Q14012
EV
Gene name |
CAMK1 |
Protein name |
Calcium/calmodulin-dependent protein kinase type 1 |
Names |
CaM kinase I, CaM-KI, CaM kinase I alpha, CaMKI-alpha |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:8536 |
EC number |
2.7.11.17: Protein-serine/threonine kinases |
Protein Class |
SERINE/THREONINE-PROTEIN KINASE (PTHR24347) |
Descriptions
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1) regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. The autoinhibitory region contains two helical structures (αR1 and αR2) and includes a pseudosubstrate sequence within it. The αR2 helix is at the N-terminal of CaM-binding domain. The αR1 interacts with the catalytic core and αR2 interacts with the ATP-binding region of CAMK1 for autoinhibition.
Autoinhibitory domains (AIDs)
Target domain |
20-276 (Protein kinase domain) |
Relief mechanism |
Ligand binding |
Assay |
Structural analysis |
Target domain |
20-276 (Protein kinase domain) |
Relief mechanism |
Ligand binding |
Assay |
Structural analysis |
Accessory elements
161-183 (Activation loop from InterPro)
Target domain |
20-276 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Yuan T et al. (2004) "Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I", Archives of biochemistry and biophysics, 421, 192-206
- Zha M et al. (2012) "Crystal structures of human CaMKIα reveal insights into the regulation mechanism of CaMKI", PloS one, 7, e44828
Autoinhibited structure
Activated structure
5 structures for Q14012
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4FG7 | X-ray | 270 A | A | 1-293 | PDB |
| 4FG8 | X-ray | 220 A | A/B | 1-315 | PDB |
| 4FG9 | X-ray | 240 A | A/B | 1-320 | PDB |
| 4FGB | X-ray | 260 A | A | 1-320 | PDB |
| AF-Q14012-F1 | Predicted | AlphaFoldDB |
285 variants for Q14012
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA2243419 rs113139851 |
3 | G>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA351735454 rs1481715197 |
3 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA351735452 rs1481715197 |
3 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA351735444 rs113139851 |
3 | G>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1199233790 CA351735441 |
4 | A>P | No |
ClinGen gnomAD |
|
|
rs561655780 CA2243418 |
5 | V>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs201983776 CA2243417 |
6 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351735378 rs1575265855 |
7 | G>C | No |
ClinGen Ensembl |
|
|
CA351735353 rs1162704077 |
7 | G>V | No |
ClinGen TOPMed |
|
|
rs752676650 CA2243416 |
9 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2243415 rs767265769 |
10 | W>R | No |
ClinGen ExAC gnomAD |
|
|
rs920145784 CA69990756 |
13 | A>E | No |
ClinGen TOPMed gnomAD |
|
|
rs920145784 CA351735228 |
13 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
rs751388407 CA2243413 |
13 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351735238 rs920145784 |
13 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA2243410 rs772591110 |
15 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs377569441 CA2243411 |
15 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2243408 rs761233875 |
16 | I>M | No |
ClinGen ExAC |
|
|
rs1253410238 CA351735146 |
18 | D>N | No |
ClinGen Ensembl |
|
|
CA2243407 rs372987743 |
19 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA69990745 rs1051580403 |
19 | I>N | No |
ClinGen TOPMed |
|
|
CA351735049 rs1407548505 |
21 | D>E | No |
ClinGen gnomAD |
|
|
CA2243403 rs779343393 |
21 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1413223424 CA351735038 |
22 | F>Y | No |
ClinGen gnomAD |
|
|
rs771056998 CA2243401 |
23 | R>* | No |
ClinGen ExAC gnomAD |
|
|
rs771056998 CA351735014 |
23 | R>G | No |
ClinGen ExAC gnomAD |
|
|
COSM1049199 rs749586067 CA2243400 |
23 | R>Q | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs190639418 CA2243398 |
28 | T>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1236572797 CA351734870 |
28 | T>P | No |
ClinGen gnomAD |
|
|
CA351732606 rs763370367 |
29 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1044606365 CA69990093 |
29 | G>V | No |
ClinGen TOPMed |
|
|
rs763370367 CA2243343 |
29 | G>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2243340 rs762000589 |
30 | A>D | No |
ClinGen ExAC |
|
|
rs765645330 CA351732576 |
30 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765645330 CA2243341 |
30 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765645330 CA2243342 |
30 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776877972 CA2243338 |
