AiPD: Autoinhibited Protein Database

Q16584

Gene name	MAP3K11
Protein name	Mitogen-activated protein kinase kinase kinase 11
Names	Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4296
EC number	2.7.11.25: Protein-serine/threonine kinases
Protein Class	SERINE-THREONINE PROTEIN KINASE (PTHR23257)

Descriptions

Mixed lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates the c-Jun N-terminal kinase (JNK) pathway through the dual phosphorylation of mitogen-activated protein kinase kinases 4/7 (MKK4/7). The catalytic domain of MLK3 is flanked by an N-terminal SH3 domain and a centrally located zipper and Cdc42/Rac-interactive binding (CRIB) motif. Zipper-mediated homo-oligomerization is required for full activity of MLK3, proper substrate phosphorylation, and activation of the JNK pathway. MLK3 is autoinhibited through an interaction between its SH3 domain and a proline-containing sequence between the zipper and the CRIB motif. Activated forms of the small GTPases Cdc42 and Rac interact with MLK3 in a CRIB motif-dependent manner to increase the autophosphorylation of MLK3 and substrate phosphorylation activity and to potentiate MLK3-induced activation of JNK. Activated Cdc42 translocates MLK3 to membranes and induces activation loop phosphorylation of MLK3.

Autoinhibitory domains (AIDs)

Target domain	463-485 (Proline-rich region)
Relief mechanism	Partner binding
Assay	Mutagenesis experiment, Deletion assay, Structural analysis

AID

41-105 (SH3 domain)

Target domain

463-485 (Proline-rich region)

Relief mechanism

Partner binding (Cdc42 binding)

Assay

Mutagenesis experiment, Deletion assay, Structural analysis

Accessory elements

266-287 (Activation loop from InterPro)

Target domain	117-379 (Protein kinase domain)
Relief mechanism
Assay

References

Zhang H et al. (2001) "Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain", The Journal of biological chemistry, 276, 45598-603

Du Y et al. (2005) "Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3", The Journal of biological chemistry, 280, 42984-93

Handley ME et al. (2007) "Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity", International journal of experimental pathology, 88, 111-26

Kokoszka ME et al. (2018) "Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3", The Journal of biological chemistry, 293, 13553-13565

Autoinhibited structure

Activated structure

5 structures for Q16584

Entry ID	Method	Resolution	Chain	Position	Source
5K26	X-ray	120 A	A/B	41-105	PDB
5K28	X-ray	150 A	A/B	44-105	PDB
6AQB	X-ray	150 A	A/B	41-108	PDB
6CQ7	X-ray	200 A	A	41-108	PDB
AF-Q16584-F1	Predicted				AlphaFoldDB

