Q14240

PR
Gene name
EIF4A2 (DDX2B, EIF4F)
Protein name
Eukaryotic initiation factor 4A-II
Names
eIF-4A-II, eIF4A-II, ATP-dependent RNA helicase eIF4A-2
Species
Homo sapiens (Human)
KEGG Pathway
hsa:1974
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q14240

Entry ID Method Resolution Chain Position Source
3BOR X-ray 185 A A 22-240 PDB
AF-Q14240-F1 Predicted AlphaFoldDB

149 variants for Q14240

Variant ID(s) Position Change Description Diseaes Association Provenance
CA2746667
COSM400629
rs764605841
 2 S>C lung [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
rs764605841
CA2746666
 2 S>F Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs760934867
CA2746665
 2 S>T No ClinGen
ExAC
CA2746669
COSM77639
rs765785108
 3 G>V ovary [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
CA355719308
rs960682898
 4 G>D No ClinGen
TOPMed
gnomAD
rs750826078
CA2746670
 4 G>S No ClinGen
ExAC
gnomAD
rs960682898
CA89648401
 4 G>V No ClinGen
TOPMed
gnomAD
CA355719313
rs1560082688
 5 S>A No ClinGen
Ensembl
CA2746672
rs779490566
 5 S>C No ClinGen
ExAC
TOPMed
gnomAD
CA355719322
rs779490566
COSM420090
 5 S>F Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs754593091
CA89648439
 6 A>P No ClinGen
ExAC
TOPMed
gnomAD
rs754593091
CA2746674
 6 A>T No ClinGen
ExAC
TOPMed
gnomAD
CA355719343
rs1423569431
 7 D>E No ClinGen
gnomAD
rs1560082706
CA355719340
 7 D>G No ClinGen
Ensembl
rs374075692
CA2746675
 7 D>N Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs908631706
CA89648440
 8 Y>C No ClinGen
TOPMed
gnomAD
rs1377442083
CA355719358
 9 N>D No ClinGen
gnomAD
CA2746677
rs143326381
 9 N>K No ClinGen
ESP
ExAC
CA355719364
rs1418086849
 9 N>S No ClinGen
gnomAD
rs1418086849
CA355719363
 9 N>T No ClinGen
gnomAD
CA355719370
rs1317806581
 10 R>G No ClinGen
gnomAD
rs1479988881
CA355719374
 10 R>T No ClinGen
TOPMed
rs1553797619
CA2746717
 12 H>Q No ClinGen
Ensembl
CA2746719
rs753573326
 15 P>T No ClinGen
ExAC
TOPMed
gnomAD
rs757324676
CA2746720
 16 E>K No ClinGen
ExAC
gnomAD
CA355720469
rs1381743588
 18 M>L No ClinGen
TOPMed
gnomAD
CA2746721
rs778995582
 20 P>L No ClinGen
ExAC
TOPMed
gnomAD
rs371691662 26 S>= Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
rs1169693407
CA355720551
 26 S>T No ClinGen
TOPMed
CA2746753
rs187041507
 27 N>K No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA89650365
rs17851348
 27 N>S No ClinGen
TOPMed
TCGA novel 30 E>G Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA355720631
rs953593626
 37 D>N No ClinGen
gnomAD
rs1248318962
CA355720635
 37 D>V No ClinGen
TOPMed
CA89650389
rs953593626
 37 D>Y No ClinGen
gnomAD
rs1382097286
CA355720683
 43 S>F No ClinGen
gnomAD
rs201474676
CA89650421
 45 L>F No ClinGen
1000Genomes
TOPMed
rs867137018
CA89650442
 47 G>D No ClinGen
Ensembl
rs11538618
CA89650451
 48 I>S No ClinGen
Ensembl
CA89650449
rs972376732
 48 I>V No ClinGen
gnomAD
CA355720716
rs1328591615
 49 Y>C No ClinGen
gnomAD
rs200752693
CA89650482
 55 K>E No ClinGen
1000Genomes
CA355720785
rs1560083657
 58 A>S Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
Ensembl
NCI-TCGA
TCGA novel 58 A>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2746762
rs776167777
 58 A>V No ClinGen
ExAC
gnomAD
CA89650504
