AiPD: Autoinhibited Protein Database

Q15438

Gene name	CYTH1
Protein name	Cytohesin-1
Names	PH, SEC7 and coiled-coil domain-containing protein 1, SEC7 homolog B2-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9267
EC number
Protein Class

Descriptions

Cytohesin-1 (CYTH1) promotes guanine-nucleotide exchange on ARF5, ARF3, and ARF6. Cytohesins share a modular architecture consisting of heptad repeats, a Sec7 domain with exchange activity for Arf1 and Arf6, a PH domain that binds phosphatidyl inositol (PI) polyphosphates, and a C-terminal helix (CtH) that overlaps with a polybasic region (PBR). In human CYTH3, it is autoinhibited by the Sec7-PH linker and CtH/PBR, which obstruct substrate binding. The autoinhibition can be relieved by Arf6-GTP binding in the presence of the PIP3 head group.

Autoinhibitory domains (AIDs)

248-260 (Sec7-PH linker) SS

Target domain	55-244 (Sec7 domain)
Relief mechanism	Partner binding
Assay

AID

248-260 (Sec7-PH linker)

Target domain

55-244 (Sec7 domain)

Relief mechanism

Partner binding (Arf6-GTP binding to allosteric site including AiEs and PH domain)

Assay

376-395 (C-terminal helix/polybasic region) SS

Target domain	55-244 (Sec7 domain)
Relief mechanism	Partner binding
Assay

AID

376-395 (C-terminal helix/polybasic region)

Target domain

55-244 (Sec7 domain)

Relief mechanism

Partner binding (Arf6-GTP binding to allosteric site including AiEs and PH domain)

Assay

Accessory elements

No accessory elements

References

Malaby AW et al. (2013) "Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors", Proceedings of the National Academy of Sciences of the United States of America, 110, 14213-8

DiNitto JP et al. (2007) "Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors", Molecular cell, 28, 569-83

Autoinhibited structure

Activated structure

3 structures for Q15438

Entry ID	Method	Resolution	Chain	Position	Source
1BC9	NMR	-	A	58-256	PDB
4A4P	X-ray	200 A	A/B	63-248	PDB
AF-Q15438-F1	Predicted				AlphaFoldDB

