Q1KME6
Gene name |
RAB6A |
Protein name |
Ras-related protein Rab-6A |
Names |
|
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:419063 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q1KME6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q1KME6-F1 | Predicted | AlphaFoldDB |
No variants for Q1KME6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q1KME6 | |||||
No associated diseases with Q1KME6
1 regional properties for Q1KME6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 13 - 169 | IPR005225 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| intra-Golgi vesicle-mediated transport | The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| protein localization to Golgi apparatus | A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6QR46 | RAB6B | Ras-related protein Rab-6B | Bos taurus (Bovine) | PR |
| Q5ZLG1 | RAB18 | Ras-related protein Rab-18 | Gallus gallus (Chicken) | PR |
| Q6IMM1 | DNAJC27 | DnaJ homolog subfamily C member 27 | Gallus gallus (Chicken) | PR |
| Q5ZKR4 | RABL3 | Rab-like protein 3 | Gallus gallus (Chicken) | PR |
| O18334 | Rab6 | Ras-related protein Rab6 | Drosophila melanogaster (Fruit fly) | PR |
| O95755 | RAB36 | Ras-related protein Rab-36 | Homo sapiens (Human) | PR |
| Q5JT25 | RAB41 | Ras-related protein Rab-41 | Homo sapiens (Human) | PR |
| Q9NRW1 | RAB6B | Ras-related protein Rab-6B | Homo sapiens (Human) | PR |
| Q9BZG1 | RAB34 | Ras-related protein Rab-34 | Homo sapiens (Human) | PR |
| P20340 | RAB6A | Ras-related protein Rab-6A | Homo sapiens (Human) | PR |
| P61294 | Rab6b | Ras-related protein Rab-6B | Mus musculus (Mouse) | PR |
| Q8CAM5 | Rab36 | Ras-related protein Rab-36 | Mus musculus (Mouse) | PR |
| P35279 | Rab6a | Ras-related protein Rab-6A | Mus musculus (Mouse) | PR |
| Q9WVB1 | Rab6a | Ras-related protein Rab-6A | Rattus norvegicus (Rat) | PR |
| P34213 | rab-6.1 | Ras-related protein rab-6.1 | Caenorhabditis elegans | PR |
| Q22782 | rab-6.2 | Ras-related protein rab-6.2 | Caenorhabditis elegans | PR |
| O80501 | RABH1B | Ras-related protein RABH1b | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFT9 | RABH1E | Ras-related protein RABH1e | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SMR4 | RABH1C | Ras-related protein RABH1c | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LV79 | RABH1A | Ras-related protein RABH1a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAGGDFGNP | LRKFKLVFLG | EQSVGKTSLI | TRFMYDSFDN | TYQATIGIDF | LSKTMYLEDR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TIRLQLWDTA | GQERFRSLIP | SYIRDSAAAV | VVYDITNVNS | FQQTTKWIDD | VRTERGSDVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IMLVGNKTDL | ADKRQVSIEE | GERKAKELNV | MFIETSAKAG | YNVKQLFRRV | AAALPGMEST |
| 190 | 200 | ||||
| QDKSREDMID | IKLEKPQEQP | VSEGGCSC |