AiPD: Autoinhibited Protein Database

Q14680

Gene name	MELK (KIAA0175)
Protein name	Maternal embryonic leucine zipper kinase
Names	hMELK, Protein kinase Eg3, pEg3 kinase, Protein kinase PK38, hPK38, Tyrosine-protein kinase MELK
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9833
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class	MAP/MICROTUBULE AFFINITY-REGULATING KINASE (PTHR24346)

Descriptions

Maternal embryonic leucine zipper kinase (hMELK) is a protein Ser/Thr kinase that has been implicated in stem cell renewal, cell cycle progression, and pre-mRNA splicing. The activity of MELK is regulated by a C-terminal KA1 domain as autoinhibition.

Autoinhibitory domains (AIDs)

Target domain	11-263 (Protein kinase domain)
Relief mechanism	PTM
Assay	Deletion assay, Mutagenesis experiment

AID

326-530 (Inhibitory segment)

Target domain

11-263 (Protein kinase domain)

Relief mechanism

PTM (Phosphorylation at Thr-167 and Ser-171

Assay

Deletion assay, Mutagenesis experiment

Accessory elements

149-173 (Activation loop from InterPro)

Target domain	11-263 (Protein kinase domain)
Relief mechanism
Assay

References

Beullens M et al. (2005) "Substrate specificity and activity regulation of protein kinase MELK", The Journal of biological chemistry, 280, 40003-11

Autoinhibited structure

Activated structure

32 structures for Q14680

Entry ID	Method	Resolution	Chain	Position	Source
4BKY	X-ray	183 A	A	2-340	PDB
4BKZ	X-ray	220 A	A	2-340	PDB
4BL1	X-ray	260 A	A	2-340	PDB
4D2P	X-ray	255 A	A/B/C/D	1-336	PDB
4D2T	X-ray	270 A	A/B/C/D	1-336	PDB
4D2V	X-ray	245 A	A/B/C/D	1-336	PDB
4D2W	X-ray	192 A	A/B/C/D	1-336	PDB
4IXP	X-ray	275 A	A	1-340	PDB
4UMP	X-ray	230 A	A/B/C/D	1-336	PDB
4UMQ	X-ray	260 A	A	1-336	PDB
4UMR	X-ray	300 A	A	1-336	PDB
4UMT	X-ray	198 A	A	1-336	PDB
4UMU	X-ray	202 A	A	1-336	PDB
5IH8	X-ray	185 A	A	3-330	PDB
5IH9	X-ray	179 A	A	3-330	PDB
5IHA	X-ray	196 A	A	3-330	PDB
5IHC	X-ray	214 A	A	3-330	PDB
5K00	X-ray	177 A	A	3-330	PDB
5M5A	X-ray	190 A	A	2-340	PDB
5MAF	X-ray	280 A	A	2-340	PDB
5MAG	X-ray	235 A	A	2-340	PDB
5MAH	X-ray	200 A	A	2-340	PDB
5MAI	X-ray	215 A	A	2-340	PDB
5TVT	X-ray	228 A	A	2-333	PDB
5TWL	X-ray	242 A	A	2-340	PDB
5TWU	X-ray	260 A	A/B	1-340	PDB
5TWY	X-ray	291 A	A/B	2-340	PDB
5TWZ	X-ray	263 A	A	2-340	PDB
5TX3	X-ray	290 A	A/B	1-340	PDB
6GVX	X-ray	224 A	A/B	1-340	PDB
6VXR	X-ray	210 A	A	1-338	PDB
AF-Q14680-F1	Predicted				AlphaFoldDB