690 variants for Q16584

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA381272573 rs760075378	3	P>S		No	ClinGen ExAC TOPMed gnomAD
rs760075378 CA6103730	3	P>T		No	ClinGen ExAC TOPMed gnomAD
rs771234612 CA6103728	6	S>N		No	ClinGen ExAC gnomAD
CA381272523 rs1352613333	10	K>R		No	ClinGen TOPMed
CA381272513 rs771826070	11	S>R		No	ClinGen ExAC gnomAD
rs771826070 CA6103725	11	S>R		No	ClinGen ExAC gnomAD
CA381272508 rs1191636105	12	P>R		No	ClinGen TOPMed gnomAD
CA381272510 rs1333391484	12	P>S		No	ClinGen TOPMed gnomAD
rs1565147146 CA381272498	14	G>E		No	ClinGen Ensembl
rs1447857589 CA381272499	14	G>R		No	ClinGen gnomAD
rs747598736 CA6103724	16	W>*		No	ClinGen ExAC gnomAD
rs1335222742 CA381272471	18	G>C		No	ClinGen gnomAD
CA381272469 rs1467914870	18	G>D		No	ClinGen gnomAD
CA6103722 rs199933724	22	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs753790026 CA6103721	23	G>C		No	ClinGen ExAC TOPMed gnomAD
CA381272436 rs1178685232	23	G>D		No	ClinGen gnomAD
CA381272434 rs1178685232	23	G>V		No	ClinGen gnomAD
rs1240874113 CA381272433	24	G>S		No	ClinGen gnomAD
rs755903893 CA6103719	24	G>V		No	ClinGen ExAC gnomAD
rs750295922 CA6103718	25	G>A		No	ClinGen ExAC TOPMed gnomAD
CA6103716 rs552446631	27	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA381272409 rs1355739728	28	G>E		No	ClinGen gnomAD
CA6103715 rs752687885	29	G>R		No	ClinGen ExAC gnomAD
CA6103712 rs147496400	31	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148528933 CA6103713	31	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1397964881 CA381272390	32	P>S		No	ClinGen gnomAD
CA381272376 rs1403384788	34	G>W		No	ClinGen gnomAD
rs771434772 CA6103710	35	S>Y		No	ClinGen ExAC gnomAD
rs1363005413 CA381272361	37	K>Q		No	ClinGen gnomAD
rs142992228 CA381272345	39	A>E		No	ClinGen ESP ExAC gnomAD
CA6103708 rs773685190	39	A>P		No	ClinGen ExAC gnomAD
CA6103707 rs142992228	39	A>V		No	ClinGen ESP ExAC gnomAD
rs768235387 CA6103704	40	G>A		No	ClinGen ExAC gnomAD
rs778465179 CA6103705	40	G>R		No	ClinGen ExAC gnomAD
rs1203126571 CA381272335	41	Y>C		No	ClinGen gnomAD
CA6103702 rs139047246	42	A>S		No	ClinGen ESP ExAC gnomAD
rs139047246 CA6103703	42	A>T		No	ClinGen ESP ExAC gnomAD
rs1026326777 CA223970517	43	N>S		No	ClinGen TOPMed
CA6103701 rs756174920	44	P>L		No	ClinGen ExAC TOPMed gnomAD
rs781077171 CA381272314	45	V>L		No	ClinGen ExAC TOPMed gnomAD
rs781077171 CA6103699	45	V>L		No	ClinGen ExAC TOPMed gnomAD
rs752914916 CA381272288	49	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1342710813 CA381272271	51	D>E		No	ClinGen TOPMed gnomAD
rs753987214 CA6103694	51	D>H		No	ClinGen ExAC TOPMed gnomAD
CA223970504 rs753987214	51	D>N		No	ClinGen ExAC TOPMed gnomAD
CA223970498 rs896569864	53	E>D		No	ClinGen TOPMed gnomAD
rs371729065 CA6103692	53	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1164471062 CA381272245	55	S>I		No	ClinGen TOPMed gnomAD
CA381272239 rs1179646952	56	G>E		No	ClinGen TOPMed
CA6103691 rs773418840	57	Q>*		No	ClinGen ExAC gnomAD
rs1433311320 CA381272223	58	D>Y		No	ClinGen gnomAD
rs767888238 CA6103690	60	L>V		No	ClinGen ExAC gnomAD
rs1478683624 CA381272168	61	A>D		No	ClinGen gnomAD
rs1034821945 CA223970493	62	L>M		No	ClinGen Ensembl
rs1438352728 CA381272154	62	L>R		No	ClinGen TOPMed
rs1198633105 CA381272123	64	K>M		No	ClinGen gnomAD
rs1489833518 CA381272112	65	G>R		No	ClinGen gnomAD
rs762110211 CA6103689	66	D>E		No	ClinGen ExAC gnomAD
rs367920151 CA223970488	66	D>G		No	ClinGen ESP TOPMed
CA6103688 rs774092295	67	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6103686 rs748790856	67	R>H		No	ClinGen ExAC TOPMed gnomAD
CA6103687 rs748790856	67	R>L		No	ClinGen ExAC TOPMed gnomAD
CA381272075 rs748790856	67	R>P		No	ClinGen ExAC TOPMed gnomAD
CA381272023 rs1590860080	70	V>G		No	ClinGen Ensembl
rs1590860066 CA381271997	72	S>F		No	ClinGen Ensembl
rs138254027 CA381271987	73	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6103684 rs138254027	73	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6103685 rs375370224	73	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs757018256 CA6103681	75	A>G		No	ClinGen ExAC gnomAD
CA6103682 rs781013413	75	A>T		No	ClinGen ExAC TOPMed gnomAD
rs755252434 CA6103678	76	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1168589417 CA381271876	81	E>K		No	ClinGen gnomAD
rs766486524 CA6103676	82	G>S		No	ClinGen ExAC gnomAD
rs756183843 CA6103675	83	W>C		No	ClinGen ExAC gnomAD
rs750897139 CA6103674	85	A>V		No	ClinGen ExAC TOPMed gnomAD
CA381271738 rs1479455998	88	V>A		No	ClinGen gnomAD
CA6103671 rs774912406	92	V>M		No	ClinGen ExAC gnomAD
CA6103668 rs763812821	96	P>L		No	ClinGen ExAC TOPMed gnomAD
CA381271642 rs763812821	96	P>R		No	ClinGen ExAC TOPMed gnomAD
rs201471095 CA381271628	97	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201471095 CA6103666	97	S>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1053101581 CA223970452	99	Y>C		No	ClinGen TOPMed
CA381271583 rs1197004983	100	V>M		No	ClinGen gnomAD
rs1223275370 CA381271551	102	R>L		No	ClinGen gnomAD
CA6103665 rs769298739	102	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1343563904 CA381271544	103	G>C		No	ClinGen gnomAD
CA381271526 rs1590859921	104	G>D		No	ClinGen Ensembl
CA6103663 rs776563704	105	G>S		No	ClinGen ExAC TOPMed gnomAD
CA223970446 rs374422083	106	P>A		No	ClinGen ESP TOPMed gnomAD
CA381271498 rs1328662251	106	P>L		No	ClinGen TOPMed gnomAD
CA381271488 rs1256126746	107	P>T		No	ClinGen TOPMed gnomAD
rs1400573402 CA381271470	108	P>L		No	ClinGen gnomAD
CA381271465 rs1400573402	108	P>R		No	ClinGen gnomAD
CA6103658 rs755162558	109	C>F		No	ClinGen ExAC gnomAD
CA381271460 rs1590859887	109	C>R		No	ClinGen Ensembl
rs750477481 CA6103654	110	E>G		No	ClinGen ExAC gnomAD
rs756165003 CA6103656	110	E>K		No	ClinGen ExAC gnomAD
CA6103655 rs756165003	110	E>Q		No	ClinGen ExAC gnomAD
rs1590859863 CA381271421	111	V>G		No	ClinGen Ensembl
CA381271412 rs1176818556	112	A>G		No	ClinGen gnomAD
rs751937250 CA223970422	118	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6103651 rs751937250	118	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs757750590 CA6103652	118	R>W		No	ClinGen ExAC TOPMed gnomAD
CA6103650 rs200642724	120	E>G		No	ClinGen ExAC TOPMed gnomAD
rs752339492 CA6103648	121	E>D		No	ClinGen ExAC gnomAD
rs763432626 CA6103649	121	E>G		No	ClinGen ExAC
rs759080222 CA6103646	122	V>G		No	ClinGen ExAC
COSM1676182 CA6103647 rs764800427	122	V>M	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6103645 rs776065218	123	I>T		No	ClinGen ExAC gnomAD
rs916549536 CA223970409	123	I>V		No	ClinGen Ensembl
CA381271225 rs1421025847	124	G>S		No	ClinGen TOPMed
CA381271198 rs1274514626	127	G>S		No	ClinGen gnomAD
rs1445309692 CA381271083	133	R>T		No	ClinGen gnomAD
rs770880024 CA6103644	135	S>C		No	ClinGen ExAC gnomAD
rs1434610251 CA381271011	137	R>*		No	ClinGen TOPMed
CA6103643 rs145388794	137	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6103642 rs773165963	139	E>G		No	ClinGen ExAC gnomAD
