Q16539

SS
Gene name
MAPK14 (CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A)
Protein name
Mitogen-activated protein kinase 14
Names
MAP kinase 14 , MAPK 14 , EC 2.7.11.24 , Cytokine suppressive anti-inflammatory drug-binding protein , CSAID-binding protein , CSBP , MAP kinase MXI2 , MAX-interacting protein 2 , Mitogen-activated protein kinase p38 alpha , MAP kinase p38 alpha , Stress-activated protein kinase 2a , SAPK2a
Species
Homo sapiens (Human)
KEGG Pathway
hsa:1432
EC number
2.7.11.24: Protein-serine/threonine kinases
Protein Class

Descriptions

MAPK1 encodes Mitogen-activated protein kinase 1, and is involved in diverse cellular responses by phosphorylating cytoplasmic and nuclear proteins. Unlike other MAP kinases, MAPK1 activates via dual phosphorylation of Thr-186 and Tyr-193 within the activation lip, and mutations at Q105 alone were sufficient for autoactivation. Additionally, in the inactive form, L76, Q10 and I87 form a structural unit that restrains intramolecular autophosphorylation by preventing interactions between activation lip residues and the catalytic base (D149) needed for phosphoryl transfer. Mutations at L76, I87 and additionally S153 increased basal specific activity via autophosphorylation of Thr-186 and Tyr-193.

Autoinhibitory domains (AIDs)

73-152 (Autoinhibitory region) SS

Target domain

24-308 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

167-187 (Activation loop from InterPro)

