AiPD: Autoinhibited Protein Database

Q15208

Gene name	STK38
Protein name	Serine/threonine-protein kinase 38
Names	NDR1 protein kinase, Nuclear Dbf2-related kinase 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11329
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class	SERINE/THREONINE-PROTEIN KINASE (PTHR24356)

Descriptions

STK38, called nuclear Dbf2-related kinase 1 (NDR1 protein kinase), is a subclass of the AGC family of protein kinases that are involved in the regulation of cell division and cell morphology. NDR kinase activity is regulated by phosphorylation and by the Ca2+-binding protein, S100B. MOB1 also stimulates NDR kinase activity and interacts with NDR.
A common feature of the NDR family of kinases is an insert in the catalytic domain of 30 - 60 amino acids between subdomains VII and VIII. The insert sequence is not highly conserved but contains in all cases many positively charged amino acids. Mutations of the residues within the insert (autoinhibitory element) increase kinase activity and the binding of MOB1 or S100B to the N-terminal domain (SMA domain) of NDR induces the release of autoinhibition.

Autoinhibitory domains (AIDs)

Target domain	89-382 (Protein kinase domain)
Relief mechanism	Partner binding
Assay	Mutagenesis experiment, Structural analysis

AID

265-276 (Autoinhibitory sequence)

Target domain

89-382 (Protein kinase domain)

Relief mechanism

Partner binding (Binding of MOB1 or S100B to the N-terminal SMA domain)

Assay

Mutagenesis experiment, Structural analysis

Accessory elements

229-241 (Activation loop from InterPro)

Target domain	89-382 (Protein kinase domain)
Relief mechanism
Assay

278-287 (Activation loop from InterPro)

Target domain	89-382 (Protein kinase domain)
Relief mechanism
Assay

References

Bichsel SJ et al. (2004) "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein", The Journal of biological chemistry, 279, 35228-35

Stegert MR et al. (2004) "Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein", The Journal of biological chemistry, 279, 23806-12

Bhattacharya S et al. (2003) "Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase", Biochemistry, 42, 14416-26

Autoinhibited structure

Activated structure

3 structures for Q15208

Entry ID	Method	Resolution	Chain	Position	Source
1PSB	NMR	-	C/D	62-87	PDB
6BXI	X-ray	220 A	A/B	82-414	PDB
AF-Q15208-F1	Predicted				AlphaFoldDB