CA223970398 rs866709252	139	E>K		No	ClinGen gnomAD
CA381270976 rs773165963	139	E>V		No	ClinGen ExAC gnomAD
CA6103641 rs771808903	140	L>P		No	ClinGen ExAC gnomAD
rs747954057 CA6103640	145	A>S		No	ClinGen ExAC gnomAD
rs371379749 CA6103637	146	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
COSM272922 rs565087687 CA6103636	147	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA381270851 rs1239623139	147	R>H		No	ClinGen gnomAD
CA381270838 rs1590859733	148	Q>P		No	ClinGen Ensembl
CA381270794 rs1226191671	150	P>L		No	ClinGen TOPMed gnomAD
CA381270796 rs1226191671	150	P>R		No	ClinGen TOPMed gnomAD
rs377000140 CA6103629	151	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6103631 rs758769421	151	D>N		No	ClinGen ExAC
rs34178129 CA223970386 VAR_040703	151	D>V		No	ClinGen UniProt Ensembl dbSNP
rs545726160 CA381270757	152	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1290332129 CA381270752	153	D>H		No	ClinGen TOPMed gnomAD
CA381270751 rs1290332129	153	D>N		No	ClinGen TOPMed gnomAD
rs1380845904 CA381270695	159	E>K		No	ClinGen gnomAD
rs760201740 CA381270678	161	V>F		No	ClinGen ExAC TOPMed gnomAD
rs760201740 CA6103625	161	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6103624 rs199497456 COSM1257262	162	R>C	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs374217526 CA223970374	162	R>H		No	ClinGen ESP ExAC gnomAD
CA6103623 rs374217526	162	R>L		No	ClinGen ESP ExAC gnomAD
rs1191445493 CA381270667	163	Q>R		No	ClinGen TOPMed
CA6103622 rs761594078	166	R>Q		No	ClinGen ExAC gnomAD
rs774075066 CA6103621	169	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6103620 rs770023643	172	A>T		No	ClinGen ExAC gnomAD
rs1022126157 CA223970364	175	N>H		No	ClinGen TOPMed
rs1010772289 CA381270569	178	A>G		No	ClinGen TOPMed gnomAD
rs1010772289 CA223970362	178	A>V		No	ClinGen TOPMed gnomAD
CA381270547 rs1267602104	182	V>M		No	ClinGen gnomAD
CA223970359 rs1026544299	184	L>R		No	ClinGen TOPMed
CA381270509 rs1323198011	187	P>L		No	ClinGen gnomAD
CA6103617 rs771076394	187	P>S		No	ClinGen ExAC gnomAD
rs1355122841 CA381270503	188	N>K		No	ClinGen TOPMed gnomAD
rs747090171 CA6103616	188	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1315870379 CA381270491	190	C>S		No	ClinGen gnomAD
CA223970348 rs963383291	192	V>M		No	ClinGen TOPMed
CA6103614 rs759030384	193	M>I		No	ClinGen ExAC gnomAD
rs748525458 CA6103613	195	Y>C		No	ClinGen ExAC gnomAD
COSM1214392 rs755401328 CA6103611	203	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA6103610 rs753384688	206	A>G		No	ClinGen ExAC gnomAD
CA6103608 rs755558681	207	G>R		No	ClinGen ExAC TOPMed gnomAD
rs755558681 CA381270390	207	G>W		No	ClinGen ExAC TOPMed gnomAD
rs767433009 COSM1214393 CA6103606	208	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA381270385 rs890154327	208	R>W		No	ClinGen gnomAD
rs1246742554 CA381270380	209	R>C		No	ClinGen TOPMed gnomAD
rs143451767 CA6103603	209	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs143451767 CA6103604	209	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1259828214 CA381270378 COSM94664	210	V>M	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
CA381270370 rs1322496622	211	P>S		No	ClinGen TOPMed gnomAD
rs918749185 CA223970320	213	H>Y		No	ClinGen Ensembl
CA6103600 rs771346201	216	V>D		No	ClinGen ExAC TOPMed gnomAD
CA223970316 rs1038555445	217	N>S		No	ClinGen Ensembl
rs941553343 CA223970314	223	A>T		No	ClinGen Ensembl
rs1398367524 CA381270290	223	A>V		No	ClinGen gnomAD
rs372958068 CA6103599	224	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA381270285 rs1466480687	224	R>H		No	ClinGen TOPMed gnomAD
CA6103598 rs772677421	227	H>P		No	ClinGen ExAC gnomAD
rs772677421 CA6103597	227	H>R		No	ClinGen ExAC gnomAD
rs748565430 CA6103596	228	Y>C		No	ClinGen ExAC gnomAD
rs779497729 CA6103595	232	E>K		No	ClinGen ExAC TOPMed gnomAD
CA381270107 rs1239634843	235	V>M		No	ClinGen TOPMed gnomAD
rs749671008 CA6103593	236	P>L		No	ClinGen ExAC
rs755824405 CA6103591	237	V>I		No	ClinGen ExAC TOPMed gnomAD
rs749916030 CA6103590	245	N>D		No	ClinGen ExAC gnomAD
rs1228392066 CA381269888	247	I>L		No	ClinGen TOPMed
CA6103573 rs566592915	251	Q>K		No	ClinGen 1000Genomes ExAC gnomAD
CA381268967 rs1451762656	251	Q>R		No	ClinGen TOPMed
VAR_030604 CA6103572 rs17855912	252	P>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs780832462 CA6103571	253	I>V		No	ClinGen ExAC
rs758407931 CA6103568	256	D>E		No	ClinGen ExAC TOPMed gnomAD
CA6103569 rs532976710	256	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs752507549 CA6103566	257	D>N		No	ClinGen ExAC gnomAD
CA6103564 rs145124492	258	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA381361781 rs1489217049	261	K>N		No	ClinGen gnomAD
CA381361729 rs1265477674	262	T>I		No	ClinGen gnomAD
CA381361597 rs1355660580	266	T>I		No	ClinGen gnomAD
CA381361595 rs1355660580	266	T>S		No	ClinGen gnomAD
rs1277935437 CA381361457	272	R>*		No	ClinGen gnomAD
rs1342930087 CA381361369	274	W>S		No	ClinGen gnomAD
CA381361312 rs1318480068	275	H>Q		No	ClinGen gnomAD
rs770083831 CA6103556	279	Q>K		No	ClinGen ExAC gnomAD
VAR_040704 CA6103554 rs34594252	282	A>G		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs746232637 CA6103555	282	A>P		No	ClinGen ExAC gnomAD
COSM1719450 RCV001261746 rs746476599 CA6103552	283	A>T	NS [Cosmic]	No	ClinGen cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
rs1168234189 CA381361078	283	A>V		No	ClinGen gnomAD
rs1424263938 CA381361055	284	G>A		No	ClinGen gnomAD
CA381360997 rs1451140348	286	Y>F		No	ClinGen gnomAD
rs1308198242 CA381360977	287	A>T		No	ClinGen TOPMed
CA6103547 rs754755551	288	W>C		No	ClinGen ExAC gnomAD
CA381360878 rs1469049424	289	M>T		No	ClinGen gnomAD
rs1379207823 CA381360754	293	V>I		No	ClinGen Ensembl
rs139170020 CA6103543	298	T>I		No	ClinGen ESP ExAC gnomAD
CA6103541 rs763030681	300	S>F		No	ClinGen ExAC gnomAD
CA381360172 rs775906919	304	D>E		No	ClinGen ExAC TOPMed gnomAD
COSM544509 CA381360209 rs1304044736	304	D>N	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA6103539 rs746858638	305	V>I		No	ClinGen ExAC gnomAD
CA381359696 rs1281353516	318	G>E		No	ClinGen TOPMed gnomAD
rs375938376 CA6103518	319	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA381359662 rs1366749993	320	V>A		No	ClinGen TOPMed
rs1283233781 CA381359587	323	R>C		No	ClinGen gnomAD
rs760960892 CA6103516	325	I>T		No	ClinGen ExAC gnomAD
CA381359517 rs1373598848	326	D>G		No	ClinGen gnomAD
CA381359492 rs1382367669	327	C>Y		No	ClinGen TOPMed
rs772856050 CA6103515	328	L>F		No	ClinGen ExAC gnomAD
rs371575835 CA6103514	330	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA381359400 rs371575835	330	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA381359360 rs1235089820	331	A>S		No	ClinGen TOPMed
CA6103512 rs774055831	332	Y>C		No	ClinGen ExAC gnomAD
CA6103513 rs747650518	332	Y>H		No	ClinGen ExAC gnomAD
CA6103511 rs768688511	334	V>I		No	ClinGen ExAC gnomAD
CA6103510 rs749202106	338	K>R		No	ClinGen ExAC
CA381359189 rs1224178382	339	L>F		No	ClinGen gnomAD