rs577099369
 63 A>G No ClinGen
1000Genomes
TOPMed
TCGA novel 63 A>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA355720855
rs577099369
 63 A>V No ClinGen
1000Genomes
TOPMed
CA2746765
rs765159897
 64 I>V No ClinGen
ExAC
rs750238082
CA2746766
 65 I>L No ClinGen
ExAC
gnomAD
rs755185062 65 I>missing Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
CA89650510
rs866637500
 66 P>L No ClinGen
Ensembl
rs1480206121
CA355721036
 73 V>M No ClinGen
gnomAD
rs11538611
CA89651048
 76 Q>R No ClinGen
Ensembl
TCGA novel 77 A>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2746839
rs773335544
 81 T>S No ClinGen
ExAC
gnomAD
TCGA novel 83 K>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA355721237
rs1579157436
 84 T>P No ClinGen
Ensembl
rs11538614
CA89651060
 85 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
Ensembl
NCI-TCGA
CA89651066
rs775555447
 86 T>S No ClinGen
Ensembl
rs201339295
CA89651089
 92 L>P No ClinGen
1000Genomes
VAR_052158
CA89651090
rs11538616
 93 Q>H No ClinGen
UniProt
1000Genomes
ExAC
TOPMed
dbSNP
gnomAD
rs751663411
CA2746842
 94 Q>H No ClinGen
ExAC
gnomAD
rs755425078
CA355721416
 97 I>M No ClinGen
ExAC
TOPMed
gnomAD
rs1368492875
CA355721411
 97 I>V No ClinGen
TOPMed
gnomAD
CA355721424
rs1579157500
 98 E>D No ClinGen
Ensembl
CA355721426
rs1579157504
 99 F>L No ClinGen
Ensembl
CA355721437
rs1366744628
 100 K>T No ClinGen
TOPMed
rs753306564
CA2746845
 103 Q>H No ClinGen
ExAC
TOPMed
gnomAD
rs1050836155
CA89651142
 109 P>T No ClinGen
Ensembl
CA355721557
rs1560084030
 112 E>Q No ClinGen
Ensembl
rs1407908695
CA355722036
 128 M>T No ClinGen
gnomAD
CA355722060
rs1327710742
 129 G>E No ClinGen
TOPMed
gnomAD
CA355722064
rs1327710742
 129 G>V No ClinGen
TOPMed
gnomAD
CA2746872
rs756828110
 131 T>A No ClinGen
ExAC
TOPMed
gnomAD
CA89652095
rs991933918
 134 A>V No ClinGen
Ensembl
TCGA novel 136 I>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA355722270
rs1579159855
 140 N>S No ClinGen
Ensembl
CA2746875
rs758037831
 143 N>S No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 147 K>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA355722401
rs1195471558
 150 A>T No ClinGen
gnomAD
TCGA novel 152 A>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA355722455
rs1560084659
 154 H>R No ClinGen
Ensembl
CA89652103
rs11538613
 154 H>Y No ClinGen
Ensembl
CA2746879
rs142804104
 155 I>T No ClinGen
ESP
ExAC
rs746817318
CA2746878
 155 I>V No ClinGen
ExAC
TOPMed
gnomAD
rs767682413 155 I>missing Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
CA2746880
COSM730070
rs781218973
 156 V>I lung [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
CA2746884
rs774265072
CA2746883
 167 L>F No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 174 P>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 176 W>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2746925
rs754554886
 176 W>G No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 179 M>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 179 M>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
VAR_035838 181 V>L a breast cancer sample; somatic mutation [UniProt] No UniProt