264 variants for Q15208

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000850355 rs1582441467	75	E>missing	Primary dilated cardiomyopathy [ClinVar]	Yes	ClinVar dbSNP
CA3780066 rs752608687	4	T>R		No	ClinGen ExAC gnomAD
CA363824242 rs1325297788	6	S>*		No	ClinGen gnomAD
rs199711424 CA137397142	6	S>T		No	ClinGen 1000Genomes gnomAD
CA3780065 rs765186896	7	T>I		No	ClinGen ExAC gnomAD
CA137397139 rs1047669517	8	P>T		No	ClinGen TOPMed
CA137397135 rs866461802	9	C>G		No	ClinGen TOPMed
CA137397137 rs866461802	9	C>R		No	ClinGen TOPMed
rs1382998209 CA363824226	9	C>Y		No	ClinGen TOPMed
rs1406688292 CA363824221	10	S>L		No	ClinGen gnomAD
CA3780064 rs754433322	10	S>P		No	ClinGen ExAC gnomAD
rs1468024058 CA363824210	12	M>L		No	ClinGen gnomAD
rs1203727544 CA363824209	12	M>T		No	ClinGen gnomAD
rs1468024058 CA363824211	12	M>V		No	ClinGen gnomAD
rs866516364 CA363824183	15	H>L		No	ClinGen TOPMed
CA137397123 rs866516364	15	H>R		No	ClinGen TOPMed
CA3780061 rs765917395	16	T>A		No	ClinGen ExAC gnomAD
CA137397122 rs904697785	16	T>I		No	ClinGen gnomAD
CA3780060 rs760374299	17	K>R		No	ClinGen ExAC gnomAD
COSM1568373 rs1561994246 CA363824166	18	E>G	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs760689344 CA137397119	22	M>V		No	ClinGen gnomAD
rs1264289428 CA363824081	30	F>I		No	ClinGen gnomAD
rs1321773616 CA363824056	32	S>N		No	ClinGen gnomAD
CA3780059 rs772801812	34	L>F		No	ClinGen ExAC gnomAD
CA363824015 rs1214740913	34	L>R		No	ClinGen gnomAD
CA3780056 rs757924948	36	A>T		No	ClinGen ExAC TOPMed gnomAD
rs774959806 CA3780055	36	A>V		No	ClinGen ExAC gnomAD
rs749849841 CA3780053	39	E>G		No	ClinGen ExAC gnomAD
rs750077787 CA3780052	42	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1170919183 CA363823839	43	M>V		No	ClinGen gnomAD
rs770056422 CA3780051	44	R>G		No	ClinGen ExAC gnomAD
rs1178349183 CA363820044	50	K>T		No	ClinGen gnomAD
rs1458451563 CA363820024	52	M>V		No	ClinGen TOPMed
CA363819973 rs1250073699	55	E>D		No	ClinGen gnomAD
rs893708880 CA137392490	56	G>V		No	ClinGen Ensembl
rs771034473 CA3780029	59	D>G		No	ClinGen ExAC TOPMed gnomAD
rs771034473 CA363819928	59	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1290630604 CA363819917	60	E>A		No	ClinGen gnomAD
CA363819923 rs1404645485	60	E>K		No	ClinGen TOPMed
CA3780028 rs747274575	61	E>G		No	ClinGen ExAC gnomAD
CA3780004 rs745860300	63	R>*		No	ClinGen ExAC gnomAD
rs780551559 CA3780003	63	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs945331100 CA137391816	64	L>F		No	ClinGen Ensembl
CA3780002 rs746088825	65	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA363819611 rs1179282139	65	R>W		No	ClinGen gnomAD
rs758786147 CA3779999	69	H>R		No	ClinGen ExAC
rs765672780 CA3779998	71	R>L		No	ClinGen ExAC TOPMed gnomAD
rs765672780 CA3779997	71	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA363819499 rs1429950517	71	R>W		No	ClinGen gnomAD
rs1463202942 CA363819417	75	E>V		No	ClinGen gnomAD
rs1582441447 CA363819376	78	R>C		No	ClinGen Ensembl
rs766543093 CA137391753	78	R>H		No	ClinGen Ensembl
rs1375905353 CA363819287	81	R>S		No	ClinGen TOPMed