CA381359080 rs1201694600	345	S>C		No	ClinGen TOPMed
rs1408968378 CA381359087	345	S>T		No	ClinGen gnomAD
CA6103506 rs141071251	346	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6103505 rs141071251	346	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381359076 rs1590857270	346	T>P		No	ClinGen Ensembl
CA6103504 rs376825039	348	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6103501 rs371854714	349	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA6103502 rs755072324	349	E>K		No	ClinGen ExAC TOPMed gnomAD
rs545865162 CA381358907	350	P>H		No	ClinGen 1000Genomes TOPMed
CA224016327 rs545865162	350	P>L		No	ClinGen 1000Genomes TOPMed
CA381358856 rs1218144252	352	A>T		No	ClinGen gnomAD
rs761098005 CA6103499	353	Q>K		No	ClinGen ExAC gnomAD
CA381358795 rs1391525641	355	M>L		No	ClinGen TOPMed
CA381358612 rs1173196729	357	D>A		No	ClinGen TOPMed gnomAD
rs886936618 CA224016322	357	D>N		No	ClinGen Ensembl
rs763902491 CA6103478	360	A>E		No	ClinGen ExAC gnomAD
rs763902491 CA6103477	360	A>V		No	ClinGen ExAC gnomAD
CA224016282 rs917618420	361	Q>K		No	ClinGen TOPMed
rs1590857173 CA381358345	362	D>A		No	ClinGen Ensembl
CA381358203 rs1188948719	364	H>Q		No	ClinGen gnomAD
CA6103475 rs543409399	365	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs543409399 CA6103476	365	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA6103473 rs759349343	370	A>V		No	ClinGen ExAC TOPMed gnomAD
CA381357985 rs1315184966	371	S>C		No	ClinGen TOPMed
CA6103472 rs776572682	372	I>V		No	ClinGen ExAC gnomAD
CA381357887 rs1248343880	374	Q>P		No	ClinGen TOPMed
CA6103471 rs770654079	376	L>V		No	ClinGen ExAC gnomAD
CA6103470 rs746813047	376	L>W		No	ClinGen ExAC gnomAD
CA6103469 rs147249960	377	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1304477677 CA381357610	378	A>G		No	ClinGen gnomAD
CA6103468 rs575103977	378	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA381357606 rs1304477677 COSM3980560	378	A>V	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
rs374611372 CA224016272	379	L>P		No	ClinGen ESP TOPMed
CA381357596 rs1446264416	380	E>A		No	ClinGen gnomAD
CA381357536 rs780040675	381	A>E		No	ClinGen ExAC gnomAD
CA6103466 rs780040675	381	A>G		No	ClinGen ExAC gnomAD
rs749367172 CA6103467	381	A>T		No	ClinGen ExAC gnomAD
rs1020532992 CA381357230	388	P>L		No	ClinGen TOPMed gnomAD
CA224016267 rs1020532992	388	P>Q		No	ClinGen TOPMed gnomAD
CA381357142 rs1590857118	390	D>A		No	ClinGen Ensembl
CA224016265 rs1010931488	390	D>E		No	ClinGen TOPMed gnomAD
rs1436047755 CA381357153	390	D>N		No	ClinGen gnomAD
CA224016263 rs375814282	391	S>F		No	ClinGen ESP TOPMed
CA381357092 rs1445889967	391	S>P		No	ClinGen TOPMed
rs1437402902 CA381356827	395	M>I		No	ClinGen gnomAD
rs1252484418 CA381356826	396	Q>*		No	ClinGen gnomAD
CA381356729 rs1177554366	397	E>G		No	ClinGen gnomAD
CA381356670 rs1384166469	398	G>D		No	ClinGen TOPMed
rs1212881027 CA381356535	401	R>C		No	ClinGen gnomAD
CA224016258 rs755142176	401	R>H		No	ClinGen Ensembl
rs1350178676 CA381356398	403	I>T		No	ClinGen gnomAD
rs554945636 CA224016255	404	Q>H		No	ClinGen 1000Genomes TOPMed
rs1239750361 CA381356353	404	Q>L		No	ClinGen gnomAD
rs977571973 CA224016253	405	G>S		No	ClinGen Ensembl
CA381356256 rs1441281148	408	D>A		No	ClinGen TOPMed
rs1441281148 CA381356252	408	D>G		No	ClinGen TOPMed
CA6103461 rs752024811	409	E>K		No	ClinGen ExAC TOPMed gnomAD
rs968973687 CA224016251	414	E>G		No	ClinGen TOPMed gnomAD
CA381355753 rs1271729182	416	E>K		No	ClinGen gnomAD
CA381355660 rs1262880736	419	S>G		No	ClinGen gnomAD
rs749434963 CA6103447	419	S>R		No	ClinGen ExAC TOPMed gnomAD
rs769708799 CA6103445	425	T>R		No	ClinGen ExAC
rs1385939653 CA381355354	427	A>E		No	ClinGen gnomAD
CA381355312 rs1362978718	429	R>G		No	ClinGen TOPMed
rs1461773554 CA381355172	433	S>P		No	ClinGen gnomAD
rs781760357 CA6103443	434	Q>R		No	ClinGen ExAC gnomAD
rs757885090 CA381355098	437	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs868760048 CA224016212	440	R>Q		No	ClinGen gnomAD
CA381355058 rs1374926279	440	R>W		No	ClinGen gnomAD
rs1432606646 CA381355038	441	R>H		No	ClinGen gnomAD
CA381355011 rs1565144637	442	E>A		No	ClinGen Ensembl
rs1195685772 CA381355021	442	E>K		No	ClinGen gnomAD
CA6103441 rs186746836	443	H>P		No	ClinGen 1000Genomes ExAC gnomAD
CA6103440 rs777957821	448	W>L		No	ClinGen ExAC gnomAD
CA224016208 rs758811212	449	E>D		No	ClinGen ExAC TOPMed gnomAD
CA381354737 rs1338670256	454	E>Q		No	ClinGen gnomAD
rs1242312183 CA381354595	459	L>V		No	ClinGen TOPMed
CA381354483 rs1411645768	463	Q>L		No	ClinGen gnomAD
rs1474898072 CA381354445	465	D>H		No	ClinGen TOPMed
CA224016203 rs995731687	466	R>H		No	ClinGen TOPMed gnomAD
rs773167892 CA381354305	468	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6103431 rs773167892	468	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1454847400 CA381354292	469	P>L		No	ClinGen gnomAD
CA381354185 rs1406803417	474	R>C		No	ClinGen gnomAD
rs775513372 CA6103428	474	R>H		No	ClinGen ExAC gnomAD
rs1345969662 CA381354161	476	G>E		No	ClinGen TOPMed
CA6103427 rs770108989	478	F>L		No	ClinGen ExAC TOPMed gnomAD
CA381354067 rs745917799	480	R>G		No	ClinGen ExAC TOPMed gnomAD
CA381354062 rs1352509256	480	R>H		No	ClinGen gnomAD
rs745917799 CA6103426	480	R>S		No	ClinGen ExAC TOPMed gnomAD
rs771164223 CA6103424	481	S>G		No	ClinGen ExAC gnomAD
rs1283166107 CA381354045	481	S>T		No	ClinGen TOPMed
rs1412829529 CA381353960	484	R>P		No	ClinGen TOPMed gnomAD
CA381353958 rs1412829529	484	R>Q		No	ClinGen TOPMed gnomAD
CA381353979 rs771234053	484	R>W		No	ClinGen TOPMed gnomAD
rs1175592890 CA381353956	485	A>P		No	ClinGen TOPMed gnomAD
rs1175592890 CA381353957	485	A>T		No	ClinGen TOPMed gnomAD
CA6103422 rs778355372	485	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1033228794 CA381353919	487	D>E		No	ClinGen TOPMed gnomAD
rs1033228794 CA224016194	487	D>E		No	ClinGen TOPMed gnomAD
rs1213199235 CA381353921	487	D>V		No	ClinGen TOPMed
rs758623501 CA6103421	488	G>S		No	ClinGen ExAC TOPMed gnomAD
rs748613462 CA6103420	489	G>S		No	ClinGen ExAC TOPMed gnomAD
CA6103419 rs778418004	490	E>K		No	ClinGen ExAC TOPMed gnomAD
CA381353841 rs1259075111	491	R>C		No	ClinGen gnomAD
rs1296574616 CA381353782	494	M>R		No	ClinGen TOPMed
CA381353807 rs1590856868	494	M>V		No	ClinGen Ensembl
rs1225060892 CA381353662	497	D>Y		No	ClinGen gnomAD
CA6103390 rs763931056	501	R>H		No	ClinGen ExAC gnomAD
CA224015976 rs779414471	506	A>V		No	ClinGen Ensembl
CA224015973 rs866556592	508	P>L		No	ClinGen Ensembl
CA381353225 rs1252000839	508	P>S		No	ClinGen gnomAD
rs867415651 CA224015967	509	G>D		No	ClinGen gnomAD
CA6103389 rs762853042	510	L>H		No	ClinGen ExAC gnomAD
rs1197980927 CA381353148	511	D>G		No	ClinGen gnomAD
CA224015961 rs754046278	511	D>H		No	ClinGen ExAC TOPMed gnomAD
rs754046278 CA6103388	511	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA381353116 rs1305691784	512	R>Q		No	ClinGen gnomAD
rs1284056410 CA381353119	512	R>W		No	ClinGen TOPMed
