Q1JPJ0

PR
Gene name
NDOR1
Protein name
NADPH-dependent diflavin oxidoreductase 1
Names
NADPH-dependent FMN and FAD-containing oxidoreductase
Species
Bos taurus (Bovine)
KEGG Pathway
bta:513873
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

153-241 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1JPJ0

Entry ID Method Resolution Chain Position Source
AF-Q1JPJ0-F1 Predicted AlphaFoldDB

260 variants for Q1JPJ0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs435543869 27 E>* No EVA
rs524108433 39 E>A No EVA
rs519082448 39 E>D No EVA
rs461987629 72 S>R No EVA
rs480491779 72 S>R No EVA
rs443404233 77 I>M No EVA
rs483121629 79 R>L No EVA
rs458139378 80 R>S No EVA
rs439597271 81 S>I No EVA
rs472611627 89 Q>E No EVA
rs454077559 90 M>I No EVA
rs442321917 91 D>V No EVA
rs475095903 96 G>A No EVA
rs456585015 99 D>G No EVA
rs438113048 104 K>* No EVA
rs443630278 107 F>L No EVA
rs476651047 112 L>R No EVA
rs458139914 129 L>R No EVA
rs378343025 139 D>E No EVA
rs472726015 143 D>H No EVA
rs460643053 145 W>G No EVA
rs442258688 146 L>V No EVA
rs475034506 147 Q>R No EVA
rs476310155 150 W>* No EVA
rs432739395 152 K>N No EVA
rs451200003 152 K>Q No EVA
rs466081301 153 V>E No EVA
rs466081301 153 V>G No EVA
rs447618711 157 H>P No EVA
rs435459230 157 H>Q No EVA
rs468410537 159 V>E No EVA
rs449825611 160 P>R No EVA
rs483191461 161 L>P No EVA
rs446008456 164 D>G No EVA
rs478846306 166 S>G No EVA
rs460352636 170 V>A No EVA
rs460352636 170 V>G No EVA
rs472215716 173 P>A No EVA
rs453715270 173 P>R No EVA
rs435488001 177 T>S No EVA
rs468450042 179 Q>E No EVA
rs456289683 180 F>L No EVA
rs464305159 182 K>R No EVA
rs446152149 184 T>P No EVA
rs478907723 184 T>S No EVA
rs481529791 189 P>R No EVA
rs463237738 192 L>V No EVA
rs444607951 193 C>G No EVA
rs477674477 195 A>G No EVA
rs459060555 197 T>A No EVA
rs439374672 198 D>A No EVA
rs441611659 211 A>P No EVA
rs474923158 212 P>H No EVA
rs437862655 213 M>I No EVA
rs456449146 213 M>V No EVA
rs380543961 215 S>N No EVA
rs452183393 220 T>R No EVA
rs466858860 221 G>W No EVA
rs481428484 222 P>R No EVA
rs477755542 231 I>F No EVA
rs459153687 234 D>A No EVA
rs447016701 236 S>P No EVA
rs460199366 238 S>F No EVA
rs441721562 239 G>W No EVA
rs460991039 248 V>A No EVA
rs475966159 249 L>Q No EVA
rs438863348 251 Q>K No EVA
rs471836637 251 Q>P No EVA
rs453315413 252 P>A No EVA
rs468024214 253 E>K No EVA
rs455939321 254 N>D No EVA
rs470386004 254 N>K No EVA
rs437350806 254 N>T No EVA
rs450527962 255 T>A No EVA
rs476904527 255 T>K No EVA
rs450527962 255 T>P No EVA
rs446361923 256 A>P No EVA
rs3423338224 258 H>Q No EVA
rs479535186 262 F>S No EVA
rs442695900 263 C>F No EVA
rs482103935 265 A>T No EVA
rs463559683 269 D>E No EVA
rs438921889 273 H>L No EVA
rs438921889 273 H>P No EVA
rs438921889 273 H>R No EVA
rs471849034 274 F>I No EVA
rs453332469 277 Q>K No EVA
rs441216200 277 Q>P No EVA
rs478324629 283 V>L No EVA
rs459807280 284 T>P No EVA
rs441327624 285 C>S No EVA
rs474237940 286 P>A No EVA
rs462154479 286 P>L No EVA
rs474237940 286 P>T No EVA
rs443937166 287 T>A No EVA
rs443937166 287 T>P No EVA
rs716353219 287 T>R No EVA
rs451813345 289 L>R No EVA
rs472588389 291 Q>E No EVA
rs434442352 291 Q>H No EVA
rs472588389 291 Q>K No EVA
rs452915420 291 Q>R No EVA
rs448826483 293 C>F No EVA
rs467381577 293 C>G No EVA
rs467381577 293 C>R No EVA
rs467381577 293 C>S No EVA
rs437081136 295 V>G No EVA
rs445070865 296 R>P No EVA
rs445475920 296 R>W No EVA
rs478033267 297 R>P No EVA
rs459521148 298 L>P No EVA
rs447834322 299 V>A No EVA
rs480744333 300 S>P No EVA
rs462132382 301 Q>* No EVA
rs443568832 301 Q>R No EVA
rs458308533 302 Y>C No EVA
rs476964959 302 Y>H No EVA
rs458308533 302 Y>S No EVA
rs472651777 303 L>R No EVA
rs439839064 303 L>V No EVA
rs473880321 304 D>A No EVA