32 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs893317804 CA69990077 |
35 | I>T | No |
ClinGen TOPMed |
|
|
CA351732454 rs1444700418 |
35 | I>V | No |
ClinGen gnomAD |
|
|
CA2243336 rs760751220 |
37 | A>E | No |
ClinGen ExAC gnomAD |
|
|
rs1280457657 CA351732394 |
37 | A>T | No |
ClinGen TOPMed |
|
|
rs772044654 CA351732284 |
39 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775439790 CA2243335 |
39 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs1396548123 CA351732308 |
39 | D>Y | No |
ClinGen gnomAD |
|
|
CA351732275 rs1455143563 |
40 | K>R | No |
ClinGen gnomAD |
|
|
rs745862612 CA2243333 |
41 | R>T | No |
ClinGen ExAC gnomAD |
|
|
CA351732195 rs1157644866 |
42 | T>M | No |
ClinGen gnomAD |
|
|
rs770894597 CA2243331 |
43 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA351732157 rs1435261400 |
43 | Q>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1442415037 CA351732097 |
45 | L>V | No |
ClinGen gnomAD |
|
|
rs1254668135 CA351732023 |
47 | A>T | No |
ClinGen gnomAD |
|
|
CA2243329 rs777431790 |
55 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA351731707 rs1238271621 |
57 | E>K | No |
ClinGen gnomAD |
|
|
CA351731704 rs1238271621 |
57 | E>Q | No |
ClinGen gnomAD |
|
|
CA351731632 rs1361784414 |
60 | E>A | No |
ClinGen gnomAD |
|
|
CA69990048 rs77335822 |
61 | G>S | No |
ClinGen Ensembl |
|
|
CA351731599 rs1315829208 |
61 | G>V | No |
ClinGen gnomAD |
|
|
rs755731269 CA2243327 |
63 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351731572 rs1575258232 |
63 | M>V | No |
ClinGen Ensembl |
|
|
CA2243326 rs750387531 |
69 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1575258163 CA351731390 |
70 | L>R | No |
ClinGen Ensembl |
|
|
rs898173600 CA69984757 |
72 | K>N | No |
ClinGen TOPMed |
|
|
rs1297302721 CA351731363 |
72 | K>Q | No |
ClinGen gnomAD |
|
|
CA2243303 rs779335679 |
74 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
CA2243301 rs754227326 |
76 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757766232 CA351729545 |
76 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA2243302 rs757766232 |
76 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA2243299 rs760931282 |
78 | I>L | No |
ClinGen ExAC gnomAD |
|
|
CA2243298 rs752906254 |
78 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1267006800 CA351729439 |
80 | A>D | No |
ClinGen gnomAD |
|
|
CA351729443 rs1196390343 |
80 | A>S | No |
ClinGen gnomAD |
|
|
CA2243295 rs149094214 |
82 | D>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs759644397 CA2243296 |
82 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA351729290 rs1347191149 |
84 | I>V | No |
ClinGen gnomAD |
|
|
rs745723089 CA69984658 |
85 | Y>* | No |
ClinGen Ensembl |
|
|
CA2243294 rs138483154 |
85 | Y>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs200398091 CA69984644 |
86 | E>* | No |
ClinGen TOPMed gnomAD |
|
|
CA351729197 rs1330382466 |
86 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
rs200398091 CA351729213 |
86 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA2243293 rs375556446 |
91 | L>R | No |
ClinGen ESP ExAC gnomAD |
|
|
CA2243292 rs773044708 |
92 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
rs1471219827 CA351728987 |
93 | L>I | No |
ClinGen gnomAD |
|
|
CA2243291 rs769524135 |
96 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA2243275 rs762960705 |
99 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2243271 rs776489826 |
105 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs768294099 CA2243270 |
106 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746723292 CA2243269 COSM274370 |
106 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA351728334 rs1553704331 |
107 | I>M | No |
ClinGen Ensembl |
|
|
rs1247530400 CA351728232 |
110 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
rs151133089 CA2243268 |
110 | K>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA351728135 rs1284090262 |
111 | G>A | No |
ClinGen gnomAD |
|
|
CA351728137 rs1284090262 |
111 | G>V | No |
ClinGen gnomAD |
|
|
CA351728016 rs1369335655 COSM1199462 |
114 | T>M | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs756662184 CA2243264 |
116 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs143182946 CA2243265 |
116 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA351727890 rs1575241877 |
117 | D>A | No |
ClinGen Ensembl |
|
|
CA351727865 rs755234937 |
118 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA2243260 rs755234937 |