Target domain

24-308 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

246 structures for Q16539

Entry ID Method Resolution Chain Position Source
1A9U X-ray 250 A A 1-360 PDB
1BL6 X-ray 250 A A 1-360 PDB
1BL7 X-ray 250 A A 1-360 PDB
1BMK X-ray 240 A A 1-360 PDB
1DI9 X-ray 260 A A 1-360 PDB
1IAN X-ray 200 A A 2-360 PDB
1KV1 X-ray 250 A A 1-360 PDB
1KV2 X-ray 280 A A 1-360 PDB
1M7Q X-ray 240 A A 1-360 PDB
1OUK X-ray 250 A A 1-360 PDB
1OUY X-ray 250 A A 1-360 PDB
1OVE X-ray 210 A A 1-360 PDB
1OZ1 X-ray 210 A A 1-360 PDB
1R39 X-ray 230 A A 1-360 PDB
1R3C X-ray 200 A A 1-360 PDB
1W7H X-ray 221 A A 2-360 PDB
1W82 X-ray 220 A A 2-360 PDB
1W83 X-ray 250 A A 2-360 PDB
1W84 X-ray 220 A A 2-360 PDB
1WBN X-ray 240 A A 2-360 PDB
1WBO X-ray 216 A A 2-360 PDB
1WBS X-ray 180 A A 2-360 PDB
1WBT X-ray 200 A A 2-360 PDB
1WBV X-ray 200 A A 2-360 PDB
1WBW X-ray 241 A A 2-360 PDB
1WFC X-ray 230 A A 1-360 PDB
1YQJ X-ray 200 A A 2-360 PDB
1ZYJ X-ray 200 A A 1-360 PDB
1ZZ2 X-ray 200 A A 1-360 PDB
1ZZL X-ray 200 A A 4-354 PDB
2BAJ X-ray 225 A A 2-360 PDB
2BAK X-ray 220 A A 2-360 PDB
2BAL X-ray 210 A A 2-360 PDB
2BAQ X-ray 280 A A 2-360 PDB
2FSL X-ray 170 A X 2-360 PDB
2FSM X-ray 186 A X 2-360 PDB
2FSO X-ray 183 A X 2-360 PDB
2FST X-ray 145 A X 2-360 PDB
2GFS X-ray 175 A A 2-360 PDB
2I0H X-ray 200 A A 1-360 PDB
2LGC NMR - A 2-354 PDB
2NPQ X-ray 180 A A 2-360 PDB
2OKR X-ray 200 A A/D 2-360 PDB
2ONL X-ray 400 A A/B 2-360 PDB
2QD9 X-ray 170 A A 2-360 PDB
2RG5 X-ray 240 A A 2-360 PDB
2RG6 X-ray 172 A A 2-360 PDB
2Y8O X-ray 195 A A 1-360 PDB
2YIS X-ray 200 A A 2-360 PDB
2YIW X-ray 200 A A 2-360 PDB
2YIX X-ray 230 A A 4-354 PDB
2ZAZ X-ray 180 A A 1-360 PDB
2ZB0 X-ray 210 A A 1-360 PDB
2ZB1 X-ray 250 A A 1-360 PDB
3BV2 X-ray 240 A A 2-360 PDB
3BV3 X-ray 259 A A 2-360 PDB
3BX5 X-ray 240 A A 2-360 PDB
3C5U X-ray 280 A A 2-360 PDB
3CTQ X-ray 195 A A 5-352 PDB
3D7Z X-ray 210 A A 1-360 PDB
3D83 X-ray 190 A A 1-360 PDB
3DS6 X-ray 290 A A/B/C/D 1-360 PDB
3DT1 X-ray 280 A A 1-360 PDB
3E92 X-ray 200 A A 1-360 PDB
3E93 X-ray 200 A A 1-360 PDB
3FC1 X-ray 240 A X 1-360 PDB
3FI4 X-ray 220 A A 1-360 PDB
3FKL X-ray 200 A A 1-360 PDB
3FKN X-ray 200 A A 1-360 PDB
3FKO X-ray 200 A A 1-360 PDB
3FL4 X-ray 180 A A 1-360 PDB
3FLN X-ray 190 A C 1-360 PDB
3FLQ X-ray 190 A A 1-360 PDB
3FLS X-ray 230 A A 1-360 PDB
3FLW X-ray 210 A A 1-360 PDB
3FLY X-ray 180 A A 1-360 PDB
3FLZ X-ray 223 A A 1-360 PDB
3FMH X-ray 190 A A 1-360 PDB
3FMJ X-ray 200 A A 1-360 PDB
3FMK X-ray 170 A A 1-360 PDB
3FML X-ray 210 A A 1-360 PDB
3FMM X-ray 200 A A 1-360 PDB
3FMN X-ray 190 A A 1-360 PDB
3FSF X-ray 210 A A 1-360 PDB
3FSK X-ray 200 A A 1-360 PDB
3GC7 X-ray 180 A A 1-360 PDB
3GCP X-ray 225 A A 2-360 PDB
3GCQ X-ray 200 A A 2-360 PDB
3GCS X-ray 210 A A 2-360 PDB
3GCU X-ray 210 A A/B 2-360 PDB
3GCV X-ray 230 A A 2-360 PDB
3GFE X-ray 210 A A 1-360 PDB
3GI3 X-ray 240 A A 1-360 PDB
3HA8 X-ray 248 A A 1-360 PDB
3HEC X-ray 250 A A 5-352 PDB
3HEG X-ray 220 A A 5-352 PDB
3HL7 X-ray 188 A A 1-360 PDB
3HLL X-ray 195 A A 1-360 PDB
3HP2 X-ray 215 A A 1-360 PDB
3HP5 X-ray 230 A A 1-360 PDB
3HRB X-ray 220 A A 2-360 PDB
3HUB X-ray 225 A A 2-360 PDB
3HUC X-ray 180 A A 2-360 PDB
3HV3 X-ray 200 A A 2-360 PDB
3HV4 X-ray 260 A A/B 2-360 PDB
3HV5 X-ray 225 A A/B 2-360 PDB
3HV6 X-ray 195 A A 2-360 PDB
3HV7 X-ray 240 A A 2-360 PDB
3HVC X-ray 210 A A 1-360 PDB
3IPH X-ray 210 A A 1-360 PDB
3ITZ X-ray 225 A A 1-360 PDB
3IW5 X-ray 250 A A 2-360 PDB
3IW6 X-ray 210 A A 2-360 PDB
3IW7 X-ray 240 A A 2-360 PDB
3IW8 X-ray 200 A A 2-360 PDB
3K3I X-ray 170 A A 5-352 PDB
3K3J X-ray 200 A A 1-360 PDB
3KF7 X-ray 200 A A 1-360 PDB
3KQ7 X-ray 180 A A 1-360 PDB
3L8S X-ray 235 A A 2-360 PDB
3L8X X-ray 215 A A 2-360 PDB
