Q1RML2

PR
Gene name
PLCZ1
Protein name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Names
Phosphoinositide phospholipase C-zeta-1, Phospholipase C-zeta-1, PLC-zeta-1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:497026
EC number
3.1.4.11: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

282-396 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1RML2

Entry ID Method Resolution Chain Position Source
AF-Q1RML2-F1 Predicted AlphaFoldDB

87 variants for Q1RML2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs479021129 41 K>E No EVA
rs434350358 57 I>L No EVA
rs452949377 63 I>L No EVA
rs452949377 63 I>V No EVA
rs465039260 76 I>N No EVA
rs432091682 90 K>E No EVA
rs451784478 96 L>W No EVA
rs476842731 100 Q>* No EVA
rs443932700 102 T>I No EVA
rs456036670 103 L>F No EVA
rs474148086 105 F>L No EVA
rs441265316 109 I>F No EVA
rs441265316 109 I>L No EVA
rs459815659 109 I>N No EVA
rs478337847 110 A>P No EVA
rs438916541 110 A>V No EVA
rs463518431 111 S>T No EVA
rs449048927 114 I>N No EVA
rs467523606 115 Q>K No EVA
rs479177598 115 Q>L No EVA
rs479177598 115 Q>R No EVA
rs432057147 117 Y>N No EVA
rs457063279 120 I>V No EVA
rs457011048 255 S>C No EVA
rs468329045 256 Q>* No EVA
rs797852517 267 T>I No EVA
rs445141274 321 E>G No EVA
rs469572073 322 F>S No EVA
rs208019489 337 A>P No EVA
rs716682782 361 G>R No EVA
rs470423282 370 I>K No EVA
rs437484228 372 I>K No EVA
rs456024945 373 S>F No EVA
rs434799806 374 M>I No EVA
rs474162142 374 M>L No EVA
rs453306797 375 A>P No EVA
rs471695736 376 L>P No EVA
rs463383010 377 S>F No EVA
rs475415030 378 D>V No EVA
rs442644313 379 L>F No EVA
rs479415700 380 V>F No EVA
rs446418300 381 I>F No EVA
rs458504986 382 Y>F No EVA
rs477095828 390 S>R No EVA
rs450657575 404 N>Y No EVA
rs470339921 410 Q>K No EVA
rs449472003 414 L>I No EVA
rs468108775 417 L>* No EVA
rs435115031 417 L>F No EVA
rs437891986 421 E>K No EVA
rs456440454 422 F>Y No EVA
rs474577186 423 I>T No EVA
rs435192504 425 H>N No EVA
rs472249847 429 F>S No EVA
rs453723767 429 F>V No EVA
rs458970104 430 I>T No EVA
rs439307697 430 I>V No EVA
rs463238307 432 R>S No EVA
rs481430307 433 V>E No EVA
rs479105501 434 Y>F No EVA
rs460582806 434 Y>H No EVA
rs446205489 436 K>E No EVA
rs464317848 436 K>T No EVA
rs482820740 437 A>G No EVA
rs449930011 444 N>I No EVA
rs468427947 446 N>H No EVA
rs435500869 446 N>T No EVA
rs465819127 448 Q>E No EVA
rs451301128 449 E>D No EVA
rs432806001 449 E>Q No EVA
rs470979464 450 F>V No EVA
rs444616223 451 W>* No EVA
rs456754408 452 N>I No EVA
rs460495241 456 Q>* No EVA
rs479019352 457 M>L No EVA
rs382574994 489 R>G No EVA
rs433503815 496 T>I No EVA
rs476610966 497 K>E No EVA
rs473657495 586 G>D No EVA
rs482888544 608 Y>S No EVA
rs449866686 609 R>H No EVA
rs449866686 609 R>P No EVA
rs447198976 617 M>I No EVA
rs462037939 617 M>L No EVA
rs480347282 617 M>R No EVA
rs432805987 618 G>A No EVA
rs465638405 618 G>C No EVA

No associated diseases with Q1RML2

5 regional properties for Q1RML2

Type Name Position InterPro Accession
domain C2 domain 492 - 615 IPR000008
domain Phosphatidylinositol-specific phospholipase C, X domain 155 - 300 IPR000909
domain Phospholipase C, phosphatidylinositol-specific, Y domain 376 - 492 IPR001711
domain EF-hand domain 35 - 70 IPR002048
domain Phosphoinositide-specific phospholipase C, EF-hand-like domain 64 - 147 IPR015359

Functions

Description
EC Number 3.1.4.11 Phosphoric diester hydrolases
Subcellular Localization
  • Nucleus
  • Cytoplasm, perinuclear region
  • Exhibits alternative cytoplasmic/nuclear localization during development
  • Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
pronucleus The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.
sperm head The part of the late spermatid or spermatozoon that contains the nucleus and acrosome.

