Q1LUA6
SS
Gene name |
trio (si:dkey-158b13.2) |
Protein name |
Triple functional domain protein |
Names |
EC 2.7.11.1 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
|
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
TRIO is a guanine nucleotide exchange factor (GEF) that activates the small GTPase RhoA, influencing cell motility and gene transcription. It plays a crucial role in tumor growth in uveal melanoma. The GEF activity of TRIO’s C-terminal module (TrioC) is autoinhibited. The pleckstrin homology (PH) domain interacts with the Dbl homology (DH) domain, blocking the Rho GTPase binding site and preventing activation. Similar to ARHGEF25, Binding of Gαq also relieves the autoinhibition of TRIO. Furthermore, mutations in the DH-PH interface found in cancer patients can disrupt this autoinhibited state, leading to increased RhoA activation and mitogenic signaling, potentially driving cancer progression.
Autoinhibitory domains (AIDs)
Target domain |
1915-2107 (DH domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for Q1LUA6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| No available structures | |||||
No variants for Q1LUA6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q1LUA6 | |||||
No associated diseases with Q1LUA6
25 regional properties for Q1LUA6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dbl homology (DH) domain | 1243 - 1418 | IPR000219-1 |
| domain | Dbl homology (DH) domain | 1920 - 2096 | IPR000219-2 |
| domain | Protein kinase domain | 2726 - 2980 | IPR000719 |
| domain | CRAL-TRIO lipid binding domain | 5 - 152 | IPR001251 |
| domain | SH3 domain | 1606 - 1671 | IPR001452-1 |
| domain | SH3 domain | 2480 - 2545 | IPR001452-2 |
| domain | Pleckstrin homology domain | 1430 - 1544 | IPR001849-1 |
| domain | Pleckstrin homology domain | 2108 - 2225 | IPR001849-2 |
| repeat | Spectrin repeat | 292 - 396 | IPR002017-1 |
| repeat | Spectrin repeat | 521 - 621 | IPR002017-2 |
| repeat | Spectrin repeat | 860 - 957 | IPR002017-3 |
| repeat | Spectrin repeat | 1091 - 1194 | IPR002017-4 |
| domain | Immunoglobulin subtype 2 | 2627 - 2696 | IPR003598 |
| domain | Immunoglobulin subtype | 2621 - 2707 | IPR003599 |
| domain | Immunoglobulin-like domain | 2615 - 2705 | IPR007110 |
| active_site | Serine/threonine-protein kinase, active site | 2841 - 2853 | IPR008271 |
| domain | Immunoglobulin I-set | 2615 - 2706 | IPR013098 |
| binding_site | Protein kinase, ATP binding site | 2732 - 2755 | IPR017441 |
| repeat | Spectrin/alpha-actinin | 161 - 517 | IPR018159-1 |
| repeat | Spectrin/alpha-actinin | 518 - 734 | IPR018159-2 |
| repeat | Spectrin/alpha-actinin | 738 - 1088 | IPR018159-3 |
| repeat | Spectrin/alpha-actinin | 1090 - 1206 | IPR018159-4 |
| domain | Kalirin/Triple functional domain protein, SH3 domain 1 | 1609 - 1668 | IPR028570 |
| domain | Kalirin/Triple functional domain protein, SH3 domain 2 | 2484 - 2542 | IPR047053 |
| domain | Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1 | 1423 - 1545 | IPR047054 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extrinsic component of membrane | The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
106 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4IFM7 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Bos taurus (Bovine) | SS |
| Q0V7M1 | PSKH1 | Serine/threonine-protein kinase H1 | Bos taurus (Bovine) | SS |
| Q0VD22 | STK33 | Serine/threonine-protein kinase 33 | Bos taurus (Bovine) | PR |
| Q96NX5 | CAMK1G | Calcium/calmodulin-dependent protein kinase type 1G | Homo sapiens (Human) | SS |
| O15075 | DCLK1 | Serine/threonine-protein kinase DCLK1 | Homo sapiens (Human) | EV |
| Q14012 | CAMK1 | Calcium/calmodulin-dependent protein kinase type 1 | Homo sapiens (Human) | EV |
| Q9UIK4 | DAPK2 | Death-associated protein kinase 2 | Homo sapiens (Human) | EV |