rs766774276 CA6103387	513	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1024901368 CA224015940	515	N>I		No	ClinGen TOPMed gnomAD
CA224015937 rs1014666874	517	F>L		No	ClinGen TOPMed
rs900261135 CA381352943	518	E>D		No	ClinGen gnomAD
rs760824405 CA6103386	518	E>K		No	ClinGen ExAC gnomAD
CA6103384 rs772428256	520	G>A		No	ClinGen ExAC
rs773390948 CA381352927	520	G>R		No	ClinGen ExAC gnomAD
rs773390948 CA6103385	520	G>R		No	ClinGen ExAC gnomAD
rs1442187639 CA381352893	521	P>S		No	ClinGen gnomAD
CA381352862 rs1353280447	523	D>N		No	ClinGen gnomAD
rs1480728022 CA381352859	523	D>V		No	ClinGen TOPMed
CA381352815 rs1393909421	525	P>L		No	ClinGen gnomAD
CA381352840 rs1410076470	525	P>S		No	ClinGen TOPMed gnomAD
CA224015921 rs891816160	526	T>A		No	ClinGen TOPMed gnomAD
rs891816160 CA381352811	526	T>P		No	ClinGen TOPMed gnomAD
CA381352806 rs891816160	526	T>S		No	ClinGen TOPMed gnomAD
CA6103383 rs762343923	527	F>Y		No	ClinGen ExAC gnomAD
CA381352706 rs1479496615	530	F>C		No	ClinGen gnomAD
rs1234561020 CA381352702	530	F>L		No	ClinGen gnomAD
rs1161517276 CA381352698	531	R>*		No	ClinGen TOPMed
rs749661072 CA6103380	531	R>L		No	ClinGen ExAC gnomAD
rs779681234 CA6103379	533	I>M		No	ClinGen ExAC gnomAD
rs942825847 CA224015910	533	I>V		No	ClinGen TOPMed
CA381352617 rs1232448416	534	Q>*		No	ClinGen gnomAD
CA381351434 rs1590856186	535	L>W		No	ClinGen Ensembl
CA381351404 rs1209765133	536	E>A		No	ClinGen gnomAD
CA6103353 rs777849778	537	P>L		No	ClinGen ExAC TOPMed gnomAD
rs778801240 CA6103350	539	E>Q		No	ClinGen ExAC gnomAD
CA381351243 rs61736582	540	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6103349 rs61736582	540	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs866483610 CA224015502	543	A>T		No	ClinGen gnomAD
rs1363650198 CA381351155	543	A>V		No	ClinGen gnomAD
rs1590856163 CA381351147	544	W>G		No	ClinGen Ensembl
CA6103347 rs750589238	546	R>C		No	ClinGen ExAC TOPMed gnomAD
CA224015491 rs1037993507	546	R>H		No	ClinGen TOPMed gnomAD
CA381351010 rs1037993507	546	R>L		No	ClinGen TOPMed gnomAD
rs1369199782 CA381350923	548	S>F		No	ClinGen gnomAD
CA381350925 rs1369199782	548	S>Y		No	ClinGen gnomAD
rs1006256054 CA381350921	549	P>A		No	ClinGen gnomAD
rs895107481 CA224015458	549	P>L		No	ClinGen gnomAD
rs895107481 CA381350894	549	P>R		No	ClinGen gnomAD
rs1006256054 CA224015465	549	P>S		No	ClinGen gnomAD
rs376244842 CA6103344	550	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA6103343 rs764566604	550	R>Q		No	ClinGen ExAC
CA6103339 rs574384864	551	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA6103340 rs574384864	551	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs776334879 CA6103338	551	R>H		No	ClinGen ExAC TOPMed gnomAD
CA6103337 rs770556617	553	E>K		No	ClinGen ExAC gnomAD
rs772898141 CA6103335	557	N>D		No	ClinGen ExAC gnomAD
rs1260593037 CA381350588	557	N>S		No	ClinGen TOPMed
rs748057055 CA6103333	560	R>Q		No	ClinGen ExAC gnomAD
rs771728761 CA6103334	560	R>W		No	ClinGen ExAC gnomAD
CA224015421 rs778997363	561	R>*		No	ClinGen ExAC gnomAD
CA6103332 rs778997363	561	R>G		No	ClinGen ExAC gnomAD
CA6103331 rs373571525	561	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA381350335 rs1166020627	563	C>R		No	ClinGen gnomAD
rs148160764 CA6103330	563	C>Y		No	ClinGen ESP ExAC gnomAD
rs554314267 CA6103329	564	W>*		No	ClinGen 1000Genomes ExAC gnomAD
rs757456029 CA6103328	565	A>T		No	ClinGen ExAC gnomAD
CA6103327 rs751805434	565	A>V		No	ClinGen ExAC gnomAD
rs1251580071 CA381350233	566	W>*		No	ClinGen gnomAD
CA381350223 rs1195910294	566	W>C		No	ClinGen gnomAD
CA381350236 rs1565143965	566	W>R		No	ClinGen Ensembl
CA6103326 rs777793382	568	P>H		No	ClinGen ExAC TOPMed gnomAD
COSM1704243 rs758480097 CA6103325	570	S>F	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA381350131 rs758480097	570	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA381350021 rs1439691829	572	K>M		No	ClinGen gnomAD
rs753146804 CA6103324	573	P>A		No	ClinGen ExAC gnomAD
CA381349955 rs1274694611	574	G>E		No	ClinGen gnomAD
rs1412779351 CA381349809	578	N>S		No	ClinGen TOPMed
rs1373657564 CA381349537	584	R>C		No	ClinGen gnomAD
rs144864133 CA381349534	584	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs144864133 CA6103298	584	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA381349527 rs1415227854	585	M>V		No	ClinGen TOPMed gnomAD
CA381349499 rs1358826764	586	D>G		No	ClinGen TOPMed
rs768612025 CA6103295	587	E>D		No	ClinGen ExAC TOPMed gnomAD
rs149401275 CA6103296	587	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA6103293 rs775506696	588	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6103294 rs775506696	588	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1305309214 CA381349402	589	T>I		No	ClinGen gnomAD
rs769523347 CA6103292	590	W>*		No	ClinGen ExAC gnomAD
rs199601318 CA6103291	593	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA381349307 rs1210465343	593	D>H		No	ClinGen gnomAD
rs1003478674 CA381349059	598	S>F		No	ClinGen TOPMed
rs1565143859 CA381349067	598	S>P		No	ClinGen Ensembl
rs1003478674 CA224015098	598	S>Y		No	ClinGen TOPMed
rs778810390 CA6103287	599	P>L		No	ClinGen ExAC TOPMed gnomAD
CA381349057 rs1565143851	599	P>S		No	ClinGen Ensembl
CA381348998 rs1353687739	601	G>R		No	ClinGen TOPMed gnomAD
CA6103286 rs755116870	602	S>C		No	ClinGen ExAC TOPMed gnomAD
rs749690694 CA6103285	603	P>L		No	ClinGen ExAC gnomAD
COSM690000 CA224015064 rs1042442533	603	P>S	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
CA6103284 rs138968470	604	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6103283 rs138968470	604	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs145297254 CA381348907	605	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6103282 rs145297254	605	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA224015025 rs1016509933	606	P>H		No	ClinGen TOPMed
CA381348889 rs1016509933	606	P>R		No	ClinGen TOPMed
CA381348895 rs1390626707	606	P>S		No	ClinGen Ensembl
CA6103280 rs141657750	607	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs943279511 CA224015010	607	P>L		No	ClinGen TOPMed gnomAD
CA381348842 rs751259676	608	A>E		No	ClinGen ExAC gnomAD
CA6103279 rs751259676	608	A>V		No	ClinGen ExAC gnomAD
rs762540493 CA6103277	610	N>S		No	ClinGen ExAC gnomAD
rs746313672 CA6103248	612	N>I		No	ClinGen ExAC gnomAD
CA381346177 rs781769081	612	N>K		No	ClinGen ExAC gnomAD
CA381346183 rs746313672	612	N>T		No	ClinGen ExAC gnomAD
rs771189864 CA381346149	614	P>L		No	ClinGen ExAC TOPMed gnomAD
rs771189864 CA6103246	614	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA6103244 rs777262484	615	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1207383117 CA381346144	615	R>W		No	ClinGen TOPMed gnomAD
rs1208972864 CA381346130	616	P>A		No	ClinGen gnomAD
rs1208972864 CA381346132	616	P>T		No	ClinGen gnomAD
CA381346120 rs758121140	617	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1223774168 CA381346112	617	S>I		No	ClinGen gnomAD
CA6103243 rs758121140	617	S>R		No	ClinGen ExAC TOPMed gnomAD