492 variants for Q14680

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1564118296 CA373435635	3	D>Y		No	ClinGen Ensembl
rs762250293 CA5057356	11	Y>C		No	ClinGen ExAC gnomAD
CA5057357 rs371313222	12	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA373435731 rs1157461127	14	H>R		No	ClinGen gnomAD
CA5057359 rs763351882	17	I>T		No	ClinGen ExAC gnomAD
rs1273998661 CA373435771	19	T>A		No	ClinGen gnomAD
rs776843063 CA373435794	20	G>D		No	ClinGen ExAC TOPMed gnomAD
rs776843063 CA5057377	20	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1227315194 CA373435796	21	G>S		No	ClinGen TOPMed
CA373435831 rs1587320233	26	K>E		No	ClinGen Ensembl
RCV000960045 CA5057378 rs114617403	26	K>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5057379 rs770248208	28	A>P		No	ClinGen ExAC gnomAD
CA5057381 rs763553481	29	C>S		No	ClinGen ExAC gnomAD
rs763553481 CA373435851	29	C>Y		No	ClinGen ExAC gnomAD
rs767018563 CA373435864	31	I>F		No	ClinGen ExAC gnomAD
CA5057384 rs760270294	31	I>M		No	ClinGen ExAC
rs774943512 CA373435866	31	I>S		No	ClinGen ExAC TOPMed gnomAD
rs774943512 CA5057383	31	I>T		No	ClinGen ExAC TOPMed gnomAD
rs767018563 CA5057382	31	I>V		No	ClinGen ExAC gnomAD
rs763697533 CA5057385	32	L>F		No	ClinGen ExAC gnomAD
rs753584662 CA5057386	34	G>R		No	ClinGen ExAC gnomAD
rs13440297 CA192873606	35	E>*		No	ClinGen Ensembl
rs199697478 CA5057388	36	M>I		No	ClinGen 1000Genomes ExAC
rs953917183 CA192873608	36	M>L		No	ClinGen TOPMed gnomAD
CA5057387 rs540286432	36	M>R		No	ClinGen 1000Genomes ExAC
CA5057390 rs758161923	37	V>A		No	ClinGen ExAC gnomAD
rs750218598 CA5057389	37	V>L		No	ClinGen ExAC gnomAD
CA192873626 rs755001911	39	I>V		No	ClinGen Ensembl
CA5057392 rs779979550	41	I>M		No	ClinGen ExAC gnomAD
rs1356602897 CA373435938	43	D>G		No	ClinGen TOPMed
rs746880889 CA373435935	43	D>N		No	ClinGen ExAC gnomAD
CA5057393 rs746880889	43	D>Y		No	ClinGen ExAC gnomAD
CA5057394 rs755117441	45	N>K		No	ClinGen ExAC gnomAD
CA192873655 rs966272252	47	L>P		No	ClinGen TOPMed gnomAD
rs530956522 CA5057412	49	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751551349 CA5057413	51	L>S		No	ClinGen ExAC gnomAD
CA5057415 rs781286890	52	P>H		No	ClinGen ExAC TOPMed gnomAD
rs781286890 CA5057417	52	P>L		No	ClinGen ExAC TOPMed gnomAD
rs781286890 CA5057416	52	P>R		No	ClinGen ExAC TOPMed gnomAD
rs754883604 CA5057414	52	P>S		No	ClinGen ExAC gnomAD
CA5057419 rs749522568	53	R>Q		No	ClinGen ExAC gnomAD
rs544701960 CA5057418	53	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs35233455 VAR_040794 CA5057422	56	T>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1322505698 CA373436461	60	A>V		No	ClinGen TOPMed
CA373436466 rs1317643805	61	L>S		No	ClinGen gnomAD
rs200697039 CA192875587	63	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200697039 CA5057425	63	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5057424 rs746421630	63	N>S		No	ClinGen ExAC gnomAD
CA5057428 rs769278274	64	L>P		No	ClinGen ExAC gnomAD
rs761241091 CA5057427	64	L>V		No	ClinGen ExAC TOPMed gnomAD
CA5057430 rs772803585	68	H>D		No	ClinGen ExAC gnomAD
rs1587346929 CA373436512	68	H>R		No	ClinGen Ensembl
CA5057431 rs762576629	69	I>L		No	ClinGen ExAC gnomAD
CA373436532 rs1259420854	71	Q>*		No	ClinGen gnomAD
CA192875612 rs575137753	74	H>R		No	ClinGen Ensembl
CA5057434 rs147513197	75	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs751324243 CA5057433	75	V>M		No	ClinGen ExAC gnomAD
CA5057436 rs752614797	77	E>*		No	ClinGen ExAC gnomAD
rs115531852 CA5057437	78	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA192875628 rs1000485883	83	F>L		No	ClinGen gnomAD
CA5057438 rs777895527	84	M>L		No	ClinGen ExAC gnomAD
CA373436702 rs777895527	84	M>V		No	ClinGen ExAC gnomAD
rs1416147604 CA373436714	85	V>I		No	ClinGen gnomAD
CA373437392 rs1441995840	93	E>K		No	ClinGen gnomAD
rs1255817156 CA373437448	97	Y>C		No	ClinGen TOPMed
rs1232092185 CA373437440	97	Y>H		No	ClinGen gnomAD
CA192877250 rs370732572	98	I>M		No	ClinGen ESP TOPMed gnomAD
CA5057455 rs764124417	98	I>V		No	ClinGen ExAC gnomAD
CA5057456 rs754005792	101	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA373437523 rs1435853016 COSM327854	103	R>C	skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA5057457 rs757367254 COSM1108932	103	R>H	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs963263698 CA192877260	106	E>K		No	ClinGen Ensembl
CA5057458 rs765573002	107	E>Q		No	ClinGen ExAC gnomAD
rs1393986319 CA373437610	110	R>L		No	ClinGen gnomAD
rs1393986319 CA373437613	110	R>Q		No	ClinGen gnomAD
rs150500682 CA5057459	110	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs758752489 CA5057460	111	V>A		No	ClinGen ExAC gnomAD
CA373437625 rs1169260004	112	V>I		No	ClinGen gnomAD
rs1408541660 CA373437641	113	F>S		No	ClinGen TOPMed
CA5057461 rs780449748	114	R>C		No	ClinGen ExAC TOPMed gnomAD
rs370963407 CA5057462	114	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1326999891 CA373437676	116	I>V		No	ClinGen gnomAD