118 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs751877547 CA351727848 |
119 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA2243259 rs751877547 |
119 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs766533357 CA69984421 |
120 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs766533357 CA2243258 |
120 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2243257 rs758368101 |
120 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs758368101 CA351727823 |
120 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA69984410 rs1046615731 |
125 | V>M | No |
ClinGen TOPMed |
|
|
rs186994904 CA2243255 |
128 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA2243254 rs761876706 |
129 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs1223178911 CA351727577 |
131 | Y>* | No |
ClinGen gnomAD |
|
|
CA351727526 rs1311320342 |
134 | D>E | No |
ClinGen gnomAD |
|
|
rs1346883303 CA351727539 |
134 | D>N | No |
ClinGen TOPMed |
|
|
CA2243251 rs780833552 |
136 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA2243250 rs760291986 |
137 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1399767855 CA351727465 |
137 | I>T | No |
ClinGen gnomAD |
|
|
rs372278723 CA2243248 |
140 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2243249 rs775086900 |
140 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA69984390 rs895334039 |
143 | K>E | No |
ClinGen TOPMed |
|
|
CA351727092 rs1433477390 |
144 | P>T | No |
ClinGen gnomAD |
|
|
CA351727019 rs1266214282 COSM176914 |
145 | E>D | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1553703907 CA351726979 |
147 | L>M | No |
ClinGen Ensembl |
|
|
CA351726913 rs1188999675 |
148 | L>P | No |
ClinGen gnomAD |
|
|
CA351726798 rs1184545354 |
151 | S>G | No |
ClinGen TOPMed gnomAD |
|
|
rs764052828 CA2243232 |
151 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs959800434 CA69983269 |
153 | D>G | No |
ClinGen Ensembl |
|
|
CA69983273 rs1012649189 |
153 | D>N | No |
ClinGen gnomAD |
|
|
rs1258139322 CA351726648 |
155 | D>G | No |
ClinGen gnomAD |
|
|
CA2243231 rs760416645 |
155 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA351726544 rs1299441598 |
159 | M>I | No |
ClinGen gnomAD |
|
|
CA2243229 rs767015539 |
159 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351726502 rs1194121365 |
160 | I>T | No |
ClinGen gnomAD |
|
|
CA351726536 rs1251121659 |
160 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA2243228 rs559224420 |
161 | S>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs925718348 CA69983241 |
162 | D>N | No |
ClinGen TOPMed |
|
|
rs1330688535 CA351726387 |
163 | F>S | No |
ClinGen gnomAD |
|
|
rs762376373 CA2243225 |
165 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769307935 CA2243223 |
168 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs777236576 CA2243224 |
168 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs1379128941 CA351726280 |
168 | M>V | No |
ClinGen TOPMed |
|
|
CA351726228 rs1575234640 |
170 | D>A | No |
ClinGen Ensembl |
|
|
rs1575234625 CA351726216 |
170 | D>E | No |
ClinGen Ensembl |
|
|
CA2243222 rs747319122 |
170 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA2243221 rs780569645 |
171 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA351726187 rs780569645 |
171 | P>Q | No |
ClinGen ExAC gnomAD |
|
|
CA351726201 rs1256503204 |
171 | P>S | No |
ClinGen gnomAD |
|
|
rs945677826 CA69983182 |
174 | V>M | No |
ClinGen TOPMed |
|
|
CA351726019 rs1375061939 |
175 | L>P | No |
ClinGen TOPMed |
|
|
CA69983151 rs902884716 |
178 | A>G | No |
ClinGen gnomAD |
|
|
CA2243214 rs540971111 |
178 | A>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1207464278 CA351725909 |
179 | C>Y | No |
ClinGen TOPMed |
|
|
CA2243213 rs756053756 |
181 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs752480324 COSM1425804 CA2243212 |
182 | P>L | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA351725811 rs767399471 |
183 | G>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351725820 rs1254882423 |
183 | G>R | No |
ClinGen TOPMed |
|
|
CA2243211 rs767399471 |
183 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351725793 rs1238040684 |
185 | V>M | No |
ClinGen gnomAD |
|
|
rs764888044 CA2243187 |
188 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761231706 CA2243186 |
189 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776024002 CA2243185 |
190 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1458004817 CA351725659 |
191 | A>T | No |
ClinGen gnomAD |
|
|
CA2243184 rs148571810 |
199 | V>M | No |
