AiPD: Autoinhibited Protein Database

Q15759

Gene name	MAPK11 (PRKM11, SAPK2, SAPK2B)
Protein name	Mitogen-activated protein kinase 11
Names	MAP kinase 11 , MAPK 11 , EC 2.7.11.24 , Mitogen-activated protein kinase p38 beta , MAP kinase p38 beta , p38b , Stress-activated protein kinase 2b , SAPK2b , p38-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5600
EC number	2.7.11.24: Protein-serine/threonine kinases
Protein Class

Descriptions

MAPK1 encodes Mitogen-activated protein kinase 1, and is involved in diverse cellular responses by phosphorylating cytoplasmic and nuclear proteins. Unlike other MAP kinases, MAPK1 activates via dual phosphorylation of Thr-186 and Tyr-193 within the activation lip, and mutations at Q105 alone were sufficient for autoactivation. Additionally, in the inactive form, L76, Q10 and I87 form a structural unit that restrains intramolecular autophosphorylation by preventing interactions between activation lip residues and the catalytic base (D149) needed for phosphoryl transfer. Mutations at L76, I87 and additionally S153 increased basal specific activity via autophosphorylation of Thr-186 and Tyr-193.

Autoinhibitory domains (AIDs)

73-152 (Autoinhibitory region) SS

Target domain	24-308 (Protein kinase domain)
Relief mechanism	PTM
Assay

AID

73-152 (Autoinhibitory region)

Target domain

24-308 (Protein kinase domain)

Relief mechanism

PTM (Autophosphorylation at Thr-186 and Tyr-193)

Assay

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100

Emrick MA et al. (2006) "The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity", Proceedings of the National Academy of Sciences of the United States of America, 103, 18101-6

Emrick MA et al. (2001) "Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations", The Journal of biological chemistry, 276, 46469-79

Autoinhibited structure

Activated structure

4 structures for Q15759

Entry ID	Method	Resolution	Chain	Position	Source
3GC8	X-ray	240 A	A/B	1-364	PDB
3GC9	X-ray	205 A	A/B	1-364	PDB
3GP0	X-ray	190 A	A	5-350	PDB
AF-Q15759-F1	Predicted				AlphaFoldDB