TCGA novel 181 V>W Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 183 D>Q Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 184 E>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 185 A>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 194 K>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1248522662
CA355723209
 195 D>V No ClinGen
TOPMed
TCGA novel 197 I>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 202 Q>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2746932
rs749201932
 207 S>N No ClinGen
ExAC
gnomAD
TCGA novel 208 I>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs765266132
CA2746971
 219 T>A No ClinGen
ExAC
gnomAD
CA2746972
rs750332310
 219 T>S No ClinGen
ExAC
gnomAD
CA355723570
rs1309985225
 223 E>K No ClinGen
gnomAD
CA2746973
rs755032307
 233 I>V No ClinGen
ExAC
gnomAD
rs868809630
CA89654935
 248 K>R No ClinGen
Ensembl
TCGA novel 251 Y>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA355724241
rs1299766512
 256 R>K No ClinGen
TOPMed
TCGA novel 265 C>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA355724446
rs1170283376
 265 C>S No ClinGen
gnomAD
rs1237593933
CA355724465
 267 L>S No ClinGen
TOPMed
rs79277600
CA2747088
 277 V>G No ClinGen
ExAC
gnomAD
rs1579163623
CA355724608
 280 L>F No ClinGen
Ensembl
rs1980299
CA89655985
 281 N>K No ClinGen
Ensembl
CA355725053
rs1579163654
 286 V>G No ClinGen
Ensembl
CA355725125
rs1579163666
 290 T>A No ClinGen
Ensembl
rs1221692747
CA355725167
 291 E>D No ClinGen
TOPMed
rs754199367
CA89656016
 291 E>G No ClinGen
Ensembl
TCGA novel 301 S>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA89656079
rs1045274054
 302 A>S No ClinGen
TOPMed
TCGA novel 306 D>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1579164782
CA355725744
 311 E>D No ClinGen
Ensembl
CA2747171
rs748724172
 313 D>E Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
TCGA novel 342 V>M Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA2747245
rs769438133
 344 L>S No ClinGen
ExAC
gnomAD
TCGA novel 347 N>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs762856383
CA2747247
 352 T>I No ClinGen
ExAC
gnomAD
CA355727394
rs1213509261
 366 R>* No ClinGen
TOPMed
TCGA novel 366 R>Q Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 366 R>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs776557195
CA2747294
 373 A>S No ClinGen
ExAC
gnomAD
CA355727721
rs1560087652
 379 E>G No ClinGen
Ensembl
TCGA novel 379 E>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 381 D>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 382 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA355727909
rs1427878661
COSM1042378
 386 R>H Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
NCI-TCGA
gnomAD
CA89658455
rs866118494
 390 T>N No ClinGen
Ensembl
CA89658458
rs554887819
 392 Y>C No ClinGen
1000Genomes
CA355728121
rs1335839025
 394 T>A No ClinGen
gnomAD
rs1406419091
CA355728139
 395 T>A No ClinGen
gnomAD
CA89658462
rs199556041
COSM1484942
 395 T>I Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
NCI-TCGA
TOPMed
gnomAD
CA89658460
rs199556041
 395 T>R No ClinGen
TOPMed
gnomAD
CA917088590
rs1579171264
 403 V>* No ClinGen
Ensembl
rs35049134
CA89658497
 405 D>A No ClinGen
Ensembl
TCGA novel 407 I>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA

No associated diseases with Q14240

6 regional properties for Q14240

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 181 - 189 IPR000629
domain Helicase, C-terminal 246 - 407 IPR001650
domain DEAD/DEAH box helicase domain 58 - 222 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 52 - 250 IPR014001
domain RNA helicase, DEAD-box type, Q motif 33 - 61 IPR014014
domain ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain 35 - 236 IPR044728

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

5 GO annotations of biological process

Name Definition
cellular response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
negative regulation of RNA-directed 5'-3' RNA polymerase activity Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity.
regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation.
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41378 Eukaryotic initiation factor 4A Triticum aestivum (Wheat) PR
P10081 TIF2 ATP-dependent RNA helicase eIF4A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3SZ54 EIF4A1 Eukaryotic initiation factor 4A-I Bos taurus (Bovine) PR
Q3SZ65 EIF4A2 Eukaryotic initiation factor 4A-II Bos taurus (Bovine) PR
Q8JFP1 EIF4A2 Eukaryotic initiation factor 4A-II Gallus gallus (Chicken) PR
A5A6N4 EIF4A1 Eukaryotic initiation factor 4A-I Pan troglodytes (Chimpanzee) PR
Q8NHQ9 DDX55 ATP-dependent RNA helicase DDX55 Homo sapiens (Human) PR
P60842 EIF4A1 Eukaryotic initiation factor 4A-I Homo sapiens (Human) PR
Q9Y6V7 DDX49 Probable ATP-dependent RNA helicase DDX49 Homo sapiens (Human) PR
Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 Homo sapiens (Human) PR
Q8TDD1 DDX54 ATP-dependent RNA helicase DDX54 Homo sapiens (Human) PR
Q9GZR7 DDX24 ATP-dependent RNA helicase DDX24 Homo sapiens (Human) PR
Q92499 DDX1 ATP-dependent RNA helicase DDX1 Homo sapiens (Human) PR
Q9NY93 DDX56 Probable ATP-dependent RNA helicase DDX56 Homo sapiens (Human) PR
Q9NUL7 DDX28 Probable ATP-dependent RNA helicase DDX28 Homo sapiens (Human) PR
Q7L014 DDX46 Probable ATP-dependent RNA helicase DDX46 Homo sapiens (Human) PR
Q41741 Eukaryotic initiation factor 4A Zea mays (Maize) PR
P60843 Eif4a1 Eukaryotic initiation factor 4A-I Mus musculus (Mouse) PR
P10630 Eif4a2 Eukaryotic initiation factor 4A-II Mus musculus (Mouse) PR
Q5RKI1 Eif4a2 Eukaryotic initiation factor 4A-II Rattus norvegicus (Rat) PR
Q6Z2Z4 Os02g0146600 Eukaryotic initiation factor 4A-3 Oryza sativa subsp japonica (Rice) PR
P35683 Os06g0701100 Eukaryotic initiation factor 4A-1 Oryza sativa subsp japonica (Rice) PR
P27639 inf-1 Eukaryotic initiation factor 4A Caenorhabditis elegans PR
Q3E9C3 RH58 DEAD-box ATP-dependent RNA helicase 58, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAI7 TIF4A-3 Eukaryotic initiation factor 4A-3 Arabidopsis thaliana (Mouse-ear cress) PR
P41376 EIF4A1 Eukaryotic initiation factor 4A-1 Arabidopsis thaliana (Mouse-ear cress) PR
P41377 TIF4A-2 Eukaryotic initiation factor 4A-2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSGGSADYNR EHGGPEGMDP DGVIESNWNE IVDNFDDMNL KESLLRGIYA YGFEKPSAIQ
70 80 90 100 110 120
QRAIIPCIKG YDVIAQAQSG TGKTATFAIS ILQQLEIEFK ETQALVLAPT RELAQQIQKV
130 140 150 160 170 180
ILALGDYMGA TCHACIGGTN VRNEMQKLQA EAPHIVVGTP GRVFDMLNRR YLSPKWIKMF
190 200 210 220 230 240
VLDEADEMLS RGFKDQIYEI FQKLNTSIQV VLLSATMPTD VLEVTKKFMR DPIRILVKKE
250 260 270 280 290 300
ELTLEGIKQF YINVEREEWK LDTLCDLYET LTITQAVIFL NTRRKVDWLT EKMHARDFTV
310 320 330 340 350 360
SALHGDMDQK ERDVIMREFR SGSSRVLITT DLLARGIDVQ QVSLVINYDL PTNRENYIHR
370 380 390 400
IGRGGRFGRK GVAINFVTEE DKRILRDIET FYNTTVEEMP MNVADLI