AiPD: Autoinhibited Protein Database

Q16513

Gene name	PKN2 (PRK2, PRKCL2)
Protein name	Serine/threonine-protein kinase N2
Names	PKN gamma, Protein kinase C-like 2, Protein-kinase C-related kinase 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5586
EC number	2.7.11.13: Protein-serine/threonine kinases
Protein Class	SERINE/THREONINE-PROTEIN KINASE (PTHR24356)

Descriptions

Serine/threonine-protein kinase N2 (PKN2) is a PKC-related serine/threonine protein kinase involved in specific signal transduction responses such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation in cells. Its kinase activity is enhanced by fatty acids such as arachidonic acid and small GTP-binding protein Rho in a GTP-dependent manner. The residues 455-511 of PKN selectively inhibits the kinase activity of the catalytic fragment of PKN2. Arachidonic acid relieves the catalytic activity of wild-type PKN from autoinhibition by residues 455-511 of PKN.

Autoinhibitory domains (AIDs)

Target domain	657-916 (Protein kinase domain)
Relief mechanism	Ligand binding, PTM
Assay	Split protein assay, Mutagenesis experiment

AID

455-511 (autoinhibitory domain)

Target domain

657-916 (Protein kinase domain)

Relief mechanism

Ligand binding (Arachidonic acid binding), PTM (Phosphorylation at Thr-816)

Assay

Split protein assay, Mutagenesis experiment

Accessory elements

799-822 (Activation loop from InterPro)

Target domain	657-916 (Protein kinase domain)
Relief mechanism
Assay

References

Yoshinaga C et al. (1999) "Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain", Journal of biochemistry, 126, 475-84

Huang X et al. (2003) "Crystal structure of an inactive Akt2 kinase domain", Structure (London, England : 1993), 11, 21-30

Truebestein L et al. (2021) "Structure of autoinhibited Akt1 reveals mechanism of PIP(3)-mediated activation", Proceedings of the National Academy of Sciences of the United States of America, 118,

Lučić I et al. (2018) "Conformational sampling of membranes by Akt controls its activation and inactivation", Proceedings of the National Academy of Sciences of the United States of America, 115, E3940-E3949

Autoinhibited structure

Activated structure

5 structures for Q16513

Entry ID	Method	Resolution	Chain	Position	Source
4CRS	X-ray	275 A	A	646-984	PDB
4RRV	X-ray	141 A	B	969-983	PDB
6CCY	X-ray	218 A	A	969-983	PDB
6GBE	NMR	-	B	973-984	PDB
AF-Q16513-F1	Predicted				AlphaFoldDB