rs1397234133 CA373437724	120	V>I		No	ClinGen TOPMed
CA373437738 rs1169745297	121	A>T		No	ClinGen TOPMed
CA373437753 rs1397250292	122	Y>C		No	ClinGen TOPMed gnomAD
rs781634266 CA5057464	123	V>M		No	ClinGen ExAC gnomAD
CA5057466 rs770367929	125	S>R		No	ClinGen ExAC TOPMed gnomAD
CA373437808 rs1587363978	126	Q>R		No	ClinGen Ensembl
rs1268638331 CA373437821	127	G>V		No	ClinGen gnomAD
CA5057467 rs774059266	130	H>Y		No	ClinGen ExAC gnomAD
CA373437880 rs1587364041	132	D>A		No	ClinGen Ensembl
rs745507803 CA5057468	132	D>N		No	ClinGen ExAC TOPMed gnomAD
CA5057469 rs771813183	133	L>H		No	ClinGen ExAC gnomAD
rs1274436447 CA373437900	134	K>E		No	ClinGen TOPMed
rs768271265 CA5057493	137	N>K		No	ClinGen ExAC TOPMed gnomAD
CA192878267 rs1002724071	138	L>M		No	ClinGen TOPMed
CA373438629 rs1409151511 COSM186681	139	L>P	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA192878270 rs1008019121	140	F>S		No	ClinGen TOPMed gnomAD
rs1412624185 CA373438672	142	E>V		No	ClinGen gnomAD
rs1317392900 CA373438688	143	Y>C		No	ClinGen gnomAD
rs770039323 CA5057497	144	H>Q		No	ClinGen ExAC gnomAD
rs762901190 CA5057499	145	K>N		No	ClinGen ExAC gnomAD
rs773390114 CA5057498	145	K>Q		No	ClinGen ExAC gnomAD
rs766645313 CA5057501	147	K>M		No	ClinGen ExAC gnomAD
rs1035556541 CA192878302	149	I>L		No	ClinGen Ensembl
rs1330685481 CA373438766	150	D>H		No	ClinGen TOPMed
rs767856840 CA5057504	154	C>S		No	ClinGen ExAC gnomAD
CA192878314 rs1019102992	155	A>T		No	ClinGen TOPMed
rs961060342 CA192878319	156	K>N		No	ClinGen Ensembl
rs547460338 CA5057525	159	G>V		No	ClinGen 1000Genomes ExAC gnomAD
CA192879071 rs199834356	160	N>D		No	ClinGen gnomAD
CA5057527 rs754234154	160	N>K		No	ClinGen ExAC gnomAD
CA5057529 rs779414890	161	K>N		No	ClinGen ExAC
CA5057528 rs757996498	161	K>T		No	ClinGen ExAC TOPMed gnomAD
rs751271828 CA5057530	162	D>E		No	ClinGen ExAC
rs887126454 CA192879081	162	D>N		No	ClinGen Ensembl
CA373439050 rs1406688806	165	L>V		No	ClinGen TOPMed gnomAD
rs1381224766 CA373439056	166	Q>*		No	ClinGen TOPMed
rs1587382570 CA373439091	171	S>G		No	ClinGen Ensembl
rs1587382588 CA373439097	171	S>R		No	ClinGen Ensembl
rs780947778 CA5057532	172	L>V		No	ClinGen ExAC gnomAD
rs1454635644 CA373439112	174	Y>C		No	ClinGen gnomAD
rs542804397 CA192879119	175	A>T		No	ClinGen Ensembl
CA192879121 rs1017019441	176	A>T		No	ClinGen Ensembl
CA5057534 rs769654094	177	P>S		No	ClinGen ExAC gnomAD
CA5057535 rs149686898	178	E>*		No	ClinGen ESP ExAC gnomAD
CA5057536 rs570619247	178	E>A		No	ClinGen 1000Genomes ExAC gnomAD
CA5057537 rs771092591	180	I>M		No	ClinGen ExAC TOPMed gnomAD
rs115586289 CA373439150	181	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs115586289 CA192879134	181	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs115586289 CA5057539	181	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5057540 rs772303710	183	K>N		No	ClinGen ExAC gnomAD
rs199880240 CA192881935	191	D>H		No	ClinGen 1000Genomes TOPMed
CA373439532 rs374075415	193	W>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5057561 rs374075415	193	W>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772076783 CA5057560	193	W>G		No	ClinGen ExAC gnomAD
CA5057562 rs146709588	195	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs146709588 CA373439548	195	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA373439544 rs1411456516	195	M>V		No	ClinGen gnomAD
rs769110780 CA5057563	196	G>V		No	ClinGen ExAC gnomAD
CA373439556 rs1376320612	197	I>L		No	ClinGen TOPMed gnomAD
rs1376320612 CA373439555	197	I>V		No	ClinGen TOPMed gnomAD
CA5057565 rs762194617	198	L>Q		No	ClinGen ExAC gnomAD
CA373439568 rs1297185065	199	L>S		No	ClinGen gnomAD
COSM1497058 rs1220796077 CA373439574	200	Y>H	kidney [Cosmic]	No	ClinGen cosmic curated TOPMed
CA192881968 rs369063583	203	M>T		No	ClinGen ESP
rs765681502 CA5057566	203	M>V		No	ClinGen ExAC gnomAD
CA373439613 rs1416948918	205	G>E		No	ClinGen gnomAD
rs773796566 CA5057567	209	F>C		No	ClinGen ExAC gnomAD
CA373439660 rs1356216039	212	D>G		No	ClinGen gnomAD
rs1224801421 CA373439677	214	V>A		No	ClinGen TOPMed gnomAD
rs1315191230 CA373439688	216	A>P		No	ClinGen TOPMed gnomAD
rs1315191230 CA373439687	216	A>T		No	ClinGen TOPMed gnomAD
CA192881976 rs1013525650	218	Y>*		No	ClinGen Ensembl
CA373439708 rs1216065000	219	K>E		No	ClinGen gnomAD
CA373439707 rs1216065000	219	K>Q		No	ClinGen gnomAD
CA5057569 rs35142210 VAR_040795	219	K>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5057583 rs748471471	227	D>H		No	ClinGen ExAC gnomAD
CA373436035 rs1391272623	230	K>*		No	ClinGen TOPMed
CA192878284 rs1049660735	230	K>R		No	ClinGen gnomAD
rs770129579 CA5057584	231	W>*		No	ClinGen ExAC TOPMed
CA5057585 rs770129579	231	W>C		No	ClinGen ExAC TOPMed
CA373436040 rs1371576447	231	W>G		No	ClinGen TOPMed
CA5057586 rs763538947	232	L>H		No	ClinGen ExAC TOPMed gnomAD
CA373436057 rs1365177589	233	S>F		No	ClinGen TOPMed
rs775172480 CA5057589	234	P>L		No	ClinGen ExAC gnomAD