ClinGen ESP ExAC gnomAD |
|
|
CA2243183 rs759883777 |
200 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs1559697631 CA351725450 |
202 | W>R | No |
ClinGen Ensembl |
|
|
CA2243181 rs771134172 |
204 | I>T | No |
ClinGen ExAC |
|
|
rs774580814 CA2243182 |
204 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1489620785 CA351725402 |
205 | G>S | No |
ClinGen TOPMed |
|
|
CA2243180 rs749573419 |
206 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs56203420 CA2243179 |
207 | I>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1318379866 CA351725376 |
207 | I>V | No |
ClinGen gnomAD |
|
|
CA2243177 rs748209976 |
208 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351725337 rs1323708723 |
209 | Y>N | No |
ClinGen gnomAD |
|
|
CA351725302 rs1465543720 |
210 | I>M | No |
ClinGen TOPMed |
|
|
CA351725292 rs1487340864 |
211 | L>S | No |
ClinGen Ensembl |
|
|
CA2243148 rs756971878 |
212 | L>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2243147 rs753380998 |
213 | C>S | No |
ClinGen ExAC gnomAD |
|
|
rs1310899787 CA351724149 |
214 | G>D | No |
ClinGen gnomAD |
|
|
CA2243145 COSM1049185 rs755492997 |
214 | G>S | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs1376877334 CA351724111 |
215 | Y>S | No |
ClinGen gnomAD |
|
|
COSM21043 rs907102077 VAR_040596 CA69981967 |
217 | P>S | a metastatic melanoma sample; somatic mutation skin [UniProt, Cosmic] | No |
ClinGen cosmic curated UniProt Ensembl dbSNP |
|
CA2243142 rs147073343 |
219 | Y>N | No |
ClinGen ESP ExAC gnomAD |
|
|
rs765378672 CA2243141 |
220 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA69981884 rs1041670618 |
221 | E>D | No |
ClinGen Ensembl |
|
|
CA2243139 rs762008030 |
221 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1362673400 CA351723816 |
223 | D>H | No |
ClinGen gnomAD |
|
|
CA351723727 rs1452502107 |
225 | K>E | No |
ClinGen gnomAD |
|
|
CA351723706 rs1158181348 |
225 | K>R | No |
ClinGen TOPMed |
|
|
rs1559696529 CA351723670 |
226 | L>F | No |
ClinGen Ensembl |
|
|
CA2243138 rs768657576 |
227 | F>S | No |
ClinGen ExAC gnomAD |
|
|
CA2243137 rs768657576 |
227 | F>Y | No |
ClinGen ExAC gnomAD |
|
|
rs760839181 CA2243136 |
228 | E>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2243133 rs747165508 |
234 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351723297 rs1237842964 |
234 | E>V | No |
ClinGen gnomAD |
|
|
rs770601593 CA2243131 |
236 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748937664 CA2243130 |
238 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA351723023 rs1374274683 |
242 | W>* | No |
ClinGen TOPMed |
|
|
rs777310726 CA2243129 |
243 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA2243127 rs747682193 |
244 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2243125 rs531632583 |
245 | I>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1342653111 CA351722854 |
247 | D>E | No |
ClinGen gnomAD |
|
|
CA2243123 rs750784176 |
248 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351722645 rs1559695195 |
249 | A>V | No |
ClinGen Ensembl |
|
|
rs1393959902 CA351722637 |
250 | K>R | No |
ClinGen gnomAD |
|
|
rs1559695168 CA351722620 |
251 | D>H | No |
ClinGen Ensembl |
|
|
CA2243074 rs139097636 |
254 | R>L | No |
ClinGen ESP ExAC TOPMed |
|
|
rs139097636 CA351722516 |
254 | R>P | No |
ClinGen ESP ExAC TOPMed |
|
|
rs139097636 CA2243075 |
254 | R>Q | No |
ClinGen ESP ExAC TOPMed |
|
|
CA2243076 rs372591129 |
254 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1442149355 CA351722483 |
255 | H>P | No |
ClinGen gnomAD |
|
|
CA351722318 rs1357998594 |
261 | P>S | No |
ClinGen gnomAD |
|
|
rs1479881974 CA351722294 |
262 | E>K | No |
ClinGen gnomAD |
|
|
CA2243072 rs200157460 |
265 | F>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1447078012 CA351722112 |
270 | A>T | No |
ClinGen TOPMed |
|
|
rs199997024 CA2243069 |
271 | L>S | No |
ClinGen ExAC gnomAD |
|
|
CA2243067 rs560292298 |
272 | Q>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs560292298 CA2243068 |
272 | Q>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA351722045 rs1301431550 |
272 | Q>P | No |
ClinGen TOPMed gnomAD |
|
|
CA2243066 rs370718078 |
273 | H>Y | No |
ClinGen ESP ExAC gnomAD |
|
|
rs148790679 CA2243065 |
274 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs771650402 CA2243045 |
276 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1385072049 CA351721877 |
277 | A>E | No |
ClinGen TOPMed gnomAD |
|
|
rs372987286 CA2243044 |
277 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1267718385 CA351721838 |
