Q1RLU9

PR
Gene name
cdk15 (pftk2, zgc:136819)
Protein name
Cyclin-dependent kinase 15
Names
Cell division protein kinase 15
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:791619
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-108 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

222-245 (Activation loop from InterPro)

Target domain

84-369 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q1RLU9

Entry ID Method Resolution Chain Position Source
AF-Q1RLU9-F1 Predicted AlphaFoldDB

No variants for Q1RLU9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1RLU9

No associated diseases with Q1RLU9

4 regional properties for Q1RLU9

Type Name Position InterPro Accession
domain Protein kinase domain 84 - 369 IPR000719
active_site Serine/threonine-protein kinase, active site 201 - 213 IPR008271
binding_site Protein kinase, ATP binding site 90 - 113 IPR017441
domain CDK15, catalytic domain 83 - 369 IPR042761

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin binding Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

2 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of transcription involved in G1/S transition of mitotic cell cycle Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00526 CDK3 Cyclin-dependent kinase 3 Homo sapiens (Human) PR
O94921 CDK14 Cyclin-dependent kinase 14 Homo sapiens (Human) PR
Q00537 CDK17 Cyclin-dependent kinase 17 Homo sapiens (Human) PR
Q96Q40 CDK15 Cyclin-dependent kinase 15 Homo sapiens (Human) PR
O35495 Cdk14 Cyclin-dependent kinase 14 Mus musculus (Mouse) PR
Q8K0D0 Cdk17 Cyclin-dependent kinase 17 Mus musculus (Mouse) PR
O35831 Cdk17 Cyclin-dependent kinase 17 Rattus norvegicus (Rat) PR
Q5Z754 CDKF-1 Cyclin-dependent kinase F-1 Oryza sativa subsp japonica (Rice) PR
Q9S713 STN7 Serine/threonine-protein kinase STN7, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
A4IIW7 cdk14 Cyclin-dependent kinase 14 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6AXJ9 cdkl1 Cyclin-dependent kinase-like 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
A8WIP6 cdk20 Cyclin-dependent kinase 20 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q8JH47 cdk8 Cyclin-dependent kinase 8 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MQNLRHAASE AFQRLGLKQR HLGYEELGEL DGVEKPQPHW FHTLQVRRLR VQRGRSNSDP
70 80 90 100 110 120
MGGKSFQQEF QWKTGLQFGN ATSYLNLEKL GEGTYATVYK GISRINGHLV ALKVIHMKTE
130 140 150 160 170 180
EGIPFTAIRE ASLLKGLKHA NIVLLHDIIH TRESLTFVFE YVQTDLAQYM IQHPGGLHSY
190 200 210 220 230 240
NIRLFMFQLL RGLSYIHGRR ILHRDLKPQN LLISYLGELK LADFGLARSK SIPCQTYSAE
250 260 270 280 290 300
VVTLWYRPPD VLMGSTDYST ALDIWGAGCI FIEMLQGSPA FPGVADVFEQ LLKIWTVIGV
310 320 330 340 350 360
PTEEIWPGVS DLPNYKPEWF LPCKPQQFRD VWKRLSQLPY KTEDLAQQML MMNPKDRISA
370 380 390 400 410
QDALLHPYFN TLPPPLMHLR DTVSIFKVPG VRLESEARDI FSPSRRTKTP LAPLAKCW