rs1410813175 CA373436064	235	S>G		No	ClinGen TOPMed gnomAD
rs376164595 CA5057592	236	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs376164595 CA5057591	236	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1468499533 CA373436103	241	Q>*		No	ClinGen gnomAD
rs1362089488 CA373436110	242	Q>E		No	ClinGen TOPMed
rs1274480816 CA373436123	243	M>I		No	ClinGen gnomAD
rs1274480816 CA373436124	243	M>I		No	ClinGen gnomAD
rs112003774 CA192878363	243	M>T		No	ClinGen Ensembl
rs1340340647 CA373436132	245	Q>*		No	ClinGen gnomAD
CA5057595 rs750413067	245	Q>P		No	ClinGen ExAC gnomAD
CA373436153 rs1461466085	246	V>G		No	ClinGen TOPMed
rs751443564 CA5057618	246	V>L		No	ClinGen ExAC TOPMed gnomAD
CA373436150 rs751443564	246	V>M		No	ClinGen ExAC TOPMed gnomAD
rs767622049 CA5057620	247	D>Y		No	ClinGen ExAC gnomAD
CA373436175 COSM167557 rs1420590272	249	K>N	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1163232021 CA373436182	250	K>N		No	ClinGen gnomAD
rs549358592 CA5057621	250	K>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA373436184 rs1384057506	251	R>Q		No	ClinGen gnomAD
CA5057622 rs758392144	251	R>W		No	ClinGen ExAC TOPMed gnomAD
CA192880331 rs1047692436	252	I>N		No	ClinGen gnomAD
CA5057624 rs201211316	253	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs146486300 CA5057625	254	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1249045304 CA373436245	260	H>R		No	ClinGen TOPMed
rs1045775545 CA192880377	260	H>Y		No	ClinGen TOPMed gnomAD
CA5057626 rs779634205	261	P>L		No	ClinGen ExAC gnomAD
rs746375465 CA5057627	262	W>C		No	ClinGen ExAC
CA373436267 rs1350748600	263	I>M		No	ClinGen TOPMed gnomAD
rs768103782 CA5057628	263	I>V		No	ClinGen ExAC gnomAD
CA5057629 rs776178978	264	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1364583583 CA373436269	264	M>V		No	ClinGen gnomAD
rs557988412 CA5057630 RCV000930724	265	Q>*		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1207174245 CA373436281	265	Q>H		No	ClinGen TOPMed
rs1189044826 CA373436313	268	N>K		No	ClinGen gnomAD
rs769455465 CA5057631	268	N>S		No	ClinGen ExAC gnomAD
CA5057632 rs772791136	270	P>T		No	ClinGen ExAC
rs934766353 CA192880415	275	S>N		No	ClinGen TOPMed
CA5057635 rs766156695	276	K>E		No	ClinGen ExAC gnomAD
CA5057636 rs774211922	276	K>N		No	ClinGen ExAC gnomAD
rs759495589 CA5057637	277	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1271799778 CA373436447	278	P>R		No	ClinGen gnomAD
rs746406905 CA373438158	279	F>L		No	ClinGen ExAC TOPMed gnomAD
rs746406905 CA5057649	279	F>V		No	ClinGen ExAC TOPMed gnomAD
rs1251804149 CA373438174	280	I>F		No	ClinGen gnomAD
rs780373461 CA5057652	282	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1420463762 CA373438225	283	D>E		No	ClinGen TOPMed
CA5057654 rs769224721	283	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1319501930 CA373438240	284	D>E		No	ClinGen gnomAD
rs1405264657 CA373438236	284	D>G		No	ClinGen gnomAD
rs772912540 CA5057655	284	D>N		No	ClinGen ExAC gnomAD
CA5057656 rs748924633	285	D>G		No	ClinGen ExAC gnomAD
CA373438263 rs1382258226	286	C>Y		No	ClinGen TOPMed
COSM3722513 RCV000902511 CA5057658 rs374744271	287	V>I	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
CA5057659 rs759203954	289	E>A		No	ClinGen ExAC TOPMed gnomAD
CA373438316 rs1329287322	290	L>V		No	ClinGen gnomAD
rs1234471786 CA373438328	291	S>P		No	ClinGen gnomAD
rs775697597 CA192888137	292	V>I		No	ClinGen Ensembl
CA5057661 rs775226736	294	H>Y		No	ClinGen ExAC gnomAD
CA5057663 rs764260106	296	N>S		No	ClinGen ExAC TOPMed gnomAD
rs547127565 CA5057664	299	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
rs1344977542 CA373438465	301	M>T		No	ClinGen TOPMed
rs1197275603 CA373438473	302	E>K		No	ClinGen gnomAD
rs761052927 CA373438534	306	S>*		No	ClinGen gnomAD
rs761052927 CA192888169	306	S>L		No	ClinGen gnomAD
CA192888187 rs903607623	307	L>V		No	ClinGen TOPMed
CA5057681 rs768899369	308	W>*		No	ClinGen ExAC gnomAD
CA5057682 rs776886956	309	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA373439257 rs1587570988	312	H>P		No	ClinGen Ensembl
CA5057684 rs116620621	314	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs116620621 CA5057685	314	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5057687 rs766636533	315	A>D		No	ClinGen ExAC gnomAD
CA373439287 rs1321196120	317	Y>*		No	ClinGen TOPMed gnomAD
rs755444724 CA5057689	317	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA5057690 rs781634477	318	L>P		No	ClinGen ExAC gnomAD
CA373439317 rs1487445346	323	K>E		No	ClinGen gnomAD
CA5057692 rs756655630	325	A>S		No	ClinGen ExAC gnomAD
CA5057694 rs148081976	326	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs146185715 CA5057695	326	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148081976 CA5057693	326	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs779966054 CA5057696	327	G>E		No	ClinGen ExAC gnomAD
CA192892890 rs140963190	331	R>C		No	ClinGen ESP gnomAD