280 | T>I | No |
ClinGen gnomAD |
|
|
CA351721821 rs1157416401 |
283 | D>A | No |
ClinGen TOPMed gnomAD |
|
|
CA351721820 rs1157416401 |
283 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
CA2243043 rs773723897 |
284 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA2243042 rs770441132 |
286 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA351721776 rs1475100852 |
288 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
CA69980283 rs776833307 |
289 | S>L | No |
ClinGen gnomAD |
|
|
CA69980259 rs913984992 |
291 | S>C | No |
ClinGen TOPMed gnomAD |
|
|
CA2243038 rs747307663 |
292 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs758465129 CA2243036 |
293 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs757250734 CA2243032 |
299 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1306048914 CA351721592 |
301 | S>T | No |
ClinGen TOPMed |
|
|
CA69980199 rs994677617 |
303 | W>C | No |
ClinGen TOPMed |
|
|
CA2243031 rs377182467 |
303 | W>R | No |
ClinGen ESP ExAC gnomAD |
|
|
rs763922235 CA2243030 |
304 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA2242979 rs753082810 |
306 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1215876523 CA351719935 |
308 | N>S | No |
ClinGen gnomAD |
|
|
rs1473298800 CA351719917 |
309 | A>D | No |
ClinGen gnomAD |
|
|
rs767810914 CA2242978 |
310 | T>M | No |
ClinGen ExAC gnomAD |
|
|
rs774504130 CA2242976 |
312 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs762951024 CA2242974 |
313 | V>E | No |
ClinGen ExAC gnomAD |
|
|
CA351719844 rs1559692493 |
313 | V>L | No |
ClinGen Ensembl |
|
|
rs200156536 CA2242972 |
314 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2242973 rs773234633 |
314 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2242970 rs781010077 |
316 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs748089150 CA2242971 |
316 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1462888983 CA351719719 |
321 | L>M | No |
ClinGen gnomAD |
|
|
rs746824562 CA2242968 |
322 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1575214646 CA351719698 |
323 | T>N | No |
ClinGen Ensembl |
|
|
CA2242967 rs779796350 |
326 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs953847648 CA69978345 |
326 | E>V | No |
ClinGen TOPMed |
|
|
rs758189766 CA2242966 |
327 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351719610 rs1186644757 |
330 | Q>K | No |
ClinGen gnomAD |
|
|
CA2242965 rs749937650 |
331 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs536063601 CA2242962 |
332 | A>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1437806689 CA351719576 |
332 | A>T | No |
ClinGen gnomAD |
|
|
rs536063601 CA2242963 |
332 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1559692246 CA351719560 |
333 | S>T | No |
ClinGen Ensembl |
|
|
CA2242959 rs201838059 |
334 | H>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA2242958 rs766586927 |
335 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1214164611 CA351719494 |
338 | L>V | No |
ClinGen gnomAD |
|
|
CA2242956 rs773323612 |
341 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1239614122 CA351719444 |
342 | A>S | No |
ClinGen TOPMed |
|
|
rs1482988022 CA351719309 |
344 | G>E | No |
ClinGen TOPMed |
|
|
CA2242925 rs777325548 |
345 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs747559252 CA2242923 |
345 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2242924 rs747559252 |
345 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1231674345 CA351719204 |
349 | C>Y | No |
ClinGen gnomAD |
|
|
CA2242922 rs200760015 |
352 | R>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs545247601 CA2242921 |
352 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1307498314 CA351719041 |
354 | C>Y | No |
ClinGen gnomAD |
|
|
rs578157926 CA2242919 |
356 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2242918 rs757567412 |
358 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2242915 rs760869166 |
360 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs752632116 CA2242914 |
360 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2242913 rs56033923 VAR_040597 |
361 | E>K | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
CA351718784 rs1158899575 |
362 | L>P | No |
ClinGen gnomAD |
|
|
rs1158899575 CA351718781 |
362 | L>R | No |
ClinGen gnomAD |
|
|
rs774266419 CA2242910 |
365 | T>K | No |
ClinGen ExAC gnomAD |
|
|
rs935195361 CA351718728 |
366 | L>M | No |
ClinGen gnomAD |
|
|
rs1575213144 CA351718708 |
367 | P>L | No |
ClinGen Ensembl |
|
|