3LFA X-ray 210 A A 2-360 PDB
3LFB X-ray 260 A A 2-360 PDB
3LFC X-ray 280 A A 2-360 PDB
3LFD X-ray 340 A A 2-360 PDB
3LFE X-ray 230 A A 2-360 PDB
3LFF X-ray 150 A A 2-360 PDB
3LHJ X-ray 331 A A 1-360 PDB
3MGY X-ray 210 A A 1-360 PDB
3MH0 X-ray 200 A A 1-360 PDB
3MH1 X-ray 220 A A 1-360 PDB
3MH2 X-ray 230 A A 1-360 PDB
3MH3 X-ray 220 A A 1-360 PDB
3MPA X-ray 210 A A 1-360 PDB
3MPT X-ray 189 A A 1-360 PDB
3MVL X-ray 280 A A/B 2-360 PDB
3MVM X-ray 200 A A/B 2-360 PDB
3MW1 X-ray 280 A A 2-360 PDB
3NEW X-ray 251 A A 1-360 PDB
3NNU X-ray 240 A A 1-354 PDB
3NNV X-ray 210 A A 1-354 PDB
3NNW X-ray 189 A A 1-354 PDB
3NNX X-ray 228 A A 1-354 PDB
3NWW X-ray 209 A A 2-360 PDB
3O8P X-ray 210 A A 1-360 PDB
3O8T X-ray 200 A A 1-360 PDB
3O8U X-ray 210 A A 1-360 PDB
3OBG X-ray 280 A A 1-360 PDB
3OBJ X-ray 240 A A 1-360 PDB
3OC1 X-ray 259 A A 1-360 PDB
3OCG X-ray 221 A A 2-360 PDB
3OD6 X-ray 268 A X 1-360 PDB
3ODY X-ray 220 A X 1-360 PDB
3ODZ X-ray 230 A X 1-360 PDB
3OEF X-ray 160 A X 1-360 PDB
3PG3 X-ray 200 A A 2-360 PDB
3QUD X-ray 200 A A 2-360 PDB
3QUE X-ray 270 A A 2-360 PDB
3RIN X-ray 220 A A 1-360 PDB
3ROC X-ray 170 A A 1-360 PDB
3S3I X-ray 180 A A 4-352 PDB
3S4Q X-ray 227 A A 2-360 PDB
3U8W X-ray 215 A A 1-360 PDB
3UVP X-ray 240 A A 2-360 PDB
3UVQ X-ray 220 A A 2-360 PDB
3UVR X-ray 210 A A 2-360 PDB
3ZS5 X-ray 160 A A 2-360 PDB
3ZSG X-ray 189 A A 2-360 PDB
3ZSH X-ray 205 A A 2-360 PDB
3ZSI X-ray 240 A A 2-360 PDB
3ZYA X-ray 190 A A 1-360 PDB
4A9Y X-ray 220 A A 2-360 PDB
4AA0 X-ray 180 A A 2-360 PDB
4AA4 X-ray 230 A A 2-360 PDB
4AA5 X-ray 238 A A 2-360 PDB
4AAC X-ray 250 A A 2-360 PDB
4DLI X-ray 191 A A 2-360 PDB
4DLJ X-ray 260 A A 2-360 PDB
4E5A X-ray 187 A X 1-360 PDB
4E5B X-ray 200 A A 1-360 PDB
4E6A X-ray 209 A A 1-360 PDB
4E6C X-ray 239 A A 1-360 PDB
4E8A X-ray 270 A A 1-360 PDB
4EH2 X-ray 200 A A 2-360 PDB
4EH3 X-ray 240 A A 2-360 PDB
4EH4 X-ray 250 A A 2-360 PDB
4EH5 X-ray 200 A A 2-360 PDB
4EH6 X-ray 210 A A 2-360 PDB
4EH7 X-ray 210 A A 2-360 PDB
4EH8 X-ray 220 A A 2-360 PDB
4EH9 X-ray 210 A A 2-360 PDB
4EHV X-ray 160 A A 2-360 PDB
4EWQ X-ray 210 A A 2-360 PDB
4F9W X-ray 200 A A 2-360 PDB
4F9Y X-ray 185 A A 2-360 PDB
4FA2 X-ray 200 A A 2-360 PDB
4GEO X-ray 166 A A 2-360 PDB
4KIN X-ray 197 A A/B/C/D 2-360 PDB
4KIP X-ray 227 A A/B 2-360 PDB
4KIQ X-ray 250 A A/B/C/D 2-360 PDB
4L8M X-ray 210 A A 2-360 PDB
4R3C X-ray 206 A A 2-360 PDB
4ZTH X-ray 215 A A 2-360 PDB
5ETA X-ray 280 A A/B 1-360 PDB
5ETC X-ray 242 A A 1-360 PDB
5ETF X-ray 240 A A 1-360 PDB
5ETI X-ray 280 A A 1-360 PDB
5ML5 X-ray 190 A A 1-360 PDB
5MTX X-ray 180 A A 1-360 PDB
5MTY X-ray 231 A A 1-360 PDB
5MZ3 X-ray 215 A A 1-360 PDB
5N63 X-ray 240 A A 1-360 PDB
5N64 X-ray 240 A A 1-360 PDB
5N65 X-ray 200 A A 1-360 PDB
5N66 X-ray 240 A A 1-360 PDB
5N67 X-ray 190 A A 1-360 PDB
5N68 X-ray 185 A A 1-360 PDB
5O8U X-ray 200 A A 1-360 PDB
5O8V X-ray 200 A A 1-360 PDB
5OMG X-ray 200 A A 1-360 PDB
5OMH X-ray 250 A A 1-360 PDB
5TBE X-ray 244 A A 1-360 PDB
5TCO X-ray 210 A A 2-360 PDB
5WJJ X-ray 160 A A 1-360 PDB
5XYX X-ray 261 A A 1-360 PDB
5XYY X-ray 170 A A 1-360 PDB
6ANL X-ray 200 A A 1-360 PDB
6HWT X-ray 170 A A 2-360 PDB
6HWU X-ray 230 A A 2-360 PDB
6HWV X-ray 170 A A 2-360 PDB
6M95 X-ray 180 A A 1-360 PDB
6M9L X-ray 245 A A 1-360 PDB
6OHD X-ray 250 A A 1-360 PDB
6QDZ X-ray 173 A A 1-360 PDB
6QE1 X-ray 185 A A 1-360 PDB
6QYX X-ray 166 A PDB
6RFO X-ray 170 A A 167-196 PDB
6SFI X-ray 160 A A 1-360 PDB
6SFJ X-ray 195 A A 1-360 PDB
6SFK X-ray 180 A A 1-360 PDB
6SFO X-ray 175 A A 1-360 PDB
6TCA X-ray 370 A B/D/F/H 1-360 PDB
6ZQS X-ray 195 A A 1-360 PDB
6ZWP X-ray 190 A A 1-360 PDB
8A8M EM 400 A A 1-360 PDB
AF-Q16539-F1 Predicted AlphaFoldDB