CA192892888 rs140963190	331	R>G		No	ClinGen ESP gnomAD
CA5057697 rs146537035	331	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs34655121 CA5057698 VAR_040796 RCV000956716	333	R>K		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1251352244 CA373439382	334	L>F		No	ClinGen TOPMed
CA5057700 rs761984042	336	S>F		No	ClinGen ExAC gnomAD
CA373439403 rs1360097388	337	F>L		No	ClinGen gnomAD
CA373439409 rs1450719235	338	S>C		No	ClinGen TOPMed gnomAD
rs1450719235 CA373439410	338	S>F		No	ClinGen TOPMed gnomAD
CA373439417 rs773538066	339	C>*		No	ClinGen ExAC gnomAD
rs773538066 CA5057702	339	C>W		No	ClinGen ExAC gnomAD
rs763062811 CA5057703	340	G>E		No	ClinGen ExAC gnomAD
rs766804647 CA5057704	341	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs774729093 CA5057705	341	Q>R		No	ClinGen ExAC gnomAD
rs1216141019 CA373439436	343	S>G		No	ClinGen gnomAD
rs1281378877 CA373439447	344	A>G		No	ClinGen gnomAD
CA373439454 rs1211975447	345	T>I		No	ClinGen gnomAD
CA373439470 rs1472438544	348	T>A		No	ClinGen gnomAD
CA5057706 VAR_040797 RCV000965104 rs55845414	348	T>I		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs369940373 CA5057709	351	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs369940373 CA373439492	351	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5057728 rs764624849	353	N>S		No	ClinGen ExAC TOPMed gnomAD
rs147502395 CA5057729	354	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs138281295 CA5057731	354	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA373439767 rs147502395	354	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1333012659 CA373439775	355	W>*		No	ClinGen gnomAD
CA373439782 rs1434544239	356	S>N		No	ClinGen gnomAD
rs543114583 CA5057732	357	L>M		No	ClinGen ExAC TOPMed gnomAD
CA5057733 rs754874504	357	L>R		No	ClinGen ExAC TOPMed gnomAD
CA373439802 rs1587590993	359	D>V		No	ClinGen Ensembl
CA5057734 rs781109217	360	V>M		No	ClinGen ExAC gnomAD
rs377133091 CA5057737	362	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA373439824 rs1474519897	363	S>N		No	ClinGen TOPMed
CA373439825 rs1474519897	363	S>T		No	ClinGen TOPMed
CA373439850 rs1587591180	366	N>K		No	ClinGen Ensembl
rs749341508 CA5057738	366	N>S		No	ClinGen ExAC gnomAD
CA373439848 rs749341508	366	N>T		No	ClinGen ExAC gnomAD
CA5057739 rs370552987 COSM3699683	369	A>E	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs370552987 CA5057740 COSM1462379	369	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA5057742 rs144405877	370	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs775750782 CA5057743	373	D>G		No	ClinGen ExAC TOPMed gnomAD
CA5057746 rs761054743	374	Y>C		No	ClinGen ExAC gnomAD
rs1587591363 CA373439920	377	C>G		No	ClinGen Ensembl
rs1164383231 CA373439947	380	D>G		No	ClinGen gnomAD
rs559946050 CA192895847	380	D>Y		No	ClinGen TOPMed gnomAD
rs777133008 CA5057748	381	L>S		No	ClinGen ExAC TOPMed gnomAD
CA192895862 rs964712181	383	T>A		No	ClinGen TOPMed gnomAD
rs765970263 CA5057750	383	T>I		No	ClinGen ExAC TOPMed gnomAD
CA373439993 rs1226570789	388	P>A		No	ClinGen TOPMed gnomAD
CA5057752 rs759231335	389	R>*		No	ClinGen ExAC TOPMed gnomAD
CA5057753 rs147684393	389	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373440001 rs1290514305	390	T>A		No	ClinGen gnomAD
rs1432334695 CA373440004	390	T>I		No	ClinGen TOPMed
rs1173589599 CA373440019	392	Q>H		No	ClinGen TOPMed
CA373440046 rs1157072746	394	T>I		No	ClinGen gnomAD
CA373440043 rs1441682935	394	T>S		No	ClinGen gnomAD
CA373440048 rs1379918110	395	K>E		No	ClinGen TOPMed gnomAD
CA373440052 rs1452717393	395	K>R		No	ClinGen gnomAD
CA5057783 rs778775531	397	W>*		No	ClinGen ExAC gnomAD
rs757220131 CA5057782	397	W>L		No	ClinGen ExAC gnomAD
rs753760464 CA5057781	397	W>R		No	ClinGen ExAC TOPMed gnomAD
CA5057784 rs750518953	398	T>P		No	ClinGen ExAC
RCV000999169 rs1587616430	399	E>missing		No	ClinVar dbSNP
CA192901409 rs867907627	400	S>L		No	ClinGen Ensembl
CA5057786 rs780212191	400	S>P		No	ClinGen ExAC TOPMed gnomAD
rs747238174 CA5057787	402	G>E		No	ClinGen ExAC gnomAD
CA373440116 rs1315989678	405	S>Y		No	ClinGen gnomAD
CA373440130 rs1258099925	407	S>*		No	ClinGen gnomAD
rs748481989 CA5057790	408	L>S		No	ClinGen ExAC gnomAD
CA192901430 rs776639034	411	A>V		No	ClinGen TOPMed gnomAD
CA192901441 rs931549512	419	K>E		No	ClinGen TOPMed gnomAD
rs745374927 CA373440224	421	K>N		No	ClinGen ExAC gnomAD
rs1350732774 CA373440244	424	E>*		No	ClinGen TOPMed
rs775055106 CA5057795	424	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1327848862 CA373440249	425	N>H		No	ClinGen TOPMed
CA5057797 rs548729347	426	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA373440260 rs548729347	426	V>G		No	ClinGen 1000Genomes ExAC gnomAD
rs760345453 CA5057796	426	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1198076957 CA373440268	427	Y>*		No	ClinGen gnomAD
CA373440280 rs1303323281	429	P>L		No	ClinGen TOPMed
CA192901502 rs954971762	432	A>T		No	ClinGen gnomAD
