator-activated receptor delta | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P10588 | NR2F6 | Nuclear receptor subfamily 2 group F member 6 | Homo sapiens (Human) | PR |
| P06401 | PGR | Progesterone receptor | Homo sapiens (Human) | EV |
| P10589 | NR2F1 | COUP transcription factor 1 | Homo sapiens (Human) | PR |
| O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (Human) | PR |
| P24468 | NR2F2 | COUP transcription factor 2 | Homo sapiens (Human) | PR |
| P49116 | NR2C2 | Nuclear receptor subfamily 2 group C member 2 | Homo sapiens (Human) | PR |
| P37231 | PPARG | Peroxisome proliferator-activated receptor gamma | Homo sapiens (Human) | PR |
| Q14995 | NR1D2 | Nuclear receptor subfamily 1 group D member 2 | Homo sapiens (Human) | PR |
| P43136 | Nr2f6 | Nuclear receptor subfamily 2 group F member 6 | Mus musculus (Mouse) | PR |
| P43135 | Nr2f2 | COUP transcription factor 2 | Mus musculus (Mouse) | PR |
| Q00175 | Pgr | Progesterone receptor | Mus musculus (Mouse) | SS |
| Q9Z0Y9 | Nr1h3 | Oxysterols receptor LXR-alpha | Mus musculus (Mouse) | PR |
| P35396 | Ppard | Peroxisome proliferator-activated receptor delta | Mus musculus (Mouse) | PR |
| O62807 | PPARG | Peroxisome proliferator-activated receptor gamma | Sus scrofa (Pig) | PR |
| O09018 | Nr2f2 | COUP transcription factor 2 | Rattus norvegicus (Rat) | PR |
| Q63449 | Pgr | Progesterone receptor | Rattus norvegicus (Rat) | SS |
| Q63504 | Nr1d2 | Nuclear receptor subfamily 1 group D member 2 | Rattus norvegicus (Rat) | PR |
| Q8SQ01 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Macaca mulatta (Rhesus macaque) | PR |
| O45460 | nhr-54 | Nuclear hormone receptor family member nhr-54 | Caenorhabditis elegans | PR |
| Q21006 | nhr-34 | Nuclear hormone receptor family member nhr-34 | Caenorhabditis elegans | PR |
| O17928 | nhr-52 | Nuclear hormone receptor family member nhr-52 | Caenorhabditis elegans | PR |
| Q21878 | nhr-1 | Nuclear hormone receptor family member nhr-1 | Caenorhabditis elegans | PR |
| O18141 | nhr-79 | Nuclear hormone receptor family member nhr-79 | Caenorhabditis elegans | PR |
| G5EFF5 | daf-12 | Nuclear hormone receptor family member daf-12 | Caenorhabditis elegans | PR |
| Q6PH18 | nr2f1b | Nuclear receptor subfamily 2 group F member 1-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQSYTNRICA | VCGDTPAKIH | YGVLACFGCK | GFFRRAVKDG | RNKYVCRFEK | NCEVTKFERN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ACRYCRFRKC | LLVGMNPDYV | RPDREKSKKG | KTVLSKKKSV | SRSLSYRLAD | PSDWTSFLSP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSRKQLSEIG | KLAETCSTST | NFDGIGNFSL | KSLIADRSLA | RKTGDSEAMD | CSNSPRQLNE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QFLGIERIVQ | CVDYIDRFLV | MLEEEHCRKF | SVEDKSALIS | DTMIHLLLFE | STSRFVAKGA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PGLEDLKLSL | AQLPICTTHL | TQKIADVFET | YLRKPPSIIE | YSVLKAYIVL | SAESTVLSNS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LNESLSLARE | NLSELLFKVI | KHSRNKTSIS | AANSLSTILH | FVYESRNLAS | RIRQSQQPFF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VRDSDPKIPF | HKILTDIINP | EVSDLLLTTA | NCRKLSTQMG | SSLSSVPPVP | PPSDTVPLFH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FSPPSLSPCQ | ISAPPPPQQQ | YTDYSQMPST | SSYPANSSPF | QSPYRPNSLS | SFPKIPLEMT |
| 490 | 500 | 510 | 520 | 530 | |
| KSIEEFLRPN | GMTTDEMNKP | LEKNWADGFR | LTPVFNKDIV | SQFFPELSNI | NQHHPF |