AiPD: Autoinhibited Protein Database

Q16566

Gene name	CAMK4 (CAMK, CAMK-GR, CAMKIV)
Protein name	Calcium/calmodulin-dependent protein kinase type IV
Names	CaMK IV, CaM kinase-GR
Species	Homo sapiens (Human)
KEGG Pathway	hsa:814
EC number	2.7.11.17: Protein-serine/threonine kinases
Protein Class

Descriptions

Calcium/calmodulin-dependent protein kinase type 4 (CAMK4) regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. In human CAMK1, the autoinhibitory region contains two helical structures (αR1 and αR2) and includes a pseudosubstrate sequence within it. The αR2 helix is at the N-terminal of CaM-binding domain. The αR1 interacts with the catalytic core and αR2 interacts with the ATP-binding region of CAMK1 for autoinhibition.

Autoinhibitory domains (AIDs)

305-321 (Autoinhibitory domain) SS

Target domain	46-300 (Protein kinase domain)
Relief mechanism	Ligand binding
Assay

AID

305-321 (Autoinhibitory domain)

Target domain

46-300 (Protein kinase domain)

Relief mechanism

Ligand binding (Ca2+-CaM binding to CaM binding domain)

Assay

Accessory elements

184-206 (Activation loop from InterPro)

Target domain	46-300 (Protein kinase domain)
Relief mechanism
Assay

References

Yuan T et al. (2004) "Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I", Archives of biochemistry and biophysics, 421, 192-206

Goldberg J et al. (1996) "Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I", Cell, 84, 875-87

Shohat G et al. (2002) "The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases", Biochimica et biophysica acta, 1600, 45-50

Cohen O et al. (1997) "DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity", The EMBO journal, 16, 998-1008

Shohat G et al. (2001) "The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism", The Journal of biological chemistry, 276, 47460-7

Stull JT et al. (2011) "Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscle", Archives of biochemistry and biophysics, 510, 120-8

Shani G et al. (2001) "Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding", The EMBO journal, 20, 1099-113

Inbal B et al. (2000) "Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis", Molecular and cellular biology, 20, 1044-54

Cheng L et al. (2022) "DCLK1 autoinhibition and activation in tumorigenesis", Innovation (Cambridge (Mass.)), 3, 100191

Autoinhibited structure

Activated structure

2 structures for Q16566

Entry ID	Method	Resolution	Chain	Position	Source
2W4O	X-ray	217 A	A	15-340	PDB
AF-Q16566-F1	Predicted				AlphaFoldDB