CA5057800 rs765168138	433	V>I		No	ClinGen ExAC TOPMed gnomAD
rs750360100 CA5057801	434	K>R		No	ClinGen ExAC gnomAD
rs374730094 CA5057803	436	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA5057804 rs139147189	437	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA373440352 rs1587617096	440	M>V		No	ClinGen Ensembl
CA5057807 rs533788949	445	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA5057809 rs756479355	453	H>N		No	ClinGen ExAC gnomAD
rs1488877953 CA373440456	454	K>R		No	ClinGen gnomAD
CA373440474 rs1265618449	456	E>D		No	ClinGen gnomAD
CA373440467 rs1193124922	456	E>K		No	ClinGen gnomAD
rs778490625 CA5057811	459	T>I		No	ClinGen ExAC TOPMed gnomAD
rs778490625 CA373440492	459	T>S		No	ClinGen ExAC TOPMed gnomAD
rs144052967 VAR_040798 CA5057812 COSM20677	460	T>M	an ovarian mucinous carcinoma sample; somatic mutation kidney ovary [UniProt, Cosmic]	No	ClinGen cosmic curated UniProt ESP ExAC TOPMed dbSNP gnomAD
rs1168295776 CA373440498	461	P>T		No	ClinGen gnomAD
rs775097745 CA5057814	462	N>D		No	ClinGen ExAC gnomAD
CA5057815 rs554033223	463	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs1294849935 CA373440513	463	R>H		No	ClinGen gnomAD
rs1028670606 CA192901646	464	Y>*		No	ClinGen TOPMed
rs1169751874 CA373440531	466	T>A		No	ClinGen Ensembl
rs776202476 CA5057817	466	T>I		No	ClinGen ExAC gnomAD
CA373440539 rs1329308756	467	P>L		No	ClinGen TOPMed
CA373440587 rs1587629432	472	N>K		No	ClinGen Ensembl
rs756604222 CA5057830	473	Q>*		No	ClinGen ExAC gnomAD
rs756604222 CA5057831	473	Q>K		No	ClinGen ExAC gnomAD
rs150974354 CA192905115	474	C>F		No	ClinGen ESP TOPMed gnomAD
rs749628951 CA5057832	475	L>P		No	ClinGen ExAC
CA192905130 rs878996483	477	E>V		No	ClinGen Ensembl
rs779228039 CA5057834	480	I>F		No	ClinGen ExAC gnomAD
rs779228039 CA373440634	480	I>V		No	ClinGen ExAC gnomAD
CA373440640 rs1292832950	481	K>E		No	ClinGen TOPMed gnomAD
rs1380548557 CA373440653	482	I>M		No	ClinGen gnomAD
CA373440648 rs1288732518	482	I>V		No	ClinGen gnomAD
rs1230062691 CA373440655	483	P>T		No	ClinGen gnomAD
CA192905208 rs972040202	485	N>S		No	ClinGen TOPMed
rs780877310 CA5057839	487	T>A		No	ClinGen ExAC gnomAD
CA373440683 rs1288503990	487	T>I		No	ClinGen gnomAD
rs1313765283 CA373440688	488	G>A		No	ClinGen TOPMed
rs959603695 CA192905245	489	T>P		No	ClinGen Ensembl
rs1414498282 CA373440702	490	D>E		No	ClinGen TOPMed
CA373440717 rs145670187	492	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373440711 rs1300515345	492	L>I		No	ClinGen TOPMed
rs773025164 CA5057842	493	M>I		No	ClinGen ExAC gnomAD
CA5057843 rs762610218	495	G>R		No	ClinGen ExAC TOPMed gnomAD
rs762610218 CA373440732	495	G>S		No	ClinGen ExAC TOPMed gnomAD
CA373440751 rs1369812218	498	S>G		No	ClinGen TOPMed
CA373440756 rs774091322	498	S>R		No	ClinGen ExAC gnomAD
CA5057845 rs774091322	498	S>R		No	ClinGen ExAC gnomAD
CA373440769 rs1165218838	500	E>D		No	ClinGen TOPMed
CA373440770 rs1165218838	500	E>D		No	ClinGen TOPMed
CA373440773 rs1336971450	501	R>K		No	ClinGen gnomAD
rs951939924 CA5057849	502	R>Q		No	ClinGen TOPMed gnomAD
rs148905986 CA5057847	502	R>W		No	ClinGen ESP TOPMed
CA5057862 rs200746617 COSM186702	504	R>C	ovary large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs769461815 CA5057863	504	R>H		No	ClinGen ExAC gnomAD
CA373440800 rs200746617	504	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1426295174 CA373440814	506	V>A		No	ClinGen gnomAD
rs2068826 CA192906857	507	E>*		No	ClinGen gnomAD
CA5057864 rs777350999	507	E>A		No	ClinGen ExAC gnomAD
rs2068826 CA373440816	507	E>K		No	ClinGen gnomAD
CA373440831 rs1205367675	509	D>A		No	ClinGen TOPMed
CA5057866 rs770629729	509	D>Y		No	ClinGen ExAC gnomAD
rs1333477296 CA373440844	511	N>Y		No	ClinGen gnomAD
CA373440859 rs1234945625	513	A>P		No	ClinGen TOPMed
rs375073240 CA192906892	515	M>T		No	ClinGen gnomAD
rs772094570 CA5057869	519	P>S		No	ClinGen ExAC gnomAD
CA192906913 rs779630366	520	K>N		No	ClinGen TOPMed
rs1261115725 CA373440918	521	R>I		No	ClinGen gnomAD
CA5057870 rs202227041	523	G>A		No	ClinGen ExAC TOPMed gnomAD
CA5057871 rs760777461	524	A>G		No	ClinGen ExAC gnomAD
rs753998985 CA5057873	529	S>C		No	ClinGen ExAC gnomAD
rs762292893 CA5057874	530	L>F		No	ClinGen ExAC gnomAD
rs1400337198 CA373440989	532	R>K		No	ClinGen TOPMed
CA5057876 rs750982765	533	G>E		No	ClinGen ExAC gnomAD
rs765492864 CA5057875	533	G>R		No	ClinGen ExAC TOPMed gnomAD
rs750982765 CA5057877	533	G>V		No	ClinGen ExAC gnomAD
CA373441009 rs559265487	535	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752218840 CA5057879	535	D>N		No	ClinGen ExAC gnomAD
rs777550738 CA5057881	537	V>F		No	ClinGen ExAC TOPMed gnomAD
rs748880215 CA5057882	538	I>N		No	ClinGen ExAC TOPMed gnomAD
CA373441025 rs1406492602	538	I>V		No	ClinGen TOPMed gnomAD
RCV000972797 CA5057883 rs62637654	540	V>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA373441036 rs1357607497	540	V>M		No	ClinGen gnomAD
CA5057885 rs745626982	541	L>P		No	ClinGen ExAC gnomAD