rs455267136 304 D>E No EVA
rs473880321 304 D>G No EVA
rs434487056 304 D>N No EVA
rs469751266 305 I>M No EVA
rs436755648 305 I>N No EVA
rs436755648 305 I>T No EVA
rs451647970 306 A>P No EVA
rs433046170 307 S>G No EVA
rs466008997 307 S>R No EVA
rs480781279 308 V>A No EVA
rs480781279 308 V>G No EVA
rs447445395 308 V>L No EVA
rs468673011 313 F>C No EVA
rs450085543 314 F>S No EVA
rs483092681 316 L>R No EVA
rs439900612 317 L>P No EVA
rs479072972 318 A>P No EVA
rs442178029 320 L>P No EVA
rs455458688 321 S>P No EVA
rs443276191 322 P>L No EVA
rs476251896 323 H>D No EVA
rs386062746 323 H>Q No EVA
rs466021251 326 E>D No EVA
rs433060739 326 E>G No EVA
rs453950107 327 R>G No EVA
rs435343081 328 E>Q No EVA
rs382862404 331 W>G No EVA
rs382862404 331 W>R No EVA
rs483180695 337 R>G No EVA
rs715581725 337 R>Q No EVA
rs445958774 341 E>Q No EVA
rs479134354 345 Y>H No EVA
rs460644984 347 T>A No EVA
rs481696243 351 R>S No EVA
rs463111403 352 T>R No EVA
rs441914194 362 H>R No EVA
rs474859867 363 T>P No EVA
rs437721862 370 D>H No EVA
rs452518086 371 Y>C No EVA
rs470587171 371 Y>H No EVA
rs452518086 371 Y>S No EVA
rs434048058 374 D>A No EVA
rs448345210 376 L>P No EVA
rs469632499 379 I>L No EVA
rs451135283 379 I>T No EVA
rs445802244 399 I>F No EVA
rs478661575 399 I>T No EVA
rs460152542 402 A>P No EVA
rs441563238 405 Q>K No EVA
rs474943105 406 Y>S No EVA
rs462841969 408 T>P No EVA
rs444275255 412 E>G No EVA
rs470652277 427 P>H No EVA
rs452183228 428 A>G No EVA
rs440473401 429 Q>E No EVA
rs473443951 429 Q>H No EVA
rs440137855 431 P>H No EVA
rs473547171 432 V>A No EVA
rs442892397 433 R>P No EVA
rs475846115 435 P>A No EVA
rs457284730 436 L>P No EVA
rs432644115 438 V>L No EVA
rs453544434 440 S>F No EVA
rs448132128 443 L>M No EVA
rs468817007 446 P>R No EVA
rs450351604 447 K>* No EVA
rs477131428 448 T>S No EVA
rs458644785 449 P>A No EVA
rs440277390 449 P>L No EVA
rs461151624 450 D>A No EVA
rs479689147 450 D>Y No EVA
rs475902869 452 P>L No EVA
rs463772578 453 V>L No EVA
rs471776956 454 I>V No EVA
rs453654967 455 M>L No EVA
rs455877596 457 G>A No EVA
rs474453432 457 G>W No EVA
rs468878264 458 P>A No EVA
rs464775957 469 I>F No EVA
rs446756227 469 I>T No EVA
rs479715197 471 E>K No EVA
rs461104572 478 T>P No EVA
rs434698053 483 F>V No EVA
rs467654729 485 G>R No EVA
rs449066836 486 C>S No EVA
rs482043720 486 C>W No EVA
rs469973560 487 R>H No EVA
rs433967683 490 D>H No EVA
rs433967683 490 D>Y No EVA
rs459691495 491 Q>P No EVA
rs480998700 492 D>A No EVA
rs462486248 492 D>E No EVA
rs441167896 492 D>Y No EVA
rs443876639 496 E>A No EVA
rs451785689 497 A>S No EVA
rs471278893 498 E>A No EVA
rs452844561 499 W>G No EVA
rs452844561 499 W>R No EVA
rs434408133 500 E>G No EVA
rs467318067 501 Q>* No EVA
rs455667124 502 L>R No EVA
rs437085623 503 Q>L No EVA
rs437085623 503 Q>P No EVA
rs445002433 509 T>P No EVA
rs478324281 511 V>A No EVA
rs466250847 518 Q>R No EVA
rs483089956 521 K>* No EVA
rs458197643 522 V>L No EVA
rs439724779 526 H>P No EVA
rs1115090626 527 R>W No EVA
rs453008760 531 L>R No EVA
rs473867881 539 L>M No EVA
rs1116463897 541 G>S No EVA
rs455286690 542 R>G No EVA
rs458308598 551 N>D No EVA
rs446279542 551 N>K No EVA
rs460689237 553 K>Q No EVA
rs440899586 553 K>R No EVA
rs473854936 554 Y>D No EVA
rs461762247 557 A>P No EVA
rs443210013 559 V>L No EVA
rs476190345 560 C>* No EVA
rs451649045 563 L>P No EVA
rs433076550 570 E>Q No EVA
rs472472567 572 G>E No EVA
rs468613007 575 D>A No EVA
rs435690173 575 D>H No EVA
rs437983852 581 Y>S No EVA
rs446342860 587 R>G No EVA
rs479309459 588 T>I No EVA
rs480365764 591 F>Y No EVA
rs461873576 592 Q>K No EVA
rs443324495 593 T>P No EVA
rs476251976 595 T>R No EVA
rs457723868 596 W>G No EVA
rs439496765 596 W>S No EVA
rs472437177 597 A>P No EVA
rs453907696 598 A>G No EVA
rs453907696 598 A>R No EVA

