Q1HG70
Gene name |
MAP2K2 (MEK2) |
Protein name |
Dual specificity mitogen-activated protein kinase kinase 2 |
Names |
MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2 |
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:611939 |
EC number |
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
Protein Class |
|
Descriptions
(Annotation based on sequence homology with P36507)
MAP2K2 encodes for Dual specificity mitogen-activated protein kinase kinase 2, belongs to MAP2Ks family, plays an important role in MAP kinase signal transduction pathway. The autoinhibitory state of MAP2K2 is more stable as dimer in the absence of its own substrates or other interacting partners. The several interactions span from the N-terminal to the C-terminal to form dimer. Dimerization of MAP2K2 blocks access to the substrate binding site and the activation loop from macromolecules. MAP2K2 has high sequence similarity with MAP2K1, and the same mechanism of autoinhibition.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
211-232 (Activation loop from InterPro)
Target domain |
72-369 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q1HG70
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q1HG70-F1 | Predicted | AlphaFoldDB |
No variants for Q1HG70
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q1HG70 | |||||
No associated diseases with Q1HG70
No regional properties for Q1HG70
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q1HG70 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.12.2 | Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase activity | Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q90891 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Gallus gallus (Chicken) | PR |
| Q24324 | Dsor1 | Dual specificity mitogen-activated protein kinase kinase dSOR1 | Drosophila melanogaster (Fruit fly) | PR |
| P36507 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens (Human) | EV |
| Q63932 | Map2k2 | Dual specificity mitogen-activated protein kinase kinase 2 | Mus musculus (Mouse) | PR |
| P36506 | Map2k2 | Dual specificity mitogen-activated protein kinase kinase 2 | Rattus norvegicus (Rat) | SS |
| Q5QN75 | MKK1 | Mitogen-activated protein kinase kinase 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q10664 | mek-2 | Dual specificity mitogen-activated protein kinase kinase mek-2 | Caenorhabditis elegans | PR |
| Q9FJV0 | MKK6 | Mitogen-activated protein kinase kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9S7U9 | MKK2 | Mitogen-activated protein kinase kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94A06 | MKK1 | Mitogen-activated protein kinase kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLARRKPVLP | ALTINPAIAE | GPSPTSEGAS | EANLVDLQKK | LAELELDEQQ | KKRLEAFLTQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KAKVGELKDD | DFERISELGA | GNGGVVTKVQ | HRPSGLIMAR | KLIHLEIKPA | IRNQIIRELQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLHECNSPYI | VGFYGAFYSD | GEISICMEHM | DGGSLDQVLK | EAKRIPEEIL | GKVSIAVLRG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAYLREKHQI | MHRDVKPSNI | LVNSRGEIKL | CDFGVSGQLI | DSMANSFVGT | RSYMSPERLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GTHYSVQSDI | WSMGLSLVEL | SIGRYPIPPP | DAKELEAIFG | RPMVDGIEGE | PHSISPRPRP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PGRPISGHGT | DSRPAMAIFE | LLDYIVNEPP | PKLPNGVFTQ | DFQEFVNKCL | IKNPAERADL |
| 370 | 380 | 390 | |||
| KMLMSHTFIK | RSEVEEVDFA | GWLCKTLRLN | QPSTPTRTAV |