Q18439
Gene name |
nas-8 (C34D4.9) |
Protein name |
Zinc metalloproteinase nas-8 |
Names |
Nematode astacin 8 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C34D4.9 |
EC number |
3.4.24.21: Metalloendopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q18439
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q18439-F1 | Predicted | AlphaFoldDB |
No variants for Q18439
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q18439 | |||||
No associated diseases with Q18439
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.24.21 | Metalloendopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
21 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9DER7 | TLL1 | Tolloid-like protein 1 | Gallus gallus (Chicken) | PR |
| P25723 | tld | Dorsal-ventral patterning protein tolloid | Drosophila melanogaster (Fruit fly) | PR |
| O43897 | TLL1 | Tolloid-like protein 1 | Homo sapiens (Human) | PR |
| P98066 | TNFAIP6 | Tumor necrosis factor-inducible gene 6 protein | Homo sapiens (Human) | PR |
| P13497 | BMP1 | Bone morphogenetic protein 1 | Homo sapiens (Human) | PR |
| Q9Y6L7 | TLL2 | Tolloid-like protein 2 | Homo sapiens (Human) | PR |
| P98063 | Bmp1 | Bone morphogenetic protein 1 | Mus musculus (Mouse) | PR |
| Q9WVM6 | Tll2 | Tolloid-like protein 2 | Mus musculus (Mouse) | PR |
| O08859 | Tnfaip6 | Tumor necrosis factor-inducible gene 6 protein | Mus musculus (Mouse) | PR |
| Q62381 | Tll1 | Tolloid-like protein 1 | Mus musculus (Mouse) | PR |
| Q6HA09 | Astl | Astacin-like metalloendopeptidase | Mus musculus (Mouse) | PR |
| P55112 | nas-4 | Zinc metalloproteinase nas-4 | Caenorhabditis elegans | PR |
| P55113 | nas-7 | Zinc metalloproteinase nas-7 | Caenorhabditis elegans | PR |
| P55115 | nas-15 | Zinc metalloproteinase nas-15 | Caenorhabditis elegans | PR |
| Q20176 | nas-39 | Zinc metalloproteinase nas-39 | Caenorhabditis elegans | PR |
| Q20942 | nas-38 | Zinc metalloproteinase nas-38 | Caenorhabditis elegans | PR |
| Q21252 | nas-3 | Zinc metalloproteinase nas-3 | Caenorhabditis elegans | PR |
| Q9U3S9 | nas-6 | Zinc metalloproteinase nas-6 | Caenorhabditis elegans | PR |
| O62243 | nas-1 | Zinc metalloproteinase nas-1 | Caenorhabditis elegans | PR |
| Q22398 | nas-22 | Zinc metalloproteinase nas-22 | Caenorhabditis elegans | PR |
| O57460 | tll1 | Dorsal-ventral patterning tolloid-like protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRRNDLLNNK | ITIFLSSLSL | FVIIIPIYAA | EKDLLPPSTS | SETFLTDEDF | LRPLNDDETF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTEKDFKNGE | KLGEDHVPAG | SILWKQVYKK | GDIRGKAAWK | LDPKNSESLR | RNGVITGTRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WPNGRIPYVI | SNQYNDRERA | VLARSFQAYH | DKTCVRFVPR | TAVDNDYLYI | GKIDGCYSDV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GRAGGRQELS | LDNGCLQYDT | AIHELMHSVG | FYHEHERWDR | DEHITILWHN | IDREAYDQFG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KVDLAESSYY | GQLYDYYSIM | HYDSLAFSKN | GFETMVAKQS | EMTAVIGAAI | DFSPIDILKM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLMYQCSDVK | LPPTVVGTTD | KTIVPVPAPS | VTVVEDDCRD | RTNLCWRWID | RCKSFFFEQI |
| 370 | 380 | 390 | 400 | ||
| MKEFCSLSCG | YCTPKALQTA | KASPPNYSNT | LLTKSSTSYL | QHG |