rs1454629225 CA363819233	82	T>I		No	ClinGen gnomAD
rs1454629225 CA363819237	82	T>R		No	ClinGen gnomAD
rs926480463 CA137391744	85	G>E		No	ClinGen Ensembl
CA363818914 rs1348901267	97	R>G		No	ClinGen TOPMed
rs1183986218 CA363816944	104	R>Q		No	ClinGen gnomAD
CA3779971 rs774643972	104	R>W		No	ClinGen ExAC TOPMed gnomAD
CA3779969 rs200294413	106	V>F		No	ClinGen 1000Genomes ExAC gnomAD
CA3779966 rs576641205	107	Q>*		No	ClinGen 1000Genomes ExAC
rs576641205 CA3779968	107	Q>E		No	ClinGen 1000Genomes ExAC
rs755258904 CA3779962	107	Q>H		No	ClinGen ExAC
CA3779961 rs755258904	107	Q>H		No	ClinGen ExAC
CA3779964 rs771763533	107	Q>L		No	ClinGen ExAC gnomAD
CA3779963 rs771763533	107	Q>P		No	ClinGen ExAC gnomAD
CA3779965 rs771763533	107	Q>R		No	ClinGen ExAC gnomAD
rs756585216 CA3779956	110	D>E		No	ClinGen ExAC
rs780450135 CA3779957	110	D>N		No	ClinGen ExAC gnomAD
CA3779955 rs750998261	111	T>K		No	ClinGen ExAC gnomAD
CA363816806 rs750998261	111	T>M		No	ClinGen ExAC gnomAD
rs764395613 CA3779952	113	H>D		No	ClinGen ExAC
CA3779951 rs764395613	113	H>N		No	ClinGen ExAC
rs756532884 CA137390332	113	H>P		No	ClinGen gnomAD
CA3779950 rs763132769	113	H>Q		No	ClinGen ExAC
CA363816727 rs1336669294	115	Y>*		No	ClinGen gnomAD
CA363816695 rs1407573411	117	M>T		No	ClinGen gnomAD
rs372031192 CA3779948	117	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA363816613 rs1279406004	120	L>F		No	ClinGen TOPMed
CA137390323 rs368701374	121	R>C		No	ClinGen ESP gnomAD
CA3779946 COSM1078550 rs773297808	121	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA137390319 rs938011110	123	A>T		No	ClinGen TOPMed gnomAD
CA137390317 COSM3702987 rs371761736	124	D>V	liver [Cosmic]	No	ClinGen cosmic curated ESP TOPMed
rs927200794 CA137390318	124	D>Y		No	ClinGen TOPMed gnomAD
CA3779944 rs761418631	125	M>L		No	ClinGen ExAC gnomAD
rs1179708121 CA363816448	125	M>T		No	ClinGen gnomAD
CA363816430 rs1481321114	126	L>F		No	ClinGen gnomAD
CA363832629 rs1156922371	135	R>H		No	ClinGen gnomAD
rs147345242 CA3779933 COSM326582	136	A>V	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA3779931 rs753024638	138	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1023060984 CA137428542	140	I>V		No	ClinGen TOPMed gnomAD
CA3779929 rs760552724	142	V>L		No	ClinGen ExAC gnomAD
CA3779928 rs375157476	143	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs767586742 CA3779927	145	D>G		No	ClinGen ExAC TOPMed gnomAD
CA137428527 rs56005153 VAR_041197	145	D>N		No	ClinGen UniProt dbSNP gnomAD
CA363832562 rs1358859893	146	S>N		No	ClinGen TOPMed
CA363832551 rs1218236186	147	L>F		No	ClinGen gnomAD
rs761709396 CA3779926	148	W>C		No	ClinGen ExAC gnomAD
CA137428472 rs926351795	149	V>I		No	ClinGen Ensembl
CA363832517 rs1430801164	152	M>I		No	ClinGen TOPMed gnomAD
rs1271617653 CA363832519	152	M>K		No	ClinGen gnomAD
rs773885454 CA3779925	154	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs754683086 CA363832496	155	S>N		No	ClinGen TOPMed gnomAD
CA137428460 rs754683086	155	S>T		No	ClinGen TOPMed gnomAD
CA363832472 rs1260097941	158	D>G		No	ClinGen TOPMed