| O94768 | STK17B | Serine/threonine-protein kinase 17B | Homo sapiens (Human) | PR |
| Q86YV6 | MYLK4 | Myosin light chain kinase family member 4 | Homo sapiens (Human) | SS |
| Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | Homo sapiens (Human) | SS |
| P11801 | PSKH1 | Serine/threonine-protein kinase H1 | Homo sapiens (Human) | SS |
| Q8N568 | DCLK2 | Serine/threonine-protein kinase DCLK2 | Homo sapiens (Human) | PR |
| Q9UEE5 | STK17A | Serine/threonine-protein kinase 17A | Homo sapiens (Human) | SS |
| Q9H1R3 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Homo sapiens (Human) | EV |
| Q32MK0 | MYLK3 | Myosin light chain kinase 3 | Homo sapiens (Human) | SS |
| Q8WWF8 | CAPSL | Calcyphosin-like protein | Homo sapiens (Human) | PR |
| P53355 | DAPK1 | Death-associated protein kinase 1 | Homo sapiens (Human) | EV |
| Q6P2M8 | PNCK | Calcium/calmodulin-dependent protein kinase type 1B | Homo sapiens (Human) | SS |
| Q9BYT3 | STK33 | Serine/threonine-protein kinase 33 | Homo sapiens (Human) | PR |
| Q8NCB2 | CAMKV | CaM kinase-like vesicle-associated protein | Homo sapiens (Human) | SS |
| O43293 | DAPK3 | Death-associated protein kinase 3 | Homo sapiens (Human) | PR |
| Q8IU85 | CAMK1D | Calcium/calmodulin-dependent protein kinase type 1D | Homo sapiens (Human) | SS |
| O60229 | KALRN | Kalirin | Homo sapiens (Human) | SS |
| Q86YR7 | MCF2L2 | Probable guanine nucleotide exchange factor MCF2L2 | Homo sapiens (Human) | SS |
| P10911 | MCF2 | Proto-oncogene DBL | Homo sapiens (Human) | EV |
| O15068 | MCF2L | Guanine nucleotide exchange factor DBS | Homo sapiens (Human) | SS |
| O75962 | TRIO | Triple functional domain protein | Homo sapiens (Human) | EV |
| Q9QYK9 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Mus musculus (Mouse) | PR |
| Q91VB2 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Mus musculus (Mouse) | SS |
| Q8BG48 | Stk17b | Serine/threonine-protein kinase 17B | Mus musculus (Mouse) | PR |
| Q8VCR8 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Mus musculus (Mouse) | SS |
| Q6PGN3 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Mus musculus (Mouse) | PR |
| Q91YS8 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Mus musculus (Mouse) | SS |
| Q3UIZ8 | Mylk3 | Myosin light chain kinase 3 | Mus musculus (Mouse) | SS |
| Q8VDF3 | Dapk2 | Death-associated protein kinase 2 | Mus musculus (Mouse) | EV |
| Q6P8Y1 | Capsl | Calcyphosin-like protein | Mus musculus (Mouse) | PR |
| Q8BW96 | Camk1d | Calcium/calmodulin-dependent protein kinase type 1D | Mus musculus (Mouse) | SS |
| Q3UHL1 | Camkv | CaM kinase-like vesicle-associated protein | Mus musculus (Mouse) | SS |
| P08414 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Mus musculus (Mouse) | SS |
| Q9JLM8 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Mus musculus (Mouse) | SS |
| Q91YA2 | Pskh1 | Serine/threonine-protein kinase H1 | Mus musculus (Mouse) | SS |
| Q80YE7 | Dapk1 | Death-associated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q62407 | Speg | Striated muscle-specific serine/threonine-protein kinase | Mus musculus (Mouse) | SS |
| Q924X7 | Stk33 | Serine/threonine-protein kinase 33 | Mus musculus (Mouse) | PR |
| O54784 | Dapk3 | Death-associated protein kinase 3 | Mus musculus (Mouse) | PR |
| Q64096 | Mcf2l | Guanine nucleotide exchange factor DBS | Mus musculus (Mouse) | SS |
| A2CG49 | Kalrn | Kalirin | Mus musculus (Mouse) | SS |
| Q0KL02 | Trio | Triple functional domain protein | Mus musculus (Mouse) | SS |
| Q7TNJ7 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Rattus norvegicus (Rat) | SS |
| P20689 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Rattus norvegicus (Rat) | SS |
| Q91XS8 | Stk17b | Serine/threonine-protein kinase 17B | Rattus norvegicus (Rat) | PR |
| O08875 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Rattus norvegicus (Rat) | PR |