202 variants for Q16539

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1173776676 3 Q>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
gnomAD
rs780050022 3 Q>L No ExAC
rs780050022 3 Q>P No ExAC
rs1762383049 4 E>K No TOPMed
rs925123454 5 R>T No TOPMed
rs200659578 6 P>A No 1000Genomes
ExAC
TOPMed
gnomAD
rs1399695551 6 P>L No gnomAD
rs199820420 7 T>K No gnomAD
rs199820420 7 T>R No gnomAD
COSM1161625
rs778624298
COSM1161626
 9 Y>* haematopoietic_and_lymphoid_tissue [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs201314635 9 Y>C No Ensembl
rs935119459 9 Y>H No TOPMed
gnomAD
rs1403476935 10 R>W No gnomAD
rs879179507 11 Q>R No Ensembl
rs201909878 12 E>G No ExAC
gnomAD
rs1016506538 13 L>P No Ensembl
rs1277802346 13 L>V No gnomAD
rs776775064 15 K>R No ExAC
TCGA novel 16 T>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs745950744 17 I>T No ExAC
gnomAD
TCGA novel
rs1286610461
 18 W>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No gnomAD
NCI-TCGA
rs1581715338 20 V>G No Ensembl
rs200060741 22 E>V No ExAC
gnomAD
rs1268130777 23 R>C No gnomAD
rs1581715379 23 R>H No Ensembl
rs1268130777 23 R>S No gnomAD
rs763416948 28 S>A No ExAC
gnomAD
rs764628833 28 S>C No ExAC
TOPMed
gnomAD
rs764628833 28 S>F No ExAC
TOPMed
gnomAD
rs1382003988 29 P>L No TOPMed
gnomAD
rs1317247230 29 P>S No Ensembl
rs767294829 35 Y>C No ExAC
TOPMed
gnomAD
rs767294829 35 Y>F No ExAC
TOPMed
gnomAD
TCGA novel 38 V>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1383330307 40 A>S No gnomAD
rs1246686968 41 A>T No gnomAD
TCGA novel 43 D>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs774943543 46 T>M No ExAC
gnomAD
rs774943543 46 T>R No ExAC
gnomAD
rs202184006 47 G>E No Ensembl
rs368785448 47 G>R No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
COSM3626130
COSM3626129
 48 L>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1202713851 49 R>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
COSM1596332
COSM1078465
 49 R>missing Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs760295301 49 R>C No ExAC
TOPMed
gnomAD
TCGA novel 49 R>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs777528977 50 V>M No Ensembl
VAR_042270 51 A>V a gastric adenocarcinoma sample; somatic mutation [UniProt] No UniProt
rs766025283 52 V>L No ExAC
gnomAD
rs201290273 56 S>C No Ensembl
rs895848314 63 I>T No TOPMed
rs1373043369 64 H>P No gnomAD
rs753358147 65 A>G No ExAC
gnomAD
rs1763453026 65 A>T No gnomAD
rs753358147
COSM245580
 65 A>V Variant assessed as Somatic; MODERATE impact. prostate [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
gnomAD
rs765162336 66 K>Q No ExAC
gnomAD
COSM1214510
rs777590539
COSM1214511
 73 R>Q large_intestine [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
COSM3873492
rs758211646
COSM3873493
 73 R>W Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
gnomAD
rs1325801246 74 L>S No gnomAD
rs1227984424 76 K>N No TOPMed
gnomAD
rs1280014164 78 M>V No gnomAD
TCGA novel 82 N>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs888335836 83 V>L No Ensembl
TCGA novel 84 I>M Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1763709830 89 V>I No Ensembl
TCGA novel 90 F>L Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1763709996 91 T>I No TOPMed
gnomAD
rs1050063083 92 P>S No TOPMed
gnomAD
rs1763710294 93 A>S No TOPMed
TCGA novel 93 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1300017525 94 R>G No gnomAD
COSM3626132
COSM3626131
 94 R>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs761097908 95 S>A No ExAC
TOPMed
gnomAD
rs1440328701 95 S>F No TOPMed
gnomAD
rs1207199507 97 E>G No Ensembl
rs770501168 97 E>K No ExAC
TOPMed
gnomAD
rs2127425281 99 F>C No Ensembl
TCGA novel
rs1581765556
 99 F>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
Ensembl
TCGA novel 99 F>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs200810274 100 N>S No ExAC
TOPMed
gnomAD
rs1763712011 101 D>V No TOPMed
rs1259766325 102 V>A No gnomAD
rs199803489 106 T>P No ExAC
TOPMed
gnomAD
rs199803489 106 T>S No ExAC
TOPMed
gnomAD
TCGA novel 109 M>I Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
COSM6174195
COSM6174196
 110 G>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1441727490 111 A>S No gnomAD
rs1764365146 113 L>V No TOPMed
rs1264678748 114 N>S No TOPMed
gnomAD
rs1769213699 118 K>R No Ensembl
rs1764365587 119 C>W No TOPMed
rs373974101 119 C>Y No ESP
ExAC
TOPMed
gnomAD
rs932275490 121 K>N No TOPMed
gnomAD
rs201131979 124 D>E No gnomAD
COSM3430579
COSM3430578
 124 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 127 V>missing Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1764366386 128 Q>R No Ensembl
rs1400589821 132 Y>* No gnomAD
rs1297059784 132 Y>F No gnomAD
rs1448445739 133 Q>K No gnomAD
rs1312460578 133 Q>R No gnomAD
COSM275989 135 L>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1315486405 136 R>* No gnomAD