5 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
phosphatidylinositol-3-phosphate binding Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
phosphatidylinositol-4,5-bisphosphate binding Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
phosphatidylinositol-5-phosphate binding Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position.

5 GO annotations of biological process

Name Definition
calcium ion transport The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
egg activation The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
positive regulation of cytosolic calcium ion concentration involved in egg activation The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32383 PLC1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P10895 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Bos taurus (Bovine) SS
P10894 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Bos taurus (Bovine) SS
P08487 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Bos taurus (Bovine) EV SS
Q2VRL0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Gallus gallus (Chicken) PR
Q9P212 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Homo sapiens (Human) SS
Q9BRC7 PLCD4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 Homo sapiens (Human) SS
Q15111 PLCL1 Inactive phospholipase C-like protein 1 Homo sapiens (Human) PR
P51178 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Homo sapiens (Human) EV
Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 Homo sapiens (Human) PR
Q8N3E9 PLCD3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Homo sapiens (Human) SS
Q86YW0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Homo sapiens (Human) PR
Q8R3B1 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Mus musculus (Mouse) SS
Q8K394 Plcl2 Inactive phospholipase C-like protein 2 Mus musculus (Mouse) PR
Q8K2J0 Plcd3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Mus musculus (Mouse) PR
Q8K4S1 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Mus musculus (Mouse) SS
Q7YRU3 PLCZ 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Sus scrofa (Pig) PR
P10688 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Rattus norvegicus (Rat) SS
Q99P84 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Rattus norvegicus (Rat) EV
Q39032 PLC1 Phosphoinositide phospholipase C 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q56W08 PLC3 Phosphoinositide phospholipase C 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NMA7 PLC9 Phosphoinositide phospholipase C 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GV43 PLC6 Phosphoinositide phospholipase C 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C2 PLC5 Phosphoinositide phospholipase C 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STZ3 PLC8 Phosphoinositide phospholipase C 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C1 PLC4 Phosphoinositide phospholipase C 4 Arabidopsis thaliana (Mouse-ear cress) PR
A5D6R3 plcd3a 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MENKWFLLMV RDDFKGGKIT LEKALKLLEK LDIQCNTIHV KYIFKDNDRL KQGRITIEEF
70 80 90 100 110 120
RTIYRIITYR EEIIEIFNTY SENRKILLEK NLVEFLMREQ YTLDFNKSIA SEIIQKYEPI
130 140 150 160 170 180
EEVKQAHQMS FEGFRRYMDS SECLLFDNKC DHVYQDMTHP LTDYFISSSH NTYLISDQLW
190 200 210 220 230 240
GPSDLWGYIS ALVKGCRCLE IDCWDGSQNE PVVYHGYTFT SKLLFKTVIQ AINKYAFLAS
250 260 270 280 290 300
EYPVVLSLEN HCSPSQQEVM ADSLLATFGD ALLSYTLDNF SDRLPSPEAL KFKILVRNKK
310 320 330 340 350 360
IGTLHETLER KGSDMHGKVE EFEEEEEIEQ EEDGSGAKEP EPVGDFQDDL AKEEQLKRVV
370 380 390 400 410 420
GIPLFRKKKI KISMALSDLV IYTKVEKFKS FHHSHLYQQF NESNSIGESQ ARKLTKLAAR
430 440 450 460 470 480
EFILHTRRFI TRVYPKALRA DSSNFNPQEF WNVGCQMVAL NFQTPGVPMD LQNGKFLDNG
490 500 510 520 530 540
CSGYVLKPRF LRDKKTKFNP HKVQIDSNPL TLTIRLISGI QLPPSYQNKA DTLVIVEIFG
550 560 570 580 590 600
VPNDQMKQQS RVIKKNAFNP RWNETFTFVI QVPELALIRF VAENQGLIAG NEFLGQYTLP
610 620 630
VLCMNRGYRR VPLFSKMGES LEPASLFIYV WYIR