496 variants for Q16513

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA26731417 rs868244289	2	A>E		No	ClinGen Ensembl
CA937274 rs780577542	5	P>L		No	ClinGen ExAC gnomAD
rs1445438865 CA341133635	6	E>Q		No	ClinGen gnomAD
CA937276 rs557475072	7	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs557475072 CA937275	7	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA341133644 rs557475072	7	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1309924103 CA341133643	7	R>W		No	ClinGen TOPMed
CA341133646 rs1225868815	8	G>R		No	ClinGen TOPMed gnomAD
CA341133655 rs1570468657	9	E>G		No	ClinGen Ensembl
rs771648470 CA937279	12	L>F		No	ClinGen ExAC TOPMed gnomAD
CA341133674 rs1469287048	12	L>P		No	ClinGen gnomAD
CA341133680 rs1212178684	13	T>R		No	ClinGen TOPMed gnomAD
CA937295 rs755439353	17	G>E		No	ClinGen ExAC gnomAD
CA340984376 rs1438871655	18	D>N		No	ClinGen gnomAD
CA937297 rs748752260	19	S>A		No	ClinGen ExAC TOPMed gnomAD
COSM912874 CA937298 COSM912873 rs369171613	20	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs370072062 CA937299	21	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA937300 rs569991850	21	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1272545321 CA340984488	22	L>F		No	ClinGen gnomAD
rs1195000769 CA340984497	22	L>P		No	ClinGen TOPMed
rs375306359 CA937301	23	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1396549478 CA340984510	23	P>S		No	ClinGen gnomAD
rs1283083806 CA340984547	25	S>P		No	ClinGen TOPMed
CA937303 rs759296341	27	N>I		No	ClinGen ExAC gnomAD
rs554901372 CA26506316	28	V>G		No	ClinGen Ensembl
rs1349403027 CA340984676	30	A>V		No	ClinGen TOPMed
rs762961632 CA937306	31	V>I		No	ClinGen ExAC gnomAD
rs1232940683 CA340984782	35	D>G		No	ClinGen TOPMed
CA937309 rs756239015	38	D>G		No	ClinGen ExAC gnomAD
rs199689449 CA937310	40	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA937311 rs754148816	47	D>V		No	ClinGen ExAC gnomAD
CA937312 rs755386338	49	K>R		No	ClinGen ExAC gnomAD
CA340985282 rs1273606227	50	D>H		No	ClinGen TOPMed
CA937313 rs200490316	51	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA340985866 COSM1627236 COSM1627235 rs1319573010	70	R>K	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
rs758978121 CA937315	70	R>W		No	ClinGen ExAC gnomAD
rs1277593226 CA340985958	75	D>N		No	ClinGen gnomAD
CA340986046 rs1353970790	78	S>N		No	ClinGen gnomAD
rs534807987 CA26506319	79	L>M		No	ClinGen 1000Genomes ExAC gnomAD
CA937319 rs776261877	79	L>S		No	ClinGen ExAC gnomAD
CA937318 rs534807987	79	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs745577228 CA937320	82	V>I		No	ClinGen ExAC gnomAD
rs775357803 CA937323	84	N>D		No	ClinGen ExAC gnomAD
rs1048925205 CA26506321	88	K>T		No	ClinGen Ensembl
rs1159473611 CA340986277	90	N>D		No	ClinGen gnomAD
CA340986359 rs1363032285	92	K>I		No	ClinGen TOPMed gnomAD
rs12039846 CA937324 VAR_050562	94	E>D		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs774201827 CA937326	98	H>Y		No	ClinGen ExAC gnomAD
CA340986558 rs1570562056	101	Q>L		No	ClinGen Ensembl
CA937328 rs766629280	104	N>S		No	ClinGen ExAC gnomAD
CA340986663 rs1355827893	106	H>R		No	ClinGen gnomAD
CA26506322 rs1004026198	108	V>A		No	ClinGen TOPMed gnomAD
CA340986713 rs1183033418	108	V>I		No	ClinGen gnomAD
rs372785607 CA937333	112	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA937334 rs372785607	112	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA937335 rs778314261	114	D>G		No	ClinGen ExAC gnomAD
rs1309968358 CA340986846	115	I>T		No	ClinGen TOPMed
rs763373764 CA937355	119	P>A		No	ClinGen ExAC gnomAD
rs1557592857 CA340992308	119	P>L		No	ClinGen Ensembl
CA26508453 rs988476536	121	T>A		No	ClinGen Ensembl
CA26508455 rs201995133	121	T>I		No	ClinGen gnomAD
CA26508454 rs201995133	121	T>S		No	ClinGen gnomAD
rs764424876 CA937356	123	D>E		No	ClinGen ExAC TOPMed gnomAD
CA340992402 rs1444853186	124	T>A		No	ClinGen TOPMed
rs965419009 CA26508456	124	T>I		No	ClinGen TOPMed gnomAD
CA937357 rs752005316	125	P>S		No	ClinGen ExAC gnomAD
rs1368280462 CA340992482	127	N>D		No	ClinGen gnomAD
rs757765901 CA937358	128	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1298647721 CA340992533	129	P>A		No	ClinGen TOPMed gnomAD
rs1311087412 CA340992545	129	P>L		No	ClinGen gnomAD
rs1298647721 CA340992535	129	P>S		No	ClinGen TOPMed gnomAD
rs780638510 CA937359	130	R>C		No	ClinGen ExAC TOPMed gnomAD
CA937360 rs749956821	130	R>H		No	ClinGen ExAC TOPMed gnomAD
CA937361 rs755666862	131	C>G		No	ClinGen ExAC gnomAD
rs779723190 CA937362	132	S>C		No	ClinGen ExAC gnomAD
CA937363 rs748955934	133	T>A		No	ClinGen ExAC gnomAD
rs976482831 CA26508457	136	N>S		No	ClinGen Ensembl
rs369178376 CA937365	137	R>G		No	ClinGen ESP ExAC gnomAD
rs1267206495 CA340992857	139	K>E		No	ClinGen gnomAD
CA937366 rs748061161	140	A>T		No	ClinGen ExAC gnomAD
CA340992897 rs430600	141	L>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340992900 rs430600	141	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340992922 rs1421789734	142	Q>K		No	ClinGen gnomAD
CA340992966 rs1360363280	144	Q>R		No	ClinGen TOPMed
rs769831827 CA340994055	153	Q>H		No	ClinGen ExAC gnomAD
CA26508458 rs894421519	159	I>L		No	ClinGen TOPMed
CA937396 rs768782342	170	R>Q		No	ClinGen ExAC gnomAD
rs1284048661 CA340996330	170	R>W		No	ClinGen gnomAD
rs774604515 CA937397	174	G>A		No	ClinGen ExAC gnomAD
rs376874389 CA26509533	176	A>T		No	ClinGen ESP TOPMed
rs1471903688 CA340996534	180	L>H		No	ClinGen gnomAD
rs1303947081 CA340996548	181	Q>*		No	ClinGen TOPMed
rs767932381 CA937399	181	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1384345143 CA340996568	182	D>N		No	ClinGen gnomAD
CA340996595 rs1440312239	183	S>G		No	ClinGen gnomAD
rs1160369095 CA340996625	184	K>R		No	ClinGen TOPMed gnomAD
rs202004408 CA26509534	185	T>I		No	ClinGen Ensembl
rs1358475710 CA340996677	187	I>V		No	ClinGen gnomAD
rs1418597625 CA340996707	189	V>I		No	ClinGen gnomAD
CA340996729 rs1334192780	191	R>Q		No	ClinGen gnomAD
CA937400 rs773693781	195	L>P		No	ClinGen ExAC gnomAD
rs35207128 CA937401 VAR_050563	197	A>E		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1458913018 CA340996774	198	V>I		No	ClinGen TOPMed
rs1570603286 CA340996798	201	N>S		No	ClinGen Ensembl
CA340996817 rs1242701866	203	L>M		No	ClinGen gnomAD
CA340996838 rs1316205175	204	A>V		No	ClinGen TOPMed gnomAD
CA937403 rs753313275	205	F>S		No	ClinGen ExAC gnomAD
CA340996862 rs1353560507	206	D>N		No	ClinGen gnomAD
CA937404 rs754570164	207	N>D		No	ClinGen ExAC
rs554689332 CA937426	209	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs554689332 CA340997137	209	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA340997156 rs1169033224	210	P>L		No	ClinGen gnomAD
rs762700932 CA937427	210	P>S		No	ClinGen ExAC gnomAD
rs960420027 CA26509641	212	I>M		No	ClinGen Ensembl
CA937428 rs763943376	212	I>V		No	ClinGen ExAC gnomAD
CA340997214 rs1387917850	214	P>S		No	ClinGen gnomAD
rs1232666178 CA340997266	218	R>Q		No	ClinGen TOPMed
rs1329787510 CA340997292	219	M>I		No	ClinGen gnomAD
rs751331530 CA937429	219	M>L		No	ClinGen ExAC gnomAD
CA937430 rs751331530	219	M>V		No	ClinGen ExAC gnomAD
rs780960176 CA937431	220	E>K		No	ClinGen ExAC TOPMed gnomAD
CA937432 rs750438603	223	R>S		No	ClinGen ExAC gnomAD
rs1342657045 CA340997352	227	R>G		No	ClinGen gnomAD
rs755033620 CA937433	227	R>S		No	ClinGen ExAC gnomAD
CA340997423 rs1255986406	237	K>R		No	ClinGen gnomAD
rs778975507 CA937434	240	M>V		No	ClinGen ExAC gnomAD
rs1570605376 CA340997461	242	L>*		No	ClinGen Ensembl
rs1570605376 CA340997460	242	L>S		No	ClinGen Ensembl
rs772307376 CA340997499	248	V>A		No	ClinGen ExAC TOPMed
rs772307376 CA937436	248	V>E		No	ClinGen ExAC TOPMed
CA340997501 rs1570605478	249	T>P		No	ClinGen Ensembl
CA340997515 rs1442594975	251	R>G		No	ClinGen TOPMed
CA340997577 rs1488991897	258	Q>R		No	ClinGen gnomAD
CA937454 rs375574349	259	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1236124411 CA340997601	261	F>L		No	ClinGen TOPMed
CA937458 rs148288884	273	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA340997713 rs1362936396	277	Q>E		No	ClinGen gnomAD
rs1320896682 CA340997722	278	R>K		No	ClinGen TOPMed
rs770448851 CA937460	279	L>*		No	ClinGen ExAC gnomAD
CA340997729 rs770448851	279	L>*		No	ClinGen ExAC gnomAD
CA937461 rs776187067	280	N>H		No	ClinGen ExAC gnomAD
rs373700833 CA340997739	280	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA937463 rs768278690	281	E>K		No	ClinGen ExAC gnomAD
CA937464 rs773858363	282	V>I		No	ClinGen ExAC gnomAD
rs1013798837 CA26509647	285	N>K		No	ClinGen TOPMed gnomAD
CA340997777 rs1244901789	286	H>Y		No	ClinGen gnomAD
rs767148393 CA937466	289	S>N		No	ClinGen ExAC TOPMed gnomAD
rs767148393 CA26509648	289	S>T		No	ClinGen ExAC TOPMed gnomAD
rs773087811 CA937467	290	R>G		No	ClinGen ExAC gnomAD
rs1557600290 CA340997817	292	I>V		No	ClinGen Ensembl
rs371630794 CA937468	293	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1570605926 CA340997825	293	I>V		No	ClinGen Ensembl
CA937469 rs766275815	295	E>G		No	ClinGen ExAC TOPMed gnomAD
CA26509649 rs925388968	296	L>F		No	ClinGen TOPMed gnomAD
CA937470 rs753843579	297	S>A		No	ClinGen ExAC TOPMed gnomAD
rs1179604608 CA340997864	299	V>A		No	ClinGen gnomAD
CA340997883 rs1348179159	302	S>L		No	ClinGen TOPMed
CA340997895 rs1158531736 COSM1344703 COSM1344702	304	T>I	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs757532415 CA937474	306	S>N		No	ClinGen ExAC gnomAD
CA937475 rs781364161	308	R>C		No	ClinGen ExAC gnomAD
CA340997916 rs1405538644	308	R>H		No	ClinGen TOPMed gnomAD
CA26509650 rs540997930	309	Q>H		No	ClinGen TOPMed
rs373232178 CA937476	310	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs749868011 CA937479	312	I>M		No	ClinGen ExAC gnomAD
rs780702051 CA937478	312	I>T		No	ClinGen ExAC gnomAD
CA937477 rs756585615	312	I>V		No	ClinGen ExAC gnomAD
rs767989088 CA937480	313	S>F		No	ClinGen ExAC gnomAD
CA26509652 rs756389305	313	S>P		No	ClinGen Ensembl
rs773912328 CA937481	314	T>A		No	ClinGen ExAC
COSM912890 rs540999973 CA937482 COSM912889	314	T>M	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs778328965 CA26509653	315	Q>R		No	ClinGen Ensembl
CA26509654 rs111704755	316	N>S		No	ClinGen Ensembl
CA937486 rs559326247	317	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759522341 CA937488	318	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs764041928 CA937489	319	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1231810798 CA340997982	319	S>R		No	ClinGen Ensembl
CA340998047 rs9651072	327	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1299447136 CA341000622	334	R>C		No	ClinGen gnomAD
rs755344967 CA937516	334	R>H		No	ClinGen ExAC TOPMed gnomAD
rs779473256 CA341000642	336	M>L		No	ClinGen ExAC TOPMed gnomAD
rs779473256 CA937517	336	M>L		No	ClinGen ExAC TOPMed gnomAD
CA341000688 rs1303851116	338	C>Y		No	ClinGen gnomAD
CA937518 rs201111346	341	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1244152921 CA341000775	342	L>V		No	ClinGen TOPMed gnomAD
CA341000797 rs1354985553	344	N>H		No	ClinGen gnomAD
CA341000876 rs770594472	348	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1253742289 CA341001003	354	V>F		No	ClinGen TOPMed
rs1253742289 CA341000995	354	V>I		No	ClinGen TOPMed
CA937524 rs745647473	355	A>P		No	ClinGen ExAC gnomAD
CA341001028 rs1346631601	355	A>V		No	ClinGen Ensembl
rs1246895158 CA341001066	357	P>R		No	ClinGen TOPMed
CA937526 rs368676500	361	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs762811155 CA341001189	362	S>C		No	ClinGen ExAC TOPMed gnomAD
CA937527 rs762811155	362	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1159838605 CA341001201	362	S>I		No	ClinGen gnomAD
rs200726637 CA937528	364	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773453237 CA937529	365	R>G		No	ClinGen ExAC
CA937530 rs760928465	366	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1483139351 CA341001349	368	F>S		No	ClinGen TOPMed
CA26511384 rs187178031	371	R>K		No	ClinGen 1000Genomes
rs1230908264 CA341001497	373	S>G		No	ClinGen TOPMed
CA341001501 rs1343128107	373	S>T		No	ClinGen TOPMed
CA937533 rs759934764	374	K>R		No	ClinGen ExAC gnomAD
rs373814749 CA937534	376	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs758934826 CA937537	378	G>R		No	ClinGen ExAC TOPMed
CA26511395 rs964069976	380	S>R		No	ClinGen Ensembl
rs371274223 CA937538	381	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA341001728 rs1373396584	383	L>I		No	ClinGen TOPMed
CA937540 rs751048428	383	L>R		No	ClinGen ExAC gnomAD
rs756803089 CA937541	387	D>N		No	ClinGen ExAC TOPMed gnomAD
CA341002305 rs1437138217	391	N>S		No	ClinGen TOPMed gnomAD
rs775740473 CA937555	393	V>I		No	ClinGen ExAC gnomAD
CA341002409 rs1297309250	400	D>G		No	ClinGen TOPMed gnomAD
rs764555959 CA937557	400	D>N		No	ClinGen ExAC TOPMed gnomAD
rs373098773 CA937558	402	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA937560 rs766948314	404	V>I		No	ClinGen ExAC
CA341002459 rs1396476418	405	G>S		No	ClinGen gnomAD
rs750024116 CA937561	406	Q>R		No	ClinGen ExAC gnomAD
rs755753660 CA937562	408	S>T		No	ClinGen ExAC gnomAD
CA937563 rs779845851	414	N>S		No	ClinGen ExAC TOPMed gnomAD
CA341002581 rs1453428827	415	Q>*		No	ClinGen TOPMed
CA937564 rs377562198	416	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA341002649 rs1279115011	420	K>R		No	ClinGen gnomAD
rs754858176 CA937565	422	T>I		No	ClinGen ExAC gnomAD
CA937566 rs778983224	427	R>K		No	ClinGen ExAC gnomAD
CA340983079 rs1443383929	436	Y>F		No	ClinGen gnomAD
rs1185759125 CA340983083	437	W>R		No	ClinGen gnomAD
rs777820496 CA937593	438	R>C		No	ClinGen ExAC gnomAD
CA937594 rs745908714	438	R>H		No	ClinGen ExAC gnomAD
CA340983109 rs1570656013	440	W>*		No	ClinGen Ensembl
CA340983107 rs1203928414	440	W>*		No	ClinGen Ensembl
rs769986492 CA937595	441	R>L		No	ClinGen ExAC TOPMed gnomAD
rs769986492 CA937596	441	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA26511520 rs868792109	441	R>W		No	ClinGen TOPMed
CA340983147 rs1451645400	444	C>S		No	ClinGen gnomAD
rs1158212770 CA340983154	445	A>T		No	ClinGen gnomAD
rs1403134535 CA340983357	456	D>N		No	ClinGen gnomAD
rs768938701 CA937598	458	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs1318213165 CA340983554	469	Q>R		No	ClinGen gnomAD
CA937601 rs772436207	471	T>S		No	ClinGen ExAC gnomAD
rs1331689756 CA340983586	473	F>L		No	ClinGen TOPMed
CA340983594 rs1323777614	474	A>T		No	ClinGen gnomAD
CA937616 rs780109890	479	F>S		No	ClinGen ExAC gnomAD
rs1280904429 CA340983682	483	I>T		No	ClinGen gnomAD
rs768885163 CA937618	500	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1360331036 CA340985240	511	N>S		No	ClinGen gnomAD
CA937649 rs762669040	512	I>N		No	ClinGen ExAC gnomAD
COSM465052 rs775227507 COSM465053 CA937648	512	I>V	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA340985272 rs1362160424	513	N>D		No	ClinGen gnomAD
CA26511790 rs777239793	520	L>P		No	ClinGen Ensembl
CA340985506 rs1570657843	522	R>T		No	ClinGen Ensembl
CA340985518 rs1291126930	523	R>G		No	ClinGen gnomAD
CA340985526 rs1166640828	523	R>K		No	ClinGen TOPMed
CA340985545 rs1317807269	523	R>S		No	ClinGen gnomAD
rs1218225852 CA340985549	524	A>T		No	ClinGen gnomAD
CA937650 rs763753464	525	I>V		No	ClinGen ExAC TOPMed gnomAD
CA937652 rs761558099	526	P>A		No	ClinGen ExAC gnomAD
rs1446341218 CA340985689	528	V>A		No	ClinGen gnomAD
rs368860135 CA26511795	531	S>Y		No	ClinGen ESP TOPMed
CA26511797 rs979679980	533	T>S		No	ClinGen TOPMed
CA340985887 rs1443021169	536	P>A		No	ClinGen TOPMed
rs1570657965 CA340985895	536	P>H		No	ClinGen Ensembl
CA26511798 rs921539670	538	A>V		No	ClinGen TOPMed
CA937657 rs201149414	541	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs201149414 CA937656	541	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs758670147 CA937658	542	T>A		No	ClinGen ExAC TOPMed gnomAD
rs758670147 CA26511800	542	T>P		No	ClinGen ExAC TOPMed gnomAD
CA937659 rs376245572	543	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs747369115 CA937660	543	T>I		No	ClinGen ExAC gnomAD
CA340986025 rs747369115	543	T>K		No	ClinGen ExAC gnomAD
rs369266668 CA937661	544	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs746393394 CA937663	547	V>I		No	ClinGen ExAC TOPMed gnomAD
rs376747132 CA937666	548	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA937664 rs373758248	548	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA937668 rs768329747	550	R>C		No	ClinGen ExAC gnomAD
COSM3741419 COSM3741418 rs761591652 CA937669	550	R>H	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA937667 rs768329747	550	R>S		No	ClinGen ExAC gnomAD
CA26511815 rs1049801507	551	I>T		No	ClinGen Ensembl
rs771912831 CA340986207	553	Q>H		No	ClinGen ExAC gnomAD
CA937671 rs369398098	554	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs786906 CA340987308	559	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1280246737 CA340987328	560	D>V		No	ClinGen TOPMed
CA937706 rs779923779	562	T>A		No	ClinGen ExAC TOPMed gnomAD
CA937707 rs770693244	564	T>S		No	ClinGen ExAC gnomAD
rs776578015 CA937708	565	K>R		No	ClinGen ExAC gnomAD
CA937709 rs745800453	569	D>H		No	ClinGen ExAC gnomAD
rs1386410735 CA340987541	570	L>F		No	ClinGen gnomAD
rs1570658738 CA340987605	573	E>D		No	ClinGen Ensembl
rs954278016 CA26511972	575	P>T		No	ClinGen TOPMed gnomAD
CA937712 rs762030874	578	P>L		No	ClinGen ExAC gnomAD
rs373655576 CA937711	578	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs767813616 CA937713	579	P>A		No	ClinGen ExAC gnomAD
rs1159144376 CA340987713	580	R>*		No	ClinGen gnomAD
rs377246617 CA937714	580	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs377246617 CA26511984 COSM912898	580	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs761087281 CA937715	582	S>A		No	ClinGen ExAC gnomAD
CA340987821 rs1261919285	586	E>K		No	ClinGen gnomAD
CA937716 rs766666908	589	E>G		No	ClinGen ExAC TOPMed gnomAD
CA26511991 rs986931132	594	R>G		No	ClinGen TOPMed
rs1248004938 CA340988017 COSM1748640	594	R>T	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
CA26511995 rs911280628	600	G>E		No	ClinGen TOPMed
CA340988205 rs1267603870	602	D>G		No	ClinGen TOPMed
CA340988195 rs1486279148	602	D>N		No	ClinGen TOPMed
CA340988248 rs1267889958	605	T>A		No	ClinGen gnomAD
CA340988267 rs1461998910	606	V>A		No	ClinGen gnomAD
rs769594034 CA937727	607	F>S		No	ClinGen ExAC TOPMed gnomAD
CA340988304 rs1241790761	609	I>L		No	ClinGen gnomAD
CA340988360 rs1325626930	612	D>N		No	ClinGen TOPMed
rs1211691466 CA340988378	613	R>G		No	ClinGen gnomAD
CA26512851 rs983007353	617	L>F		No	ClinGen Ensembl
CA340988456 rs1423339098	618	P>S		No	ClinGen TOPMed gnomAD
rs772333395 CA937730	623	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1156752845 CA340988621	624	Y>C		No	ClinGen TOPMed gnomAD
CA340988602 rs1230801475	624	Y>N		No	ClinGen TOPMed gnomAD
rs1470066131 CA340988716	628	T>I		No	ClinGen gnomAD
CA340988698 rs1387655808	628	T>S		No	ClinGen gnomAD
rs368473517 CA937732	629	P>S		No	ClinGen ESP ExAC gnomAD
CA937733 rs766724728	632	G>V		No	ClinGen ExAC gnomAD
CA937734 rs371912104	635	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs759987617 CA937735	638	I>V		No	ClinGen ExAC TOPMed gnomAD
CA340989725 rs1557625591	641	L>F		No	ClinGen Ensembl
rs1173659133 CA340989737	643	D>N		No	ClinGen TOPMed
rs753261243 CA937737	644	R>G		No	ClinGen ExAC gnomAD
rs757849741 CA937738	644	R>T		No	ClinGen ExAC gnomAD
rs373058309 CA937763	646	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA937764 rs543625646	646	S>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA340989779 rs1427313267	647	Q>H		No	ClinGen gnomAD
CA26513058 rs1027330042	649	R>M		No	ClinGen Ensembl
CA340989794 rs1406378056	649	R>S		No	ClinGen gnomAD
rs12085658 VAR_050564 CA937767	655	Q>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA937769 rs373212914	656	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA937770 rs376189560	657	F>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA937771 rs781216106	658	R>G		No	ClinGen ExAC gnomAD
CA937772 rs746109655	658	R>S		No	ClinGen ExAC gnomAD
rs1292588892 CA340989950	658	R>T		No	ClinGen gnomAD
rs1272121284 CA340989965	659	C>R		No	ClinGen TOPMed
CA340989996 rs1219664976	660	C>S		No	ClinGen gnomAD
rs1265040340 CA340990016	660	C>W		No	ClinGen gnomAD
CA340990039 rs559447625	661	A>G		No	ClinGen 1000Genomes ExAC gnomAD
rs770106331 CA937773	661	A>T		No	ClinGen ExAC gnomAD
rs559447625 CA937774	661	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA340990048 rs1247725230	662	V>I		No	ClinGen TOPMed
rs200476994 CA937783	672	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA340990488 rs1161901805	676	Y>C		No	ClinGen TOPMed gnomAD
rs537574477 CA937784	677	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1456985864 CA340990515	677	K>R		No	ClinGen gnomAD
rs527828717 CA937786	680	N>H		No	ClinGen ExAC gnomAD
CA340990691 rs1253381552	682	M>T		No	ClinGen TOPMed gnomAD
rs1445959210 CA340990670	682	M>V		No	ClinGen gnomAD
rs778702394 CA937787	684	A>T		No	ClinGen ExAC TOPMed gnomAD
rs752696183 CA937788	685	I>V		No	ClinGen ExAC gnomAD
rs1286611110 CA340990920	687	A>V		No	ClinGen TOPMed gnomAD
rs1249369191 CA340990988	689	K>R		No	ClinGen TOPMed
rs1227504888 CA340991034	692	D>E		No	ClinGen gnomAD
CA340991031 rs1484365654	692	D>G		No	ClinGen gnomAD
CA937789 rs757217967	693	I>V		No	ClinGen ExAC gnomAD
rs1207495832 CA340991047	695	A>T		No	ClinGen gnomAD
CA937792 rs756311106	696	R>P		No	ClinGen ExAC gnomAD
CA937793 rs756311106	696	R>Q		No	ClinGen ExAC gnomAD
rs1570662411 CA340991076	699	V>G		No	ClinGen Ensembl
rs371052905 CA937795	699	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA26513220 rs902226854	700	D>G		No	ClinGen TOPMed gnomAD
CA937822 rs770578016	703	M>I		No	ClinGen ExAC gnomAD
CA937823 rs770578016	703	M>I		No	ClinGen ExAC gnomAD
rs1570670588 CA340993256	707	R>I		No	ClinGen Ensembl
CA340993268 rs1271838633	708	I>V		No	ClinGen TOPMed gnomAD
rs371286273 CA26517064	710	E>G		No	ClinGen Ensembl
rs1340765745 CA340993331	711	T>A		No	ClinGen gnomAD
CA340993346 rs1372507976	711	T>I		No	ClinGen TOPMed gnomAD
CA340993363 rs1222773849	712	V>A		No	ClinGen gnomAD
rs1450260161 CA340993376	713	N>D		No	ClinGen gnomAD
rs1198569288 CA340993391	713	N>K		No	ClinGen gnomAD
rs1333499772 CA340993385	713	N>T		No	ClinGen gnomAD
CA937826 rs375403448	715	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs375403448 CA937827	715	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557630068 CA340993592	723	L>F		No	ClinGen Ensembl
rs1165253894 CA340993596	723	L>H		No	ClinGen gnomAD
CA340993723 rs1424066184	729	T>I		No	ClinGen TOPMed
CA340993731 rs1474371890	730	K>E		No	ClinGen TOPMed
rs1322644227 CA340993751	731	E>Q		No	ClinGen gnomAD
rs1557630135 CA340993871	737	M>I		No	ClinGen Ensembl
rs754016442 CA937832	741	A>P		No	ClinGen ExAC gnomAD
rs1285643093 CA340993973	742	G>D		No	ClinGen gnomAD
CA340993965 rs1246008778	742	G>S		No	ClinGen gnomAD
CA340994130 rs1444218188	751	T>A		No	ClinGen TOPMed
CA937838 rs747523531	757	P>R		No	ClinGen ExAC gnomAD
rs780873749 CA937840	760	V>I		No	ClinGen ExAC gnomAD
rs1367003563 CA524694719	761	F>K		No	ClinGen gnomAD
CA937863 rs748894392	765	C>S		No	ClinGen ExAC gnomAD
CA340996363 rs1375814312	766	V>L		No	ClinGen gnomAD
rs768396536 CA340996402	767	V>D		No	ClinGen ExAC TOPMed gnomAD
CA937864 rs768396536	767	V>G		No	ClinGen ExAC TOPMed gnomAD
rs754877895 CA937865	769	G>A		No	ClinGen ExAC TOPMed gnomAD
rs754877895 CA340996434	769	G>V		No	ClinGen ExAC TOPMed gnomAD
rs771964322 CA937867	776	H>R		No	ClinGen ExAC gnomAD
rs773089379 CA937868	777	K>E		No	ClinGen ExAC gnomAD
rs955947651 CA26523505	777	K>R		No	ClinGen gnomAD
rs1388838532 CA340996674	779	V>I		No	ClinGen gnomAD
rs780243341 CA937888	784	K>I		No	ClinGen ExAC
CA340996993 rs1570688526	788	L>F		No	ClinGen Ensembl
rs771912894 CA937891	789	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1425171956 CA340997050	792	T>A		No	ClinGen gnomAD
CA26525012 rs373246980	797	K>E		No	ClinGen Ensembl
rs766955935 CA937904	807	G>A		No	ClinGen ExAC TOPMed gnomAD
rs753253980 CA937905	809	G>R		No	ClinGen ExAC gnomAD
rs754548194 CA937906	810	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA340998107 rs1279195169	812	D>G		No	ClinGen gnomAD
CA340998099 rs1223152007	812	D>H		No	ClinGen TOPMed gnomAD
CA937907 rs549143118	821	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs747812169 CA340998526	833	S>C		No	ClinGen ExAC gnomAD
CA937908 rs747812169	833	S>F		No	ClinGen ExAC gnomAD
rs777452279 CA937910	837	A>V		No	ClinGen ExAC TOPMed gnomAD
rs369061418 CA937911	843	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA937914 rs749368391	850	M>V		No	ClinGen ExAC gnomAD
rs1389244485 CA341000032	860	D>G		No	ClinGen gnomAD
rs1268303501 CA341000114	864	E>D		No	ClinGen gnomAD
rs993285599 CA26529462	867	D>E		No	ClinGen TOPMed
CA937943 rs529717698	872	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA341000290 rs1354714458	878	R>G		No	ClinGen gnomAD
CA937945 rs760058873	882	T>A		No	ClinGen ExAC gnomAD
CA937946 rs765783936	883	E>K		No	ClinGen ExAC gnomAD
CA937947 rs370637742	887	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs548272772 CA937948	888	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs763668194 CA937966	894	R>G		No	ClinGen ExAC gnomAD
CA341000554 rs1173805917	896	P>T		No	ClinGen gnomAD
CA341000591 rs1392961527	898	R>Q		No	ClinGen TOPMed
CA26529666 rs924904381 COSM426787	898	R>W	breast [Cosmic]	No	ClinGen cosmic curated Ensembl
CA937968 rs374663309	899	R>C		No	ClinGen ESP ExAC gnomAD
CA341000607 rs1308196149	899	R>H		No	ClinGen gnomAD
rs1172812441 CA341000641	902	A>T		No	ClinGen TOPMed
rs1352735528 CA341000673	903	S>N		No	ClinGen gnomAD
CA937970 rs571156003	904	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA341000714 rs1332170076	905	K>*		No	ClinGen gnomAD
rs750215404 CA341000721	905	K>N		No	ClinGen ExAC gnomAD
CA341000751 rs1301347895	907	A>S		No	ClinGen gnomAD
CA341000760 rs1391923175	907	A>V		No	ClinGen TOPMed
rs201403675 CA341000787	909	D>H		No	ClinGen 1000Genomes ExAC gnomAD
rs201403675 CA937972	909	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs370300406 CA26529702	910	V>I		No	ClinGen ESP gnomAD
CA937973 rs766407679	911	K>R		No	ClinGen ExAC gnomAD
rs753829610 CA937974	912	K>R		No	ClinGen ExAC gnomAD
CA26529711 rs867620344	913	H>N		No	ClinGen Ensembl
CA937975 rs758343619	914	P>L		No	ClinGen ExAC TOPMed gnomAD
CA937977 rs188265897	917	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA937976 rs777940241	917	R>W		No	ClinGen ExAC gnomAD
COSM912907 CA937996 rs765126182	923	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs557444302 CA937997	923	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1570701203 CA341001210	924	L>V		No	ClinGen Ensembl
CA341001310 rs1271245559	927	K>R		No	ClinGen TOPMed gnomAD
rs1334071427 CA341001380	929	V>A		No	ClinGen gnomAD
rs910467616 CA26529865	931	P>A		No	ClinGen TOPMed
CA341001461 rs1553160536	932	P>S		No	ClinGen Ensembl
CA937999 rs781331012	934	I>M		No	ClinGen ExAC gnomAD
CA937998 rs575369896	934	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs746091445 CA938000	935	P>S		No	ClinGen ExAC gnomAD
rs1190349629 CA341001562	936	T>I		No	ClinGen Ensembl
CA938001 rs543193317	937	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA341001609 rs1206823557	938	R>S		No	ClinGen Ensembl
rs749668259 CA938003	939	G>E		No	ClinGen ExAC gnomAD
CA938002 rs780486404	939	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1417855819 COSM1602755 CA341001632	940	R>*	liver [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1417855819 CA341001629	940	R>G		No	ClinGen TOPMed gnomAD
CA938004 rs769178347	940	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA938005 rs200518024	948	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA938006 rs368185560	951	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA341001895 rs1204354896	952	S>L		No	ClinGen TOPMed
CA341001935 rs1416464537	954	A>T		No	ClinGen gnomAD
rs772933738 CA938008	955	P>L		No	ClinGen ExAC gnomAD
rs1289909072 CA341001957	956	I>S		No	ClinGen TOPMed
CA938009 rs760435988	959	P>L		No	ClinGen ExAC gnomAD
CA938010 rs770800677	960	P>R		No	ClinGen ExAC gnomAD
rs1314658560 CA341001981 COSM197959	961	R>*	large_intestine breast [Cosmic]	No	ClinGen cosmic curated gnomAD
CA341001982 rs776454578	961	R>P		No	ClinGen ExAC TOPMed gnomAD
rs776454578 CA938011	961	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1292289982 CA341001996	963	P>L		No	ClinGen TOPMed
CA938016 rs761812508	964	R>K		No	ClinGen ExAC gnomAD
rs761812508 CA938015	964	R>T		No	ClinGen ExAC gnomAD
rs756302912 CA938018	965	I>T		No	ClinGen ExAC TOPMed gnomAD
rs750590810 CA938017	965	I>V		No	ClinGen ExAC TOPMed gnomAD
COSM3806048 rs200905692 CA938019	967	S>L	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA341002018 rs200905692	967	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1400238899 CA341002040	970	E>V		No	ClinGen gnomAD
rs1360903011 CA341002051	972	E>K		No	ClinGen gnomAD
CA938023 rs779420119	973	M>I		No	ClinGen ExAC gnomAD
rs779420119 CA938022	973	M>I		No	ClinGen ExAC gnomAD
CA341002063 rs1433113248	973	M>T		No	ClinGen gnomAD
rs1374660522 CA341002074	975	R>G		No	ClinGen gnomAD
rs771669324 CA938024	976	D>A		No	ClinGen ExAC gnomAD
rs1281262714 CA341002105	979	Y>H		No	ClinGen gnomAD
CA341002115 rs1222774819	980	I>T		No	ClinGen gnomAD
CA938025 rs777447363	980	I>V		No	ClinGen ExAC gnomAD
rs746556962 CA938026	981	A>T		No	ClinGen ExAC gnomAD
CA341002125 rs1349340841	982	D>N		No	ClinGen gnomAD
rs1183089997 CA341002136	983	W>*		No	ClinGen TOPMed
CA938027 rs184754507	983	W>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341002141 rs1473696683	984	C>R		No	ClinGen TOPMed

No associated diseases with Q16513

3 regional properties for Q16513

Type	Name	Position	InterPro Accession
domain	Pectinesterase, catalytic	222 - 517	IPR000070
domain	Pectinesterase inhibitor domain	27 - 179	IPR006501
active_site	Pectinesterase, Asp active site	365 - 374	IPR033131

Functions

		Description
EC Number	2.7.11.13	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Nucleus Membrane Cell projection, lamellipodium Cytoplasm, cytoskeleton Cleavage furrow Midbody Cell junction	Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis Recruited to nascent cell-cell contacts at the apical surface of cells In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm
PANTHER Family	PTHR24356	SERINE/THREONINE-PROTEIN KINASE
PANTHER Subfamily	PTHR24356:SF322	SERINE_THREONINE-PROTEIN KINASE N2
PANTHER Protein Class	non-receptor serine/threonine protein kinase protein modifying enzyme
PANTHER Pathway Category	Alzheimer disease-amyloid secretase pathway PKC Muscarinic acetylcholine receptor 1 and 3 signaling pathway PKC PDGF signaling pathway PKC

14 GO annotations of cellular component

Name	Definition
apical junction complex	A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cleavage furrow	The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intermediate filament cytoskeleton	Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

12 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
calcium-dependent protein kinase C activity	Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
histone deacetylase binding	Binding to histone deacetylase.
kinase activity	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA polymerase binding	Binding to an RNA polymerase molecule or complex.
small GTPase binding	Binding to a small monomeric GTPase.

15 GO annotations of biological process

Name	Definition
apical junction assembly	The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents.
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cell projection organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
epithelial cell migration	The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of cytokinesis	Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
positive regulation of mitotic cell cycle	Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
positive regulation of viral genome replication	Any process that activates or increases the frequency, rate or extent of viral genome replication.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of cell motility	Any process that modulates the frequency, rate or extent of cell motility.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