rs1764368102 137 G>D No gnomAD
rs1764403101 141 I>V No Ensembl
rs1764403243 143 S>L No TOPMed
COSM299324 144 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs760536219 145 D>G No ExAC
TOPMed
gnomAD
rs1200419654 146 I>V No TOPMed
rs1764403706 148 H>N No TOPMed
rs768171262
COSM1150401
COSM742200
 158 V>M lung Variant assessed as Somatic; MODERATE impact. breast [Cosmic, NCI-TCGA] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
gnomAD
rs201771693 161 D>N No Ensembl
rs1581796013 170 G>V No TOPMed
rs745636935 171 L>V No ExAC
TOPMed
gnomAD
rs768935139 173 R>P No ExAC
gnomAD
TCGA novel 173 R>W Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1218676934 176 D>N No gnomAD
rs1259625474 177 D>N No gnomAD
rs1764513647 177 D>V No TOPMed
TCGA novel 178 E>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 183 V>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM3626133
COSM3626134
 186 R>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1764514547 190 A>P No gnomAD
COSM1137516
COSM483987
 191 P>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs760289835 194 M>I No TOPMed
gnomAD
rs202156045 194 M>V No Ensembl
TCGA novel 204 V>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1764515425 204 V>I No TOPMed
rs1359839823 210 G>* No TOPMed
gnomAD
rs1359839823 210 G>R No TOPMed
gnomAD
rs1764539798 211 C>R No gnomAD
rs1308218777 213 M>V No TOPMed
rs150550578 228 H>Y No ESP
ExAC
TOPMed
gnomAD
rs1131205 230 D>H No ExAC
gnomAD
rs139802452 238 L>F No ESP
ExAC
TOPMed
gnomAD
rs1765431491 238 L>P No gnomAD
rs200081934 239 V>F No TOPMed
gnomAD
rs200081934 239 V>I No TOPMed
gnomAD
rs200081934 239 V>L No TOPMed
gnomAD
rs2127467883 242 P>T No Ensembl
rs376583872 244 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No 1000Genomes
ESP
ExAC
NCI-TCGA
gnomAD
rs1050580 245 E>D No Ensembl
TCGA novel 247 L>F Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
COSM1596330 249 K>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1765432705 250 I>F No Ensembl
rs150174370 250 I>S Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1374234730 252 S>L No gnomAD
TCGA novel 252 S>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1765432960 253 E>D No Ensembl
rs756073196 253 E>G No ExAC
gnomAD
rs1765673422 261 S>C No Ensembl
rs750609500 265 M>L No ExAC
gnomAD
rs867617022
COSM1078467
COSM1596329
 266 P>L Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
TOPMed
rs201624180 268 M>I No ExAC
TOPMed
gnomAD
rs780319980 268 M>V No ExAC
gnomAD
rs200108942 269 N>I No ExAC
gnomAD
rs779505423 271 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
TCGA novel 274 F>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs746727002 274 F>Y No ExAC
gnomAD
rs1765675058 275 I>V No Ensembl
COSM78054 278 N>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM1444065
COSM1444066
rs765160248
 278 N>S large_intestine [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs765160248 278 N>T No ExAC
TOPMed
gnomAD
rs766713239 282 V>I No ExAC
gnomAD
TCGA novel 283 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM6174192
COSM6174191
 288 M>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1765835102 290 V>A No TOPMed
gnomAD
rs1765835195 297 I>V No TOPMed
COSM1329723
rs1765835426
COSM1329724
 299 A>V ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No NCI-TCGA Cosmic
cosmic curated
TOPMed
rs201675478 305 H>R No Ensembl
rs1765835899 306 A>V No Ensembl
rs1765835998 309 A>V No Ensembl
COSM186555
COSM1621580
 313 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1478173788 314 P>S No 1000Genomes
gnomAD
rs1195668384 315 D>G No gnomAD
rs1765836483 318 P>S No Ensembl
rs142415666 321 D>H No ESP
ExAC
TOPMed
gnomAD
rs142415666 321 D>N No ESP
ExAC
TOPMed
gnomAD
rs780844650 322 P>A No ExAC
TOPMed
gnomAD
rs1765837157
VAR_042271
COSM12875
 322 P>R lung a lung adenocarcinoma sample; somatic mutation [Cosmic, UniProt] No cosmic curated
TOPMed
UniProt
rs780844650 322 P>T No ExAC
TOPMed
gnomAD
COSM1078469
COSM1596327
 324 D>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1262554805 325 Q>H No TOPMed
gnomAD
rs1765837610 330 R>K No TOPMed
rs779680505 332 L>R No ExAC
TOPMed
gnomAD
rs151291391 333 L>F No ESP
ExAC
TOPMed
gnomAD
rs1328955029 335 D>V No gnomAD
rs1266196629 336 E>G No TOPMed
VAR_042272
rs45496794
 343 D>G No UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs542518608 343 D>N No 1000Genomes
ExAC
gnomAD
rs748836123 345 V>F No ExAC
gnomAD
rs748836123 345 V>I No ExAC
gnomAD
rs202086142 346 I>S No ExAC
TOPMed
gnomAD
rs202086142 346 I>T No ExAC
TOPMed
gnomAD
rs754407761 346 I>V No ExAC
TOPMed
gnomAD
rs199703351 347 S>N No ExAC
TOPMed
gnomAD
rs1369642877 350 P>Q No TOPMed
gnomAD
rs1459336613 350 P>S No TOPMed
gnomAD
rs772108703 351 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
rs1765865367 353 L>F No Ensembl
rs1176500208 356 E>G No gnomAD
rs1204419088 357 E>K No TOPMed

