Q17QI8
PR
Gene name |
Rhov |
Protein name |
Rho-related GTP-binding protein RhoV |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:538143 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q17QI8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q17QI8-F1 | Predicted | AlphaFoldDB |
43 variants for Q17QI8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs446807624 | 2 | P>T | No | EVA | |
| rs479850305 | 3 | P>R | No | EVA | |
| rs467708927 | 5 | E>D | No | EVA | |
| rs449182323 | 8 | E>G | No | EVA | |
| rs482041622 | 10 | E>G | No | EVA | |
| rs463574627 | 11 | S>A | No | EVA | |
| rs473594638 | 24 | G>C | No | EVA | |
| rs443061937 | 29 | E>A | No | EVA | |
| rs475877262 | 37 | V>G | No | EVA | |
| rs457384298 | 40 | G>V | No | EVA | |
| rs465468461 | 41 | A>V | No | EVA | |
| rs453369597 | 42 | V>G | No | EVA | |
| rs434812130 | 44 | K>N | No | EVA | |
| rs467745757 | 46 | S>G | No | EVA | |
| rs449270189 | 47 | L>I | No | EVA | |
| rs482135312 | 55 | G>R | No | EVA | |
| rs470039127 | 56 | Y>S | No | EVA | |
| rs459420623 | 62 | P>S | No | EVA | |
| rs480046780 | 63 | T>K | No | EVA | |
| rs440876841 | 63 | T>P | No | EVA | |
| rs440876841 | 63 | T>S | No | EVA | |
| rs475916131 | 66 | D>A | No | EVA | |
| rs457635316 | 69 | S>P | No | EVA | |
| rs458279428 | 79 | V>G | No | EVA | |
| rs439666397 | 81 | I>M | No | EVA | |
| rs479124987 | 82 | E>D | No | EVA | |
| rs444263152 | 91 | D>E | No | EVA | |
| rs470760147 | 96 | R>S | No | EVA | |
| rs452209517 | 102 | D>G | No | EVA | |
| rs433693482 | 112 | V>L | No | EVA | |
| rs454534756 | 127 | P>A | No | EVA | |
| rs481506725 | 130 | R>S | No | EVA | |
| rs435929919 | 143 | T>P | No | EVA | |
| rs450282875 | 151 | V>G | No | EVA | |
| rs438215486 | 160 | G>R | No | EVA | |
| rs477252722 | 164 | G>D | No | EVA | |
| rs460428335 | 166 | V>A | No | EVA | |
| rs448441731 | 168 | Q>H | No | EVA | |
| rs137334192 | 191 | Q>H | No | EVA | |
| rs133163659 | 192 | K>N | No | EVA | |
| rs134348329 | 196 | E>D | No | EVA | |
| rs134173534 | 212 | L>P | No | EVA | |
| rs132814418 | 213 | E>G | No | EVA |
No associated diseases with Q17QI8
1 regional properties for Q17QI8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 32 - 199 | IPR005225 |
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome membrane | The lipid bilayer surrounding an endosome. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| metal ion binding | Binding to a metal ion. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| Cdc42 protein signal transduction | The series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| establishment or maintenance of cell polarity | Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. |
36 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P61585 | RHOA | Transforming protein RhoA | Bos taurus (Bovine) | PR |
| Q1RMJ6 | RHOC | Rho-related GTP-binding protein RhoC | Bos taurus (Bovine) | PR |
| Q2HJ68 | RND1 | Rho-related GTP-binding protein Rho6 | Bos taurus (Bovine) | PR |
| Q3ZBW5 | RHOB | Rho-related GTP-binding protein RhoB | Bos taurus (Bovine) | PR |
| Q9PSX7 | RHOC | Rho-related GTP-binding protein RhoC | Gallus gallus (Chicken) | PR |