274 variants for Q15759

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1449343256 CA412144457	2	S>L		No	ClinGen gnomAD
CA412144454 rs1195820320	3	G>C		No	ClinGen gnomAD
rs1431675741 CA412144412	5	R>C		No	ClinGen TOPMed gnomAD
CA412144414 rs1431675741	5	R>G		No	ClinGen TOPMed gnomAD
rs1267015005 CA412144398	6	A>S		No	ClinGen gnomAD
CA412144404 rs1267015005	6	A>T		No	ClinGen gnomAD
CA10311365 rs374096034	7	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201775880 CA325511994	9	Y>*		No	ClinGen TOPMed gnomAD
CA412144341 rs1204373387	9	Y>C		No	ClinGen gnomAD
CA412144336 rs773430832	10	R>G		No	ClinGen ExAC TOPMed
CA10311362 rs769938948	10	R>Q		No	ClinGen ExAC gnomAD
rs1230713841 CA412144316	11	Q>R		No	ClinGen gnomAD
CA412144217 rs1307345435	17	V>L		No	ClinGen gnomAD
CA412144199 rs1364819785	18	W>*		No	ClinGen gnomAD
CA412144172 rs1212682950	19	E>D		No	ClinGen TOPMed
CA325511986 rs867172027	21	P>S		No	ClinGen TOPMed
rs1601656048 CA412144125	22	Q>H		No	ClinGen Ensembl
rs780277636 CA10311357	25	Q>*		No	ClinGen ExAC gnomAD
CA10311356 rs758945230	26	G>R		No	ClinGen ExAC gnomAD
CA412144062 rs1176067096	27	L>M		No	ClinGen TOPMed gnomAD
CA10311355 rs750834315	28	R>C		No	ClinGen ExAC TOPMed gnomAD
CA10311353 rs778413667	29	P>L		No	ClinGen ExAC TOPMed gnomAD
rs778413667 CA412144029	29	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1601656002 CA412144012	30	V>G		No	ClinGen Ensembl
CA325511970 rs923876072	32	S>F		No	ClinGen TOPMed gnomAD
CA10311350 rs763789031	35	Y>H		No	ClinGen ExAC gnomAD
rs1198656218 CA412143931	36	G>D		No	ClinGen gnomAD
rs1469496709 CA412143272	41	A>V		No	ClinGen gnomAD
CA10311329 rs754691660	42	Y>*		No	ClinGen ExAC gnomAD
rs201998129 CA325510747	42	Y>C		No	ClinGen Ensembl
CA412143261 rs1208663785	43	D>Y		No	ClinGen gnomAD
CA412143253 rs1339456601	44	A>T		No	ClinGen gnomAD
rs766480324 CA10311327	45	R>L		No	ClinGen ExAC gnomAD
rs766480324 CA412143238	45	R>Q		No	ClinGen ExAC gnomAD
rs751375132 CA10311328	45	R>W		No	ClinGen ExAC gnomAD
CA412143221 rs1441922896	47	R>H		No	ClinGen gnomAD
CA412143219 rs1441922896	47	R>L		No	ClinGen gnomAD
rs762978721 CA10311326	49	K>Q		No	ClinGen ExAC gnomAD
TCGA novel	51	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412143181 rs1404911493	52	V>L		No	ClinGen gnomAD
rs1397266287 CA412143165	53	K>R		No	ClinGen gnomAD
CA412143123 rs1601654401	57	R>H		No	ClinGen Ensembl
rs1389350491 CA412143114	58	P>S		No	ClinGen gnomAD
rs760970146 CA10311323	62	L>P		No	ClinGen ExAC gnomAD
CA412143054 rs775531934	64	H>D		No	ClinGen ExAC gnomAD
CA10311321 rs772304418	64	H>R		No	ClinGen ExAC gnomAD
rs775531934 CA10311322	64	H>Y		No	ClinGen ExAC gnomAD
rs746283641 CA10311320	66	R>L		No	ClinGen ExAC gnomAD
rs1340577288 CA412143025	67	R>K		No	ClinGen gnomAD
rs1235550902 CA412143003	69	Y>C		No	ClinGen TOPMed gnomAD
rs1235550902 CA412143005	69	Y>S		No	ClinGen TOPMed gnomAD
CA412142994 rs1370179109	70	R>Q		No	ClinGen gnomAD
rs1436005224 CA412142979	72	L>M		No	ClinGen gnomAD
CA10311316 rs569191044	73	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs867971990 CA325510679	73	R>W		No	ClinGen Ensembl
CA10311314 rs747866967	74	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1369807725 CA412142933	77	H>R		No	ClinGen gnomAD