199 variants for Q15438

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1481375033 CA401290342	2	E>K		No	ClinGen TOPMed gnomAD
CA401290309 rs1271192963	3	E>A		No	ClinGen gnomAD
rs373215397 CA8806277	3	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8806276 rs748162768	4	D>N		No	ClinGen ExAC TOPMed gnomAD
CA294424207 rs578011422	5	D>H		No	ClinGen 1000Genomes
rs1242944391 CA401290226	7	Y>H		No	ClinGen gnomAD
CA401288631 rs1201627020	9	P>R		No	ClinGen gnomAD
CA294431402 rs886835136	9	P>S		No	ClinGen TOPMed
CA401288628 rs1321574841	10	S>G		No	ClinGen TOPMed gnomAD
CA401288612 rs1254483787	12	L>V		No	ClinGen TOPMed
rs1185405737 CA401288578	17	R>C		No	ClinGen TOPMed
CA294431387 rs200086754	17	R>H		No	ClinGen TOPMed gnomAD
rs1293635572 CA401288571	18	Q>R		No	ClinGen gnomAD
CA401288551 rs1407229112	21	E>A		No	ClinGen gnomAD
CA8806236 rs772567954	24	R>G		No	ClinGen ExAC gnomAD
CA8806235 rs746383819 COSM985184	24	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8806233 rs771352076	25	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8806231 rs780868802	26	R>K		No	ClinGen ExAC gnomAD
CA8806230 rs147755371	28	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA401288483 rs1598863138	32	A>S		No	ClinGen Ensembl
rs1324897024 CA401288470	34	I>V		No	ClinGen TOPMed
CA401287694 rs1299926802	37	L>M		No	ClinGen TOPMed
CA401287689 rs1331188781	37	L>P		No	ClinGen TOPMed
CA8806211 rs746673102	39	D>N		No	ClinGen ExAC gnomAD
rs758011881 CA8806209	43	E>G		No	ClinGen ExAC gnomAD
rs749938915 CA8806208	45	A>T		No	ClinGen ExAC
CA294430118 rs145550753	46	N>K		No	ClinGen ESP TOPMed gnomAD
rs778884815 CA8806207	46	N>S		No	ClinGen ExAC gnomAD
rs1268338941 CA401287489	48	I>T		No	ClinGen TOPMed
rs753659136 CA8806205	50	N>D		No	ClinGen ExAC TOPMed gnomAD
CA8806203 rs370371477	51	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8806202 rs752942068	52	G>R		No	ClinGen ExAC gnomAD
rs896924628 CA294430071	56	E>K		No	ClinGen TOPMed
CA294425589 rs533920880	59	N>D		No	ClinGen Ensembl
rs1387856298 CA401286392	60	M>T		No	ClinGen gnomAD
rs777499031 CA8806186	60	M>V		No	ClinGen ExAC gnomAD
CA8806185 rs755937409	61	Q>R		No	ClinGen ExAC gnomAD
rs200729734 CA294425562	64	K>E		No	ClinGen 1000Genomes
rs752529445 CA8806184	65	Q>R		No	ClinGen ExAC gnomAD
rs1598851679 CA401286266	66	V>G		No	ClinGen Ensembl
CA8806183 rs767704954	66	V>L		No	ClinGen ExAC gnomAD
rs960291823 CA294425531	67	A>V		No	ClinGen Ensembl
rs766382307 CA8806180	72	K>R		No	ClinGen ExAC TOPMed gnomAD
rs773886609 CA8806178	73	F>V		No	ClinGen ExAC gnomAD
rs765884357 CA8806177	76	D>G		No	ClinGen ExAC gnomAD
CA401286053 rs765884357	76	D>V		No	ClinGen ExAC gnomAD
CA401286021 rs1468751560	78	K>R		No	ClinGen gnomAD
CA8806155 rs759182326	82	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1447390123 CA401285829	82	Q>R		No	ClinGen TOPMed gnomAD
rs1567843602 CA401285781	84	L>F		No	ClinGen Ensembl
rs770661079 CA8806153	88	D>N		No	ClinGen ExAC TOPMed gnomAD
CA401285653 rs762428542	92	N>K		No	ClinGen ExAC TOPMed gnomAD
CA8806152 rs762428542	92	N>K		No	ClinGen ExAC TOPMed gnomAD
CA8806151 rs772768266	93	T>I		No	ClinGen ExAC gnomAD
CA8806150 rs148749723	94	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA401285629 rs1254691881	94	C>W		No	ClinGen gnomAD
CA294425174 rs775200767	97	I>V		No	ClinGen Ensembl
rs1008269647 CA294425143	102	Y>C		No	ClinGen Ensembl
rs780914454 CA8806148	102	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs878922373 CA294425138	103	K>I		No	ClinGen Ensembl
rs746860002 CA8806146 COSM985181	105	E>K	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8806142 rs779136505	113	G>S		No	ClinGen ExAC gnomAD
rs891125553 CA294425099	114	D>N		No	ClinGen Ensembl
rs371306094 CA8806139	118	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA401285336 rs1429364523	123	N>S		No	ClinGen gnomAD
rs760662251 CA401285319	125	Q>H		No	ClinGen ExAC gnomAD
rs760662251 CA8806112	125	Q>H		No	ClinGen ExAC gnomAD
rs1266172190 CA401285310	127	L>V		No	ClinGen gnomAD