| P48148 | Rho1 | Ras-like GTP-binding protein Rho1 | Drosophila melanogaster (Fruit fly) | PR |
| P62745 | RHOB | Rho-related GTP-binding protein RhoB | Homo sapiens (Human) | PR |
| P08134 | RHOC | Rho-related GTP-binding protein RhoC | Homo sapiens (Human) | PR |
| Q92730 | RND1 | Rho-related GTP-binding protein Rho6 | Homo sapiens (Human) | PR |
| O94844 | RHOBTB1 | Rho-related BTB domain-containing protein 1 | Homo sapiens (Human) | PR |
| P61587 | RND3 | Rho-related GTP-binding protein RhoE | Homo sapiens (Human) | PR |
| O94955 | RHOBTB3 | Rho-related BTB domain-containing protein 3 | Homo sapiens (Human) | EV |
| P61586 | RHOA | Transforming protein RhoA | Homo sapiens (Human) | PR |
| Q96L33 | RHOV | Rho-related GTP-binding protein RhoV | Homo sapiens (Human) | PR |
| Q62159 | Rhoc | Rho-related GTP-binding protein RhoC | Mus musculus (Mouse) | PR |
| Q8BLR7 | Rnd1 | Rho-related GTP-binding protein Rho6 | Mus musculus (Mouse) | PR |
| Q9QUI0 | Rhoa | Transforming protein RhoA | Mus musculus (Mouse) | PR |
| P61588 | Rnd3 | Rho-related GTP-binding protein RhoE | Mus musculus (Mouse) | PR |
| Q9DAK3 | Rhobtb1 | Rho-related BTB domain-containing protein 1 | Mus musculus (Mouse) | PR |
| Q9CTN4 | Rhobtb3 | Rho-related BTB domain-containing protein 3 | Mus musculus (Mouse) | SS |
| P62746 | Rhob | Rho-related GTP-binding protein RhoB | Mus musculus (Mouse) | PR |
| Q8VDU1 | Rhov | Rho-related GTP-binding protein RhoV | Mus musculus (Mouse) | PR |
| O77683 | RND3 | Rho-related GTP-binding protein RhoE | Sus scrofa (Pig) | PR |
| Q6SA80 | Rnd3 | Rho-related GTP-binding protein RhoE | Rattus norvegicus (Rat) | PR |
| P62747 | Rhob | Rho-related GTP-binding protein RhoB | Rattus norvegicus (Rat) | PR |
| P61589 | Rhoa | Transforming protein RhoA | Rattus norvegicus (Rat) | PR |
| Q9Z1Y0 | Rhov | Rho-related GTP-binding protein RhoV | Rattus norvegicus (Rat) | PR |
| Q9SSX0 | RAC1 | Rac-like GTP-binding protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z808 | RAC3 | Rac-like GTP-binding protein 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q68Y52 | RAC2 | Rac-like GTP-binding protein 2 | Oryza sativa subsp japonica (Rice) | PR |
| Q67VP4 | RAC4 | Rac-like GTP-binding protein 4 | Oryza sativa subsp japonica (Rice) | PR |
| Q22038 | rho-1 | Ras-like GTP-binding protein rhoA | Caenorhabditis elegans | PR |
| Q9SU67 | ARAC8 | Rac-like GTP-binding protein ARAC8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O82480 | ARAC7 | Rac-like GTP-binding protein ARAC7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38903 | ARAC2 | Rac-like GTP-binding protein ARAC2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O82481 | ARAC10 | Rac-like GTP-binding protein ARAC10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPPRELSEAE | SSPLRSPTPP | PGRGSASPEL | GIKCVLVGDG | AVGKSSLIVS | YTCNGYPARY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RPTALDTFSV | QVLVDGAPVR | IELWDTAGQE | DLDRLRSLCY | PDTDVFLACF | SVVQPSSFQN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ITEKWLPEIR | THNPQAPVLL | VGTQADLRDD | VNVLIQLDQG | GREGPVPQPQ | AQGLAEKIRA |
| 190 | 200 | 210 | 220 | 230 | |
| CCYLECSALT | QKNLKEVFDS | AILSAIEHKA | RLEKKLNAKG | VRTLSRCRWK | KFFCFV |