308 variants for Q16566

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA3366180 rs746404317	3	K>E		No	ClinGen ExAC TOPMed gnomAD
CA360699324 rs746404317	3	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA3366181 rs770093750	5	T>M		No	ClinGen ExAC gnomAD
CA3366183 rs748901600	6	V>L		No	ClinGen ExAC gnomAD
rs748901600 CA360699342	6	V>M		No	ClinGen ExAC gnomAD
CA3366184 rs768256755	7	P>S		No	ClinGen ExAC gnomAD
rs906144758 CA125389709	8	S>F		No	ClinGen TOPMed
rs1389065507 CA360699358	9	C>R		No	ClinGen gnomAD
rs761462897 CA3366186	10	S>C		No	ClinGen ExAC gnomAD
CA360699370 rs367616588	11	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3366188 rs367616588	11	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA360699378 rs760714420	12	S>*		No	ClinGen ExAC gnomAD
CA3366189 rs760714420	12	S>L		No	ClinGen ExAC gnomAD
CA3366191 rs753581560	13	S>C		No	ClinGen ExAC TOPMed gnomAD
rs1035863406 CA125389710	14	C>S		No	ClinGen TOPMed
CA360699392 rs1383075078	15	S>T		No	ClinGen gnomAD
CA125389711 rs145633003	16	S>W		No	ClinGen ESP TOPMed
CA360699409 rs1362608073	18	T>P		No	ClinGen TOPMed
rs751606904 CA3366194	19	A>S		No	ClinGen ExAC gnomAD
rs751606904 CA3366195	19	A>T		No	ClinGen ExAC gnomAD
rs370357101 CA3366196	21	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs896540832 CA125389714	23	P>R		No	ClinGen Ensembl
rs199721159 CA3366198	24	G>E		No	ClinGen ESP ExAC gnomAD
rs943648847 CA125389716	25	T>A		No	ClinGen Ensembl
rs943648847 CA360699448	25	T>P		No	ClinGen Ensembl
CA3366200 rs749668332	26	A>G		No	ClinGen ExAC gnomAD
rs780459960 CA3366199	26	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1173499506 CA360699459	27	S>G		No	ClinGen gnomAD
rs768328095 CA3366201	29	V>L		No	ClinGen ExAC gnomAD
CA360699478 rs1338267810	30	P>A		No	ClinGen gnomAD
CA360699480 rs1406556113	30	P>L		No	ClinGen TOPMed gnomAD
CA360699481 rs1406556113	30	P>R		No	ClinGen TOPMed gnomAD
rs1275149937 CA360699486	31	D>G		No	ClinGen gnomAD
CA360699483 rs1258844386	31	D>H		No	ClinGen TOPMed
CA3366203 rs747837871	32	Y>*		No	ClinGen ExAC gnomAD
rs773919552 CA3366202	32	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA360699503 rs1286574499	33	W>C		No	ClinGen gnomAD
CA360699515 rs1317630979	35	D>A		No	ClinGen gnomAD
rs1215922691 CA360699523	36	G>D		No	ClinGen TOPMed gnomAD
CA360699525 rs1215922691	36	G>V		No	ClinGen TOPMed gnomAD
CA360699539 rs1490965209	38	N>K		No	ClinGen gnomAD
CA360699542 rs1561344615	39	R>K		No	ClinGen Ensembl
rs370574051 CA3366204	40	D>H		No	ClinGen ESP ExAC
CA125389718 rs991922432	41	A>S		No	ClinGen TOPMed gnomAD
CA3366206 rs760624102	44	D>G		No	ClinGen ExAC gnomAD
CA3366208 rs776474522	47	E>Q		No	ClinGen ExAC gnomAD
CA360699602 rs1324582274	48	V>M		No	ClinGen TOPMed
CA3366210 rs765112045	49	E>K		No	ClinGen ExAC
CA3366213 rs767515073	53	G>V		No	ClinGen ExAC gnomAD
COSM1173081 CA360699643 rs1324106270	54	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
CA360699659 rs1462285868	55	G>C		No	ClinGen gnomAD
rs779229223 CA125403568	57	T>K		No	ClinGen Ensembl
rs755524875 CA3366235	59	I>V		No	ClinGen ExAC gnomAD
rs1580623704 CA360699690	60	V>A		No	ClinGen Ensembl
CA360699708 rs1561426688	63	C>R		No	ClinGen Ensembl
CA360699711 rs1424131579	63	C>Y		No	ClinGen gnomAD
CA3366239 rs753181636	64	K>N		No	ClinGen ExAC TOPMed gnomAD
CA360699738 rs1329594615	67	G>W		No	ClinGen gnomAD
CA3366240 rs534475500	69	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs371545365 CA3366242	70	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA360699781 rs1338770422	73	A>G		No	ClinGen gnomAD
rs534737957 CA3366243	74	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA360699807 rs1401544597	77	L>*		No	ClinGen TOPMed
CA360699846 rs1580669380	81	V>M		No	ClinGen Ensembl