40 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P24583	PKC1	Protein kinase C-like 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
A1A4I4	PKN1	Serine/threonine-protein kinase N1	Bos taurus (Bovine)	SS
P83099	Pkcdelta	Putative protein kinase C delta type homolog	Drosophila melanogaster (Fruit fly)	PR
A1Z7T0	Pkn	Serine/threonine-protein kinase N	Drosophila melanogaster (Fruit fly)	SS
Q96LW2	RSKR	Ribosomal protein S6 kinase-related protein	Homo sapiens (Human)	PR
O15530	PDPK1	3-phosphoinositide-dependent protein kinase 1	Homo sapiens (Human)	EV
Q05513	PRKCZ	Protein kinase C zeta type	Homo sapiens (Human)	SS
P41743	PRKCI	Protein kinase C iota type	Homo sapiens (Human)	EV
Q16512	PKN1	Serine/threonine-protein kinase N1	Homo sapiens (Human)	EV
Q6P5Z2	PKN3	Serine/threonine-protein kinase N3	Homo sapiens (Human)	SS
P24723	PRKCH	Protein kinase C eta type	Homo sapiens (Human)	SS
Q02156	PRKCE	Protein kinase C epsilon type	Homo sapiens (Human)	SS
Q04759	PRKCQ	Protein kinase C theta type	Homo sapiens (Human)	PR
Q05655	PRKCD	Protein kinase C delta type	Homo sapiens (Human)	SS
P17252	PRKCA	Protein kinase C alpha type	Homo sapiens (Human)	EV
P05129	PRKCG	Protein kinase C gamma type	Homo sapiens (Human)	SS
P05771	PRKCB	Protein kinase C beta type	Homo sapiens (Human)	SS
P31751	AKT2	RAC-beta serine/threonine-protein kinase	Homo sapiens (Human)	EV SS
P31749	AKT1	RAC-alpha serine/threonine-protein kinase	Homo sapiens (Human)	EV
Q9Y243	AKT3	RAC-gamma serine/threonine-protein kinase	Homo sapiens (Human)	SS
Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	Homo sapiens (Human)	SS
Q9HBY8	SGK2	Serine/threonine-protein kinase Sgk2	Homo sapiens (Human)	SS
O00141	SGK1	Serine/threonine-protein kinase Sgk1	Homo sapiens (Human)	PR
Q15208	STK38	Serine/threonine-protein kinase 38	Homo sapiens (Human)	EV
Q9Y2H1	STK38L	Serine/threonine-protein kinase 38-like	Homo sapiens (Human)	EV
Q6A1A2	PDPK2P	Putative 3-phosphoinositide-dependent protein kinase 2	Homo sapiens (Human)	PR
P23298	Prkch	Protein kinase C eta type	Mus musculus (Mouse)	PR
Q02111	Prkcq	Protein kinase C theta type	Mus musculus (Mouse)	PR
P16054	Prkce	Protein kinase C epsilon type	Mus musculus (Mouse)	PR
P28867	Prkcd	Protein kinase C delta type	Mus musculus (Mouse)	PR
P70268	Pkn1	Serine/threonine-protein kinase N1	Mus musculus (Mouse)	SS
Q8K045	Pkn3	Serine/threonine-protein kinase N3	Mus musculus (Mouse)	SS
Q8BWW9	Pkn2	Serine/threonine-protein kinase N2	Mus musculus (Mouse)	SS
Q63433	Pkn1	Serine/threonine-protein kinase N1	Rattus norvegicus (Rat)	SS
Q64617	Prkch	Protein kinase C eta type	Rattus norvegicus (Rat)	PR
P09216	Prkce	Protein kinase C epsilon type	Rattus norvegicus (Rat)	PR
P09215	Prkcd	Protein kinase C delta type	Rattus norvegicus (Rat)	PR
O08874	Pkn2	Serine/threonine-protein kinase N2	Rattus norvegicus (Rat)	SS
P34722	tpa-1	Protein kinase C-like 1	Caenorhabditis elegans	PR
A7MBL8	pkn2	Serine/threonine-protein kinase N2	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MASNPERGEI	LLTELQGDSR	SLPFSENVSA	VQKLDFSDTM	VQQKLDDIKD	RIKREIRKEL
70	80	90	100	110	120
KIKEGAENLR	KVTTDKKSLA	YVDNILKKSN	KKLEELHHKL	QELNAHIVVS	DPEDITDCPR
130	140	150	160	170	180
TPDTPNNDPR	CSTSNNRLKA	LQKQLDIELK	VKQGAENMIQ	MYSNGSSKDR	KLHGTAQQLL
190	200	210	220	230	240
QDSKTKIEVI	RMQILQAVQT	NELAFDNAKP	VISPLELRME	ELRHHFRIEF	AVAEGAKNVM
250	260	270	280	290	300
KLLGSGKVTD	RKALSEAQAR	FNESSQKLDL	LKYSLEQRLN	EVPKNHPKSR	IIIEELSLVA
310	320	330	340	350	360
ASPTLSPRQS	MISTQNQYST	LSKPAALTGT	LEVRLMGCQD	ILENVPGRSK	ATSVALPGWS
370	380	390	400	410	420
PSETRSSFMS	RTSKSKSGSS	RNLLKTDDLS	NDVCAVLKLD	NTVVGQTSWK	PISNQSWDQK
430	440	450	460	470	480
FTLELDRSRE	LEISVYWRDW	RSLCAVKFLR	LEDFLDNQRH	GMCLYLEPQG	TLFAEVTFFN
490	500	510	520	530	540
PVIERRPKLQ	RQKKIFSKQQ	GKTFLRAPQM	NINIATWGRL	VRRAIPTVNH	SGTFSPQAPV
550	560	570	580	590	600
PTTVPVVDVR	IPQLAPPASD	STVTKLDFDL	EPEPPPAPPR	ASSLGEIDES	SELRVLDIPG
610	620	630	640	650	660
QDSETVFDIQ	NDRNSILPKS	QSEYKPDTPQ	SGLEYSGIQE	LEDRRSQQRF	QFNLQDFRCC
670	680	690	700	710	720
AVLGRGHFGK	VLLAEYKNTN	EMFAIKALKK	GDIVARDEVD	SLMCEKRIFE	TVNSVRHPFL
730	740	750	760	770	780
VNLFACFQTK	EHVCFVMEYA	AGGDLMMHIH	TDVFSEPRAV	FYAACVVLGL	QYLHEHKIVY
790	800	810	820	830	840
RDLKLDNLLL	DTEGFVKIAD	FGLCKEGMGY	GDRTSTFCGT	PEFLAPEVLT	ETSYTRAVDW
850	860	870	880	890	900
WGLGVLIYEM	LVGESPFPGD	DEEEVFDSIV	NDEVRYPRFL	STEAISIMRR	LLRRNPERRL
910	920	930	940	950	960
GASEKDAEDV	KKHPFFRLID	WSALMDKKVK	PPFIPTIRGR	EDVSNFDDEF	TSEAPILTPP
970	980
REPRILSEEE	QEMFRDFDYI	ADWC