No associated diseases with Q16539

5 regional properties for Q16539

Type Name Position InterPro Accession
domain Protein kinase domain 98 - 355 IPR000719
domain AGC-kinase, C-terminal 356 - 431 IPR000961
active_site Serine/threonine-protein kinase, active site 218 - 230 IPR008271
binding_site Protein kinase, ATP binding site 104 - 136 IPR017441
domain Protein kinase, C-terminal 376 - 423 IPR017892

Functions

Description
EC Number 2.7.11.24 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
ficolin-1-rich granule lumen Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
secretory granule lumen The volume enclosed by the membrane of a secretory granule.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

9 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
MAP kinase activity Catalysis of the reaction
MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
mitogen-activated protein kinase p38 binding Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation.
NFAT protein binding Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
protein phosphatase binding Binding to a protein phosphatase.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions

65 GO annotations of biological process

Name Definition
3'-UTR-mediated mRNA stabilization An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
bone development The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
cartilage condensation The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
cell morphogenesis The developmental process in which the size or shape of a cell is generated and organized.
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
cellular response to ionizing radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to lipoteichoic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
cellular response to UV-B Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.
cellular response to vascular endothelial growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
cellular response to virus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
cellular senescence A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
chondrocyte differentiation The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
DNA damage checkpoint signaling A signal transduction process that contributes to a DNA damage checkpoint.
fatty acid oxidation The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
glucose import The directed movement of the hexose monosaccharide glucose into a cell or organelle.
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipopolysaccharide-mediated signaling pathway The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
negative regulation of hippo signaling Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
negative regulation of inflammatory response to antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
osteoblast differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
osteoclast differentiation The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
p38MAPK cascade An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
placenta development The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
platelet activation A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
positive regulation of brown fat cell differentiation Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
positive regulation of cardiac muscle cell proliferation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
positive regulation of cyclase activity Any process that activates or increases the activity of a cyclase.
positive regulation of erythrocyte differentiation Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of glucose import Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
positive regulation of interleukin-12 production Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
positive regulation of muscle cell differentiation Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
positive regulation of myoblast differentiation Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
positive regulation of myoblast fusion Any process that activates or increases the frequency, rate or extent of myoblast fusion.
positive regulation of myotube differentiation Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
positive regulation of protein import into nucleus Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
positive regulation of reactive oxygen species metabolic process Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of cytokine production involved in inflammatory response Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.
regulation of ossification Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
regulation of synaptic membrane adhesion Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to dietary excess The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.
response to insulin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
response to muramyl dipeptide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
response to muscle stretch Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
signal transduction in response to DNA damage A cascade of processes induced by the detection of DNA damage within a cell.
skeletal muscle tissue development The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are
stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
stress-activated MAPK cascade The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.
stress-activated protein kinase signaling cascade The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal.
stress-induced premature senescence A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.
striated muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transmembrane receptor protein serine/threonine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
vascular endothelial growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