CA3366269 rs749250902	82	D>E		No	ClinGen ExAC TOPMed gnomAD
CA360699859 rs1433531649	83	K>Q		No	ClinGen gnomAD
CA360699874 rs1198463646	84	K>N		No	ClinGen gnomAD
rs893058549 CA125407393	85	I>V		No	ClinGen TOPMed gnomAD
rs371603420 CA3366271	86	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs371603420 CA360699882	86	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1185999076 CA360699891	87	R>S		No	ClinGen TOPMed
CA3366272 rs747136676	88	T>A		No	ClinGen ExAC gnomAD
CA360699895 rs1359980318	88	T>S		No	ClinGen TOPMed gnomAD
rs771255670 CA360699904	89	E>D		No	ClinGen ExAC TOPMed gnomAD
rs776561276 CA3366274	90	I>V		No	ClinGen ExAC gnomAD
CA360699938 rs1386520704 COSM167705	95	R>C	large_intestine urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
CA3366276 rs149873223	95	R>H		No	ClinGen ESP ExAC gnomAD
CA360699953 rs1309437270	98	H>N		No	ClinGen gnomAD
CA360699981 rs1214421507	101	I>M		No	ClinGen gnomAD
rs928027119 CA125407609	102	I>V		No	ClinGen Ensembl
rs762274428 CA3366300	103	K>R		No	ClinGen ExAC gnomAD
rs767800747 CA3366301	107	I>V		No	ClinGen ExAC TOPMed gnomAD
CA360700043 rs1435602798	109	E>K		No	ClinGen TOPMed
rs1399024556 CA360700054	110	T>N		No	ClinGen gnomAD
rs1443945722 CA360700064	112	T>A		No	ClinGen TOPMed gnomAD
rs374581815 CA360700123	121	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs374581815 COSM1291994 CA3366304	121	V>I	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs753416937 CA3366305	123	G>E		No	ClinGen ExAC gnomAD
rs1288790380 CA360602113	129	R>S		No	ClinGen gnomAD
rs924346292 CA124878430	130	I>V		No	ClinGen TOPMed
rs1185230347 CA360602137	133	K>Q		No	ClinGen gnomAD
rs1174385043 COSM140519 CA360602182	139	R>*	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
rs371085970 CA3366326	139	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA3366330 rs764687788	143	D>H		No	ClinGen ExAC TOPMed gnomAD
CA3366329 rs764687788	143	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA3366332 rs373586836	145	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA360602224 rs1466835057	146	K>Q		No	ClinGen gnomAD
rs751458628 COSM145191 CA3366333	147	Q>K	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA360602270 rs1486145950	153	A>S		No	ClinGen TOPMed
CA3366355 rs577692445	154	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs996678393 CA124907698	156	H>Q		No	ClinGen TOPMed
rs755163074 CA3366356	156	H>R		No	ClinGen ExAC TOPMed gnomAD
CA360604124 rs913969260	158	N>I		No	ClinGen TOPMed gnomAD
CA124907700 rs913969260	158	N>S		No	ClinGen TOPMed gnomAD
rs1205537240 CA360604166	162	H>R		No	ClinGen gnomAD
rs1312724543 CA360604162	162	H>Y		No	ClinGen gnomAD
rs1260987863 COSM362352 CA360604175	163	R>C	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1260987863 CA360604173	163	R>G		No	ClinGen TOPMed gnomAD
rs779048280 CA3366357	163	R>H		No	ClinGen ExAC TOPMed gnomAD
CA360604203 rs1393250247	166	K>Q		No	ClinGen TOPMed
rs1289684217 CA360604224	168	E>Q		No	ClinGen gnomAD
CA124907707 rs781124981	172	Y>C		No	ClinGen gnomAD
CA360604298 rs1162868761	174	T>A		No	ClinGen TOPMed
CA3366359 rs758919973	174	T>N		No	ClinGen ExAC gnomAD
CA3366360 rs778292987	176	A>T		No	ClinGen ExAC
rs771238434 CA3366362	177	P>L		No	ClinGen ExAC TOPMed gnomAD
rs745528963 CA3366365	178	D>E		No	ClinGen ExAC gnomAD
CA360604333 rs35548075	178	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000904404 VAR_040605 rs35548075 CA3366363	178	D>N		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs775042537 CA3366366	180	P>A		No	ClinGen ExAC TOPMed gnomAD
CA3366368 rs375191310	182	K>R		No	ClinGen ESP ExAC gnomAD
CA360604784 rs1279534213	184	A>G		No	ClinGen gnomAD
rs1173126830 CA360604392	184	A>T		No	ClinGen TOPMed gnomAD
CA3366394 rs752814437	188	L>V		No	ClinGen ExAC gnomAD
rs1280423112 CA360604845	190	K>Q		No	ClinGen TOPMed
rs1269055417 CA360604879	192	V>G		No	ClinGen gnomAD
rs1211358337 CA360604899	194	H>Y		No	ClinGen TOPMed
CA3366397 rs751694743	195	Q>E		No	ClinGen ExAC gnomAD
rs1341256979 CA360604922	196	V>L		No	ClinGen TOPMed
CA360604946 rs1295185051	198	M>T		No	ClinGen Ensembl
rs1478403473 CA360605046	207	Y>C		No	ClinGen gnomAD
rs750970862 CA3366400	209	A>T		No	ClinGen ExAC TOPMed gnomAD
CA360603744 COSM735100 rs1561509623	210	P>H	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
CA3366419 rs750834121	210	P>S		No	ClinGen ExAC TOPMed gnomAD
CA3366421 rs766646584	213	L>F		No	ClinGen ExAC gnomAD
CA124917448 rs544684230	216	C>Y		No	ClinGen Ensembl
rs1459155642 CA360603845	218	Y>C		No	ClinGen gnomAD
CA3366423 rs754657855	219	G>E		No	ClinGen ExAC gnomAD
rs1403754549 CA360603867	220	P>S		No	ClinGen TOPMed
rs1159534163 CA360603929	224	M>I		No	ClinGen gnomAD
rs778752233 CA3366424	224	M>V		No	ClinGen ExAC gnomAD
CA360603963 rs747837965	227	V>I		No	ClinGen ExAC gnomAD
CA3366425 rs747837965	227	V>L		No	ClinGen ExAC gnomAD
rs1421934559 CA360603989	229	I>V		No	ClinGen TOPMed
rs988750749 CA124917459	231	T>S		No	ClinGen TOPMed
CA360605434 rs1257100479	240	P>L		No	ClinGen TOPMed gnomAD
rs775265030 CA3366454	242	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs775265030 CA360605488	242	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA3366456 rs146711371	247	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA360605707 rs1177694821	250	M>L		No	ClinGen gnomAD
rs1580807427 CA360605725	250	M>T		No	ClinGen Ensembl
rs1177694821 CA360605710	250	M>V		No	ClinGen gnomAD
CA360605949 rs1375510009	256	N>K		No	ClinGen gnomAD
CA124918671 rs867765394	263	S>F		No	ClinGen Ensembl
CA3366458 rs370296107	265	W>L		No	ClinGen ESP ExAC gnomAD
CA3366459 rs140425791	268	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1431129339 CA360606059	270	S>T		No	ClinGen gnomAD
CA3366461 rs760133605	274	K>R		No	ClinGen ExAC TOPMed gnomAD
rs931759347 CA124919584	277	V>I		No	ClinGen TOPMed
CA3366483 rs764387900	282	V>D		No	ClinGen ExAC gnomAD
rs143584280 CA360606688	284	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143584280 CA3366484	284	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1059491 rs1467647797 CA360606738	286	K>N	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA360606753 rs1411804064	287	K>E		No	ClinGen Ensembl
CA360606776 rs1191132469	288	R>G		No	ClinGen TOPMed gnomAD
rs761376306 CA3366485	288	R>Q		No	ClinGen ExAC gnomAD
CA360606778 rs1191132469	288	R>W		No	ClinGen TOPMed gnomAD
CA360606830 rs1157904670	291	T>I		No	ClinGen gnomAD
CA360606914 rs1405569625	295	L>F		No	ClinGen TOPMed gnomAD
rs1405569625 CA360606912	295	L>V		No	ClinGen TOPMed gnomAD
CA3366488 rs756021185	296	Q>H		No	ClinGen ExAC gnomAD
rs1393937416 CA360606991	298	P>L		No	ClinGen gnomAD
CA360607026 rs1332245994	299	W>C		No	ClinGen TOPMed
CA360607029 rs1333517007	300	V>I		No	ClinGen gnomAD
CA360607099 rs1580812335	304	A>T		No	ClinGen Ensembl
CA360607113 rs1406932683	305	A>T		No	ClinGen TOPMed
rs753752146 CA3366490	306	N>K		No	ClinGen ExAC gnomAD
CA3366491 rs754754366	311	D>N		No	ClinGen ExAC gnomAD
rs1329640890 CA360607232	312	T>S		No	ClinGen Ensembl
CA3366493 rs747191487	313	A>T		No	ClinGen ExAC TOPMed gnomAD
RCV001199844 rs1755482400 RCV001728096	314	Q>*		No	ClinVar dbSNP
rs781411517 CA124919601	323	R>G		No	ClinGen ExAC TOPMed gnomAD
rs745997457 CA3366496	323	R>Q		No	ClinGen ExAC gnomAD
rs781411517 COSM1644472 CA3366495	323	R>W	salivary_gland [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs765081287 CA3366516	328	A>S		No	ClinGen ExAC gnomAD
CA360607566 rs1270266001	329	A>V		No	ClinGen gnomAD
