Q18212
PR
Gene name |
hel-1 |
Protein name |
Spliceosome RNA helicase DDX39B homolog |
Names |
DEAD box protein UAP56 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C26D10.2 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q18212
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q18212-F1 | Predicted | AlphaFoldDB |
No variants for Q18212
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q18212 | |||||
No associated diseases with Q18212
4 regional properties for Q18212
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
| transcription regulator complex | A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| transcription factor binding | Binding to a transcription factor, a protein required to initiate or regulate transcription. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| nuclear mRNA surveillance | A process that identifies and degrades defective or aberrant mRNAs within the nucleus. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q07478 | SUB2 | ATP-dependent RNA helicase SUB2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3T147 | DDX39B | Spliceosome RNA helicase DDX39B | Bos taurus (Bovine) | PR |
| Q5ZHZ0 | DDX39B | Spliceosome RNA helicase DDX39B | Gallus gallus (Chicken) | PR |
| P60024 | DDX39B | Spliceosome RNA helicase DDX39B | Pan troglodytes (Chimpanzee) | PR |
| Q5WR10 | DDX39B | Spliceosome RNA helicase DDX39B | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| O00148 | DDX39A | ATP-dependent RNA helicase DDX39A | Homo sapiens (Human) | PR |
| Q13838 | DDX39B | Spliceosome RNA helicase DDX39B | Homo sapiens (Human) | PR |
| Q9Z1N5 | Ddx39b | Spliceosome RNA helicase Ddx39b | Mus musculus (Mouse) | PR |
| Q8VDW0 | Ddx39a | ATP-dependent RNA helicase DDX39A | Mus musculus (Mouse) | PR |
| Q29024 | DDX39B | Spliceosome RNA helicase DDX39B | Sus scrofa (Pig) | PR |
| Q5U216 | Ddx39a | ATP-dependent RNA helicase DDX39A | Rattus norvegicus (Rat) | PR |
| Q63413 | Ddx39b | Spliceosome RNA helicase Ddx39b | Rattus norvegicus (Rat) | PR |
| Q5TM17 | DDX39B | Spliceosome RNA helicase DDX39B | Macaca mulatta (Rhesus macaque) | PR |
| Q5JK84 | AIP2 | DEAD-box ATP-dependent RNA helicase 15 | Oryza sativa subsp japonica (Rice) | PR |
| Q0JM17 | AIP1 | DEAD-box ATP-dependent RNA helicase 56 | Oryza sativa subsp japonica (Rice) | PR |
| O01836 | glh-3 | ATP-dependent RNA helicase glh-3 | Caenorhabditis elegans | PR |
| D0PV95 | laf-1 | ATP-dependent RNA helicase laf-1 | Caenorhabditis elegans | SS |
| Q56XG6 | RH15 | DEAD-box ATP-dependent RNA helicase 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFN6 | RH56 | DEAD-box ATP-dependent RNA helicase 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEEQLLDYE | EEQEEIQDKQ | PEVGGGDARK | TKGTYASIHS | SGFRDFLLKP | EILRAIGDCG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FEHPSEVQHE | CIPQAILGMD | VVCQAKSGMG | KTAVFVITTL | QQLEPVDGEV | SVVCMCHTRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LAFQISKEYE | RFSKYLPGVK | VAVFFGGMAI | KKDEERLAND | CPHIVVGTPG | RMLALARSGK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKLDKVKYFV | LDECDKMIGD | ADMRRDVQEI | VKMTPQQKQV | MMFSATLPKE | LRTVCKRFMQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DPMEVYVDDE | AKLTLHGLQQ | HYVKLKEAEK | NRRLLNLLDA | LEFNQVVIFV | KAVKRCEALH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QLLTEQNFPS | IAIHRQMAQE | ERLSRYQAFK | DFQKRILVAT | DLFGRGMDIE | RVNIVFNYDM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEDSDSYLHR | VARAGRFGTK | GLAITFVSDE | NDAKTLNSVQ | DRFDISITEL | PEKIDVSTYI |
| EGRTN |