CA224010487 rs1016317747	619	E>D		No	ClinGen TOPMed gnomAD
rs1290682547 CA381346067	620	P>H		No	ClinGen gnomAD
CA224010486 rs1005917008	620	P>S		No	ClinGen TOPMed
rs376240928 CA6103242	621	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA224010483 rs376240928	621	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA381346023 rs1304476407	622	E>D		No	ClinGen TOPMed
rs754488458 CA6103240	623	P>L		No	ClinGen ExAC TOPMed gnomAD
CA381346008 rs754488458	623	P>R		No	ClinGen ExAC TOPMed gnomAD
CA6103237 rs753716966	625	R>T		No	ClinGen ExAC gnomAD
CA381345968 rs573026581	626	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs573026581 CA6103236	626	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6103235 rs573026581	626	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381345939 rs1414128469	628	P>A		No	ClinGen gnomAD
rs1182749295 CA381345922	628	P>L		No	ClinGen gnomAD
CA6103233 rs753834812	629	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1052224019 CA224010438	631	R>C		No	ClinGen TOPMed gnomAD
CA6103232 rs763182102	631	R>H		No	ClinGen ExAC TOPMed gnomAD
CA381345887 rs763182102	631	R>P		No	ClinGen ExAC TOPMed gnomAD
rs769940928 CA381345880	632	G>C		No	ClinGen ExAC TOPMed gnomAD
rs769940928 CA6103229	632	G>S		No	ClinGen ExAC TOPMed gnomAD
CA6103228 rs759751814	635	S>F		No	ClinGen ExAC TOPMed gnomAD
rs947432304 CA224010433	636	G>E		No	ClinGen TOPMed
CA224010426 rs747721707	637	T>M		No	ClinGen TOPMed
CA381345748 rs1354321094	638	P>L		No	ClinGen gnomAD
rs1229528448 CA381345749	638	P>S		No	ClinGen gnomAD
CA381345737 rs1397478572	639	K>T		No	ClinGen gnomAD
rs933398144 CA224010417	642	Q>R		No	ClinGen TOPMed
rs778215901 CA224010402	643	R>Q		No	ClinGen TOPMed gnomAD
rs771511538 CA6103226	643	R>W		No	ClinGen ExAC TOPMed gnomAD
CA6103225 COSM3980559 rs199635742	644	A>V	ovary [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs1162788032 CA381345607	646	L>M		No	ClinGen TOPMed gnomAD
CA224010383 rs984302953	647	R>C		No	ClinGen gnomAD
CA6103222 rs747732702	647	R>H		No	ClinGen ExAC TOPMed gnomAD
CA224010380 rs938290041	648	G>S		No	ClinGen TOPMed gnomAD
CA6103220 rs754471887	649	T>A		No	ClinGen ExAC gnomAD
CA381345557 rs1264131233	650	A>T		No	ClinGen gnomAD
CA224010366 rs766364469	653	A>T		No	ClinGen TOPMed gnomAD
CA6103216 rs750345450	653	A>V		No	ClinGen ExAC gnomAD
CA6103215 rs749294156	654	S>L		No	ClinGen ExAC TOPMed gnomAD
CA381345432 rs1295178937	657	L>P		No	ClinGen gnomAD
CA381345415 rs1459532849	658	G>V		No	ClinGen gnomAD
CA6103214 rs761531372	659	R>C		No	ClinGen ExAC TOPMed gnomAD
COSM39634 rs752958965 CA6103213	659	R>H	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs752958965 CA381345404	659	R>L		No	ClinGen ExAC TOPMed gnomAD
rs776901400 CA6103210	660	D>G		No	ClinGen ExAC gnomAD
CA6103212 rs765625058	660	D>N		No	ClinGen ExAC gnomAD
rs776901400 CA6103211	660	D>V		No	ClinGen ExAC gnomAD
CA224010347 rs1032192769	662	Q>R		No	ClinGen TOPMed gnomAD
CA6103208 rs761204178	663	P>L		No	ClinGen ExAC TOPMed gnomAD
rs370331573 CA6103206	664	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1462235316 CA381345332	666	G>D		No	ClinGen TOPMed
rs1442610236 CA381345338	666	G>S		No	ClinGen gnomAD
rs768336877 CA6103203	669	R>C		No	ClinGen ExAC TOPMed gnomAD
rs779565351 CA6103202	669	R>H		No	ClinGen ExAC TOPMed gnomAD
rs779565351 CA6103201	669	R>P		No	ClinGen ExAC TOPMed gnomAD
rs755607002 CA6103200	670	E>K		No	ClinGen ExAC TOPMed gnomAD
CA381345272 rs1391630281	671	R>C		No	ClinGen gnomAD
CA6103198 rs781052493	671	R>H		No	ClinGen ExAC TOPMed gnomAD
CA6103199 rs781052493	671	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6103196 rs751442598	672	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1590853137 CA381345223	674	S>F		No	ClinGen Ensembl
rs1454145339 CA381345230	674	S>T		No	ClinGen TOPMed gnomAD
CA6103193 COSM1214391 rs551941259	675	P>L	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA6103190 rs773754882	676	T>R		No	ClinGen ExAC gnomAD
rs774745538 CA6103185	678	P>L		No	ClinGen ExAC gnomAD
rs549942073 CA6103186	678	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA6103183 rs769028417	679	P>A		No	ClinGen ExAC gnomAD
CA6103182 rs748895865 COSM1719449	679	P>L	NS [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs199769348 CA6103179	680	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA381345131 rs1421151535	680	T>P		No	ClinGen TOPMed
rs199769348 CA381345121	680	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6103177 rs372241785	681	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1408098964 CA381345087	682	T>M		No	ClinGen gnomAD
CA381345080 rs145992599	683	P>A		No	ClinGen ExAC TOPMed gnomAD
CA6103175 rs145992599 COSM110554	683	P>S	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs754035122 CA6103173	684	A>T		No	ClinGen ExAC TOPMed gnomAD
rs374573657 CA224010161	684	A>V		No	ClinGen ESP TOPMed gnomAD
rs201108277 CA6103171	685	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6103170 rs113014372	687	P>L		No	ClinGen ExAC TOPMed gnomAD
rs762256510 CA6103168	688	T>N		No	ClinGen ExAC gnomAD
CA6103166 rs764372087	689	E>K		No	ClinGen ExAC TOPMed gnomAD
rs763236463 CA6103165	690	P>A		No	ClinGen ExAC gnomAD
rs775207886 CA6103164	690	P>L		No	ClinGen ExAC TOPMed gnomAD
CA381344951 rs1266210797	691	P>L		No	ClinGen gnomAD
rs909448899 CA224010112	691	P>T		No	ClinGen TOPMed
CA6103162 rs144595056	692	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs775959086 CA6103161	694	P>L		No	ClinGen ExAC TOPMed
CA6103156 rs563384057	696	I>M		No	ClinGen 1000Genomes ExAC gnomAD
CA6103157 rs11227236	696	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6103154 rs374223116	698	F>L		No	ClinGen ESP ExAC gnomAD
CA6103153 rs756339382	699	S>L		No	ClinGen ExAC TOPMed gnomAD
CA6103151 rs781205052	700	L>H		No	ClinGen ExAC gnomAD
CA6103150 rs752003340	702	T>K		No	ClinGen ExAC TOPMed gnomAD
rs752003340 CA6103149	702	T>M		No	ClinGen ExAC TOPMed gnomAD
rs753055866 CA6103146	704	D>G		No	ClinGen ExAC TOPMed gnomAD
rs763348971 CA6103147	704	D>N		No	ClinGen ExAC TOPMed gnomAD
CA381344762 rs763348971	704	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA6103143 rs201727045 COSM1355984	706	P>L	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs201727045 CA6103142	706	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs760321394 CA6103141	707	P>L		No	ClinGen ExAC
CA381344684 rs1354278764	709	P>S		No	ClinGen gnomAD
CA381344673 rs1221859252	710	A>V		No	ClinGen TOPMed
rs1365010117 CA381344650	712	L>P		No	ClinGen TOPMed gnomAD
rs1365010117 CA381344644	712	L>R		No	ClinGen TOPMed gnomAD
CA6103138 rs772174216	712	L>V		No	ClinGen ExAC gnomAD
CA6103136 rs778522527	713	L>F		No	ClinGen ExAC gnomAD
rs143609435 CA6103134	717	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs143609435 CA6103133	717	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA381344559 rs1415287978	718	I>V		No	ClinGen gnomAD
rs887510001 CA224009935	722	Q>H		No	ClinGen Ensembl