CA360607602 rs1256587891	335	A>V		No	ClinGen gnomAD
CA360607610 rs1474078636	336	S>F		No	ClinGen gnomAD
rs746112718 CA3366520 COSM1671799	338	R>C	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA360607619 rs972309056	338	R>H		No	ClinGen gnomAD
CA124919824 rs972309056	338	R>L		No	ClinGen gnomAD
rs756201485 CA3366521	341	S>G		No	ClinGen ExAC gnomAD
CA360607636 rs1427340921	341	S>N		No	ClinGen gnomAD
CA360607638 rs1435943134	341	S>R		No	ClinGen gnomAD
CA3366522 rs779999425	342	A>T		No	ClinGen ExAC gnomAD
CA3366523 rs139181917	343	S>G		No	ClinGen ESP ExAC gnomAD
CA360607665 rs1464912848	343	S>N		No	ClinGen TOPMed
rs769100994 CA3366524	345	S>I		No	ClinGen ExAC TOPMed gnomAD
rs769100994 CA3366525	345	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1319894590 CA360607719	346	H>R		No	ClinGen gnomAD
CA124919835 rs201284909	349	I>N		No	ClinGen 1000Genomes ExAC gnomAD
CA3366526 rs201284909	349	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs772454448 CA3366527	350	Q>*		No	ClinGen ExAC gnomAD
rs1580813828 CA360607790	350	Q>R		No	ClinGen Ensembl
rs577632827 CA3366530	352	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs776075749 CA3366531	353	H>D		No	ClinGen ExAC TOPMed gnomAD
rs759508095 CA3366532	354	K>N		No	ClinGen ExAC gnomAD
rs765140144 CA3366533	355	A>G		No	ClinGen ExAC gnomAD
rs1262167336 CA360607947	357	R>*		No	ClinGen TOPMed gnomAD
CA360607951 rs368611073	357	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs368611073 CA3366534	357	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA3366535 rs758216235	358	D>E		No	ClinGen ExAC gnomAD
rs763990773 CA3366537	359	P>H		No	ClinGen ExAC gnomAD
CA3366536 rs763990773	359	P>L		No	ClinGen ExAC gnomAD
CA3366538 rs756467199	361	P>S		No	ClinGen ExAC TOPMed gnomAD
CA3366539 rs77423024	362	I>V		No	ClinGen 1000Genomes ExAC
rs1561516046 CA360608096	363	Q>H		No	ClinGen Ensembl
CA360608112 rs1272361752	364	D>Y		No	ClinGen TOPMed
rs749375824 CA3366540	365	G>S		No	ClinGen ExAC TOPMed gnomAD
CA3366541 rs755478608	365	G>V		No	ClinGen ExAC gnomAD
CA360608171 rs748677635	366	N>K		No	ClinGen ExAC TOPMed gnomAD
CA3366542 rs779246352	366	N>S		No	ClinGen ExAC gnomAD
rs772366765 CA3366544	367	E>K		No	ClinGen ExAC TOPMed gnomAD
rs772366765 CA3366545	367	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs376502428 CA3366546	368	D>H		No	ClinGen ExAC TOPMed gnomAD
rs376502428 CA124919867	368	D>N		No	ClinGen ExAC TOPMed gnomAD
rs371660564 CA124919870	369	M>L		No	ClinGen ESP gnomAD
CA3366547 rs200094743	370	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA124919873 rs867856157	371	A>V		No	ClinGen Ensembl
rs776185795 CA3366548	372	I>S		No	ClinGen ExAC gnomAD
CA360608275 rs1440926092	372	I>V		No	ClinGen gnomAD
COSM1718315 rs1561516125 CA360608293	373	P>L	NS [Cosmic]	No	ClinGen cosmic curated Ensembl
CA124919877 rs867091227	375	G>E		No	ClinGen Ensembl
rs1451924691 COSM1696030 CA360608312	375	G>R	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs759011394 CA3366549	378	I>L		No	ClinGen ExAC TOPMed gnomAD
CA3366550 rs769380463	380	G>D		No	ClinGen ExAC TOPMed gnomAD
CA360608399 rs1580814075	381	D>E		No	ClinGen Ensembl
rs775508053 CA3366551	381	D>N		No	ClinGen ExAC gnomAD
CA360608395 rs1275231002	381	D>V		No	ClinGen TOPMed gnomAD
CA360608414 rs1193015329	383	A>P		No	ClinGen gnomAD
rs751454476 CA360608426	384	Q>E		No	ClinGen ExAC gnomAD
rs751454476 CA3366554	384	Q>K		No	ClinGen ExAC gnomAD
CA3366556 COSM2990796 rs751581823	386	A>T	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs754120828 CA3366557	389	G>V		No	ClinGen ExAC TOPMed gnomAD
CA360608497 rs1396126836	390	A>S		No	ClinGen gnomAD
CA124919891 rs901315404	391	Q>*		No	ClinGen Ensembl
