Q1LWG4
PR
Gene name |
lpcat1 (aytl2, si:dkey-261i16.4, zgc:158232) |
Protein name |
Lysophosphatidylcholine acyltransferase 1 |
Names |
LPC acyltransferase 1, LPCAT-1, LysoPC acyltransferase 1, 1-acylglycerol-3-phosphate O-acyltransferase, 1-acylglycerophosphocholine O-acyltransferase, 1-alkenylglycerophosphocholine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, Acetyl-CoA:lyso-platelet-activating factor acetyltransferase, Acetyl-CoA:lyso-PAF acetyltransferase, Lyso-PAF acetyltransferase, LysoPAFAT, Acyltransferase-like 2 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:555969 |
EC number |
2.3.1.23: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q1LWG4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q1LWG4-F1 | Predicted | AlphaFoldDB |
No variants for Q1LWG4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q1LWG4 | |||||
No associated diseases with Q1LWG4
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.23 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. |
| 1-acylglycerophosphocholine O-acyltransferase activity | Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. |
| 1-alkenylglycerophosphocholine O-acyltransferase activity | Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA. |
| 1-alkylglycerophosphocholine O-acetyltransferase activity | Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| plasmalogen synthase activity | Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| phospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8NF37 | LPCAT1 | Lysophosphatidylcholine acyltransferase 1 | Homo sapiens (Human) | PR |
| Q6NVG1 | Lpcat4 | Lysophospholipid acyltransferase LPCAT4 | Mus musculus (Mouse) | PR |
| Q3TFD2 | Lpcat1 | Lysophosphatidylcholine acyltransferase 1 | Mus musculus (Mouse) | PR |
| Q1HAQ0 | Lpcat1 | Lysophosphatidylcholine acyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q8L7R3 | LPEAT1 | Lysophospholipid acyltransferase LPEAT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8S8S2 | LPEAT2 | Lysophospholipid acyltransferase LPEAT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A3KGT9 | agpat9l | Glycerol-3-phosphate acyltransferase 3-like | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRFPNRKLHT | AVNGGDSGVS | THFRNPFVHE | LRFTTLQKLK | IAVMTVTLFP | VRLLFAAFMM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLAWPFAFVA | TVGRSENAVE | PLSWWRWLVD | LALKAIMRAM | WFSGGFHWVR | VKGRPALPSE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| APILTMAPHS | SYFDAIPVTM | TMASIVMKAE | SKDIPVWGTL | IKFIRPVFVS | RSDQDSRRKT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VEEIKRRASS | NGEWPQIMIF | PEGTCTNRSC | LIAFKPGAFI | PGVPVQPVVL | RYPNELDTIS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WTWQGPGAFK | ILWLTLCQLH | NFVEIEYLPT | YTPSEEEKKD | PALFASNVRR | IMAKALGLPI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IDYSFEDCQL | AMAKGPLRLP | KHTCLLEFAR | LVRLLGLKTK | VTDEVLQEEA | CSARQLCGRR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LDMEGFAQYL | HQPMTEAVQD | IFSLFEEHGM | MDVREYVIAL | SVVCRPFRYL | DTVKLAFRMF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EAQEDGAIVE | DELTVILKTA | LGVGDLAVSE | LFRAIDSQDK | GKITFDELCS | FMEKCPDLVE |
| 490 | 500 | 510 | |||
| QYHCLCESIS | QHSRESTSSS | NGFCADFSPR | NHSKKQD |