CA363832476 rs1204972697	158	D>N		No	ClinGen TOPMed
rs1057095209 CA137428454	161	N>K		No	ClinGen TOPMed gnomAD
rs1561981875 CA363832438	163	Y>*		No	ClinGen Ensembl
CA3779924 rs762656891	163	Y>C		No	ClinGen ExAC gnomAD
CA3779923 rs762656891	163	Y>F		No	ClinGen ExAC gnomAD
rs1003401992 CA137428435	166	M>V		No	ClinGen TOPMed
CA3779906 rs751511539	173	D>N		No	ClinGen ExAC gnomAD
rs751511539 CA363832166	173	D>Y		No	ClinGen ExAC gnomAD
CA3779905 rs763604721	175	M>I		No	ClinGen ExAC gnomAD
rs868104228 CA137426717	176	T>I		No	ClinGen Ensembl
rs1462177432 CA363832115	178	L>M		No	ClinGen TOPMed
rs1471974594 CA363832081	180	K>N		No	ClinGen gnomAD
CA3779903 rs775072441	184	L>V		No	ClinGen ExAC gnomAD
CA363831904 rs542165994	192	Y>D		No	ClinGen 1000Genomes ExAC gnomAD
rs542165994 CA3779901	192	Y>N		No	ClinGen 1000Genomes ExAC gnomAD
rs776974267 CA3779899	193	I>R		No	ClinGen ExAC TOPMed gnomAD
rs759222962 CA3779900	193	I>V		No	ClinGen ExAC gnomAD
rs1296977401 CA363831813	199	A>T		No	ClinGen TOPMed
rs370542304 CA3779898	200	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA3779897 rs747489495	201	D>A		No	ClinGen ExAC gnomAD
rs1350077656 CA363831764	202	S>A		No	ClinGen gnomAD
rs773594967 CA3779896	202	S>F		No	ClinGen ExAC gnomAD
rs1426617277 CA363831747	203	I>V		No	ClinGen TOPMed gnomAD
rs1582427888 CA363831734	204	H>Y		No	ClinGen Ensembl
rs368036526 CA3779894	206	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA363831619 rs1404123009	209	I>L		No	ClinGen gnomAD
CA137426627 rs575027344	210	H>P		No	ClinGen 1000Genomes
rs982696056 CA137426626	213	I>V		No	ClinGen TOPMed
CA3779893 rs779183722	218	L>V		No	ClinGen ExAC gnomAD
CA363830113 rs1442522138	225	H>R		No	ClinGen TOPMed
CA363830115 rs1258961324	225	H>Y		No	ClinGen TOPMed
CA363830079 rs1321732569	230	D>G		No	ClinGen gnomAD
rs993745810 CA137418905	232	G>V		No	ClinGen TOPMed
CA363830047 rs1386857046	235	T>A		No	ClinGen gnomAD
CA363830035 rs1373609028	237	L>M		No	ClinGen gnomAD
CA3779863 rs764668826	243	T>I		No	ClinGen ExAC gnomAD
rs1429701140 CA363829955	248	N>Y		No	ClinGen TOPMed gnomAD
CA3779860 rs765971207	249	L>P		No	ClinGen ExAC TOPMed gnomAD
CA363829947 rs765971207	249	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA363829910 rs1187795017	254	P>L		No	ClinGen gnomAD
CA137418879 rs543749058	255	S>R		No	ClinGen 1000Genomes
CA3779844 rs778851113	260	Q>R		No	ClinGen ExAC gnomAD
rs1484178204 CA363829711	263	N>S		No	ClinGen TOPMed gnomAD
CA3779843 VAR_041198 rs56105564	267	K>R		No	ClinGen UniProt ExAC dbSNP gnomAD
rs753268035 CA3779842	271	W>*		No	ClinGen ExAC gnomAD
CA363829532 rs1486481793	273	R>S		No	ClinGen gnomAD
CA3779840 rs755718782	276	R>C		No	ClinGen ExAC gnomAD
rs766073970 CA137417737	276	R>H		No	ClinGen gnomAD
CA137412159 rs1014130757	283	V>G		No	ClinGen Ensembl
CA363827918 rs1158639006	286	P>L		No	ClinGen gnomAD
CA363827895 rs1248711888	288	Y>C		No	ClinGen gnomAD
rs751937208 CA3779819	288	Y>H		No	ClinGen ExAC gnomAD
CA137412139 rs902992850	289	I>L		No	ClinGen TOPMed
CA363827878 rs1294349898	290	A>S		No	ClinGen TOPMed gnomAD
rs189442615 CA3779818	293	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3779817 rs142707584	295	M>L		No	ClinGen ESP ExAC
CA3779815 rs142707584	295	M>V		No	ClinGen ESP ExAC
rs753260473 CA3779814	297	T>A		No	ClinGen ExAC gnomAD
CA137412039 rs1001307563	298	G>R		No	ClinGen gnomAD
CA3779811 rs776783643	303	C>Y		No	ClinGen ExAC gnomAD
CA363827691 rs1240039027	306	W>S		No	ClinGen TOPMed
CA3779810 rs766566533	307	S>L		No	ClinGen ExAC gnomAD
rs1561971847 CA363827665	309	G>R		No	ClinGen Ensembl
rs547986167 CA3779807	312	M>I		No	ClinGen 1000Genomes ExAC gnomAD
CA363827630 rs1328851105	312	M>T		No	ClinGen gnomAD
rs371119515 CA3779808	312	M>V		No	ClinGen ESP ExAC gnomAD
CA137411996 rs762696453	313	Y>C		No	ClinGen Ensembl
CA363827516 rs1474617304	316	L>P		No	ClinGen TOPMed
CA3779806 rs536306219	317	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA3779805 rs368447865	318	G>S		No	ClinGen ESP ExAC TOPMed
CA3779788 rs775245465	319	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA363827126 rs1391866742	333	K>E		No	ClinGen TOPMed
rs1170531831 CA363827097	335	M>V		No	ClinGen gnomAD
rs1450224640 CA363827069	336	N>S		No	ClinGen gnomAD
CA363827061 rs1185289698	337	W>R		No	ClinGen gnomAD
CA363827043 rs1473944028	338	K>Q		No	ClinGen gnomAD
CA3779784 rs770575695	339	E>Q		No	ClinGen ExAC TOPMed
rs979128316 CA137410679	340	T>I		No	ClinGen TOPMed
CA137410676 rs1035258410	341	L>F		No	ClinGen TOPMed
rs1238430348 CA363826981	341	L>S		No	ClinGen gnomAD
CA3779783 rs746591612	344	P>L		No	ClinGen ExAC TOPMed gnomAD
rs761349436 CA3779782	345	P>A		No	ClinGen ExAC TOPMed gnomAD
CA363826918 rs1194568950	345	P>L		No	ClinGen TOPMed gnomAD
CA363826920 rs1194568950	345	P>R		No	ClinGen TOPMed gnomAD
CA363826897 rs1487813410	347	V>I		No	ClinGen TOPMed
CA363826787 rs1488582332	352	K>N		No	ClinGen TOPMed
rs748523374 CA3779780	353	A>P		No	ClinGen ExAC gnomAD
rs779186920 COSM76623 CA3779779	354	K>N	ovary [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA3779757 rs780573081	361	C>F		No	ClinGen ExAC gnomAD
CA3779756 rs756141345	362	C>W		No	ClinGen ExAC gnomAD
rs1445200763 CA363826533	362	C>Y		No	ClinGen TOPMed
CA363826513 rs1460143096	363	E>D		No	ClinGen gnomAD
rs1285547385 CA363826529	363	E>K		No	ClinGen TOPMed
rs1414672833 CA363826501	364	W>*		No	ClinGen gnomAD
CA363826449 rs1159381378	366	H>R		No	ClinGen gnomAD
rs1472078297 CA363826445	367	R>G		No	ClinGen gnomAD
CA3779755 rs750497236	368	I>T		No	ClinGen ExAC gnomAD
CA137410093 rs752951597	370	A>D		No	ClinGen TOPMed
rs767953815 CA137410086	371	P>H		No	ClinGen ExAC TOPMed gnomAD
CA3779753 rs767953815	371	P>L		No	ClinGen ExAC TOPMed gnomAD
CA3779752 rs751740902	373	V>I		No	ClinGen ExAC gnomAD
CA363826195 rs1462798991	378	S>N		No	ClinGen gnomAD
CA3779750 rs759433974	380	S>C		No	ClinGen ExAC gnomAD
CA3779748 rs753777266	381	F>S		No	ClinGen ExAC gnomAD
rs766397110 CA3779747	382	F>V		No	ClinGen ExAC gnomAD
rs775349162 CA137410020	384	G>D		No	ClinGen TOPMed gnomAD
CA363826061 rs1189490167	385	V>A		No	ClinGen Ensembl
CA3779745 rs78764904	385	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3779743 rs78764904	385	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3779744 rs78764904	385	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1321611778 CA363825974	390	I>V		No	ClinGen gnomAD
rs1457093316 CA363825964	391	R>G		No	ClinGen gnomAD
CA3779725 rs761261884	392	E>G		No	ClinGen ExAC gnomAD
CA363825227 rs1200866771	396	A>G		No	ClinGen TOPMed
CA137409278 rs916197266	396	A>T		No	ClinGen gnomAD
rs1262530775 CA363825210	397	I>T		No	ClinGen TOPMed
CA363825219 rs1467394320	397	I>V		No	ClinGen gnomAD
CA3779724 rs774009047	399	I>V		No	ClinGen ExAC TOPMed gnomAD
CA3779722 rs762637869	401	I>M		No	ClinGen ExAC gnomAD
CA363825151 rs1426459496	401	I>V		No	ClinGen gnomAD
rs1049279785 CA137409242	402	K>E		No	ClinGen Ensembl
CA3779721 rs775815099	402	K>N		No	ClinGen ExAC gnomAD
rs1279946252 CA363825118	403	S>R		No	ClinGen gnomAD
rs1273023951 CA363825104	404	I>T		No	ClinGen TOPMed gnomAD
CA363825036 rs1208804471	408	S>A		No	ClinGen gnomAD
rs770153395 CA3779719	411	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1227371162 CA363824940	413	F>S		No	ClinGen gnomAD
rs746316301 CA3779718	418	I>S		No	ClinGen ExAC TOPMed gnomAD
CA363824829 rs746316301	418	I>T		No	ClinGen ExAC TOPMed gnomAD
rs777033679 CA3779717	421	P>A		No	ClinGen ExAC TOPMed gnomAD
CA137409174 rs919405114	421	P>L		No	ClinGen gnomAD
rs777033679 CA137409183	421	P>S		No	ClinGen ExAC TOPMed gnomAD
CA3779697 rs375380153	425	T>A		No	ClinGen ExAC gnomAD
rs375380153 CA363824672	425	T>P		No	ClinGen ExAC gnomAD
rs1196054816 CA363824664	426	S>N		No	ClinGen gnomAD
rs747617944 CA3779696	427	N>T		No	ClinGen ExAC gnomAD
rs773412288 CA3779695	429	P>T		No	ClinGen ExAC gnomAD
CA3779693 rs748314684	430	E>V		No	ClinGen ExAC gnomAD
CA3779692 rs779310318	432	D>N		No	ClinGen ExAC gnomAD
CA363824607 rs1271697795	434	K>R		No	ClinGen TOPMed gnomAD
rs376687611 CA3779688	435	N>K		No	ClinGen ESP ExAC gnomAD
CA3779689 rs781083563	435	N>S		No	ClinGen ExAC TOPMed gnomAD
rs751559591 CA3779687	441	I>V		No	ClinGen ExAC gnomAD
CA3779686 rs777194680	442	N>S		No	ClinGen ExAC TOPMed gnomAD
COSM1161627 rs757931650 CA3779685	444	T>M	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA3779682 rs535837576	447	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754148134 CA3779681	450	G>S		No	ClinGen ExAC gnomAD
CA3779679 rs202246450	455	G>R		No	ClinGen ExAC TOPMed gnomAD
CA363824464 rs202246450	455	G>R		No	ClinGen ExAC TOPMed gnomAD
rs202246450 CA3779680	455	G>W		No	ClinGen ExAC TOPMed gnomAD
COSM1672351 rs773860206 CA3779677	457	I>T	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA363824446 rs1204814632	458	P>S		No	ClinGen TOPMed gnomAD
CA3779674 rs762008347	459	S>F		No	ClinGen ExAC gnomAD
CA363824433 rs1210956779	460	Y>C		No	ClinGen TOPMed gnomAD
rs762900991 CA363824429	461	M>L		No	ClinGen ExAC TOPMed gnomAD
rs762900991 CA3779673	461	M>L		No	ClinGen ExAC TOPMed gnomAD
CA3779672 rs568489292	461	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762900991 CA363824428	461	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1346449856 CA363824395	465	K>N		No	ClinGen gnomAD