rs754962551 CA3366558	392	A>P		No	ClinGen ExAC gnomAD
CA124919895 rs755042933	394	L>V		No	ClinGen TOPMed gnomAD
CA360608533 rs1368126909	395	M>I		No	ClinGen gnomAD
rs1436374140 CA360608541	396	K>N		No	ClinGen TOPMed
rs779066316 CA3366559	397	V>G		No	ClinGen ExAC gnomAD
CA360608558 rs1236542156	399	A>D		No	ClinGen gnomAD
CA360608557 rs1334973428	399	A>S		No	ClinGen gnomAD
rs367701970 CA3366561	400	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA360608574 rs1206445374	401	E>D		No	ClinGen TOPMed
CA3366562 rs778102584	405	G>V		No	ClinGen ExAC gnomAD
CA124919904 rs888959228	407	D>G		No	ClinGen TOPMed
CA3366563 rs747426080	407	D>Y		No	ClinGen ExAC gnomAD
rs564406339 CA3366564	409	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780670278 CA3366565	411	E>A		No	ClinGen ExAC TOPMed gnomAD
CA360608694 rs780670278	411	E>G		No	ClinGen ExAC TOPMed gnomAD
CA3366568 rs147516085	413	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3366567 rs147516085	413	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3366569 rs371455365	414	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1454777583 CA360608766	415	K>E		No	ClinGen TOPMed gnomAD
CA3366571 rs752777797	415	K>R		No	ClinGen ExAC TOPMed gnomAD
rs752777797 CA3366570	415	K>T		No	ClinGen ExAC TOPMed gnomAD
CA124919918 rs1007270187	416	M>I		No	ClinGen Ensembl
CA124919921 rs1037329025	417	V>A		No	ClinGen Ensembl
CA360608801 rs1419019755	417	V>M		No	ClinGen gnomAD
CA360608818 rs1475361239	420	A>T		No	ClinGen gnomAD
CA3366573 rs767364762	422	E>K		No	ClinGen ExAC gnomAD
rs1463029846 CA360608849	424	G>E		No	ClinGen gnomAD
rs1298694306 CA360608862	426	K>T		No	ClinGen gnomAD
CA3366574 rs528974906	428	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs765297266 CA124919930	431	E>K		No	ClinGen ExAC gnomAD
CA3366576 rs765297266	431	E>Q		No	ClinGen ExAC gnomAD
CA124919934 rs756355340	433	E>Q		No	ClinGen gnomAD
rs777904792 CA360609434	435	G>C		No	ClinGen gnomAD
rs1309345941 CA360609435	435	G>D		No	ClinGen gnomAD
CA124919940 rs777904792	435	G>S		No	ClinGen gnomAD
rs550729462 CA3366577	439	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758885402 CA3366578	441	L>R		No	ClinGen ExAC gnomAD
CA124919945 rs1014030447	442	K>E		No	ClinGen gnomAD
rs143979132 CA3366579	443	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757517291 CA3366581	444	V>M		No	ClinGen ExAC gnomAD
rs970113594 CA124919950	445	E>G		No	ClinGen Ensembl
CA360609610 rs1338040251	446	E>Q		No	ClinGen gnomAD
CA124919952 rs1042101	447	A>V		No	ClinGen Ensembl
rs749615259 CA124919954	449	A>P		No	ClinGen Ensembl
CA3366582 rs781621581	450	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1429779295 CA360609676	450	P>T		No	ClinGen gnomAD
rs1371974991 CA360609732	453	G>R		No	ClinGen gnomAD
CA360609769 rs1427787062	455	G>R		No	ClinGen gnomAD
CA124919958 rs951870750	458	A>V		No	ClinGen TOPMed gnomAD
rs796512436 CA124919962	462	E>D		No	ClinGen Ensembl
CA360609921 rs1462983743	463	V>A		No	ClinGen gnomAD
CA360609913 rs1490328458	463	V>L		No	ClinGen TOPMed
rs769540190 CA3366584	465	Q>*		No	ClinGen ExAC gnomAD
rs56360861 RCV000956297 CA3366585 VAR_040606	465	Q>R		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA3366586 rs142533405	466	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA360609996 rs1194725086	467	D>E		No	ClinGen gnomAD
CA360609988 rs1322355095	467	D>G		No	ClinGen TOPMed
rs922833566 CA124919968	468	V>M		No	ClinGen gnomAD
rs1239950009 VAR_040607 COSM12952 CA360610011	469	I>M	lung a lung large cell carcinoma sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt Ensembl dbSNP
CA3366587 rs202093306	472	E>*		No	ClinGen ExAC TOPMed gnomAD
CA360610037 rs1222251103	472	E>V		No	ClinGen TOPMed
CA360610060 rs1281611760	473	Y>*		No	ClinGen gnomAD