rs772147603 CA5057886	542	T>S		No	ClinGen ExAC
CA192907070 rs950944093	545	K>E		No	ClinGen TOPMed gnomAD
CA5057889 rs147882939	545	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA5057888 rs147882939	545	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5057890 rs776957298	547	K>E		No	ClinGen ExAC gnomAD
rs1478388216 CA373441088	548	G>D		No	ClinGen gnomAD
rs765463389 CA5057892	549	S>A		No	ClinGen ExAC TOPMed gnomAD
CA5057893 rs141614983	550	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA192907121 rs868229295	550	A>V		No	ClinGen Ensembl
CA5057894 rs574362937	551	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs766879169 CA5057895	551	R>K		No	ClinGen ExAC gnomAD
rs115242044 CA192907148	552	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370307671 CA5057898	553	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5057897 rs370307671	553	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1364726683 CA373441118	554	P>S		No	ClinGen gnomAD
CA192907156 rs921796646	556	R>T		No	ClinGen Ensembl
CA373441454 rs1201522619	559	L>F		No	ClinGen gnomAD
CA373441459 rs1337939441	559	L>P		No	ClinGen TOPMed
CA192910080 rs947774243	561	Y>C		No	ClinGen TOPMed gnomAD
CA192910086 rs906033420	563	V>M		No	ClinGen TOPMed gnomAD
rs753300807 CA5057918	564	T>A		No	ClinGen ExAC TOPMed gnomAD
CA373441530 rs1587645230	564	T>I		No	ClinGen Ensembl
rs1421068911 CA373441537	565	T>A		No	ClinGen gnomAD
CA373441551 rs1361833915	566	T>N		No	ClinGen gnomAD
rs1173026495 CA373441589	569	V>G		No	ClinGen gnomAD
rs764863651 CA5057920	569	V>M		No	ClinGen ExAC gnomAD
rs1408234242 CA373441617	571	P>L		No	ClinGen gnomAD
rs1335535593 CA373441633	572	D>E		No	ClinGen gnomAD
CA5057921 rs750084683	572	D>H		No	ClinGen ExAC TOPMed gnomAD
rs758314348 CA373441642	573	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA5057922 rs758314348	573	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA5057924 rs751356487	575	L>F		No	ClinGen ExAC
CA587801480 rs1564239335	576	N>D		No	ClinGen Ensembl
CA5057925 rs754898159	576	N>D		No	ClinGen ExAC gnomAD
rs781130506 CA5057926	577	E>*		No	ClinGen ExAC gnomAD
rs897387671 CA373441722	578	I>M		No	ClinGen gnomAD
CA5057928 rs748183359	578	I>V		No	ClinGen ExAC TOPMed gnomAD
CA5057929 rs117713820	581	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141986091 CA5057930	583	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs952851652 CA192910200	584	K>R		No	ClinGen Ensembl
CA192910205 rs1001633150	585	K>N		No	ClinGen TOPMed
rs1564239437 CA373441798	586	H>D		No	ClinGen Ensembl
rs749491516 CA5057931	590	V>L		No	ClinGen ExAC TOPMed gnomAD
rs199547857 CA5057933	591	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs150268458 CA192910219	592	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA192910228 rs766786487	593	G>S		No	ClinGen Ensembl
rs756200115 CA5057947	595	T>I		No	ClinGen ExAC gnomAD
rs1289908106 CA373441888	597	K>N		No	ClinGen gnomAD
CA373441890 rs1402379156	598	C>R		No	ClinGen TOPMed
rs997128159 CA192911995	599	Q>*		No	ClinGen TOPMed
rs1212844520 CA373441920	602	S>A		No	ClinGen gnomAD
CA5057951 rs749328178	602	S>L		No	ClinGen ExAC gnomAD
rs779040914 CA5057953	603	D>E		No	ClinGen ExAC gnomAD
CA5057952 rs771154763	603	D>N		No	ClinGen ExAC gnomAD
CA373441933 rs1481302828	604	F>S		No	ClinGen TOPMed gnomAD
rs1289953901 CA373441958	608	T>A		No	ClinGen gnomAD
rs539841275 CA5057954	609	M>I		No	ClinGen ExAC gnomAD
CA373441972 rs1421664244	610	Q>*		No	ClinGen TOPMed
CA5057955 rs772468153	610	Q>H		No	ClinGen ExAC gnomAD
rs775907942 CA373442013	615	V>A		No	ClinGen ExAC gnomAD
rs775907942 CA5057956	615	V>G		No	ClinGen ExAC gnomAD
rs200440363 CA192912048	616	C>W		No	ClinGen ExAC TOPMed gnomAD
rs761210411 CA5057957	616	C>Y		No	ClinGen ExAC gnomAD
rs1444783320 CA373442025	617	Q>H		No	ClinGen gnomAD
CA192912058 rs751020991	617	Q>R		No	ClinGen TOPMed gnomAD
rs762498744 CA5057960	620	K>N		No	ClinGen ExAC gnomAD
CA373442050 rs1424372582	621	P>S		No	ClinGen gnomAD
CA5057962 rs751254508	622	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1288856837 CA373442129	626	I>S		No	ClinGen gnomAD
rs1259248372 CA373442120	626	I>V		No	ClinGen TOPMed
rs767323630 CA5057965	629	Q>R		No	ClinGen ExAC gnomAD
CA5057967 rs557719031	630	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs752618361 CA5057966	630	R>W		No	ClinGen ExAC TOPMed gnomAD
CA5057969 rs544001717	634	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs757324107 CA5057971	636	W>*		No	ClinGen ExAC gnomAD
CA192912215 rs1027998064	639	K>E		No	ClinGen TOPMed
CA192912218 rs955254978	639	K>R		No	ClinGen TOPMed gnomAD
rs779162176 CA5057972	644	D>Y		No	ClinGen ExAC gnomAD
rs113044021 CA192912255	649	C>G		No	ClinGen ESP
CA192912253 rs113044021	649	C>R		No	ClinGen ESP
CA192912274 rs1005897614	649	C>W		No	ClinGen Ensembl
rs758725930 CA5057974	649	C>Y		No	ClinGen ExAC gnomAD
CA5057976 rs138922465	651	V>L		No	ClinGen ESP ExAC TOPMed gnomAD