No associated diseases with Q15208

5 regional properties for Q15208

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	89 - 382	IPR000719
domain	AGC-kinase, C-terminal	383 - 455	IPR000961
active_site	Serine/threonine-protein kinase, active site	208 - 220	IPR008271
binding_site	Protein kinase, ATP binding site	95 - 118	IPR017441
domain	Protein kinase, C-terminal	401 - 445	IPR017892

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Nucleus Cytoplasm
PANTHER Family	PTHR24356	SERINE/THREONINE-PROTEIN KINASE
PANTHER Subfamily	PTHR24356:SF221	SERINE_THREONINE-PROTEIN KINASE 38
PANTHER Protein Class	non-receptor serine/threonine protein kinase protein modifying enzyme
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
magnesium ion binding	Binding to a magnesium (Mg) ion.
mitogen-activated protein kinase kinase kinase binding	Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

4 GO annotations of biological process

Name	Definition
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of MAP kinase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
protein phosphorylation	The process of introducing a phosphate group on to a protein.

28 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P53894	CBK1	Serine/threonine-protein kinase CBK1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
A2VDV2	STK38	Serine/threonine-protein kinase 38	Bos taurus (Bovine)	SS
Q9NBK5	trc	Serine/threonine-protein kinase tricornered	Drosophila melanogaster (Fruit fly)	SS
Q96LW2	RSKR	Ribosomal protein S6 kinase-related protein	Homo sapiens (Human)	PR
O15530	PDPK1	3-phosphoinositide-dependent protein kinase 1	Homo sapiens (Human)	EV
Q05513	PRKCZ	Protein kinase C zeta type	Homo sapiens (Human)	SS
P41743	PRKCI	Protein kinase C iota type	Homo sapiens (Human)	EV
Q16512	PKN1	Serine/threonine-protein kinase N1	Homo sapiens (Human)	EV
Q6P5Z2	PKN3	Serine/threonine-protein kinase N3	Homo sapiens (Human)	SS
Q16513	PKN2	Serine/threonine-protein kinase N2	Homo sapiens (Human)	EV
P24723	PRKCH	Protein kinase C eta type	Homo sapiens (Human)	SS
Q02156	PRKCE	Protein kinase C epsilon type	Homo sapiens (Human)	SS
Q04759	PRKCQ	Protein kinase C theta type	Homo sapiens (Human)	PR
Q05655	PRKCD	Protein kinase C delta type	Homo sapiens (Human)	SS
P17252	PRKCA	Protein kinase C alpha type	Homo sapiens (Human)	EV
P05129	PRKCG	Protein kinase C gamma type	Homo sapiens (Human)	SS
P05771	PRKCB	Protein kinase C beta type	Homo sapiens (Human)	SS
P31751	AKT2	RAC-beta serine/threonine-protein kinase	Homo sapiens (Human)	EV SS
P31749	AKT1	RAC-alpha serine/threonine-protein kinase	Homo sapiens (Human)	EV
Q9Y243	AKT3	RAC-gamma serine/threonine-protein kinase	Homo sapiens (Human)	SS
Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	Homo sapiens (Human)	SS
Q9HBY8	SGK2	Serine/threonine-protein kinase Sgk2	Homo sapiens (Human)	SS
O00141	SGK1	Serine/threonine-protein kinase Sgk1	Homo sapiens (Human)	PR
Q9Y2H1	STK38L	Serine/threonine-protein kinase 38-like	Homo sapiens (Human)	EV
Q6A1A2	PDPK2P	Putative 3-phosphoinositide-dependent protein kinase 2	Homo sapiens (Human)	PR
Q7TSE6	Stk38l	Serine/threonine-protein kinase 38-like	Mus musculus (Mouse)	SS
Q91VJ4	Stk38	Serine/threonine-protein kinase 38	Mus musculus (Mouse)	SS
Q2L6W9	sax-1	Serine/threonine-protein kinase sax-1	Caenorhabditis elegans	SS

10	20	30	40	50	60
MAMTGSTPCS	SMSNHTKERV	TMTKVTLENF	YSNLIAQHEE	REMRQKKLEK	VMEEEGLKDE
70	80	90	100	110	120
EKRLRRSAHA	RKETEFLRLK	RTRLGLEDFE	SLKVIGRGAF	GEVRLVQKKD	TGHVYAMKIL
130	140	150	160	170	180
RKADMLEKEQ	VGHIRAERDI	LVEADSLWVV	KMFYSFQDKL	NLYLIMEFLP	GGDMMTLLMK
190	200	210	220	230	240
KDTLTEEETQ	FYIAETVLAI	DSIHQLGFIH	RDIKPDNLLL	DSKGHVKLSD	FGLCTGLKKA
250	260	270	280	290	300
HRTEFYRNLN	HSLPSDFTFQ	NMNSKRKAET	WKRNRRQLAF	STVGTPDYIA	PEVFMQTGYN
310	320	330	340	350	360
KLCDWWSLGV	IMYEMLIGYP	PFCSETPQET	YKKVMNWKET	LTFPPEVPIS	EKAKDLILRF
370	380	390	400	410	420
CCEWEHRIGA	PGVEEIKSNS	FFEGVDWEHI	RERPAAISIE	IKSIDDTSNF	DEFPESDILK
430	440	450	460
PTVATSNHPE	TDYKNKDWVF	INYTYKRFEG	LTARGAIPSY	MKAAK