No associated diseases with Q16566

3 regional properties for Q16566

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	46 - 300	IPR000719
active_site	Serine/threonine-protein kinase, active site	160 - 172	IPR008271
binding_site	Protein kinase, ATP binding site	52 - 75	IPR017441

Functions

		Description
EC Number	2.7.11.17	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Nucleus	Localized in hippocampal neuron nuclei In spermatids, associated with chromatin and nuclear matrix (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
fibrillar center	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
postsynapse	The part of a synapse that is part of the post-synaptic cell.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium-dependent protein serine/threonine kinase activity	Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein kinase activity	Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

12 GO annotations of biological process

Name	Definition
adaptive immune response	An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
long-term memory	The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
myeloid dendritic cell differentiation	The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of transcription, DNA-templated	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of osteoclast differentiation	Any process that modulates the frequency, rate or extent of osteoclast differentiation.
regulation of T cell differentiation in thymus	Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

103 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A4IFM7	MYLK2	Myosin light chain kinase 2, skeletal/cardiac muscle	Bos taurus (Bovine)	SS
Q0V7M1	PSKH1	Serine/threonine-protein kinase H1	Bos taurus (Bovine)	SS
Q0VD22	STK33	Serine/threonine-protein kinase 33	Bos taurus (Bovine)	PR
Q96NX5	CAMK1G	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (Human)	SS
O15075	DCLK1	Serine/threonine-protein kinase DCLK1	Homo sapiens (Human)	EV
Q14012	CAMK1	Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (Human)	EV
Q9UIK4	DAPK2	Death-associated protein kinase 2	Homo sapiens (Human)	EV
O94768	STK17B	Serine/threonine-protein kinase 17B	Homo sapiens (Human)	PR
Q86YV6	MYLK4	Myosin light chain kinase family member 4	Homo sapiens (Human)	SS
P11801	PSKH1	Serine/threonine-protein kinase H1	Homo sapiens (Human)	SS
Q8N568	DCLK2	Serine/threonine-protein kinase DCLK2	Homo sapiens (Human)	PR
Q9UEE5	STK17A	Serine/threonine-protein kinase 17A	Homo sapiens (Human)	SS
O75962	TRIO	Triple functional domain protein	Homo sapiens (Human)	EV
Q9H1R3	MYLK2	Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (Human)	EV
Q32MK0	MYLK3	Myosin light chain kinase 3	Homo sapiens (Human)	SS
Q8WWF8	CAPSL	Calcyphosin-like protein	Homo sapiens (Human)	PR
P53355	DAPK1	Death-associated protein kinase 1	Homo sapiens (Human)	EV
Q6P2M8	PNCK	Calcium/calmodulin-dependent protein kinase type 1B	Homo sapiens (Human)	SS
Q9BYT3	STK33	Serine/threonine-protein kinase 33	Homo sapiens (Human)	PR
Q8NCB2	CAMKV	CaM kinase-like vesicle-associated protein	Homo sapiens (Human)	SS
O43293	DAPK3	Death-associated protein kinase 3	Homo sapiens (Human)	PR
Q8IU85	CAMK1D	Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (Human)	SS
Q8IW41	MAPKAPK5	MAP kinase-activated protein kinase 5	Homo sapiens (Human)	SS
Q16644	MAPKAPK3	MAP kinase-activated protein kinase 3	Homo sapiens (Human)	SS
P49137	MAPKAPK2	MAP kinase-activated protein kinase 2	Homo sapiens (Human)	EV
Q9QYK9	Pnck	Calcium/calmodulin-dependent protein kinase type 1B	Mus musculus (Mouse)	PR
Q91VB2	Camk1g	Calcium/calmodulin-dependent protein kinase type 1G	Mus musculus (Mouse)	SS
Q8BG48	Stk17b	Serine/threonine-protein kinase 17B	Mus musculus (Mouse)	PR
Q8VCR8	Mylk2	Myosin light chain kinase 2, skeletal/cardiac muscle	Mus musculus (Mouse)	SS
Q6PGN3	Dclk2	Serine/threonine-protein kinase DCLK2	Mus musculus (Mouse)	PR
Q91YS8	Camk1	Calcium/calmodulin-dependent protein kinase type 1	Mus musculus (Mouse)	SS
Q3UIZ8	Mylk3	Myosin light chain kinase 3	Mus musculus (Mouse)	SS
Q8VDF3	Dapk2	Death-associated protein kinase 2	Mus musculus (Mouse)	EV
Q6P8Y1	Capsl	Calcyphosin-like protein	Mus musculus (Mouse)	PR
Q8BW96	Camk1d	Calcium/calmodulin-dependent protein kinase type 1D	Mus musculus (Mouse)	SS
Q3UHL1	Camkv	CaM kinase-like vesicle-associated protein	Mus musculus (Mouse)	SS
Q9JLM8	Dclk1	Serine/threonine-protein kinase DCLK1	Mus musculus (Mouse)	SS
Q91YA2	Pskh1	Serine/threonine-protein kinase H1	Mus musculus (Mouse)	SS
Q80YE7	Dapk1	Death-associated protein kinase 1	Mus musculus (Mouse)	SS
Q62407	Speg	Striated muscle-specific serine/threonine-protein kinase	Mus musculus (Mouse)	SS
Q0KL02	Trio	Triple functional domain protein	Mus musculus (Mouse)	SS
Q924X7	Stk33	Serine/threonine-protein kinase 33	Mus musculus (Mouse)	PR
O54784	Dapk3	Death-associated protein kinase 3	Mus musculus (Mouse)	PR
P08414	Camk4	Calcium/calmodulin-dependent protein kinase type IV	Mus musculus (Mouse)	SS
Q7TNJ7	Camk1g	Calcium/calmodulin-dependent protein kinase type 1G	Rattus norvegicus (Rat)	SS
P20689	Mylk2	Myosin light chain kinase 2, skeletal/cardiac muscle	Rattus norvegicus (Rat)	SS
F1M0Z1	Trio	Triple functional domain protein	Rattus norvegicus (Rat)	SS
Q91XS8	Stk17b	Serine/threonine-protein kinase 17B	Rattus norvegicus (Rat)	PR
O08875	Dclk1	Serine/threonine-protein kinase DCLK1	Rattus norvegicus (Rat)	PR
E9PT87	Mylk3	Myosin light chain kinase 3	Rattus norvegicus (Rat)	SS