91 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32485 HOG1 Mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A5PKJ4 MAPK7 Mitogen-activated protein kinase 7 Bos taurus (Bovine) SS
Q3T0N5 MAPK13 Mitogen-activated protein kinase 13 Bos taurus (Bovine) SS
P46196 MAPK1 Mitogen-activated protein kinase 1 Bos taurus (Bovine) SS
Q5F3W3 MAPK6 Mitogen-activated protein kinase 6 Gallus gallus (Chicken) SS
Q9N272 MAPK13 Mitogen-activated protein kinase 13 Pan troglodytes (Chimpanzee) SS
Q95NE7 MAPK14 Mitogen-activated protein kinase 14 Pan troglodytes (Chimpanzee) SS
Q9W354 Erk7 Extracellular signal-regulated kinase 7 Drosophila melanogaster (Fruit fly) SS
P40417 rl Mitogen-activated protein kinase ERK-A Drosophila melanogaster (Fruit fly) SS
P83100 p38c Putative mitogen-activated protein kinase 14C Drosophila melanogaster (Fruit fly) SS
O62618 p38a Mitogen-activated protein kinase p38a Drosophila melanogaster (Fruit fly) SS
O61443 p38b Mitogen-activated protein kinase p38b Drosophila melanogaster (Fruit fly) SS
P20794 MAK Serine/threonine-protein kinase MAK Homo sapiens (Human) PR
Q9UQ07 MOK MAPK/MAK/MRK overlapping kinase Homo sapiens (Human) PR
Q8TD08 MAPK15 Mitogen-activated protein kinase 15 Homo sapiens (Human) SS
P45984 MAPK9 Mitogen-activated protein kinase 9 Homo sapiens (Human) SS
P45983 MAPK8 Mitogen-activated protein kinase 8 Homo sapiens (Human) EV
P53779 MAPK10 Mitogen-activated protein kinase 10 Homo sapiens (Human) EV
Q9UBE8 NLK Serine/threonine-protein kinase NLK Homo sapiens (Human) SS
P27361 MAPK3 Mitogen-activated protein kinase 3 Homo sapiens (Human) SS
P28482 MAPK1 Mitogen-activated protein kinase 1 Homo sapiens (Human) EV
P31152 MAPK4 Mitogen-activated protein kinase 4 Homo sapiens (Human) SS
Q16659 MAPK6 Mitogen-activated protein kinase 6 Homo sapiens (Human) SS
Q13164 MAPK7 Mitogen-activated protein kinase 7 Homo sapiens (Human) SS
P53778 MAPK12 Mitogen-activated protein kinase 12 Homo sapiens (Human) SS
O15264 MAPK13 Mitogen-activated protein kinase 13 Homo sapiens (Human) SS
Q15759 MAPK11 Mitogen-activated protein kinase 11 Homo sapiens (Human) SS
Q9Z1B7 Mapk13 Mitogen-activated protein kinase 13 Mus musculus (Mouse) SS
Q61532 Mapk6 Mitogen-activated protein kinase 6 Mus musculus (Mouse) SS
Q63844 Mapk3 Mitogen-activated protein kinase 3 Mus musculus (Mouse) SS
P63085 Mapk1 Mitogen-activated protein kinase 1 Mus musculus (Mouse) SS
Q9WVS8 Mapk7 Mitogen-activated protein kinase 7 Mus musculus (Mouse) SS
Q9WUI1 Mapk11 Mitogen-activated protein kinase 11 Mus musculus (Mouse) SS
O08911 Mapk12 Mitogen-activated protein kinase 12 Mus musculus (Mouse) SS
Q80Y86 Mapk15 Mitogen-activated protein kinase 15 Mus musculus (Mouse) SS
Q6P5G0 Mapk4 Mitogen-activated protein kinase 4 Mus musculus (Mouse) SS
P47811 Mapk14 Mitogen-activated protein kinase 14 Mus musculus (Mouse) SS
Q9WTY9 Mapk13 Mitogen-activated protein kinase 13 Rattus norvegicus (Rat) SS
P63086 Mapk1 Mitogen-activated protein kinase 1 Rattus norvegicus (Rat) SS
Q9Z2A6 Mapk15 Mitogen-activated protein kinase 15 Rattus norvegicus (Rat) SS
P27704 Mapk6 Mitogen-activated protein kinase 6 Rattus norvegicus (Rat) SS
P21708 Mapk3 Mitogen-activated protein kinase 3 Rattus norvegicus (Rat) SS
Q63538 Mapk12 Mitogen-activated protein kinase 12 Rattus norvegicus (Rat) SS
Q63454 Mapk4 Mitogen-activated protein kinase 4 Rattus norvegicus (Rat) SS
P0C865 Mapk7 Mitogen-activated protein kinase 7 Rattus norvegicus (Rat) SS
P70618 Mapk14 Mitogen-activated protein kinase 14 Rattus norvegicus (Rat) SS
Q5ZCI1 MPK10 Mitogen-activated protein kinase 10 Oryza sativa subsp. japonica (Rice) SS
Q5VP69 MPK16 Mitogen-activated protein kinase 16 Oryza sativa subsp. japonica (Rice) SS
Q5SN53 MPK8 Mitogen-activated protein kinase 8 Oryza sativa subsp. japonica (Rice) SS
Q0E459 MPK13 Mitogen-activated protein kinase 13 Oryza sativa subsp. japonica (Rice) SS
Q6Z437 MPK3 Mitogen-activated protein kinase 3 Oryza sativa subsp. japonica (Rice) SS