| E9PT87 | Mylk3 | Myosin light chain kinase 3 | Rattus norvegicus (Rat) | SS |
| O70150 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Rattus norvegicus (Rat) | PR |
| Q63092 | Camkv | CaM kinase-like vesicle-associated protein | Rattus norvegicus (Rat) | SS |
| Q63638 | Speg | Striated muscle-specific serine/threonine-protein kinase | Rattus norvegicus (Rat) | SS |
| O88764 | Dapk3 | Death-associated protein kinase 3 | Rattus norvegicus (Rat) | PR |
| P13234 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Rattus norvegicus (Rat) | SS |
| Q63450 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Rattus norvegicus (Rat) | EV |
| P97924 | Kalrn | Kalirin | Rattus norvegicus (Rat) | SS |
| Q5MPA9 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Rattus norvegicus (Rat) | PR |
| Q63406 | Mcf2l | Guanine nucleotide exchange factor DBS | Rattus norvegicus (Rat) | SS |
| F1M0Z1 | Trio | Triple functional domain protein | Rattus norvegicus (Rat) | SS |
| Q5VQQ5 | CPK2 | Calcium-dependent protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q8LPZ7 | CPK3 | Calcium-dependent protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6K968 | CPK6 | Calcium-dependent protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| P53684 | CPK7 | Calcium-dependent protein kinase 7 | Oryza sativa subsp japonica (Rice) | PR |
| Q75GE8 | CPK8 | Calcium-dependent protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6I5I8 | CPK16 | Calcium-dependent protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6AVM3 | CCAMK | Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase | Oryza sativa subsp japonica (Rice) | PR |
| Q84SL0 | CPK20 | Calcium-dependent protein kinase 20 | Oryza sativa subsp. japonica (Rice) | SS |
| P53682 | CPK23 | Calcium-dependent protein kinase 23 | Oryza sativa subsp japonica (Rice) | PR |
| Q9TXJ0 | cmk-1 | Calcium/calmodulin-dependent protein kinase type 1 | Caenorhabditis elegans | PR |
| O44997 | dapk-1 | Death-associated protein kinase dapk-1 | Caenorhabditis elegans | SS |
| Q95QC4 | zyg-8 | Serine/threonine-protein kinase zyg-8 | Caenorhabditis elegans | PR |
| P28583 | Calcium-dependent protein kinase SK5 | Glycine max (Soybean) (Glycine hispida) | PR | |
| Q9M9V8 | CPK10 | Calcium-dependent protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39016 | CPK11 | Calcium-dependent protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FX86 | CRK8 | CDPK-related kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SSF8 | CPK30 | Calcium-dependent protein kinase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38872 | CPK6 | Calcium-dependent protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7XJR9 | CPK16 | Calcium-dependent protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIQ7 | CPK24 | Calcium-dependent protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJ61 | CPK25 | Calcium-dependent protein kinase 25 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZV15 | CPK20 | Calcium-dependent protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93759 | GK-1 | Calcium-dependent protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8S8S2 | LPEAT2 | Lysophospholipid acyltransferase LPEAT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38870 | CPK2 | Calcium-dependent protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LJL9 | CRK2 | CDPK-related kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SG12 | CRK6 | CDPK-related kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCS2 | CRK5 | CDPK-related kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4I7 | CPK13 | Calcium-dependent protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NLQ6 | CPK32 | Calcium-dependent protein kinase 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZSA4 | CPK27 | Calcium-dependent protein kinase 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38869 | CPK4 | Calcium-dependent protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42479 | CPK3 | Calcium-dependent protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PE17 | CPK18 | Calcium-dependent protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q06850 | CPK1 | Calcium-dependent protein kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMP5 | CPK17 | Calcium-dependent protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38873 | CPK7 | Calcium-dependent protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E9C0 | CPK34 | Calcium-dependent protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42438 | CPK8 | Calcium-dependent protein kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42396 | CPK12 | Calcium-dependent protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FKW4 | CPK28 | Calcium-dependent protein kinase 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| A8C984 | mylk3 | Myosin light chain kinase 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SY49 | camkv | CaM kinase-like vesicle-associated protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKAMEVLPIL | KEKVAFLSGG | RDKRGGPVLT | FPSRTNHDRI | RHEDLRRLIA | YLAGIPSEDV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CKHGFTVIVD | MRGSKWDSIK | PLLKILQESF | PCCIHIALII | KPDNFWQKQR | TNFGSSKFEF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETTMVSLEGL | SKVVDPSQLT | ADFEGSLDYN | HEEWIEIRVA | FEDFTGNARH | LLARLEEMHE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TVTRKDLPQD | LDGARRMIEE | HAALKKRVIK | APVEEVDNEG | QRLLQRIQSS | ESYANRTVPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PPGQREGQGQ | PNADTQGLVP | RITALLEKLH | STRQNLHQSW | HIRKLQLDQC | FQLRLFEQDA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EKMFDWIMHN | KGLFLAGYTE | IGNNHPHAME | LQTQHNHFAM | NCMNVYVNIN | RIMSVGNRLL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EAGHYASQQI | KQISGQLEQE | WKAFAAALDE | RSALLEMSAT | FHQKCDQYMS | NVDSWCKACG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EVDLPSELQE | LEDAIHHHQG | LYEHITAAYS | EVSQDGKALL | DKLQRPLTPG | SADSLTASAN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YTKAVNHVLD | IIHEVLHHQR | QLENIWQHRK | VRLHQRLQLC | VFQQDVQQVL | DWIENHGEAF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LSKHTGVGKS | LHRARALQKR | HEDFEEVAQN | TYTNADKLLE | AAEQLAQTGE | CDPEEIYQAA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HQLEDRIQDF | VRRVEQRKVL | LDMSVAFHTH | VKELWTWLEE | LQKELLDDVY | AESVEAVQDL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IKRFGQQQQT | TLQFTVNVIK | EGEDLIQQLR | DLAISSNKTP | HNSSINHIES | VLQQLDEAQA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QMEELFQERK | IKLELFLQLR | IFERDAIDII | SDLDSWNEEL | SQQMNEFDTE | DLTLAEQRLQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| HHADKALTMN | NLAFHVIHQG | QELLQYVNEV | QASGVELLCD | RDVDMATRVQ | DLLEFLHEKQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QELDVAAEQH | RRHLEQCVQL | RHLQAEVKQV | LGWIRNGESM | LNAGLITASS | LQEAEQLQRE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| HEQFQHAIEK | THQSALQVQQ | KAEALLQANH | YDMDMIRDCA | ENVASHWQQL | MLKMEDRLKL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| VNASVAFYKT | SEQVCSVLES | LEQEYKREED | WCGGADKLGP | NCESDHVTPM | ISKHLEQKEA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| FLKACTLARR | NADVFLKYMH | RNSVSMPGML | SHVKAPEQQV | KNILNELLQR | ENRVLHFWTM |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RKRRLDQCQQ | YVVFERSAKQ | ALEWIHDTGE | FYLSTHTSTG | SSIHHTQELL | KEHEDFHITA |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KQTKERVKLL | IQLADGFCDK | GHSHAAEIKK | WVTAVDKRYR | DFSLRMDKYR | TSLEKALGIS |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SDSNKASKDL | QLDIIPASAP | GSEVKLRDAA | HELNEEKRKS | ARRKDFIMAE | LIQTEKAYVR |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| DLRECMDTYL | WEMTSGVEEI | PPGIVNKEHI | IFGNMQDLYE | FHHNIFLKEL | EKYEQLPEDV |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| GHCFVTWADK | FQMYVNYCKN | KPDSTQLILE | HAGGYFDEIQ | QRHRLANSIS | SYLIKPVQRI |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| TKYQLLLKEL | LTCCEEGKGE | IKDGLEVMLS | VPKRANDAMH | LSMLEGFDEN | IESQGELILQ |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| EAFQVWDPKT | LIRKGRERHL | FLFEMSLIFS | KEVKDSNGRS | KYIYKSKLFT | SELGVTEHVE |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| GDPCKFALWV | GRTPTSDNKI | VLKASGIENK | QDWIKHIREV | IQERTVHLKG | ALKEPIHIPK |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| ASTAKHKGRR | DGEDLDSQGD | GSSQPDTISL | ASRTSQNTLD | SDKLSGGCEL | TVVIHDFMAG |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| NSNELTIRRG | QTVEVLERLH | DKPDWCLVRT | TDRSPALEGL | VPCAMLCIAH | SRSSMEMEGI |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| FNHKDALSVC | SNDAIMPGSS | ATLQPGHVMG | SQSSPGPKRP | GNTLRKWLTS | PVRRLSSGKA |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| DGHVKKLAHK | HKKSRDVRKS | ADAGSQKDSD | DSAATPQDET | LEERVRNEGL | SSGTLSKSSS |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| SGMQSCGEEE | GEEGADAVPL | PPPMAIQQHS | LLQPDAQDDK | TSSRLSVRPS | SSETPSAAEL |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| VSAIEELVKS | KMALEDRPST | LSVEQGDSSS | PSFNPSDNSL | LSSSSPIDEI | EERKTGFFKK |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| RHYVLLELIE | TERDYVRDLS | LVVEGYMARM | REDGVPDDMK | GKDKIVFGNI | QQIYDWHKDF |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| FLGELEKCLE | DPDRLGPLFL | KHERRLHMYI | VYCQNKPKSE | HIVSEYIDTY | FEDLKQRLGH |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| RLQITDLLIK | PVQRIMKYQL | LLKDFLKFSK | KIGTDSIELE | KAVEVMCIVP | KRCNDMMNVG |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| RLQGFDGKIV | AQGRLLLQDT | FMVAEPEGGL | LNRMKERRVF | LFEQIVIFSE | PLDKKRGFSM |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| PGYLYKYSIK | VNCLGLEDSV | DGDPCKFALT | SRTSNSSKDA | FILHSSHPGV | RQVWMLQISQ |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| ILESQRNFLN | ALTSPIDYQR | NHVEGPGVSG | SGVQAGGSGG | QMMAPGGGVG | VPAGPGSRSR |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| PSRIPQPSRL | PQPLRHHSPA | LGPGAHEHDG | PDKLSGMSPR | PLSRGPSPSC | TTEPEPKVKL |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| PASPHPKQTD | SQQTESPAKE | IPRATVAPLA | LVKPRPGTVS | PMASPLATPA | FKDSIPPCSP |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| GPKTGSSSFW | SSVPASPASR | PASFTFPGDA | CDTLSRPNHN | QSQRHSTHSK | DADRMSTCSS |
| 2470 | 2480 | 2490 | 2500 | 2510 | 2520 |
| TSEQSIQSTQ | SNGSESSSSS | NISTMLVTQD | YVALKEDEIN | VGQGEVVQIL | ASNQQNMFLV |
| 2530 | 2540 | 2550 | 2560 | 2570 | 2580 |
| FRAATEQCPA | AEGWIPGYVL | GHTSAIIPDA | PDGTIKKSSS | SWHTSLRIRK | KSEKREKDNK |
| 2590 | 2600 | 2610 | 2620 | 2630 | 2640 |
| KEAKLENGYR | KSREGLTNKV | SVKLLNPNYI | YDVLPEFLVP | LSDVTCDKGE | CVTLRCKVCG |
| 2650 | 2660 | 2670 | 2680 | 2690 | 2700 |
| RPKATVTWKG | PEQKTLTNNG | HFSIAYSETG | EATLRIVGVT | SEDDGSYTCI | ATNDIGSVAS |
| 2710 | 2720 | 2730 | 2740 | 2750 | 2760 |
| SASLRVLGTT | SDGIRVMWKD | NFESFYTEVA | ELGRGRFSVV | KRCDQRGSKR | TVAVKFVNKK |
| 2770 | 2780 | 2790 | 2800 | 2810 | 2820 |
| LMKRDQVTHE | FSVLQRLQHP | HLVRLLDTFE | TSSSYALVLE | MSDQGRLLDY | IVSWGNLTEE |
| 2830 | 2840 | 2850 | 2860 | 2870 | 2880 |
| KVAFYLRDIL | EALQYLHNCR | IVHLDLKPEN | LVVEQSPSQP | LVKLTDFGDA | VQLNSTPYVH |
| 2890 | 2900 | 2910 | 2920 | 2930 | 2940 |
| PLLGSPEFAA | PELVLGDPVS | LSSDLWSLGV | LTYVMLSGAS | PFLDESVEET | CLNICRLDFS |
| 2950 | 2960 | 2970 | 2980 | 2990 | 3000 |
| FPDDYFQGVS | QAARDFMCLL | LRMEPSKRPP | ATSCLQEPWL | RAGGGRRSAE | CIDTSRLISF |
| 3010 | 3020 | ||||
| IDRRKHQNDL | RPLTGIRAFL | QTRLQPRI |