O70150	Pnck	Calcium/calmodulin-dependent protein kinase type 1B	Rattus norvegicus (Rat)	PR
Q63092	Camkv	CaM kinase-like vesicle-associated protein	Rattus norvegicus (Rat)	SS
Q63638	Speg	Striated muscle-specific serine/threonine-protein kinase	Rattus norvegicus (Rat)	SS
O88764	Dapk3	Death-associated protein kinase 3	Rattus norvegicus (Rat)	PR
Q63450	Camk1	Calcium/calmodulin-dependent protein kinase type 1	Rattus norvegicus (Rat)	EV
P97924	Kalrn	Kalirin	Rattus norvegicus (Rat)	SS
Q5MPA9	Dclk2	Serine/threonine-protein kinase DCLK2	Rattus norvegicus (Rat)	PR
P13234	Camk4	Calcium/calmodulin-dependent protein kinase type IV	Rattus norvegicus (Rat)	SS
Q6AVM3	CCAMK	Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase	Oryza sativa subsp japonica (Rice)	PR
P53682	CPK23	Calcium-dependent protein kinase 23	Oryza sativa subsp japonica (Rice)	PR
P53684	CPK7	Calcium-dependent protein kinase 7	Oryza sativa subsp japonica (Rice)	PR
Q5VQQ5	CPK2	Calcium-dependent protein kinase 2	Oryza sativa subsp. japonica (Rice)	SS
Q6I5I8	CPK16	Calcium-dependent protein kinase 16	Oryza sativa subsp. japonica (Rice)	SS
Q6K968	CPK6	Calcium-dependent protein kinase 6	Oryza sativa subsp. japonica (Rice)	SS
Q75GE8	CPK8	Calcium-dependent protein kinase 8	Oryza sativa subsp. japonica (Rice)	SS
Q84SL0	CPK20	Calcium-dependent protein kinase 20	Oryza sativa subsp. japonica (Rice)	SS
Q8LPZ7	CPK3	Calcium-dependent protein kinase 3	Oryza sativa subsp. japonica (Rice)	SS
Q9TXJ0	cmk-1	Calcium/calmodulin-dependent protein kinase type 1	Caenorhabditis elegans	PR
O44997	dapk-1	Death-associated protein kinase dapk-1	Caenorhabditis elegans	SS
Q95QC4	zyg-8	Serine/threonine-protein kinase zyg-8	Caenorhabditis elegans	PR
P28583		Calcium-dependent protein kinase SK5	Glycine max (Soybean) (Glycine hispida)	PR
Q9M9V8	CPK10	Calcium-dependent protein kinase 10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FX86	CRK8	CDPK-related kinase 8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SSF8	CPK30	Calcium-dependent protein kinase 30	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SIQ7	CPK24	Calcium-dependent protein kinase 24	Arabidopsis thaliana (Mouse-ear cress)	PR
P93759	GK-1	Calcium-dependent protein kinase 14	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8S8S2	LPEAT2	Lysophospholipid acyltransferase LPEAT2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LJL9	CRK2	CDPK-related kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SG12	CRK6	CDPK-related kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SCS2	CRK5	CDPK-related kinase 5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8W4I7	CPK13	Calcium-dependent protein kinase 13	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6NLQ6	CPK32	Calcium-dependent protein kinase 32	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38873	CPK7	Calcium-dependent protein kinase 7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q42438	CPK8	Calcium-dependent protein kinase 8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q06850	CPK1	Calcium-dependent protein kinase 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38869	CPK4	Calcium-dependent protein kinase 4	Arabidopsis thaliana (Mouse-ear cress)	SS
Q38870	CPK2	Calcium-dependent protein kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38872	CPK6	Calcium-dependent protein kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q39016	CPK11	Calcium-dependent protein kinase 11	Arabidopsis thaliana (Mouse-ear cress)	SS
Q3E9C0	CPK34	Calcium-dependent protein kinase 34	Arabidopsis thaliana (Mouse-ear cress)	PR
Q42396	CPK12	Calcium-dependent protein kinase 12	Arabidopsis thaliana (Mouse-ear cress)	SS
Q42479	CPK3	Calcium-dependent protein kinase 3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q7XJR9	CPK16	Calcium-dependent protein kinase 16	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FMP5	CPK17	Calcium-dependent protein kinase 17	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SJ61	CPK25	Calcium-dependent protein kinase 25	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZSA4	CPK27	Calcium-dependent protein kinase 27	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZV15	CPK20	Calcium-dependent protein kinase 20	Arabidopsis thaliana (Mouse-ear cress)	PR
Q1PE17	CPK18	Calcium-dependent protein kinase 18	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FKW4	CPK28	Calcium-dependent protein kinase 28	Arabidopsis thaliana (Mouse-ear cress)	SS
Q38997	KIN10	SNF1-related protein kinase catalytic subunit alpha KIN10	Arabidopsis thaliana (Mouse-ear cress)	SS
Q1LUA6	trio	Triple functional domain protein	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
A8C984	mylk3	Myosin light chain kinase 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q7SY49	camkv	CaM kinase-like vesicle-associated protein	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MLKVTVPSCS	ASSCSSVTAS	AAPGTASLVP	DYWIDGSNRD	ALSDFFEVES	ELGRGATSIV
70	80	90	100	110	120
YRCKQKGTQK	PYALKVLKKT	VDKKIVRTEI	GVLLRLSHPN	IIKLKEIFET	PTEISLVLEL
130	140	150	160	170	180
VTGGELFDRI	VEKGYYSERD	AADAVKQILE	AVAYLHENGI	VHRDLKPENL	LYATPAPDAP
190	200	210	220	230	240
LKIADFGLSK	IVEHQVLMKT	VCGTPGYCAP	EILRGCAYGP	EVDMWSVGII	TYILLCGFEP
250	260	270	280	290	300
FYDERGDQFM	FRRILNCEYY	FISPWWDEVS	LNAKDLVRKL	IVLDPKKRLT	TFQALQHPWV
310	320	330	340	350	360
TGKAANFVHM	DTAQKKLQEF	NARRKLKAAV	KAVVASSRLG	SASSSHGSIQ	ESHKASRDPS
370	380	390	400	410	420
PIQDGNEDMK	AIPEGEKIQG	DGAQAAVKGA	QAELMKVQAL	EKVKGADINA	EEAPKMVPKA
430	440	450	460	470
VEDGIKVADL	ELEEGLAEEK	LKTVEEAAAP	REGQGSSAVG	FEVPQQDVIL	PEY