rs772680696 CA2242907 |
367 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1486837209 CA351718702 |
368 | H>Y | No |
ClinGen gnomAD |
|
|
CA2242905 rs541448857 |
369 | Q>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs769257385 CA2242906 |
369 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1299525314 CA351718648 |
370 | L>F | No |
ClinGen TOPMed |
No associated diseases with Q14012
9 regional properties for Q14012
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 25 - 283 | IPR000719 |
| domain | EF-hand domain | 326 - 397 | IPR002048-1 |
| domain | EF-hand domain | 398 - 467 | IPR002048-2 |
| active_site | Serine/threonine-protein kinase, active site | 145 - 157 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 31 - 54 | IPR017441 |
| binding_site | EF-Hand 1, calcium-binding site | 339 - 351 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 375 - 387 | IPR018247-2 |
| binding_site | EF-Hand 1, calcium-binding site | 411 - 423 | IPR018247-3 |
| binding_site | EF-Hand 1, calcium-binding site | 445 - 457 | IPR018247-4 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.17 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | PTHR24347 | SERINE/THREONINE-PROTEIN KINASE |
| PANTHER Subfamily | PTHR24347:SF197 | CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1 |
| PANTHER Protein Class |
non-receptor serine/threonine protein kinase
protein modifying enzyme |
|
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| calmodulin-dependent protein kinase activity | Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| negative regulation of protein binding | Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| nucleocytoplasmic transport | The directed movement of molecules between the nucleus and the cytoplasm. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| positive regulation of dendritic spine development | Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. |
| positive regulation of muscle cell differentiation | Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| positive regulation of peptidyl-serine phosphorylation | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
| positive regulation of protein acetylation | Any process that activates or increases the frequency, rate or extent of protein acetylation. |
| positive regulation of protein export from nucleus | Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. |
| positive regulation of protein serine/threonine kinase activity | Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. |
| positive regulation of synapse structural plasticity | Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity. |
| positive regulation of syncytium formation by plasma membrane fusion | Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of muscle cell differentiation | Any process that modulates the frequency, rate or extent of muscle cell differentiation. |
| regulation of protein binding | Any process that modulates the frequency, rate or extent of protein binding. |
| regulation of protein localization | Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
106 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4IFM7 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Bos taurus (Bovine) | SS |
| Q0V7M1 | PSKH1 | Serine/threonine-protein kinase H1 | Bos taurus (Bovine) | SS |
| Q0VD22 | STK33 | Serine/threonine-protein kinase 33 | Bos taurus (Bovine) | PR |
| O15075 | DCLK1 | Serine/threonine-protein kinase DCLK1 | Homo sapiens (Human) | EV |
| Q9UIK4 | DAPK2 | Death-associated protein kinase 2 | Homo sapiens (Human) | EV |
| O94768 | STK17B | Serine/threonine-protein kinase 17B | Homo sapiens (Human) | PR |
| Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | Homo sapiens (Human) | SS |
| Q8N568 | DCLK2 | Serine/threonine-protein kinase DCLK2 | Homo sapiens (Human) | PR |
| Q9UEE5 | STK17A | Serine/threonine-protein kinase 17A | Homo sapiens (Human) | SS |
| O75962 | TRIO | Triple functional domain protein | Homo sapiens (Human) | EV |
| Q8WWF8 | CAPSL | Calcyphosin-like protein | Homo sapiens (Human) | PR |
| P53355 | DAPK1 | Death-associated protein kinase 1 | Homo sapiens (Human) | EV |
| Q9BYT3 | STK33 | Serine/threonine-protein kinase 33 | Homo sapiens (Human) | PR |
| O43293 | DAPK3 | Death-associated protein kinase 3 | Homo sapiens (Human) | PR |
| P11801 | PSKH1 | Serine/threonine-protein kinase H1 | Homo sapiens (Human) | SS |
| Q9H1R3 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Homo sapiens (Human) | EV |