CA8806111 rs367956043	129	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1250363765 CA401285296	129	A>S		No	ClinGen TOPMed gnomAD
CA294424600 rs976586199	135	E>G		No	ClinGen TOPMed
rs1334900039 CA401285225	139	L>P		No	ClinGen TOPMed
CA294424587 rs139968035	140	N>Y		No	ClinGen ESP TOPMed
rs771332106 CA8806107	146	R>Q		No	ClinGen ExAC gnomAD
CA401284797 rs1168209983	153	R>Q		No	ClinGen gnomAD
rs748215703 CA8806084	153	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1444974209 CA401284705	161	I>V		No	ClinGen gnomAD
CA401284691 rs1185249623	162	D>N		No	ClinGen gnomAD
CA8806080 rs780397308	163	R>Q		No	ClinGen ExAC gnomAD
rs910328420 CA294423160	164	M>L		No	ClinGen TOPMed
rs756798702 CA8806079	167	A>S		No	ClinGen ExAC gnomAD
rs376465403 CA8806078	167	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1029973056 CA294423113	171	R>Q		No	ClinGen gnomAD
CA401284562 rs1243247969	172	Y>H		No	ClinGen gnomAD
CA401284549 rs1339411172	173	C>R		No	ClinGen gnomAD
CA294423097 rs993149843	173	C>Y		No	ClinGen TOPMed
rs1328926356 CA401284530	174	Q>R		No	ClinGen gnomAD
CA401284518 rs1486440455	175	C>Y		No	ClinGen TOPMed gnomAD
CA8806074 rs767552281	178	G>R		No	ClinGen ExAC TOPMed gnomAD
rs138054490 CA8806072	179	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs375995404 CA8806070	183	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1415674002 CA401284420	183	T>P		No	ClinGen gnomAD
CA8806052 rs762785415	185	T>A		No	ClinGen ExAC gnomAD
CA8806050 rs765492162	188	V>I		No	ClinGen ExAC TOPMed gnomAD
rs141177293 CA8806049	193	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1272675835 CA401284073	194	I>T		No	ClinGen gnomAD
CA8806048 rs776630136	195	M>I		No	ClinGen ExAC TOPMed gnomAD
CA8806046 rs574814614	204	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1386612304 CA401283863	205	V>I		No	ClinGen gnomAD
CA294421938 rs900423792	206	K>R		No	ClinGen TOPMed
rs1446512339 CA401283719	210	T>I		No	ClinGen TOPMed
CA8806044 rs772507196	216	A>T		No	ClinGen ExAC gnomAD
rs1189632267 CA401283579	216	A>V		No	ClinGen gnomAD
CA8806043 rs746234210	218	N>D		No	ClinGen ExAC gnomAD
CA401283499 rs1312504437	219	R>*		No	ClinGen gnomAD
rs779215895 COSM122474 CA8806042	219	R>Q	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8806041 rs747817213	221	I>L		No	ClinGen ExAC TOPMed gnomAD
rs747817213 CA8806040	221	I>V		No	ClinGen ExAC TOPMed gnomAD
rs369357942 CA8806039	222	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs754567835 CA8806038	226	D>G		No	ClinGen ExAC gnomAD
rs375897965 CA8806037	228	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs375897965 CA401282872	228	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs758333238 CA8806035	229	E>V		No	ClinGen ExAC gnomAD
rs750164978 CA8806034	230	E>D		No	ClinGen ExAC gnomAD
CA401282849 rs1364417526	232	L>F		No	ClinGen gnomAD
rs754087658 CA8806031	233	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8806032 rs757417957	233	R>W		No	ClinGen ExAC gnomAD
CA8806017 rs758297163	235	L>H		No	ClinGen ExAC gnomAD
rs1418765318 CA401282813	236	Y>C		No	ClinGen TOPMed
rs745810798 CA8806016	237	E>Q		No	ClinGen ExAC gnomAD
CA8806015 rs372622338	238	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8806014 rs757011876	239	I>M		No	ClinGen ExAC
CA401282794 rs1386586695	239	I>V		No	ClinGen TOPMed
rs753680020 CA8806013	241	N>S		No	ClinGen ExAC gnomAD
rs1426050540 CA401282763	243	P>H		No	ClinGen gnomAD
CA294421302 rs145755308	246	I>M		No	ClinGen ESP
rs1412200646 CA401282736	247	P>S		No	ClinGen gnomAD
rs1454403249 CA401282698	252	N>S		No	ClinGen TOPMed
CA401282694 rs1447903281	253	D>N		No	ClinGen gnomAD
rs1307286602 CA401282685	254	L>V		No	ClinGen TOPMed
rs760039197 CA8806008	258	F>I		No	ClinGen ExAC gnomAD
CA8806006 rs774754881	258	F>L		No	ClinGen ExAC gnomAD
rs767036902 CA8806005	260	N>S		No	ClinGen ExAC gnomAD
CA8806004 rs763390900	263	R>Q		No	ClinGen ExAC gnomAD