CA6103130 rs764029799	723	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA381344414 rs1387873069	723	R>W		No	ClinGen TOPMed gnomAD
rs967941073 CA224009933	724	S>L		No	ClinGen TOPMed
rs1002373767 CA224009910	725	A>T		No	ClinGen TOPMed
rs1252321329 CA381344334	725	A>V		No	ClinGen gnomAD
CA6103128 rs753282799	726	K>R		No	ClinGen ExAC gnomAD
rs375853883 CA6103127	727	S>I		No	ClinGen ESP ExAC
CA224009907 rs375853883	727	S>T		No	ClinGen ESP ExAC
rs753529001 CA6103125	729	R>*		No	ClinGen ExAC gnomAD
rs373143339 CA224009900	729	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs373143339 CA6103124	729	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1046610350 CA224009892	730	R>C		No	ClinGen TOPMed gnomAD
rs35487354 CA6103123 COSM930451	730	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs377553569 CA224009886	732	E>K		No	ClinGen Ensembl
rs767076424 CA6103121	734	P>R		No	ClinGen ExAC gnomAD
CA6103120 rs201522259	735	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6103119 rs369239714	735	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs202052634 CA381344118	736	G>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1287608112 CA381343952	736	G>E		No	ClinGen TOPMed
rs202052634 CA6103117	736	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381343920 rs1481088102	738	T>A		No	ClinGen gnomAD
rs1237051133 CA381343914	738	T>I		No	ClinGen TOPMed gnomAD
rs766868287 CA6103101	739	V>I		No	ClinGen ExAC gnomAD
rs766868287 CA381343910	739	V>L		No	ClinGen ExAC gnomAD
rs552024637 CA6103100	740	S>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1326549691 CA381343859	741	P>S		No	ClinGen gnomAD
rs1191605550 CA381343820	742	P>R		No	ClinGen TOPMed
rs1188793626 CA381343829	742	P>S		No	ClinGen Ensembl
COSM1355981 CA381343802 rs1409843441	743	P>L	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA6103097 rs762717646	743	P>S		No	ClinGen ExAC TOPMed gnomAD
CA6103098 rs762717646	743	P>T		No	ClinGen ExAC TOPMed gnomAD
CA381343745 rs1382252887	745	T>I		No	ClinGen TOPMed
rs376714195 CA6103094	747	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1355980 rs569473618 CA6103093	747	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA381343725 rs569473618	747	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6103092 rs372545474	748	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA224009067 rs372545474	748	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs148864387 CA6103091	749	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA224009047 rs148864387	749	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1419706686 CA381343669	750	P>L		No	ClinGen gnomAD
rs1161465365 CA381343672	750	P>S		No	ClinGen gnomAD
rs1310728192 CA381343625	751	G>D		No	ClinGen TOPMed
CA381343613 rs1590852367	752	T>P		No	ClinGen Ensembl
rs1244127009 CA381343517	757	R>C		No	ClinGen TOPMed gnomAD
CA6103088 rs147829902 COSM1214389	757	R>H	ovary large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA381343484 rs1270507044	758	S>L		No	ClinGen gnomAD
CA224009004 rs560632256	760	P>S		No	ClinGen 1000Genomes TOPMed gnomAD
rs1590852317 CA381343422	761	L>P		No	ClinGen Ensembl
rs756551018 CA6103086	763	L>F		No	ClinGen ExAC gnomAD
CA6103085 rs750035582	766	R>*		No	ClinGen ExAC gnomAD
CA6103084 rs780952481	766	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs11541016 CA224008983	767	P>L		No	ClinGen Ensembl
CA381343295 rs1390785873	768	R>Q		No	ClinGen gnomAD
CA381343298 rs1432543023	768	R>W		No	ClinGen gnomAD
CA6103083 rs756714986	769	P>H		No	ClinGen ExAC
CA6103082 rs751118360	770	S>L		No	ClinGen ExAC gnomAD
rs1163029839 CA381343223	771	P>L		No	ClinGen gnomAD
CA381343256 rs1367934205	771	P>T		No	ClinGen gnomAD
rs747830130 CA224008962	772	L>F		No	ClinGen Ensembl
CA6103081 rs763537644	773	R>C		No	ClinGen ExAC gnomAD
rs1386032470 CA381343181	773	R>H		No	ClinGen gnomAD
rs1448005729 CA381343124	774	S>I		No	ClinGen gnomAD
rs762840511 CA6103080	775	R>C		No	ClinGen ExAC gnomAD
rs752639569 CA6103079	775	R>H		No	ClinGen ExAC gnomAD
rs1263148067 CA381342943	778	P>A		No	ClinGen gnomAD
rs1565141260 CA381342790	781	F>C		No	ClinGen Ensembl
CA381342639 rs1425836523	783	S>L		No	ClinGen TOPMed
rs773304406 CA6103076	785	G>E		No	ClinGen ExAC gnomAD
CA6103074 rs761774934	787	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs772378784 CA6103075	787	R>W		No	ClinGen ExAC TOPMed gnomAD
CA6103073 rs774438025	788	P>L		No	ClinGen ExAC gnomAD
CA381342434 rs1359522449	790	P>A		No	ClinGen gnomAD
rs925717245 CA224008916	790	P>R		No	ClinGen TOPMed
CA6103070 rs780716514	794	P>A		No	ClinGen ExAC gnomAD
rs373649447 CA224008906	796	P>L		No	ClinGen ESP
rs1277325090 CA381342142	797	A>S		No	ClinGen TOPMed
rs1380818233 CA381342110	797	A>V		No	ClinGen TOPMed
rs746307972 CA6103068	798	P>S		No	ClinGen ExAC gnomAD
CA6103067 rs375614171	799	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6103066 rs756887799	799	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1433123930 CA381342003	800	R>*		No	ClinGen TOPMed gnomAD
rs751204773 CA6103065	800	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs777274087 CA6103064	802	P>L		No	ClinGen ExAC gnomAD
rs757921400 CA6103063	804	T>P		No	ClinGen ExAC gnomAD
CA381341719 rs1203892287	807	P>L		No	ClinGen TOPMed
rs759296633 CA6103060	809	S>*		No	ClinGen ExAC gnomAD
CA6103057 rs762054182	810	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1474417339 CA381341293	816	P>L		No	ClinGen TOPMed
rs1406876432 CA381341274	817	P>L		No	ClinGen gnomAD
CA381341260 rs1307709692	819	N>D		No	ClinGen gnomAD
CA6103054 rs763179055	820	P>L		No	ClinGen ExAC gnomAD
rs1372574239 CA381341132	822	Q>*		No	ClinGen gnomAD
rs1488862929 CA381341125	822	Q>P		No	ClinGen Ensembl
CA6103053 rs758537099	823	G>E		No	ClinGen ExAC TOPMed gnomAD
CA381341056 rs1168871573	823	G>W		No	ClinGen gnomAD
CA381341028 rs1376468437	824	G>S		No	ClinGen gnomAD
rs1178833565 CA381341016	824	G>V		No	ClinGen TOPMed gnomAD
CA6103052 rs770461213	825	P>L		No	ClinGen ExAC gnomAD
rs1483834657 CA381340993	826	Q>*		No	ClinGen TOPMed gnomAD
rs968279036 CA224008813	826	Q>L		No	ClinGen Ensembl
CA6103050 rs781581951	827	D>H		No	ClinGen ExAC gnomAD
CA381340934 rs1260028893	828	C>S		No	ClinGen gnomAD
rs147700629 CA6103049	830	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA381340765 rs1224018565	833	K>E		No	ClinGen TOPMed gnomAD
CA381340762 rs1324431117	833	K>R		No	ClinGen gnomAD
CA6103047 rs777460184	836	G>C		No	ClinGen ExAC gnomAD
rs1229218887 CA381340629	837	A>T		No	ClinGen Ensembl
rs1337781168 CA381340609	837	A>V		No	ClinGen gnomAD
CA381340592 rs368733999	838	Q>*		No	ClinGen ESP ExAC gnomAD
rs368733999 CA6103046	838	Q>K		No	ClinGen ESP ExAC gnomAD
CA6103045 rs373717045	840	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA381340537 rs1220236268	840	P>S		No	ClinGen TOPMed
rs996449396 CA224008730	841	W>C		No	ClinGen Ensembl
CA381340474 rs1270916302	841	W>R		No	ClinGen TOPMed
rs753749962 CA6103042	843	P>L		No	ClinGen ExAC gnomAD