rs1374229485 CA412142914	79	K>*		No	ClinGen TOPMed
CA412142916 rs1374229485	79	K>E		No	ClinGen TOPMed
CA325510658 rs932280353	79	K>N		No	ClinGen Ensembl
CA412142896 rs754643839	80	H>Q		No	ClinGen ExAC gnomAD
rs751465056 CA10311311	81	E>*		No	ClinGen ExAC TOPMed gnomAD
rs766209362 CA10311310	81	E>D		No	ClinGen ExAC gnomAD
CA412142887 rs1470280542	81	E>G		No	ClinGen gnomAD
rs751465056 CA325510655	81	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1376087500 CA412142880	82	N>D		No	ClinGen TOPMed gnomAD
TCGA novel	89	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1319996803 CA412142756	90	F>C		No	ClinGen gnomAD
rs758226467 CA412142743	91	T>K		No	ClinGen ExAC gnomAD
rs758226467 CA10311289	91	T>R		No	ClinGen ExAC gnomAD
CA325510492 rs913028772	92	P>R		No	ClinGen TOPMed
rs757207162 CA10311286	94	T>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	95	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412142709 rs1433916513	95	S>P		No	ClinGen gnomAD
rs752787958 CA10311285	99	F>L		No	ClinGen ExAC gnomAD
rs1281266667 CA412142653	100	S>C		No	ClinGen TOPMed
rs1281266667 CA412142657	100	S>R		No	ClinGen TOPMed
CA10311284 rs767568809	100	S>R		No	ClinGen ExAC gnomAD
rs1313895578 CA412142627	102	V>A		No	ClinGen gnomAD
rs1360383981 CA412142634	102	V>L		No	ClinGen gnomAD
CA10311259 rs777155538	108	L>V		No	ClinGen ExAC TOPMed gnomAD
CA412142525 rs1257491842	110	G>V		No	ClinGen gnomAD
CA10311255 rs775125128	111	A>G		No	ClinGen ExAC gnomAD
rs760309330 CA10311256	111	A>T		No	ClinGen ExAC gnomAD
rs376747986 CA10311253	114	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs376747986 CA325510309	114	N>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA10311252 rs778587552	115	N>I		No	ClinGen ExAC
rs770710299 CA10311251	117	V>G		No	ClinGen ExAC gnomAD
CA412142454 rs1258793717	117	V>L		No	ClinGen TOPMed
rs1304886815 CA412142392	121	A>S		No	ClinGen gnomAD
TCGA novel	123	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749219347 CA10311249	124	D>G		No	ClinGen ExAC gnomAD
rs1160180514 CA412142361	124	D>N		No	ClinGen gnomAD
COSM1035398 CA10311248 rs542078670	125	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs1279556699 CA412142304	128	Q>H		No	ClinGen gnomAD
rs1185901094 CA412142298	129	F>V		No	ClinGen TOPMed
rs750605640 CA412142237	133	Q>H		No	ClinGen ExAC gnomAD
CA412142240 rs1294416251	133	Q>R		No	ClinGen gnomAD
CA10311242 rs765547984	134	L>M		No	ClinGen ExAC gnomAD
CA10311240 rs754232386	136	R>H		No	ClinGen ExAC gnomAD
rs1601653761 CA412142178	139	K>R		No	ClinGen Ensembl
rs1385489765 CA412142122	140	Y>H		No	ClinGen TOPMed
CA10311212 rs748111329	143	S>*		No	ClinGen ExAC gnomAD
rs1371147911 CA412142065	145	G>E		No	ClinGen gnomAD
CA10311210 rs768455266	145	G>R		No	ClinGen ExAC gnomAD
TCGA novel	149	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412141964 rs1211331814	150	D>E		No	ClinGen gnomAD
TCGA novel	151	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1261538849 CA412141927	153	P>L		No	ClinGen gnomAD
CA412141853 rs1230525575	160	E>K		No	ClinGen gnomAD
rs908840626 CA325510086	161	D>N		No	ClinGen TOPMed
CA10311189 rs749552440	163	E>A		No	ClinGen ExAC TOPMed gnomAD
rs749552440 CA325510078	163	E>G		No	ClinGen ExAC TOPMed gnomAD
rs778181955 CA10311188	164	L>F		No	ClinGen ExAC gnomAD
TCGA novel	166	I>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1450470450 CA412141779	168	D>N		No	ClinGen gnomAD
CA412141758 CA10311165 rs760748	169	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA412141753 rs780471725 CA10311163	170	G>R		No	ClinGen ExAC TOPMed gnomAD
CA412141730 rs1555914905	172	A>E		No	ClinGen Ensembl
rs373672413 CA325509976	173	R>C		No	ClinGen ESP TOPMed gnomAD
rs1239677114 CA412141714	173	R>P		No	ClinGen gnomAD
rs199640167 CA325509974	175	A>P		No	ClinGen Ensembl
rs200171398 CA10311160	176	D>E		No	ClinGen ExAC TOPMed gnomAD
rs530545117 CA10311157	177	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1297327116 CA412141664	177	E>G		No	ClinGen Ensembl
CA10311158 rs202139039	177	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA412141633 rs1315217256	179	M>T		No	ClinGen TOPMed
rs200417198 CA10311152	181	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs202165975 CA325509953	182	Y>*		No	ClinGen TOPMed
TCGA novel	182	Y>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412141588 rs1439239740	183	V>L		No	ClinGen gnomAD
CA325509950 rs1013345854	184	A>T		No	ClinGen Ensembl
rs765353722 CA10311150	185	T>M		No	ClinGen ExAC gnomAD
CA412141555 rs1392392060	186	R>C		No	ClinGen TOPMed gnomAD
CA10311147 rs201260779	187	W>R		No	ClinGen ExAC gnomAD
CA412141525 rs1202981586	188	Y>D		No	ClinGen TOPMed
CA412141527 rs1202981586	188	Y>H		No	ClinGen TOPMed
TCGA novel	190	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412141440 rs1189835125	194	M>T		No	ClinGen TOPMed
rs200053495 CA325509927	195	L>R		No	ClinGen Ensembl
rs1253734954 CA412141421	196	N>S		No	ClinGen TOPMed
CA325509924 rs201819627	197	W>*		No	ClinGen Ensembl
CA325509919 rs200843353	197	W>C		No	ClinGen gnomAD
CA412141399 rs1422297366	198	M>V		No	ClinGen TOPMed
rs1036838107 CA325509916	199	H>R		No	ClinGen gnomAD
CA412141341 rs1205755012	201	N>I		No	ClinGen gnomAD
CA412141335 rs775827348	201	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1249358408 CA412141307	203	T>I		No	ClinGen gnomAD
CA10311071 rs757173321	206	I>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs201856367 CA325509670	206	I>V		No	ClinGen gnomAD
CA10311069 COSM94668 rs781182842	209	V>M	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA10311068 rs755209490	210	G>S		No	ClinGen ExAC gnomAD
rs199788809 CA325509655	212	I>V		No	ClinGen gnomAD
CA412140655 rs1601652924	215	E>A		No	ClinGen Ensembl
rs565706201 CA10311067	218	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA412140552 rs1325793874	221	A>T		No	ClinGen gnomAD
VAR_042264	221	A>V	a lung neuroendocrine carcinoma sample; somatic mutation [UniProt]	No	UniProt
rs1222834590 CA412140511	224	P>A		No	ClinGen gnomAD
CA10311065 rs201406886	224	P>R		No	ClinGen ExAC gnomAD
CA10311063 rs373329238	225	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	226	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs199575518 CA10311062	226	S>I		No	ClinGen ExAC gnomAD
rs201592296 CA325509636	226	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA10311060 rs763646740	227	D>N		No	ClinGen ExAC TOPMed gnomAD
CA10311059 rs760434220	228	Y>H		No	ClinGen ExAC gnomAD
rs767268371 CA10311040	230	D>G		No	ClinGen ExAC gnomAD