CA8806003 rs563411933	267	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs778692007 CA8805997 COSM1563614	271	G>R	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs200353991 CA294415719	273	G>V		No	ClinGen Ensembl
CA401282006 rs1598833062	283	F>V		No	ClinGen Ensembl
CA8805958 rs762842090	288	N>S		No	ClinGen ExAC TOPMed gnomAD
rs769822835 CA8805956	294	E>Q		No	ClinGen ExAC gnomAD
CA401281064 rs1405695192	302	R>C		No	ClinGen gnomAD
rs765084883 CA8805937	302	R>H		No	ClinGen ExAC gnomAD
CA294404406 rs900213459	304	I>V		No	ClinGen Ensembl
CA8805936 rs761821370	311	S>N		No	ClinGen ExAC gnomAD
CA401281000 rs1458652478	312	I>V		No	ClinGen TOPMed
rs142007379 CA8805934	313	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1386481 rs776237586 CA8805935	313	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1473708784 CA401280990	314	E>Q		No	ClinGen gnomAD
rs746836781 CA8805933	315	V>A		No	ClinGen ExAC gnomAD
CA294404363 rs770665897	317	D>Y		No	ClinGen Ensembl
CA401280910 rs1322397748	323	C>Y		No	ClinGen gnomAD
CA8805915 rs760532115	326	L>V		No	ClinGen ExAC gnomAD
CA8805914 rs376879430	328	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8805912 rs759853440	330	D>N		No	ClinGen ExAC TOPMed gnomAD
CA294403562 rs907425708	331	N>S		No	ClinGen TOPMed
CA8805911 rs774248624	333	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1454054814 CA401280833	334	Q>R		No	ClinGen gnomAD
rs1241297352 CA401280804	338	A>V		No	ClinGen TOPMed
CA8805910 rs771074240	342	E>K		No	ClinGen ExAC gnomAD
CA401280768 rs1254706763	343	A>V		No	ClinGen TOPMed
rs770347515 CA401280750	346	R>L		No	ClinGen ExAC gnomAD
COSM294288 rs770347515 CA8805907	346	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs781545237 CA8805905	353	T>I		No	ClinGen ExAC gnomAD
rs757994747 CA8805904	354	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8805903 rs750104667	355	Y>D		No	ClinGen ExAC gnomAD
CA401280695 rs1598810523	355	Y>S		No	ClinGen Ensembl
CA401280686 rs1410112940	356	R>L		No	ClinGen TOPMed gnomAD
CA401280687 rs1410112940	356	R>Q		No	ClinGen TOPMed gnomAD
rs1269699403 CA401280689	356	R>W		No	ClinGen gnomAD
CA8805899 rs764088076	360	P>L		No	ClinGen ExAC gnomAD
CA401280664 rs764088076	360	P>Q		No	ClinGen ExAC gnomAD
rs753345906 CA8805900	360	P>S		No	ClinGen ExAC gnomAD
rs370098507 CA8805896	361	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1377007579 CA401280649	363	E>A		No	ClinGen TOPMed
CA8805893 rs771108245	363	E>K		No	ClinGen ExAC TOPMed
CA401280640 rs1181943930	364	E>G		No	ClinGen gnomAD
rs147739265 CA8805892	365	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773234558 CA8805891	366	E>K		No	ClinGen ExAC gnomAD
rs1396102453 CA401280620	367	E>Q		No	ClinGen gnomAD
CA401280581 rs1209704476	372	I>V		No	ClinGen TOPMed gnomAD
CA8805863 rs202219559	374	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA8805862 rs374248686	377	S>T		No	ClinGen ESP ExAC gnomAD
CA401280536 rs1598802280	378	R>G		No	ClinGen Ensembl
CA401280531 rs1435262786	378	R>S		No	ClinGen gnomAD
CA401280512 rs1233155780	381	F>S		No	ClinGen TOPMed
rs1178005836 CA401280494	383	E>A		No	ClinGen gnomAD
CA401280499 COSM1710857 rs1377795513	383	E>K	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
CA401280490 rs1452269324	384	M>V		No	ClinGen gnomAD
rs376898813 COSM77552 CA8805858	386	A>T	ovary large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs143836975 CA8805856	388	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs371956931 CA294399528	388	R>W		No	ClinGen ESP TOPMed gnomAD
rs1178515996 CA401280450	390	K>R		No	ClinGen TOPMed
rs890738952 CA294399524	393	S>F		No	ClinGen TOPMed gnomAD
rs1256738831 CA401280424	394	S>F		No	ClinGen gnomAD
rs766104458 CA8805855	395	T>M		No	ClinGen ExAC TOPMed gnomAD
CA401280408 rs750577717 COSM985169	397	R>*	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8805853 rs750577717	397	R>G		No	ClinGen ExAC TOPMed gnomAD
rs146162992 CA8805852	397	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1598802075 CA401280403	398	H>N		No	ClinGen Ensembl