| Q16816 | PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | Homo sapiens (Human) | PR |
| P15735 | PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform | Homo sapiens (Human) | PR |
| Q13554 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (Human) | EV |
| Q9UQM7 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (Human) | EV |
| Q13555 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Homo sapiens (Human) | EV |
| Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Homo sapiens (Human) | EV |
| Q32MK0 | MYLK3 | Myosin light chain kinase 3 | Homo sapiens (Human) | SS |
| Q86YV6 | MYLK4 | Myosin light chain kinase family member 4 | Homo sapiens (Human) | SS |
| Q6P2M8 | PNCK | Calcium/calmodulin-dependent protein kinase type 1B | Homo sapiens (Human) | SS |
| Q96NX5 | CAMK1G | Calcium/calmodulin-dependent protein kinase type 1G | Homo sapiens (Human) | SS |
| Q8IU85 | CAMK1D | Calcium/calmodulin-dependent protein kinase type 1D | Homo sapiens (Human) | SS |
| Q8NCB2 | CAMKV | CaM kinase-like vesicle-associated protein | Homo sapiens (Human) | SS |
| Q9QYK9 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Mus musculus (Mouse) | PR |
| Q91VB2 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Mus musculus (Mouse) | SS |
| Q8BG48 | Stk17b | Serine/threonine-protein kinase 17B | Mus musculus (Mouse) | PR |
| Q8VCR8 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Mus musculus (Mouse) | SS |
| Q6PGN3 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Mus musculus (Mouse) | PR |
| Q3UIZ8 | Mylk3 | Myosin light chain kinase 3 | Mus musculus (Mouse) | SS |
| Q8VDF3 | Dapk2 | Death-associated protein kinase 2 | Mus musculus (Mouse) | EV |
| Q6P8Y1 | Capsl | Calcyphosin-like protein | Mus musculus (Mouse) | PR |
| Q8BW96 | Camk1d | Calcium/calmodulin-dependent protein kinase type 1D | Mus musculus (Mouse) | SS |
| Q3UHL1 | Camkv | CaM kinase-like vesicle-associated protein | Mus musculus (Mouse) | SS |
| P08414 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Mus musculus (Mouse) | SS |
| Q9JLM8 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Mus musculus (Mouse) | SS |
| Q91YA2 | Pskh1 | Serine/threonine-protein kinase H1 | Mus musculus (Mouse) | SS |
| Q80YE7 | Dapk1 | Death-associated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q62407 | Speg | Striated muscle-specific serine/threonine-protein kinase | Mus musculus (Mouse) | SS |
| Q0KL02 | Trio | Triple functional domain protein | Mus musculus (Mouse) | SS |
| Q924X7 | Stk33 | Serine/threonine-protein kinase 33 | Mus musculus (Mouse) | PR |
| O54784 | Dapk3 | Death-associated protein kinase 3 | Mus musculus (Mouse) | PR |
| Q91YS8 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Mus musculus (Mouse) | SS |
| Q7TNJ7 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Rattus norvegicus (Rat) | SS |
| P20689 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Rattus norvegicus (Rat) | SS |
| F1M0Z1 | Trio | Triple functional domain protein | Rattus norvegicus (Rat) | SS |
| Q91XS8 | Stk17b | Serine/threonine-protein kinase 17B | Rattus norvegicus (Rat) | PR |
| O08875 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Rattus norvegicus (Rat) | PR |
| E9PT87 | Mylk3 | Myosin light chain kinase 3 | Rattus norvegicus (Rat) | SS |
| O70150 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Rattus norvegicus (Rat) | PR |
| Q63092 | Camkv | CaM kinase-like vesicle-associated protein | Rattus norvegicus (Rat) | SS |
| Q63638 | Speg | Striated muscle-specific serine/threonine-protein kinase | Rattus norvegicus (Rat) | SS |
| O88764 | Dapk3 | Death-associated protein kinase 3 | Rattus norvegicus (Rat) | PR |
| P13234 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Rattus norvegicus (Rat) | SS |
| P97924 | Kalrn | Kalirin | Rattus norvegicus (Rat) | SS |
| Q5MPA9 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Rattus norvegicus (Rat) | PR |
| Q63450 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Rattus norvegicus (Rat) | EV |
| Q6AVM3 | CCAMK | Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase | Oryza sativa subsp japonica (Rice) | PR |
| P53682 | CPK23 | Calcium-dependent protein kinase 23 | Oryza sativa subsp japonica (Rice) | PR |
| P53684 | CPK7 | Calcium-dependent protein kinase 7 | Oryza sativa subsp japonica (Rice) | PR |
