Q1ECX4

PR
Gene name
tlk2
Protein name
Serine/threonine-protein kinase tousled-like 2
Names
PKU-alpha, Tousled-like kinase 2
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:407732
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

247-399 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1ECX4

Entry ID Method Resolution Chain Position Source
AF-Q1ECX4-F1 Predicted AlphaFoldDB

No variants for Q1ECX4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1ECX4

No associated diseases with Q1ECX4

11 regional properties for Q1ECX4

Type Name Position InterPro Accession
domain B-box-type zinc finger 84 - 125 IPR000315
domain Zinc finger, RING-type 16 - 57 IPR001841
domain B30.2/SPRY domain 275 - 474 IPR001870
domain SPRY domain 345 - 473 IPR003877
domain Butyrophylin-like, SPRY domain 291 - 308 IPR003879-1
domain Butyrophylin-like, SPRY domain 330 - 354 IPR003879-2
domain Butyrophylin-like, SPRY domain 360 - 373 IPR003879-3
domain Butyrophylin-like, SPRY domain 404 - 428 IPR003879-4
domain SPRY-associated 292 - 344 IPR006574
conserved_site Zinc finger, RING-type, conserved site 31 - 40 IPR017907
domain Zinc finger, RING-type, eukaryotic 16 - 54 IPR027370

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Nucleus, nucleoplasm
  • Cytoplasm, perinuclear region
  • Cytoplasm, cytoskeleton
  • Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle (By similarity)
  • Present in the perinuclear region at S phase and in the nucleus at late G2 (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08CW1 tlk2 Serine/threonine-protein kinase tousled-like 2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q8AYG3 ttk Dual specificity protein kinase Ttk Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MMEELHSLDP RRQELLEARF TGVGVAKGSG HNESSNQSLC SVGSLSDKEL ETPEKKSNDQ
70 80 90 100 110 120
RTRKRKGDPF DSQGKGGGRG HKISDYFEFA GGSGTGTSPA RGIPPVARSS PQHSLSNPPA
130 140 150 160 170 180
AVQQGSPSSI SSVNTDHSHT STSHKPASIH TQHRASQSEL TMEKLAALES SKSSDLEKKE
190 200 210 220 230 240
GRIDDLLRVN CDLRRQIDEQ QKMLEWCKER LNKCVTMSKK LLIEKSKQEK IACREKSMQD
250 260 270 280 290 300
RLRLGHFTTV RHGASFTEQW TDGYAFQNLV KQQERVNGQR EEIERQRKLL IKKKPPSASQ
310 320 330 340 350 360
TPPPNLEPNK RKSKSNGAEN EMLSLAEYHE QEEIFKLRLG HLKKEEAEIQ VELERLERVR
370 380 390 400 410 420
NLHIRELKRI HNEDNSQFKD HPTLNDRYLL LHLLGRGGFS EVYKAFDLTE QRYVAVKIHQ
430 440 450 460 470 480
LNKNWRDEKK ENYHKHACRE YRIHKELDHP RIVKLYDYFS LDTDSFCTVL EYCEGNDLDF
490 500 510 520 530 540
YLKQHKLMSE KEARSIIMQV VNALKYLNEI RPPIIHYDLK PGNILLVNGT ACGEIKITDF
550 560 570 580 590 600
GLSKIMDDDN YGVDGMELTS QGAGTYWYLP PECFVVGKEP PKISNKVDVW SVGVIFYQCL
610 620 630 640 650 660
YGKKPFGHNQ SQQDILQENT ILKATEVQFP PKPGVSPEAK AFIRRCLVYR KEDRIDVHQL
670 680 690
ASDPYLLPHI RKSVAATGNS SMAVASTSNS SNSSASN