Q18331
PR
Gene name |
gcy-11 |
Protein name |
Receptor-type guanylate cyclase gcy-11 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
|
EC number |
4.6.1.2: Phosphorus-oxygen lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q18331
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q18331-F1 | Predicted | AlphaFoldDB |
No variants for Q18331
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q18331 | |||||
No associated diseases with Q18331
Functions
| Description | ||
|---|---|---|
| EC Number | 4.6.1.2 | Phosphorus-oxygen lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| guanylate cyclase activity | Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. |
| metal ion binding | Binding to a metal ion. |
| peptide receptor activity | Combining with an extracellular or intracellular peptide to initiate a change in cell activity. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cGMP biosynthetic process | The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| receptor guanylyl cyclase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P46197 | NPR2 | Atrial natriuretic peptide receptor 2 | Bos taurus (Bovine) | PR |
| O02740 | GUCY2F | Retinal guanylyl cyclase 2 | Bos taurus (Bovine) | PR |
| P51841 | GUCY2F | Retinal guanylyl cyclase 2 | Homo sapiens (Human) | PR |
| Q02846 | GUCY2D | Retinal guanylyl cyclase 1 | Homo sapiens (Human) | PR |
| P20594 | NPR2 | Atrial natriuretic peptide receptor 2 | Homo sapiens (Human) | PR |
| P52785 | Gucy2e | Retinal guanylyl cyclase 1 | Mus musculus (Mouse) | PR |
| Q6VVW5 | Npr2 | Atrial natriuretic peptide receptor 2 | Mus musculus (Mouse) | PR |
| Q5SDA5 | Gucy2f | Retinal guanylyl cyclase 2 | Mus musculus (Mouse) | PR |
| P51840 | Gucy2e | Retinal guanylyl cyclase 1 | Rattus norvegicus (Rat) | PR |
| P18910 | Npr1 | Atrial natriuretic peptide receptor 1 | Rattus norvegicus (Rat) | PR |
| P16067 | Npr2 | Atrial natriuretic peptide receptor 2 | Rattus norvegicus (Rat) | PR |
| P51842 | Gucy2f | Retinal guanylyl cyclase 2 | Rattus norvegicus (Rat) | PR |
| Q09435 | gcy-1 | Receptor-type guanylate cyclase gcy-1 | Caenorhabditis elegans | PR |
| Q10029 | gcy-2 | Receptor-type guanylate cyclase gcy-2 | Caenorhabditis elegans | PR |
| Q23682 | gcy-5 | Receptor-type guanylate cyclase gcy-5 | Caenorhabditis elegans | PR |
| O16544 | gcy-19 | Receptor-type guanylate cyclase gcy-19 | Caenorhabditis elegans | PR |
| X5M8U1 | gcy-17 | Receptor-type guanylate cyclase gcy-17 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPCREIFLLW | ILVPIASSSD | HITFFGRYAC | NVDFKTDYCT | PDTYVGRAFY | YGLEDGGGIT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TNGTFVNSDI | TVEFFDPTVQ | GNFSIGRQDG | NYMSSMLDIM | LADTKKNDGL | LGVVGVENDC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KEIAALAQAY | DASSLLVNCE | DQVGESQMPS | STALQMSSTQ | GGKYRAFAKL | AKSVGWNNLA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VINFVEDGPA | DISYHDQLLD | ALSAESISLD | FVKKGGFSST | ITSAMFTGLE | SVIDVILETY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MKTRIYVIVL | DLPVSGTFFM | NAMSTMGLLE | TGKYFVVMMS | SIESDAANYF | GFNVNRGNMI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FKTIDYGISD | ADIRQYYRSF | MYFTDVPHYT | KDFSDEWTSF | QKRVDGDASK | TFCPPMCNTK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AKGIANNDPW | SDDAYWYSES | PSIVDAYDLG | RLLSETVKVH | GASLLRDPES | LVQTMSGRGV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TSLLGYVTKF | NTNGVSQREY | ILWAPQQASS | SNGPIPLPEW | ATLAARMLPD | GKGNYSIIWK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NLTQLGIFNG | ELPQSKPECG | FNNELCPAGI | RNLSELEIIV | IAVCVVAILI | LVGVIAYIAR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WIAYERRLES | SYFLVHRKHV | QLVDMTKFGS | SRGGSMIQSA | MSMRSQYEDS | GPVGGATMNF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YTNGIRKAAI | RRNQMQRSDK | GPAANRDEWL | EIVDWHLAKY | ENTLVTVRKI | NKTQLKLTRE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MKQEIDLLMN | ETHENLNRFF | GLINESDLIF | TIHSYGPRKS | LMDLLRNDDL | RLDRMFKVSF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VEDVVKGLQF | LHEGSKIGYH | GNLKSSNCIV | DAYWRIKLSN | YGMEQIRVEE | PESKPDDLLW |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FAPEIIRRYA | VKHDLSKLEL | AKADIYSLAI | VLYEIYGRQG | PFGDDLLDSD | EIIEQLKFPD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GGALTRPDIH | LITKAPYPLA | SVVEKCWVED | PASRPSIKKV | RELLKPLSKG | LKGNIADNIM |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NLLDRYRNNL | EDVIKERTEQ | LEDERKRNES | LLLQLLPKSV | ANSLKNGQPV | DAEFYDSVSI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| YFSDIVGFTA | LSSKSTPLQV | VNMLNNLYTN | FDTIIDKFDC | YKVETIGDAY | MFVSGLPEVN |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SYLHAGEVAS | ASLELLDSIK | TFTVSHCPDE | KLRLRIGNHT | GPVVTGVVGI | RMPRYCLFGD |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| TVIIANMMES | SGEPMRIQIS | SDAYELILKC | GGYVTEQREK | IVLKNKLEVM | TYWMNDYSKD |
| 1150 | 1160 | ||||
| ARLARLVAHQ | EKFPHLEHLI | HKFNKGVR |