| Q5VQQ5 | CPK2 | Calcium-dependent protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6I5I8 | CPK16 | Calcium-dependent protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6K968 | CPK6 | Calcium-dependent protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| Q75GE8 | CPK8 | Calcium-dependent protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q84SL0 | CPK20 | Calcium-dependent protein kinase 20 | Oryza sativa subsp. japonica (Rice) | SS |
| Q8LPZ7 | CPK3 | Calcium-dependent protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| O44997 | dapk-1 | Death-associated protein kinase dapk-1 | Caenorhabditis elegans | SS |
| Q95QC4 | zyg-8 | Serine/threonine-protein kinase zyg-8 | Caenorhabditis elegans | PR |
| Q9TXJ0 | cmk-1 | Calcium/calmodulin-dependent protein kinase type 1 | Caenorhabditis elegans | PR |
| P28583 | Calcium-dependent protein kinase SK5 | Glycine max (Soybean) (Glycine hispida) | PR | |
| Q9M9V8 | CPK10 | Calcium-dependent protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FX86 | CRK8 | CDPK-related kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SSF8 | CPK30 | Calcium-dependent protein kinase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIQ7 | CPK24 | Calcium-dependent protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93759 | GK-1 | Calcium-dependent protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8S8S2 | LPEAT2 | Lysophospholipid acyltransferase LPEAT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LJL9 | CRK2 | CDPK-related kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SG12 | CRK6 | CDPK-related kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCS2 | CRK5 | CDPK-related kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4I7 | CPK13 | Calcium-dependent protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NLQ6 | CPK32 | Calcium-dependent protein kinase 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38873 | CPK7 | Calcium-dependent protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42438 | CPK8 | Calcium-dependent protein kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q06850 | CPK1 | Calcium-dependent protein kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38869 | CPK4 | Calcium-dependent protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q38870 | CPK2 | Calcium-dependent protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38872 | CPK6 | Calcium-dependent protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39016 | CPK11 | Calcium-dependent protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E9C0 | CPK34 | Calcium-dependent protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42396 | CPK12 | Calcium-dependent protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42479 | CPK3 | Calcium-dependent protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7XJR9 | CPK16 | Calcium-dependent protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMP5 | CPK17 | Calcium-dependent protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJ61 | CPK25 | Calcium-dependent protein kinase 25 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZSA4 | CPK27 | Calcium-dependent protein kinase 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZV15 | CPK20 | Calcium-dependent protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PE17 | CPK18 | Calcium-dependent protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FKW4 | CPK28 | Calcium-dependent protein kinase 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q38997 | KIN10 | SNF1-related protein kinase catalytic subunit alpha KIN10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1LUA6 | trio | Triple functional domain protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A8C984 | mylk3 | Myosin light chain kinase 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SY49 | camkv | CaM kinase-like vesicle-associated protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLGAVEGPRW | KQAEDIRDIY | DFRDVLGTGA | FSEVILAEDK | RTQKLVAIKC | IAKEALEGKE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GSMENEIAVL | HKIKHPNIVA | LDDIYESGGH | LYLIMQLVSG | GELFDRIVEK | GFYTERDASR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LIFQVLDAVK | YLHDLGIVHR | DLKPENLLYY | SLDEDSKIMI | SDFGLSKMED | PGSVLSTACG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TPGYVAPEVL | AQKPYSKAVD | CWSIGVIAYI | LLCGYPPFYD | ENDAKLFEQI | LKAEYEFDSP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YWDDISDSAK | DFIRHLMEKD | PEKRFTCEQA | LQHPWIAGDT | ALDKNIHQSV | SEQIKKNFAK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SKWKQAFNAT | AVVRHMRKLQ | LGTSQEGQGQ | TASHGELLTP | VAGGPAAGCC | CRDCCVEPGT |
| ELSPTLPHQL |