No associated diseases with Q16584

6 regional properties for Q16584

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	117 - 379	IPR000719
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	117 - 376	IPR001245
domain	SH3 domain	41 - 105	IPR001452
active_site	Serine/threonine-protein kinase, active site	237 - 249	IPR008271
binding_site	Protein kinase, ATP binding site	123 - 144	IPR017441
domain	MLK1-3, SH3 domain	45 - 102	IPR035779

Functions

		Description
EC Number	2.7.11.25	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	Location is cell cycle dependent
PANTHER Family	PTHR23257	SERINE-THREONINE PROTEIN KINASE
PANTHER Subfamily	PTHR23257:SF757	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE
PANTHER Protein Class	non-receptor serine/threonine protein kinase protein modifying enzyme
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

12 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
JUN kinase kinase kinase activity	Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
MAP kinase kinase kinase activity	Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
mitogen-activated protein kinase kinase binding	Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase.
mitogen-activated protein kinase kinase kinase binding	Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
small GTPase binding	Binding to a small monomeric GTPase.

11 GO annotations of biological process

Name	Definition
cell cycle G1/S phase transition	The cell cycle process by which a cell in G1 phase commits to S phase.
cell death	Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
JNK cascade	An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
MAPK cascade	An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
microtubule-based process	Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of JNK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
positive regulation of JUN kinase activity	Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
positive regulation of neuron apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.

41 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A2VDU3	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Bos taurus (Bovine)	SS
Q4TVR5	DSTYK	Dual serine/threonine and tyrosine protein kinase	Bos taurus (Bovine)	PR
Q3SZJ2	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	Bos taurus (Bovine)	PR
Q6XUX0	DSTYK	Dual serine/threonine and tyrosine protein kinase	Gallus gallus (Chicken)	PR
P83104	Takl1	Putative mitogen-activated protein kinase kinase kinase 7-like	Drosophila melanogaster (Fruit fly)	PR
Q95UN8	slpr	Mitogen-activated protein kinase kinase kinase	Drosophila melanogaster (Fruit fly)	EV
P00540	MOS	Proto-oncogene serine/threonine-protein kinase mos	Homo sapiens (Human)	PR
Q5TCX8	MAP3K21	Mitogen-activated protein kinase kinase kinase 21	Homo sapiens (Human)	PR
Q6XUX3	DSTYK	Dual serine/threonine and tyrosine protein kinase	Homo sapiens (Human)	PR
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (Human)	SS
Q9NYL2	MAP3K20	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (Human)	PR
Q38SD2	LRRK1	Leucine-rich repeat serine/threonine-protein kinase 1	Homo sapiens (Human)	EV
O43353	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (Human)	PR
Q02779	MAP3K10	Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (Human)	SS
P80192	MAP3K9	Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (Human)	SS
Q13418	ILK	Integrin-linked protein kinase	Homo sapiens (Human)	PR
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (Human)	EV
P10398	ARAF	Serine/threonine-protein kinase A-Raf	Homo sapiens (Human)	PR
P15056	BRAF	Serine/threonine-protein kinase B-raf	Homo sapiens (Human)	EV
Q8NB16	MLKL	Mixed lineage kinase domain-like protein	Homo sapiens (Human)	EV
P58801	Ripk2	Receptor-interacting serine/threonine-protein kinase 2	Mus musculus (Mouse)	PR
Q62073	Map3k7	Mitogen-activated protein kinase kinase kinase 7	Mus musculus (Mouse)	EV
Q9D2Y4	Mlkl	Mixed lineage kinase domain-like protein	Mus musculus (Mouse)	SS
Q9ESL4	Map3k20	Mitogen-activated protein kinase kinase kinase 20	Mus musculus (Mouse)	PR
P00536	Mos	Proto-oncogene serine/threonine-protein kinase mos	Mus musculus (Mouse)	PR
Q66L42	Map3k10	Mitogen-activated protein kinase kinase kinase 10	Mus musculus (Mouse)	SS
Q3U1V8	Map3k9	Mitogen-activated protein kinase kinase kinase 9	Mus musculus (Mouse)	SS
Q8VDG6	Map3k21	Mitogen-activated protein kinase kinase kinase 21	Mus musculus (Mouse)	PR
Q80XI6	Map3k11	Mitogen-activated protein kinase kinase kinase 11	Mus musculus (Mouse)	PR
P0C8E4	Map3k7	Mitogen-activated protein kinase kinase kinase 7	Rattus norvegicus (Rat)	SS
D3ZG83	Map3k10	Mitogen-activated protein kinase kinase kinase 10	Rattus norvegicus (Rat)	SS
P00539	Mos	Proto-oncogene serine/threonine-protein kinase mos	Rattus norvegicus (Rat)	PR
Q66HA1	Map3k11	Mitogen-activated protein kinase kinase kinase 11	Rattus norvegicus (Rat)	PR
Q9TZM3	lrk-1	Leucine-rich repeat serine/threonine-protein kinase 1	Caenorhabditis elegans	SS
Q9FPR3	EDR1	Serine/threonine-protein kinase EDR1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q2MHE4	HT1	Serine/threonine/tyrosine-protein kinase HT1	Arabidopsis thaliana (Mouse-ear cress)	PR
O22558	STY8	Serine/threonine-protein kinase STY8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8RWL6	STY17	Serine/threonine-protein kinase STY17	Arabidopsis thaliana (Mouse-ear cress)	PR
F4JTP5	STY46	Serine/threonine-protein kinase STY46	Arabidopsis thaliana (Mouse-ear cress)	PR
Q05609	CTR1	Serine/threonine-protein kinase CTR1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q67E00	dstyk	Dual serine/threonine and tyrosine protein kinase	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MEPLKSLFLK	SPLGSWNGSG	SGGGGGGGGG	RPEGSPKAAG	YANPVWTALF	DYEPSGQDEL
70	80	90	100	110	120
ALRKGDRVEV	LSRDAAISGD	EGWWAGQVGG	QVGIFPSNYV	SRGGGPPPCE	VASFQELRLE
130	140	150	160	170	180
EVIGIGGFGK	VYRGSWRGEL	VAVKAARQDP	DEDISVTAES	VRQEARLFAM	LAHPNIIALK
190	200	210	220	230	240
AVCLEEPNLC	LVMEYAAGGP	LSRALAGRRV	PPHVLVNWAV	QIARGMHYLH	CEALVPVIHR
250	260	270	280	290	300
DLKSNNILLL	QPIESDDMEH	KTLKITDFGL	AREWHKTTQM	SAAGTYAWMA	PEVIKASTFS
310	320	330	340	350	360
KGSDVWSFGV	LLWELLTGEV	PYRGIDCLAV	AYGVAVNKLT	LPIPSTCPEP	FAQLMADCWA
370	380	390	400	410	420
QDPHRRPDFA	SILQQLEALE	AQVLREMPRD	SFHSMQEGWK	REIQGLFDEL	RAKEKELLSR
430	440	450	460	470	480
EEELTRAARE	QRSQAEQLRR	REHLLAQWEL	EVFERELTLL	LQQVDRERPH	VRRRRGTFKR
490	500	510	520	530	540
SKLRARDGGE	RISMPLDFKH	RITVQASPGL	DRRRNVFEVG	PGDSPTFPRF	RAIQLEPAEP
550	560	570	580	590	600
GQAWGRQSPR	RLEDSSNGER	RACWAWGPSS	PKPGEAQNGR	RRSRMDEATW	YLDSDDSSPL
610	620	630	640	650	660
GSPSTPPALN	GNPPRPSLEP	EEPKRPVPAE	RGSSSGTPKL	IQRALLRGTA	LLASLGLGRD
670	680	690	700	710	720
LQPPGGPGRE	RGESPTTPPT	PTPAPCPTEP	PPSPLICFSL	KTPDSPPTPA	PLLLDLGIPV
730	740	750	760	770	780
GQRSAKSPRR	EEEPRGGTVS	PPPGTSRSAP	GTPGTPRSPP	LGLISRPRPS	PLRSRIDPWS
790	800	810	820	830	840
FVSAGPRPSP	LPSPQPAPRR	APWTLFPDSD	PFWDSPPANP	FQGGPQDCRA	QTKDMGAQAP

WVPEAGP