Q18846

PR
Gene name
rskn-2 (C54G4.1)
Protein name
Putative ribosomal protein S6 kinase alpha-2
Names
Ribosomal protein S6 kinase alpha-5 homolog
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

520-552 (Activation loop from InterPro)

Target domain

382-653 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q18846

Entry ID Method Resolution Chain Position Source
AF-Q18846-F1 Predicted AlphaFoldDB

No variants for Q18846

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q18846

No associated diseases with Q18846

8 regional properties for Q18846

Type Name Position InterPro Accession
domain Protein kinase domain 17 - 284 IPR000719-1
domain Protein kinase domain 382 - 653 IPR000719-2
domain AGC-kinase, C-terminal 285 - 353 IPR000961
active_site Serine/threonine-protein kinase, active site 141 - 153 IPR008271-1
active_site Serine/threonine-protein kinase, active site 496 - 508 IPR008271-2
binding_site Protein kinase, ATP binding site 23 - 49 IPR017441-1
binding_site Protein kinase, ATP binding site 388 - 411 IPR017441-2
domain Protein kinase, C-terminal 307 - 343 IPR017892

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P18652 RPS6KA Ribosomal protein S6 kinase 2 alpha Gallus gallus (Chicken) SS
Q5F3L1 RPS6KA5 Ribosomal protein S6 kinase alpha-5 Gallus gallus (Chicken) SS
Q9UK32 RPS6KA6 Ribosomal protein S6 kinase alpha-6 Homo sapiens (Human) SS
Q96S38 RPS6KC1 Ribosomal protein S6 kinase delta-1 Homo sapiens (Human) PR
P51812 RPS6KA3 Ribosomal protein S6 kinase alpha-3 Homo sapiens (Human) EV
Q15349 RPS6KA2 Ribosomal protein S6 kinase alpha-2 Homo sapiens (Human) SS
Q15418 RPS6KA1 Ribosomal protein S6 kinase alpha-1 Homo sapiens (Human) EV
O75676 RPS6KA4 Ribosomal protein S6 kinase alpha-4 Homo sapiens (Human) SS
O75582 RPS6KA5 Ribosomal protein S6 kinase alpha-5 Homo sapiens (Human) SS
Q9WUT3 Rps6ka2 Ribosomal protein S6 kinase alpha-2 Mus musculus (Mouse) SS
P18654 Rps6ka3 Ribosomal protein S6 kinase alpha-3 Mus musculus (Mouse) SS
Q8BLK9 Rps6kc1 Ribosomal protein S6 kinase delta-1 Mus musculus (Mouse) PR
P18653 Rps6ka1 Ribosomal protein S6 kinase alpha-1 Mus musculus (Mouse) SS
Q9Z2B9 Rps6ka4 Ribosomal protein S6 kinase alpha-4 Mus musculus (Mouse) SS
Q8C050 Rps6ka5 Ribosomal protein S6 kinase alpha-5 Mus musculus (Mouse) PR
Q63531 Rps6ka1 Ribosomal protein S6 kinase alpha-1 Rattus norvegicus (Rat) SS
Q21734 rskn-1 Putative ribosomal protein S6 kinase alpha-1 Caenorhabditis elegans SS
10 20 30 40 50 60
MEDILMPEGE KVSMENFALL RVLGKGAYGK VFLVRKVGGK DHNTIYAMKV LRKTRVLTKQ
70 80 90 100 110 120
KTLEHTMAER QVLERLRGTP FLVNLFYAFQ TDTKLHIVME YVRGGELFTH LCSRGHFDLE
130 140 150 160 170 180
AARFVIAELV VAIDSLHQRK VIYRDLKLEN ILLDEEGHVK LTDFGLSKLF LPGELDRANS
190 200 210 220 230 240
YCGTIEYMSP EVINRPEGGY SDVVDWWSLG VISFELLTGC SPFTVDGAQN SSKDIAKRIM
250 260 270 280 290 300
TKKVPFPKTM DVDARDFIGQ LLEKKLEKRL GYNGVDEIKN HKFMSSIDWD AAVKRTLKPV
310 320 330 340 350 360
IVPRIGHDLD TQFFSAEFTS QPPLYSPAES PLNANTLFRG YSYVSPSVIF ANDNVIGEEL
370 380 390 400 410 420
MAEDVNALLA SSSFFAKYKL DKSDAGLLGK GAFSVVRRCE RVVDGAQFAV KIVSQKFASQ
430 440 450 460 470 480
AQREARILEM VQGHPNIVQL HDVHSDPLHF YLVMEILTGN ELLERIRKLE RFTESEAADI
490 500 510 520 530 540
MRQLVSAVKY LHDKRIVHRD LKPENILFES IDSSARLRLV DFGFARLLPN SMEQQLKSVQ
550 560 570 580 590 600
VLRKMTPCFT LQYAAPEVLD VGDSQPEYNE QCDLWSLGVV LFTMLSGQVP FHARSRQESA
610 620 630 640 650 660
TEIMQRICRA EFSFTGDAWT NVSADAKNLI TGLLTVDPKK RLSMQELTAH MWLKSSASMD
670 680 690 700 710 720
TPLQTPSILP SSADETFNET LRAFLHANRD GFHLLDVAAA PLMKRRGIKR QSGDKDASGN
730 740 750 760 770
SKNSRVTQFE CLPEEQEAEM TSSTSRPSNL GMMNYREPNS GTIRETRGSD SS