No associated diseases with Q1JPJ0

No regional properties for Q1JPJ0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q1JPJ0

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, perinuclear region
  • Concentrated in perinuclear structure
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

8 GO annotations of molecular function

Name Definition
electron transfer activity Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
FMN binding Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
NADPH-hemoprotein reductase activity Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP.
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein.

3 GO annotations of biological process

Name Definition
cell death Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
cellular response to menadione Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position.
iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P29473 NOS3 Nitric oxide synthase, endothelial Bos taurus (Bovine) EV
Q9UBK8 MTRR Methionine synthase reductase Homo sapiens (Human) PR
Q9UHB4 NDOR1 NADPH-dependent diflavin oxidoreductase 1 Homo sapiens (Human) PR
A2AI05 Ndor1 NADPH-dependent diflavin oxidoreductase 1 Mus musculus (Mouse) PR
Q498R1 Mtrr Methionine synthase reductase Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MPSARLLVLF GSQTGTAQDV SERLGREARR RQLSCRVEEL DSYPVVNLIN EPLVIFVCAT
70 80 90 100 110 120
TGQGDPPDNM KSFWRFIFRR SLPSTALRQM DFAVLGLGDS SYAKFNFVAK KLHRRLLQLG
130 140 150 160 170 180
GSALLPVCLG DDQHELGPDA AIDPWLQDLW EKVLGPHPVP LNLDLSPPGV LWPSKFTLQF
190 200 210 220 230 240
LKDTPSSGPE ELCAAGTDPQ GPPSELQPFL APMVSNQRVT GPSHFQDVRL IEFDISGSGI
250 260 270 280 290 300
SFAAGDLVLI QPENTASHVQ QFCQALGLDP EQHFTLQPRE PGVTCPTRLP QPCSVRRLVS
310 320 330 340 350 360
QYLDIASVPR RSFFELLACL SPHELEREKL WEFGSARGQE ELCEYCTRPR RTALEVLCDF
370 380 390 400 410 420
PHTAAAVPPD YLLDLLPLIR PRAFSIASSL RAHPSRLQIL VAVVQYQTRL REPRRGLCSS
430 440 450 460 470 480
WLASLDPAQG PVRVPLWVRS GGLTFPKTPD VPVIMVGPGT GVAPFRAAIQ ERVAQGETGN
490 500 510 520 530 540
VLFFGCRRRD QDFYWEAEWE QLQARGCLTL VTAFSREQEQ KVYVQHRLRA LGPLVWELLD
550 560 570 580 590
GRGAHFYLAG NAKYMPADVC DTLLSIFREE GGLSDPDAAA YLAQLQRTLR FQTETWA