COSM1035394 CA412140266 rs1213569489	234	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA412140263 rs200495263	234	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10311039 rs200495263	234	R>L		No	ClinGen ExAC gnomAD
rs200495263 CA325509520	234	R>P		No	ClinGen ExAC gnomAD
rs1171786672 CA412140258	235	I>L		No	ClinGen TOPMed
CA412140235 rs1412362803	236	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1292395219 CA412140171	238	V>A		No	ClinGen gnomAD
CA412140164 rs1247986304	239	V>L		No	ClinGen gnomAD
rs1247986304 CA412140167	239	V>M		No	ClinGen gnomAD
TCGA novel	240	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412140143 rs1356976680	241	T>A		No	ClinGen gnomAD
rs537246174 CA10311038	242	P>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1228632054 CA412140084	243	S>T		No	ClinGen gnomAD
CA412140044 rs1286548063	246	V>I		No	ClinGen TOPMed gnomAD
CA325509506 rs199613364	248	A>T		No	ClinGen gnomAD
CA412139953 rs1304245759	250	I>S		No	ClinGen gnomAD
CA10311036 rs762912240	251	S>F		No	ClinGen ExAC gnomAD
rs570272844 CA10311034	252	S>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1555914777 CA10311031	253	E>Q		No	ClinGen Ensembl
rs746024959 CA10311028	254	H>L		No	ClinGen ExAC gnomAD
CA10311029 rs746024959	254	H>P		No	ClinGen ExAC gnomAD
rs779927969 CA10311030	254	H>Y		No	ClinGen ExAC gnomAD
rs201247220 CA10311009	256	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1323668346 CA412139712	256	R>W		No	ClinGen TOPMed gnomAD
rs1304295348 CA412139697	257	T>A		No	ClinGen TOPMed gnomAD
rs749737248 CA10311008	257	T>I		No	ClinGen ExAC gnomAD
CA325509191 rs62241160	259	I>M		No	ClinGen 1000Genomes
CA325509195 rs200181697	259	I>V		No	ClinGen TOPMed
rs201774593 CA412139583	263	P>A		No	ClinGen TOPMed gnomAD
CA325509188 rs201774593	263	P>S		No	ClinGen TOPMed gnomAD
CA412139560 rs1413972922	265	M>T		No	ClinGen TOPMed
CA412139522 rs1406586918	267	Q>E		No	ClinGen TOPMed
CA325509178 rs1000452403	267	Q>H		No	ClinGen Ensembl
rs778216937 CA10311007	269	D>N		No	ClinGen ExAC TOPMed gnomAD
rs778216937 CA412139473	269	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs780787294 CA10311004	273	I>N		No	ClinGen ExAC gnomAD
CA10311005 rs753098424	273	I>V		No	ClinGen ExAC gnomAD
CA10311003 rs754489536	275	R>C		No	ClinGen ExAC TOPMed gnomAD
rs33932986 CA10311002 VAR_025176	275	R>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs33932986 CA412139357	275	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs33932986 CA325509165	275	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA325509162 rs760373580	276	G>R		No	ClinGen Ensembl
CA412139341 rs1303205718	277	A>G		No	ClinGen Ensembl
rs766082850 CA10311001 CA412139331	278	N>K		No	ClinGen ExAC gnomAD
rs1178743542 CA412139335	278	N>S		No	ClinGen gnomAD
CA412139246 rs1445018685	282	I>T		No	ClinGen TOPMed gnomAD
rs867812372 CA325509051	283	D>E		No	ClinGen TOPMed gnomAD
CA325509053 rs200642822	283	D>H		No	ClinGen Ensembl
rs1313074281 CA412139228	284	L>F		No	ClinGen TOPMed
CA412139204 rs1460505067	286	G>E		No	ClinGen gnomAD
CA325509043 rs764349580	286	G>R		No	ClinGen gnomAD
CA10310984 rs748517519	287	R>K		No	ClinGen ExAC TOPMed gnomAD
CA412139176 rs1206250525	288	M>I		No	ClinGen gnomAD
CA10310979 rs758066433	293	S>R		No	ClinGen ExAC gnomAD
rs757050182 CA10310976	297	V>F		No	ClinGen ExAC TOPMed gnomAD
rs1601651937 CA412139060	297	V>G		No	ClinGen Ensembl
rs1383984509 CA412139010	301	E>D		No	ClinGen gnomAD
rs764003550 CA10310974	305	H>L		No	ClinGen ExAC gnomAD
rs753653017 CA10310975	305	H>N		No	ClinGen ExAC gnomAD
rs199785816 CA10310972	306	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs572173960 CA10310970	312	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10310967 rs748522591	313	D>A		No	ClinGen ExAC gnomAD
CA10310968 rs770037849	313	D>N		No	ClinGen ExAC TOPMed gnomAD
rs747463005 CA10310964	314	P>L		No	ClinGen ExAC gnomAD
CA10310965 rs199590131	314	P>S		No	ClinGen ExAC gnomAD
CA10310961 rs745358763	315	E>K		No	ClinGen ExAC gnomAD
CA412138816 rs1220557167	318	P>T		No	ClinGen gnomAD
CA325509007 rs956274936	319	E>D		No	ClinGen TOPMed gnomAD
rs1355985684 CA412138804	319	E>G		No	ClinGen gnomAD
rs778487368 CA10310960	320	A>G		No	ClinGen ExAC gnomAD
rs777567293 CA10310957	321	E>K		No	ClinGen ExAC TOPMed gnomAD
CA325508999 rs375893595	323	Y>F		No	ClinGen ESP TOPMed
rs1301122232 CA412138717	325	E>D		No	ClinGen gnomAD
rs1367222559 CA412138726	325	E>Q		No	ClinGen gnomAD
COSM1035390 CA10310954 rs200220148	327	V>I	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA325508994 rs200220148	327	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	328	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372915323 CA325508989	328	E>V		No	ClinGen ESP
TCGA novel	330	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763177148 CA412138646	331	E>D		No	ClinGen ExAC gnomAD
rs1474153464 CA412138654	331	E>K		No	ClinGen gnomAD
CA412138638 rs1193578749	332	R>C		No	ClinGen gnomAD
CA10310952 rs368652751	332	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA10310950 rs202228682	333	T>M		No	ClinGen ExAC TOPMed gnomAD
rs202228682 CA325508973	333	T>R		No	ClinGen ExAC TOPMed gnomAD
rs150537389 CA412138585 CA10310948	336	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1197727931 CA412138592	336	E>G		No	ClinGen TOPMed gnomAD
CA412138588 rs1197727931	336	E>V		No	ClinGen TOPMed gnomAD
CA412138558 rs760993249	338	K>N		No	ClinGen ExAC TOPMed gnomAD
CA10310923 rs141669191	339	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10310922 rs773050210	343	Q>L		No	ClinGen ExAC gnomAD
rs769559904 CA10310921	344	E>A		No	ClinGen ExAC gnomAD
CA412138447 rs137925943	345	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA10310920 rs137925943	345	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs781072058 CA10310919	348	F>C		No	ClinGen ExAC gnomAD
CA10310918 rs754890022	350	P>H		No	ClinGen ExAC gnomAD
rs1364020487 CA412138354	353	P>A		No	ClinGen TOPMed
CA10310917 rs377401964	354	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs201607135 CA10310916	354	P>L		No	ClinGen ExAC TOPMed gnomAD
rs753846809 CA10310913	355	K>T		No	ClinGen ExAC gnomAD
rs764306722 CA10310912	357	P>L		No	ClinGen ExAC gnomAD
rs112868013 CA325508739	358	G>C		No	ClinGen gnomAD
CA412138297 rs1301695781	358	G>D		No	ClinGen gnomAD
rs112868013 CA412138304	358	G>S		No	ClinGen gnomAD
rs200627432 CA325508738	360	L>Q		No	ClinGen gnomAD
CA412138276 rs200627432	360	L>R		No	ClinGen gnomAD
rs199675711 CA325508737	361	E>K		No	ClinGen gnomAD
rs201120066 CA10310910	362	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with Q15759

3 regional properties for Q15759

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	24 - 308	IPR000719
conserved_site	Mitogen-activated protein (MAP) kinase, conserved site	59 - 162	IPR003527
binding_site	Protein kinase, ATP binding site	30 - 54	IPR017441

Functions

		Description
EC Number	2.7.11.24	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase activity	Catalysis of the reaction
protein serine kinase activity	Catalysis of the reactions
protein serine/threonine kinase activity	Catalysis of the reactions

16 GO annotations of biological process

Name	Definition
bone development	The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
cardiac muscle cell proliferation	The expansion of a cardiac muscle cell population by cell division.
cellular response to interleukin-1	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
cellular response to UV-B	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.
cellular response to virus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
cellular senescence	A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of cardiac muscle cell proliferation	Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation.
osteoblast differentiation	The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
p38MAPK cascade	An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of interleukin-12 production	Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
positive regulation of muscle cell differentiation	Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
stress-activated MAPK cascade	The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.
stress-activated protein kinase signaling cascade	The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal.

91 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32485	HOG1	Mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
A5PKJ4	MAPK7	Mitogen-activated protein kinase 7	Bos taurus (Bovine)	SS
Q3T0N5	MAPK13	Mitogen-activated protein kinase 13	Bos taurus (Bovine)	SS
P46196	MAPK1	Mitogen-activated protein kinase 1	Bos taurus (Bovine)	SS
Q5F3W3	MAPK6	Mitogen-activated protein kinase 6	Gallus gallus (Chicken)	SS
Q95NE7	MAPK14	Mitogen-activated protein kinase 14	Pan troglodytes (Chimpanzee)	SS
Q9N272	MAPK13	Mitogen-activated protein kinase 13	Pan troglodytes (Chimpanzee)	SS
Q9W354	Erk7	Extracellular signal-regulated kinase 7	Drosophila melanogaster (Fruit fly)	SS
P40417	rl	Mitogen-activated protein kinase ERK-A	Drosophila melanogaster (Fruit fly)	SS
P83100	p38c	Putative mitogen-activated protein kinase 14C	Drosophila melanogaster (Fruit fly)	SS
O62618	p38a	Mitogen-activated protein kinase p38a	Drosophila melanogaster (Fruit fly)	SS
O61443	p38b	Mitogen-activated protein kinase p38b	Drosophila melanogaster (Fruit fly)	SS
P20794	MAK	Serine/threonine-protein kinase MAK	Homo sapiens (Human)	PR
Q9UQ07	MOK	MAPK/MAK/MRK overlapping kinase	Homo sapiens (Human)	PR
Q8TD08	MAPK15	Mitogen-activated protein kinase 15	Homo sapiens (Human)	SS
P45984	MAPK9	Mitogen-activated protein kinase 9	Homo sapiens (Human)	SS
P45983	MAPK8	Mitogen-activated protein kinase 8	Homo sapiens (Human)	EV
P53779	MAPK10	Mitogen-activated protein kinase 10	Homo sapiens (Human)	EV
Q9UBE8	NLK	Serine/threonine-protein kinase NLK	Homo sapiens (Human)	SS
P27361	MAPK3	Mitogen-activated protein kinase 3	Homo sapiens (Human)	SS
P28482	MAPK1	Mitogen-activated protein kinase 1	Homo sapiens (Human)	EV
P31152	MAPK4	Mitogen-activated protein kinase 4	Homo sapiens (Human)	SS
Q16659	MAPK6	Mitogen-activated protein kinase 6	Homo sapiens (Human)	SS
Q13164	MAPK7	Mitogen-activated protein kinase 7	Homo sapiens (Human)	SS
P53778	MAPK12	Mitogen-activated protein kinase 12	Homo sapiens (Human)	SS
O15264	MAPK13	Mitogen-activated protein kinase 13	Homo sapiens (Human)	SS
Q16539	MAPK14	Mitogen-activated protein kinase 14	Homo sapiens (Human)	SS
Q9Z1B7	Mapk13	Mitogen-activated protein kinase 13	Mus musculus (Mouse)	SS
P47811	Mapk14	Mitogen-activated protein kinase 14	Mus musculus (Mouse)	SS
Q61532	Mapk6	Mitogen-activated protein kinase 6	Mus musculus (Mouse)	SS
Q63844	Mapk3	Mitogen-activated protein kinase 3	Mus musculus (Mouse)	SS
P63085	Mapk1	Mitogen-activated protein kinase 1	Mus musculus (Mouse)	SS
Q9WVS8	Mapk7	Mitogen-activated protein kinase 7	Mus musculus (Mouse)	SS
O08911	Mapk12	Mitogen-activated protein kinase 12	Mus musculus (Mouse)	SS
Q80Y86	Mapk15	Mitogen-activated protein kinase 15	Mus musculus (Mouse)	SS
Q6P5G0	Mapk4	Mitogen-activated protein kinase 4	Mus musculus (Mouse)	SS
Q9WUI1	Mapk11	Mitogen-activated protein kinase 11	Mus musculus (Mouse)	SS
P70618	Mapk14	Mitogen-activated protein kinase 14	Rattus norvegicus (Rat)	SS
Q9WTY9	Mapk13	Mitogen-activated protein kinase 13	Rattus norvegicus (Rat)	SS
P63086	Mapk1	Mitogen-activated protein kinase 1	Rattus norvegicus (Rat)	SS
Q9Z2A6	Mapk15	Mitogen-activated protein kinase 15	Rattus norvegicus (Rat)	SS
P27704	Mapk6	Mitogen-activated protein kinase 6	Rattus norvegicus (Rat)	SS