1 associated diseases with Q14680

Without disease ID

3 regional properties for Q14680

Type	Name	Position	InterPro Accession
domain	Poly(ADP-ribose) polymerase, regulatory domain	250 - 384	IPR004102
domain	WGR domain	153 - 260	IPR008893
domain	Poly(ADP-ribose) polymerase, catalytic domain	378 - 605	IPR012317

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cell membrane ; Peripheral membrane protein
PANTHER Family	PTHR24346	MAP/MICROTUBULE AFFINITY-REGULATING KINASE
PANTHER Subfamily	PTHR24346:SF30	MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE
PANTHER Protein Class	non-receptor serine/threonine protein kinase protein modifying enzyme
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cell cortex	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium ion binding	Binding to a calcium ion (Ca2+).
lipid binding	Binding to a lipid.
non-membrane spanning protein tyrosine kinase activity	Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

10 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell population proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.
G2/M transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
hemopoiesis	The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
intrinsic apoptotic signaling pathway in response to oxidative stress	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
neural precursor cell proliferation	The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.

69 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q02066		Abscisic acid-inducible protein kinase	Triticum aestivum (Wheat)	PR
Q5GLH2	TRIB2	Tribbles homolog 2	Bos taurus (Bovine)	SS
Q0VCE3	TRIB3	Tribbles homolog 3	Bos taurus (Bovine)	SS
Q3SZW1	TSSK1B	Testis-specific serine/threonine-protein kinase 1	Bos taurus (Bovine)	PR
Q92519	TRIB2	Tribbles homolog 2	Homo sapiens (Human)	SS
Q96RU7	TRIB3	Tribbles homolog 3	Homo sapiens (Human)	PR
Q96RU8	TRIB1	Tribbles homolog 1	Homo sapiens (Human)	EV
Q15831	STK11	Serine/threonine-protein kinase STK11	Homo sapiens (Human)	PR
Q96RG2	PASK	PAS domain-containing serine/threonine-protein kinase	Homo sapiens (Human)	EV
O14757	CHEK1	Serine/threonine-protein kinase Chk1	Homo sapiens (Human)	EV
Q8IWQ3	BRSK2	Serine/threonine-protein kinase BRSK2	Homo sapiens (Human)	PR
Q8TDC3	BRSK1	Serine/threonine-protein kinase BRSK1	Homo sapiens (Human)	SS
P57059	SIK1	Serine/threonine-protein kinase SIK1	Homo sapiens (Human)	PR
Q9NRH2	SNRK	SNF-related serine/threonine-protein kinase	Homo sapiens (Human)	SS
Q9BXA7	TSSK1B	Testis-specific serine/threonine-protein kinase 1	Homo sapiens (Human)	PR
O60285	NUAK1	NUAK family SNF1-like kinase 1	Homo sapiens (Human)	PR
Q13131	PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (Human)	EV
P54646	PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (Human)	EV
Q8K4K3	Trib2	Tribbles homolog 2	Mus musculus (Mouse)	SS
Q61241	Tssk1b	Testis-specific serine/threonine-protein kinase 1	Mus musculus (Mouse)	PR
Q8K4K2	Trib3	Tribbles homolog 3	Mus musculus (Mouse)	SS
O54863	Tssk2	Testis-specific serine/threonine-protein kinase 2	Mus musculus (Mouse)	PR
Q8K4K4	Trib1	Tribbles homolog 1	Mus musculus (Mouse)	SS
Q5EG47	Prkaa1	5'-AMP-activated protein kinase catalytic subunit alpha-1	Mus musculus (Mouse)	SS
Q8BRK8	Prkaa2	5'-AMP-activated protein kinase catalytic subunit alpha-2	Mus musculus (Mouse)	SS
Q61846	Melk	Maternal embryonic leucine zipper kinase	Mus musculus (Mouse)	PR
Q28948	PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2	Sus scrofa (Pig)	SS
Q9WTQ6	Trib3	Tribbles homolog 3	Rattus norvegicus (Rat)	SS
P54645	Prkaa1	5'-AMP-activated protein kinase catalytic subunit alpha-1	Rattus norvegicus (Rat)	EV
Q09137	Prkaa2	5'-AMP-activated protein kinase catalytic subunit alpha-2	Rattus norvegicus (Rat)	EV
Q5QNM6	CIPK13	Putative CBL-interacting protein kinase 13	Oryza sativa subsp japonica (Rice)	PR
Q5JLQ9	CIPK30	CBL-interacting protein kinase 30	Oryza sativa subsp japonica (Rice)	PR
Q5N942	SAPK4	Serine/threonine-protein kinase SAPK4	Oryza sativa subsp japonica (Rice)	PR
Q852Q0	OSK3	Serine/threonine protein kinase OSK3	Oryza sativa subsp. japonica (Rice)	SS
Q75LR7	SAPK1	Serine/threonine-protein kinase SAPK1	Oryza sativa subsp japonica (Rice)	PR
Q75H77	SAPK10	Serine/threonine-protein kinase SAPK10	Oryza sativa subsp japonica (Rice)	PR
Q7Y0B9	SAPK8	Serine/threonine-protein kinase SAPK8	Oryza sativa subsp japonica (Rice)	PR
Q7XQP4	SAPK7	Serine/threonine-protein kinase SAPK7	Oryza sativa subsp japonica (Rice)	PR
Q852Q2	OSK1	Serine/threonine protein kinase OSK1	Oryza sativa subsp. japonica (Rice)	SS
Q6ZLP5	CIPK23	CBL-interacting protein kinase 23	Oryza sativa subsp japonica (Rice)	PR
Q0D4J7	SAPK2	Serine/threonine-protein kinase SAPK2	Oryza sativa subsp japonica (Rice)	PR
Q8LIG4	CIPK3	CBL-interacting protein kinase 3	Oryza sativa subsp japonica (Rice)	PR
Q852Q1	OSK4	Serine/threonine protein kinase OSK4	Oryza sativa subsp. japonica (Rice)	SS
Q6ERS4	CIPK16	CBL-interacting protein kinase 16	Oryza sativa subsp japonica (Rice)	PR
P0C5D6	SAPK3	Serine/threonine-protein kinase SAPK3	Oryza sativa subsp japonica (Rice)	PR
Q2RAX3	CIPK33	CBL-interacting protein kinase 33	Oryza sativa subsp japonica (Rice)	PR
Q75V57	SAPK9	Serine/threonine-protein kinase SAPK9	Oryza sativa subsp japonica (Rice)	PR
Q21017	kin-29	Serine/threonine-protein kinase kin-29	Caenorhabditis elegans	SS
P45894	aak-1	5'-AMP-activated protein kinase catalytic subunit alpha-1	Caenorhabditis elegans	SS
Q95ZQ4	aak-2	5'-AMP-activated protein kinase catalytic subunit alpha-2	Caenorhabditis elegans	SS
P43291	SRK2A	Serine/threonine-protein kinase SRK2A	Arabidopsis thaliana (Mouse-ear cress)	PR
Q93VD3	CIPK23	CBL-interacting serine/threonine-protein kinase 23	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C958	SRK2B	Serine/threonine-protein kinase SRK2B	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M9E9	SRK2C	Serine/threonine-protein kinase SRK2C	Arabidopsis thaliana (Mouse-ear cress)	PR
O64812	SRK2J	Serine/threonine-protein kinase SRK2J	Arabidopsis thaliana (Mouse-ear cress)	PR
Q2V452	CIPK3	CBL-interacting serine/threonine-protein kinase 3	Arabidopsis thaliana (Mouse-ear cress)	SS
O22971	CIPK13	CBL-interacting serine/threonine-protein kinase 13	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38997	KIN10	SNF1-related protein kinase catalytic subunit alpha KIN10	Arabidopsis thaliana (Mouse-ear cress)	SS
P92958	KIN11	SNF1-related protein kinase catalytic subunit alpha KIN11	Arabidopsis thaliana (Mouse-ear cress)	PR
Q39192	SRK2D	Serine/threonine-protein kinase SRK2D	Arabidopsis thaliana (Mouse-ear cress)	PR
O65554	CIPK6	CBL-interacting serine/threonine-protein kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q940H6	SRK2E	Serine/threonine-protein kinase SRK2E	Arabidopsis thaliana (Mouse-ear cress)	PR
P43292	SRK2G	Serine/threonine-protein kinase SRK2G	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LDI3	CIPK24	CBL-interacting serine/threonine-protein kinase 24	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FJ54	CIPK20	CBL-interacting serine/threonine-protein kinase 20	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94CG0	CIPK21	CBL-interacting serine/threonine-protein kinase 21	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FFP9	SRK2H	Serine/threonine-protein kinase SRK2H	Arabidopsis thaliana (Mouse-ear cress)	PR
Q39193	SRK2I	Serine/threonine-protein kinase SRK2I	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FLZ3	KIN12	SNF1-related protein kinase catalytic subunit alpha KIN12	Arabidopsis thaliana (Mouse-ear cress)	SS

10	20	30	40	50	60
MKDYDELLKY	YELHETIGTG	GFAKVKLACH	ILTGEMVAIK	IMDKNTLGSD	LPRIKTEIEA
70	80	90	100	110	120
LKNLRHQHIC	QLYHVLETAN	KIFMVLEYCP	GGELFDYIIS	QDRLSEEETR	VVFRQIVSAV
130	140	150	160	170	180
AYVHSQGYAH	RDLKPENLLF	DEYHKLKLID	FGLCAKPKGN	KDYHLQTCCG	SLAYAAPELI
190	200	210	220	230	240
QGKSYLGSEA	DVWSMGILLY	VLMCGFLPFD	DDNVMALYKK	IMRGKYDVPK	WLSPSSILLL
250	260	270	280	290	300
QQMLQVDPKK	RISMKNLLNH	PWIMQDYNYP	VEWQSKNPFI	HLDDDCVTEL	SVHHRNNRQT
310	320	330	340	350	360
MEDLISLWQY	DHLTATYLLL	LAKKARGKPV	RLRLSSFSCG	QASATPFTDI	KSNNWSLEDV
370	380	390	400	410	420
TASDKNYVAG	LIDYDWCEDD	LSTGAATPRT	SQFTKYWTES	NGVESKSLTP	ALCRTPANKL
430	440	450	460	470	480
KNKENVYTPK	SAVKNEEYFM	FPEPKTPVNK	NQHKREILTT	PNRYTTPSKA	RNQCLKETPI
490	500	510	520	530	540
KIPVNSTGTD	KLMTGVISPE	RRCRSVELDL	NQAHMEETPK	RKGAKVFGSL	ERGLDKVITV
550	560	570	580	590	600
LTRSKRKGSA	RDGPRRLKLH	YNVTTTRLVN	PDQLLNEIMS	ILPKKHVDFV	QKGYTLKCQT
610	620	630	640	650
QSDFGKVTMQ	FELEVCQLQK	PDVVGIRRQR	LKGDAWVYKR	LVEDILSSCK	V