No associated diseases with Q15438

2 regional properties for Q15438

Type	Name	Position	InterPro Accession
domain	Sec7 domain	55 - 244	IPR000904
domain	Pleckstrin homology domain	260 - 379	IPR001849

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Peripheral membrane protein Cytoplasm, cytosol Cell junction, tight junction Cell junction, adherens junction	Colocalized with TJP1 during epithelial polarization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
adherens junction	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
bicellular tight junction	An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of cytoplasmic side of plasma membrane	The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
lipid binding	Binding to a lipid.

4 GO annotations of biological process

Name	Definition
establishment of epithelial cell polarity	The specification and formation of anisotropic intracellular organization of an epithelial cell.
regulation of ARF protein signal transduction	Any process that modulates the frequency, rate or extent of ARF protein signal transduction.
regulation of cell adhesion	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
vesicle-mediated transport	A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

17 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2KI41	CYTH2	Cytohesin-2	Bos taurus (Bovine)	SS
Q9Y6D5	ARFGEF2	Brefeldin A-inhibited guanine nucleotide-exchange protein 2	Homo sapiens (Human)	PR
Q9Y6D6	ARFGEF1	Brefeldin A-inhibited guanine nucleotide-exchange protein 1	Homo sapiens (Human)	PR
Q5JU85	IQSEC2	IQ motif and SEC7 domain-containing protein 2	Homo sapiens (Human)	EV
Q9UPP2	IQSEC3	IQ motif and SEC7 domain-containing protein 3	Homo sapiens (Human)	SS
Q6DN90	IQSEC1	IQ motif and SEC7 domain-containing protein 1	Homo sapiens (Human)	EV
Q99418	CYTH2	Cytohesin-2	Homo sapiens (Human)	SS
Q9UIA0	CYTH4	Cytohesin-4	Homo sapiens (Human)	SS
O43739	CYTH3	Cytohesin-3	Homo sapiens (Human)	EV
Q92538	GBF1	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	Homo sapiens (Human)	PR
P63034	Cyth2	Cytohesin-2	Mus musculus (Mouse)	SS
O08967	Cyth3	Cytohesin-3	Mus musculus (Mouse)	EV
Q80YW0	Cyth4	Cytohesin-4	Mus musculus (Mouse)	SS
Q9QX11	Cyth1	Cytohesin-1	Mus musculus (Mouse)	SS
P97696	Cyth3	Cytohesin-3	Rattus norvegicus (Rat)	SS
P63035	Cyth2	Cytohesin-2	Rattus norvegicus (Rat)	SS
P97694	Cyth1	Cytohesin-1	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MEEDDSYVPS	DLTAEERQEL	ENIRRRKQEL	LADIQRLKDE	IAEVANEIEN	LGSTEERKNM
70	80	90	100	110	120
QRNKQVAMGR	KKFNMDPKKG	IQFLIENDLL	KNTCEDIAQF	LYKGEGLNKT	AIGDYLGERD
130	140	150	160	170	180
EFNIQVLHAF	VELHEFTDLN	LVQALRQFLW	SFRLPGEAQK	IDRMMEAFAQ	RYCQCNNGVF
190	200	210	220	230	240
QSTDTCYVLS	FAIIMLNTSL	HNPNVKDKPT	VERFIAMNRG	INDGGDLPEE	LLRNLYESIK
250	260	270	280	290	300
NEPFKIPEDD	GNDLTHTFFN	PDREGWLLKL	GGGRVKTWKR	RWFILTDNCL	YYFEYTTDKE
310	320	330	340	350	360
PRGIIPLENL	SIREVEDSKK	PNCFELYIPD	NKDQVIKACK	TEADGRVVEG	NHTVYRISAP
370	380	390
TPEEKEEWIK	CIKAAISRDP	FYEMLAARKK	KVSSTKRH