P21708	Mapk3	Mitogen-activated protein kinase 3	Rattus norvegicus (Rat)	SS
Q63538	Mapk12	Mitogen-activated protein kinase 12	Rattus norvegicus (Rat)	SS
Q63454	Mapk4	Mitogen-activated protein kinase 4	Rattus norvegicus (Rat)	SS
P0C865	Mapk7	Mitogen-activated protein kinase 7	Rattus norvegicus (Rat)	SS
Q5ZCI1	MPK10	Mitogen-activated protein kinase 10	Oryza sativa subsp. japonica (Rice)	SS
Q5VP69	MPK16	Mitogen-activated protein kinase 16	Oryza sativa subsp. japonica (Rice)	SS
Q5SN53	MPK8	Mitogen-activated protein kinase 8	Oryza sativa subsp. japonica (Rice)	SS
Q0E459	MPK13	Mitogen-activated protein kinase 13	Oryza sativa subsp. japonica (Rice)	SS
Q6Z437	MPK3	Mitogen-activated protein kinase 3	Oryza sativa subsp. japonica (Rice)	SS
Q75KK8	MPK14	Mitogen-activated protein kinase 14	Oryza sativa subsp. japonica (Rice)	SS
Q67C40	MPK7	Mitogen-activated protein kinase 7	Oryza sativa subsp. japonica (Rice)	SS
Q6L5F7	MPK17	Mitogen-activated protein kinase 17	Oryza sativa subsp. japonica (Rice)	SS
Q5VN19	MPK11	Mitogen-activated protein kinase 11	Oryza sativa subsp. japonica (Rice)	SS
Q5Z859	MPK4	Mitogen-activated protein kinase 4	Oryza sativa subsp. japonica (Rice)	SS
Q5Z9J0	MPK12	Mitogen-activated protein kinase 12	Oryza sativa subsp. japonica (Rice)	SS
Q53N72	MPK15	Mitogen-activated protein kinase 15	Oryza sativa subsp. japonica (Rice)	SS
Q336X9	MPK6	Mitogen-activated protein kinase 6	Oryza sativa subsp. japonica (Rice)	SS
Q5J4W4	MPK2	Mitogen-activated protein kinase 2	Oryza sativa subsp. japonica (Rice)	SS
Q84UI5	MPK1	Mitogen-activated protein kinase 1	Oryza sativa subsp. japonica (Rice)	SS
Q10N20	MPK5	Mitogen-activated protein kinase 5	Oryza sativa subsp. japonica (Rice)	SS
Q11179	mapk-15	Mitogen-activated protein kinase 15	Caenorhabditis elegans	SS
O44514	pmk-3	Mitogen-activated protein kinase pmk-3	Caenorhabditis elegans	PR
P39745	mpk-1	Mitogen-activated protein kinase mpk-1	Caenorhabditis elegans	SS
G5EBT1	sma-5	Mitogen-activated protein kinase sma-5	Caenorhabditis elegans	SS
Q8MXI4	pmk-2	Mitogen-activated protein kinase pmk-2	Caenorhabditis elegans	SS
Q17446	pmk-1	Mitogen-activated protein kinase pmk-1	Caenorhabditis elegans	SS
Q39021	MPK1	Mitogen-activated protein kinase 1	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9LM33	MPK8	Mitogen-activated protein kinase 8	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9C5C0	MPK18	Mitogen-activated protein kinase 18	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39022	MPK2	Mitogen-activated protein kinase 2	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9C9U4	MPK15	Mitogen-activated protein kinase 15	Arabidopsis thaliana (Mouse-ear cress)	SS
Q84M93	MPK17	Mitogen-activated protein kinase 17	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39027	MPK7	Mitogen-activated protein kinase 7	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9SJG9	MPK20	Mitogen-activated protein kinase 20	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9LUC3	MPK19	Mitogen-activated protein kinase 19	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9LV37	MPK9	Mitogen-activated protein kinase 9	Arabidopsis thaliana (Mouse-ear cress)	SS
O23236	MPK14	Mitogen-activated protein kinase 14	Arabidopsis thaliana (Mouse-ear cress)	SS
Q8W4J2	MPK16	Mitogen-activated protein kinase 16	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39023	MPK3	Mitogen-activated protein kinase 3	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39026	MPK6	Mitogen-activated protein kinase 6	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39025	MPK5	Mitogen-activated protein kinase 5	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39024	MPK4	Mitogen-activated protein kinase 4	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9M1Z5	MPK10	Mitogen-activated protein kinase 10	Arabidopsis thaliana (Mouse-ear cress)	SS
Q8GYQ5	MPK12	Mitogen-activated protein kinase 12	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9LMM5	MPK11	Mitogen-activated protein kinase 11	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9LQQ9	MPK13	Mitogen-activated protein kinase 13	Arabidopsis thaliana (Mouse-ear cress)	SS
O42376	mapk12	Mitogen-activated protein kinase 12	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q9DGE1	mapk14b	Mitogen-activated protein kinase 14B	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q9DGE2	mapk14a	Mitogen-activated protein kinase 14A	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MSGPRAGFYR	QELNKTVWEV	PQRLQGLRPV	GSGAYGSVCS	AYDARLRQKV	AVKKLSRPFQ
70	80	90	100	110	120
SLIHARRTYR	ELRLLKHLKH	ENVIGLLDVF	TPATSIEDFS	EVYLVTTLMG	ADLNNIVKCQ
130	140	150	160	170	180
ALSDEHVQFL	VYQLLRGLKY	IHSAGIIHRD	LKPSNVAVNE	DCELRILDFG	LARQADEEMT
190	200	210	220	230	240
GYVATRWYRA	PEIMLNWMHY	NQTVDIWSVG	CIMAELLQGK	ALFPGSDYID	QLKRIMEVVG
250	260	270	280	290	300
TPSPEVLAKI	SSEHARTYIQ	SLPPMPQKDL	SSIFRGANPL	AIDLLGRMLV	LDSDQRVSAA
310	320	330	340	350	360
EALAHAYFSQ	YHDPEDEPEA	EPYDESVEAK	ERTLEEWKEL	TYQEVLSFKP	PEPPKPPGSL

EIEQ