Q75KK8 MPK14 Mitogen-activated protein kinase 14 Oryza sativa subsp. japonica (Rice) SS
Q67C40 MPK7 Mitogen-activated protein kinase 7 Oryza sativa subsp. japonica (Rice) SS
Q6L5F7 MPK17 Mitogen-activated protein kinase 17 Oryza sativa subsp. japonica (Rice) SS
Q5VN19 MPK11 Mitogen-activated protein kinase 11 Oryza sativa subsp. japonica (Rice) SS
Q5Z859 MPK4 Mitogen-activated protein kinase 4 Oryza sativa subsp. japonica (Rice) SS
Q5Z9J0 MPK12 Mitogen-activated protein kinase 12 Oryza sativa subsp. japonica (Rice) SS
Q53N72 MPK15 Mitogen-activated protein kinase 15 Oryza sativa subsp. japonica (Rice) SS
Q336X9 MPK6 Mitogen-activated protein kinase 6 Oryza sativa subsp. japonica (Rice) SS
Q5J4W4 MPK2 Mitogen-activated protein kinase 2 Oryza sativa subsp. japonica (Rice) SS
Q84UI5 MPK1 Mitogen-activated protein kinase 1 Oryza sativa subsp. japonica (Rice) SS
Q10N20 MPK5 Mitogen-activated protein kinase 5 Oryza sativa subsp. japonica (Rice) SS
Q11179 mapk-15 Mitogen-activated protein kinase 15 Caenorhabditis elegans SS
O44514 pmk-3 Mitogen-activated protein kinase pmk-3 Caenorhabditis elegans PR
P39745 mpk-1 Mitogen-activated protein kinase mpk-1 Caenorhabditis elegans SS
G5EBT1 sma-5 Mitogen-activated protein kinase sma-5 Caenorhabditis elegans SS
Q8MXI4 pmk-2 Mitogen-activated protein kinase pmk-2 Caenorhabditis elegans SS
Q17446 pmk-1 Mitogen-activated protein kinase pmk-1 Caenorhabditis elegans SS
Q39021 MPK1 Mitogen-activated protein kinase 1 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LM33 MPK8 Mitogen-activated protein kinase 8 Arabidopsis thaliana (Mouse-ear cress) SS
Q9C5C0 MPK18 Mitogen-activated protein kinase 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q39022 MPK2 Mitogen-activated protein kinase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q9C9U4 MPK15 Mitogen-activated protein kinase 15 Arabidopsis thaliana (Mouse-ear cress) SS
Q84M93 MPK17 Mitogen-activated protein kinase 17 Arabidopsis thaliana (Mouse-ear cress) SS
Q39027 MPK7 Mitogen-activated protein kinase 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SJG9 MPK20 Mitogen-activated protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LUC3 MPK19 Mitogen-activated protein kinase 19 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LV37 MPK9 Mitogen-activated protein kinase 9 Arabidopsis thaliana (Mouse-ear cress) SS
O23236 MPK14 Mitogen-activated protein kinase 14 Arabidopsis thaliana (Mouse-ear cress) SS
Q8W4J2 MPK16 Mitogen-activated protein kinase 16 Arabidopsis thaliana (Mouse-ear cress) SS
Q39023 MPK3 Mitogen-activated protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q39026 MPK6 Mitogen-activated protein kinase 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q39025 MPK5 Mitogen-activated protein kinase 5 Arabidopsis thaliana (Mouse-ear cress) SS
Q39024 MPK4 Mitogen-activated protein kinase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M1Z5 MPK10 Mitogen-activated protein kinase 10 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GYQ5 MPK12 Mitogen-activated protein kinase 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LMM5 MPK11 Mitogen-activated protein kinase 11 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LQQ9 MPK13 Mitogen-activated protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) SS
O42376 mapk12 Mitogen-activated protein kinase 12 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DGE2 mapk14a Mitogen-activated protein kinase 14A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DGE1 mapk14b Mitogen-activated protein kinase 14B Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ
70 80 90 100 110 120
SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ
130 140 150 160 170 180
KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT
190 200 210 220 230 240
GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG
250 260 270 280 290 300
TPGAELLKKI SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
310 320 330 340 350
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES