AiPD: Autoinhibited Protein Database

Q13882

Gene name	PTK6 (BRK)
Protein name	Protein-tyrosine kinase 6
Names	Breast tumor kinase, Tyrosine-protein kinase BRK
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5753
EC number	2.7.10.2: Protein-tyrosine kinases
Protein Class	TYROSINE-PROTEIN KINASE (PTHR24418)

Descriptions

Human PTK6 (also known as breast tumor kinase (Brk)) is a non-receptor protein-tyrosine kinase. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors, PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. PTK6 is composed of SH3, SH2, and catalytic domains. The SH3 domain binds the proline-rich linker region between the SH2 domain and the catalytic domain. The disruption of the interaction enhances the oncogenic property of PTK6. In addition, mutation at SH2 domain of PTK6 resulted in higher catalytic activity. The site plays an important role in its negative regulation of the enzyme activity. Tyr(P) peptide derived from the C-terminal region of PTK6 including Tyr(P)-447 successfully bound to the SH2 domain, supporting the autoinhibitory role of PTK6 protein.

Autoinhibitory domains (AIDs)

Target domain	191-445 (Protein kinase domain)
Relief mechanism	Ligand binding
Assay	Structural analysis, Mutagenesis experiment

AID

76-170 (SH2 domain)

Target domain

191-445 (Protein kinase domain)

Relief mechanism

Ligand binding (Phosphotyrosine-containing peptide binding)

Assay

Structural analysis, Mutagenesis experiment

Target domain	171-191 (Linker region between the SH2 domain and the catalytic domain)
Relief mechanism	Ligand binding
Assay	Mutagenesis experiment, Structural analysis

AID

8-72 (SH3 domain)

Target domain

171-191 (Linker region between the SH2 domain and the catalytic domain)

Relief mechanism

Ligand binding (Proline-rich peptide binding)

Assay

Mutagenesis experiment, Structural analysis

Accessory elements

329-352 (Activation loop from InterPro)

Target domain	191-445 (Protein kinase domain)
Relief mechanism
Assay

References

Hong E et al. (2004) "Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain", The Journal of biological chemistry, 279, 29700-8

Ko S et al. (2009) "Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6", Biochemical and biophysical research communications, 384, 236-42

Qiu H et al. (2002) "Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition", The Journal of biological chemistry, 277, 34634-41

Autoinhibited structure

Activated structure

9 structures for Q13882

Entry ID	Method	Resolution	Chain	Position	Source
1RJA	NMR	-	A	75-174	PDB
2KGT	NMR	-	A	1-72	PDB
5D7V	X-ray	233 A	A/B/C/D	185-446	PDB
5DA3	X-ray	170 A	A	185-446	PDB
5H2U	X-ray	224 A	A/B/C/D	185-446	PDB
6CZ2	X-ray	250 A	A	182-443	PDB
6CZ3	X-ray	180 A	A	182-443	PDB
6CZ4	X-ray	150 A	A	182-443	PDB
AF-Q13882-F1	Predicted				AlphaFoldDB

440 variants for Q13882

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs777792665 RCV000678663 CA409660325	356	P>T	Keratoconus [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
rs757424929 CA9960016	2	V>A		No	ClinGen ExAC gnomAD
rs757424929 CA317426110	2	V>E		No	ClinGen ExAC gnomAD
rs1291869539 CA409650898	2	V>L		No	ClinGen gnomAD
rs1291869539 CA409650899	2	V>M		No	ClinGen gnomAD
CA409650894 rs1289345903	3	S>T		No	ClinGen gnomAD
CA9960013 rs377401604	4	R>P		No	ClinGen ExAC TOPMed gnomAD
rs377401604 CA9960012	4	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs764440367 CA9960014	4	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1288779164 CA409650886	5	D>H		No	ClinGen TOPMed
rs1441545887 CA409650882	5	D>V		No	ClinGen gnomAD
rs930471507 CA317426089	7	A>G		No	ClinGen gnomAD
COSM2150039 rs1569014700 CA409650859	8	H>Q	central_nervous_system [Cosmic]	No	ClinGen cosmic curated Ensembl
CA317426088 rs779381541	9	L>M		No	ClinGen TOPMed
CA9960010 rs763010795	10	G>A		No	ClinGen ExAC TOPMed gnomAD
rs763010795 CA409650851	10	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1162023523 CA409650845	11	P>R		No	ClinGen gnomAD
CA409650839 rs1200521102	12	K>N		No	ClinGen TOPMed
rs973208171 CA317426078	12	K>Q		No	ClinGen Ensembl
rs199502943 CA409650841	12	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199502943 CA9960009	12	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1408250590 CA409650824	14	V>A		No	ClinGen TOPMed gnomAD
CA409650826 rs1408250590	14	V>G		No	ClinGen TOPMed gnomAD
CA9960008 rs769673576	15	G>D		No	ClinGen ExAC
rs1452777486 CA409650823	15	G>R		No	ClinGen TOPMed
rs1468099698 CA409650807	17	W>*		No	ClinGen gnomAD
rs1270456414 CA409650794	19	F>V		No	ClinGen gnomAD
rs1199995195 CA409650786	20	K>E		No	ClinGen gnomAD
rs1200390955 CA409650778	21	S>P		No	ClinGen Ensembl
rs776091058 CA9960006	22	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9960007 rs149831201	22	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs139847446 CA9960004	23	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs139847446 CA9960003	23	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA409650760 rs758695104	24	D>E		No	ClinGen ExAC TOPMed gnomAD
CA9960000 rs746185360	25	E>K		No	ClinGen ExAC TOPMed gnomAD
CA409650750 rs1028504421	26	E>*		No	ClinGen gnomAD
CA317425996 rs1011785686	26	E>A		No	ClinGen gnomAD
CA317425998 rs1028504421	26	E>K		No	ClinGen gnomAD
rs1011785686 CA409650748	26	E>V		No	ClinGen gnomAD
rs779583267 CA409650733	28	S>R		No	ClinGen ExAC TOPMed gnomAD
CA9959998 rs374913291	30	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA9959997 rs754007821	30	R>H		No	ClinGen ExAC gnomAD
CA9959993 rs142028257	31	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9959995 rs201907843	31	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9959994 rs201907843	31	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9959992 rs142028257	31	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs929638114 CA317425940	32	G>E		No	ClinGen TOPMed gnomAD
rs201488747 CA9959989	33	D>E		No	ClinGen ExAC gnomAD
CA409650679 rs1267525030	33	D>V		No	ClinGen TOPMed
rs1188219162 CA409650686	33	D>Y		No	ClinGen gnomAD
rs141973561 CA9959987	34	V>I		No	ClinGen ESP ExAC gnomAD
rs919470599 CA317425924	35	F>Y		No	ClinGen TOPMed
rs148206034 CA409650616	36	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA9959985 rs757318592	37	V>M		No	ClinGen ExAC gnomAD
rs1265305922 CA409650603	39	R>G		No	ClinGen gnomAD
rs1381976366 CA409650601	39	R>T		No	ClinGen TOPMed
CA9959984 rs566860816	40	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1322936894 CA409650589	41	E>K		No	ClinGen gnomAD
CA9959983 rs551801284	42	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs533250243 CA9959981	43	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
rs749796714 CA9959980	43	Q>H		No	ClinGen ExAC gnomAD
rs1296222113 CA409650571	43	Q>R		No	ClinGen gnomAD
rs1012845657 CA317425881	44	W>*		No	ClinGen TOPMed
CA409650567 rs1429106651	44	W>R		No	ClinGen gnomAD
CA409650550 rs1366706438	45	W>*		No	ClinGen TOPMed
CA9959979 rs778061555	46	W>*		No	ClinGen ExAC TOPMed gnomAD
CA9959978 rs756149302	48	T>M		No	ClinGen ExAC TOPMed
rs1418764982 CA409650458	52	E>G		No	ClinGen gnomAD
CA409650464 rs1429070092	52	E>K		No	ClinGen TOPMed gnomAD
rs765004968 CA409650441	53	A>G		No	ClinGen ExAC TOPMed gnomAD
rs765004968 CA9959973	53	A>V		No	ClinGen ExAC TOPMed gnomAD
rs764035120 CA9959970	55	G>R		No	ClinGen ExAC gnomAD
CA409650409 rs760125592	56	A>G		No	ClinGen ExAC gnomAD
rs760125592 CA9959969	56	A>V		No	ClinGen ExAC gnomAD
rs771660336 CA9959967	57	V>M		No	ClinGen ExAC TOPMed gnomAD
CA409650377 rs1196333103	59	Q>*		No	ClinGen TOPMed
CA317425782 rs752341537	61	Y>F		No	ClinGen TOPMed
rs1037130163 CA317425780	62	V>E		No	ClinGen TOPMed
rs1213162833 CA409650339	62	V>M		No	ClinGen gnomAD
rs912565634 CA317425778	64	H>Q		No	ClinGen gnomAD
CA409650260 rs1249095820	67	L>R		No	ClinGen gnomAD
CA317425764 rs987171522	68	A>T		No	ClinGen gnomAD
CA409650244 rs368004687	69	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368004687 CA9959961	69	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9959962 rs368004687	69	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9959960 rs200350226	70	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA9959958 rs755214177	71	E>Q		No	ClinGen ExAC gnomAD
CA9959957 rs751778467	72	T>M		No	ClinGen ExAC TOPMed gnomAD
CA9959955 rs137987106	73	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs753580768 CA9959954	75	S>L		No	ClinGen ExAC TOPMed gnomAD
rs763957272 CA9959950	77	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9959949 rs763957272	77	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA9959951 rs763957272	77	P>R		No	ClinGen ExAC TOPMed gnomAD
CA409650133 rs1251186162	77	P>S		No	ClinGen gnomAD
rs775514718 CA9959919	78	W>*		No	ClinGen ExAC TOPMed gnomAD
rs374840053 CA9959920	78	W>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA409649137 rs772329894	80	F>L		No	ClinGen ExAC TOPMed gnomAD
CA9959915 rs371338421	85	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9959916 rs371338421	85	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146949365 CA9959914	85	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA409649107 rs146949365	85	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA409649103 rs574498831	86	S>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9959913 rs574498831	86	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409649093 rs1303320172	88	A>T		No	ClinGen TOPMed
rs202221029 CA9959909	88	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs750095520 CA9959907	89	V>A		No	ClinGen ExAC gnomAD
rs758195609 CA9959908	89	V>M		No	ClinGen ExAC gnomAD
CA9959906 rs758335320	90	R>C		No	ClinGen ExAC gnomAD
rs762262372 CA9959905	90	R>H		No	ClinGen ExAC gnomAD
CA9959903 rs200150366	91	R>G		No	ClinGen ExAC TOPMed gnomAD
rs761146317 CA9959902	91	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9959904 rs200150366	91	R>W		No	ClinGen ExAC TOPMed gnomAD
CA409649071 rs1406966653	93	Q>*		No	ClinGen gnomAD
rs747926721 CA317423406	93	Q>R		No	ClinGen gnomAD
CA9959901 rs775604556	94	A>S		No	ClinGen ExAC gnomAD
CA317423400 rs927648031	94	A>V		No	ClinGen TOPMed gnomAD
CA317423381 rs903536480	95	E>K		No	ClinGen gnomAD
rs1205176174 CA409649044	97	N>I		No	ClinGen gnomAD
rs367577047 CA317423353	98	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs367577047 CA9959898	98	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs570303251 CA317423351	99	T>A		No	ClinGen 1000Genomes
CA9959896 rs748018659	99	T>M		No	ClinGen ExAC gnomAD
CA9959897 rs748018659	99	T>R		No	ClinGen ExAC gnomAD
CA409649029 rs1251885865	100	G>V		No	ClinGen gnomAD
CA9959893 rs150179834	101	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA317423332 rs778695622	102	F>V		No	ClinGen Ensembl
rs757995553 CA9959891	104	I>M		No	ClinGen ExAC gnomAD
rs374984991 CA9959890	106	V>I		No	ClinGen ESP ExAC gnomAD
CA9959888 rs754276353	108	E>*		No	ClinGen ExAC TOPMed gnomAD
CA9959887 rs754276353	108	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9959886 rs764429260	109	K>T		No	ClinGen ExAC gnomAD
rs546666611 CA9959885	110	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs546666611 CA9959884	110	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1184772439 CA409648963	111	S>N		No	ClinGen gnomAD
rs774252880 CA9959880	112	A>V		No	ClinGen ExAC gnomAD
rs909224996 CA317423182	113	D>H		No	ClinGen gnomAD
CA409648954 rs909224996	113	D>Y		No	ClinGen gnomAD
CA9959877 rs776639683	114	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs1293641513 CA409648946	114	Y>D		No	ClinGen gnomAD
rs570467678 CA317423181	114	Y>F		No	ClinGen 1000Genomes gnomAD
rs1272442692 CA409648941	115	V>D		No	ClinGen TOPMed
CA9959876 rs145627260	115	V>F		No	ClinGen ESP ExAC TOPMed
rs145627260 CA9959875	115	V>I		No	ClinGen ESP ExAC TOPMed
rs754079436 CA317423166	117	S>L		No	ClinGen TOPMed gnomAD
rs140481984 CA9959873	117	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9959817 rs757619229	118	V>G		No	ClinGen ExAC gnomAD
CA409648929 rs976316745	118	V>L		No	ClinGen Ensembl
CA317423124 rs976316745	118	V>M		No	ClinGen Ensembl
CA409648478 rs1410257726	119	R>Q		No	ClinGen gnomAD
CA9959816 rs375933047	119	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA409648459 rs1166534162	120	D>G		No	ClinGen gnomAD
CA409648448 rs1447851809	121	T>A		No	ClinGen gnomAD
rs914062739 CA317422370	121	T>K		No	ClinGen TOPMed gnomAD
CA409648442 rs914062739	121	T>M		No	ClinGen TOPMed gnomAD
rs751325121 CA9959813	124	V>L		No	ClinGen ExAC gnomAD
CA9959809 rs142305389	125	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9959811 rs114992630	125	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1426308457 CA409648375	128	K>E		No	ClinGen TOPMed
CA409648364 rs1195063436	129	I>N		No	ClinGen gnomAD
rs370344358 CA409648348	131	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9959807 rs370344358	131	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs761258775 CA9959808	131	R>W		No	ClinGen ExAC gnomAD
CA9959806 rs768315390	132	R>C		No	ClinGen ExAC TOPMed gnomAD
rs747373941 CA9959805	132	R>H		No	ClinGen ExAC TOPMed gnomAD
rs770529793 CA317422322	133	A>V		No	ClinGen gnomAD
CA9959803 rs772765529	134	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1387248665 CA409648323	135	G>S		No	ClinGen gnomAD
CA317422293 rs1019365267	136	R>Q		No	ClinGen TOPMed gnomAD
rs377350675 CA9959802	136	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757424832 CA9959800	138	H>R		No	ClinGen ExAC gnomAD
CA409648277 rs377406653	140	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs148770935 CA9959797	141	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs145345355 CA409648265	142	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145345355 CA9959796	142	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs750376707 CA9959793	144	S>F		No	ClinGen ExAC gnomAD
rs1341653650 CA409648241	145	F>S		No	ClinGen TOPMed gnomAD
rs538487397 CA317422241	146	L>F		No	ClinGen Ensembl
rs1472451221 CA409648215	148	L>P		No	ClinGen TOPMed
rs1349782156 CA409648208	149	P>H		No	ClinGen gnomAD
CA9959792 rs765115063	149	P>S		No	ClinGen ExAC TOPMed gnomAD
rs763704391 CA9959789	150	E>A		No	ClinGen ExAC
rs150072173 CA9959788	150	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9959790 rs565530751	150	E>K		No	ClinGen ExAC gnomAD
CA9959786 rs772567343	151	L>P		No	ClinGen ExAC gnomAD
CA9959785 rs746176036	152	V>L		No	ClinGen ExAC
rs1457578319 CA409648182	153	N>D		No	ClinGen gnomAD
rs140172380 CA317422184	157	A>T		No	ClinGen ESP TOPMed gnomAD
rs1169486629 CA409648127	158	Q>R		No	ClinGen gnomAD
CA9959783 rs771520165	159	S>G		No	ClinGen ExAC gnomAD
CA9959782 rs749363732	159	S>T		No	ClinGen ExAC TOPMed gnomAD
rs373140729 CA317422155	160	L>P		No	ClinGen ESP
CA409648073 rs1408869244	161	S>F		No	ClinGen TOPMed
CA409648082 rs1481600629	161	S>P		No	ClinGen gnomAD
rs1268522173 CA409648059	162	H>R		No	ClinGen gnomAD
CA9959780 rs756347319	163	G>S		No	ClinGen ExAC TOPMed gnomAD
CA9959778 rs781336947	165	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs145079156 CA9959779	165	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs771991525 CA317422105	167	A>P		No	ClinGen gnomAD
CA409647961 rs750184076	168	A>S		No	ClinGen ExAC TOPMed gnomAD
rs750184076 CA9959776	168	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9959775 rs61736392	168	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1384934478 CA409647938	169	P>R		No	ClinGen gnomAD
rs1365743533 CA409647917	170	C>*		No	ClinGen TOPMed gnomAD
CA409647909 rs753348065	171	R>G		No	ClinGen ExAC TOPMed gnomAD
rs763657910 CA9959772	171	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9959773 rs753348065	171	R>W		No	ClinGen ExAC TOPMed gnomAD
CA409647795 rs753815746	173	H>Q		No	ClinGen ExAC gnomAD
CA9959754 rs371541793	174	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA409647747 rs1275059185	176	E>D		No	ClinGen TOPMed gnomAD
rs1022404779 CA317421627	177	P>H		No	ClinGen gnomAD
rs752210834 CA9959752	180	H>L		No	ClinGen ExAC gnomAD
rs759241674 CA9959750	182	D>N		No	ClinGen ExAC gnomAD
rs772714640 CA9959749	185	E>Q		No	ClinGen ExAC gnomAD
rs766759689 CA9959748	187	P>L		No	ClinGen ExAC TOPMed gnomAD
rs773793344 CA9959746	188	R>K		No	ClinGen ExAC TOPMed gnomAD
CA409647558 rs1406061232	189	E>D		No	ClinGen TOPMed gnomAD
CA9959745 rs770161732	190	E>K		No	ClinGen ExAC gnomAD
rs200799038 CA409647503	192	T>K		No	ClinGen ExAC TOPMed gnomAD
CA9959742 rs200799038	192	T>M		No	ClinGen ExAC TOPMed gnomAD
CA9959740 rs747229957	197	L>P		No	ClinGen ExAC TOPMed
CA9959739 rs372528046	198	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs770771274 CA9959738	199	S>F		No	ClinGen ExAC TOPMed gnomAD
rs777794066 CA9959736	200	G>S		No	ClinGen ExAC TOPMed gnomAD
CA9959735 rs755969076	202	F>S		No	ClinGen ExAC TOPMed gnomAD
CA409647271 rs1600935891	203	G>R		No	ClinGen Ensembl
CA409647225 rs1600935886	205	V>I		No	ClinGen Ensembl
CA409647198 rs1357378008	206	F>L		No	ClinGen gnomAD
rs200723492 CA9959731	207	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9959732 rs200723492	207	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs538512651 CA317421553	209	L>F		No	ClinGen Ensembl
rs267606054 CA317421532	210	W>*		No	ClinGen Ensembl
CA9959729 rs763408293	210	W>C		No	ClinGen ExAC gnomAD
rs569376679 CA317421513	211	K>*		No	ClinGen gnomAD
CA9959728 rs750723721	211	K>N		No	ClinGen ExAC gnomAD
rs765826183 CA9959727	212	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1389618552 CA409647030	213	R>L		No	ClinGen TOPMed gnomAD
CA409647038 rs1389618552	213	R>Q		No	ClinGen TOPMed gnomAD
rs1405570524 CA409647042	213	R>W		No	ClinGen TOPMed gnomAD
rs1240448700 CA409646999	215	Q>*		No	ClinGen TOPMed
CA409646869 rs1160946830	221	I>V		No	ClinGen gnomAD
CA9959726 rs762297755	222	S>A		No	ClinGen ExAC gnomAD
CA317421453 rs1040766082	222	S>F		No	ClinGen Ensembl
CA9959725 rs553979804	223	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs943681215 CA317421443	223	R>P		No	ClinGen Ensembl
rs1600934842 CA409646609	225	N>T		No	ClinGen Ensembl
CA9959691 rs757639084	228	H>Y		No	ClinGen ExAC gnomAD
rs764621665 CA9959689	231	M>K		No	ClinGen ExAC gnomAD
CA9959688 rs559931657	234	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1248954559 CA409646325	236	I>T		No	ClinGen gnomAD
CA409646286 rs1180368790	238	A>P		No	ClinGen TOPMed
CA409646280 rs1180368790	238	A>S		No	ClinGen TOPMed
rs545082053 CA317420169	239	M>I		No	ClinGen 1000Genomes
CA9959685 rs759591955	239	M>K		No	ClinGen ExAC TOPMed gnomAD
CA9959684 rs774447281	240	K>M		No	ClinGen ExAC gnomAD
CA9959683 rs766670309	240	K>N		No	ClinGen ExAC gnomAD
rs1441051379 CA409646163	242	L>M		No	ClinGen TOPMed
rs898499840 CA317420154	242	L>R		No	ClinGen gnomAD
rs141203356 CA9959680	243	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147379855 CA9959681	243	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1296430449 CA409646128	244	H>N		No	ClinGen gnomAD
rs1569011663 CA409646098	244	H>Q		No	ClinGen Ensembl
CA409646106 rs1164724326	244	H>R		No	ClinGen TOPMed
rs746920191 CA9959679	246	H>Q		No	ClinGen ExAC gnomAD
rs1569011654 CA409646039	247	I>T		No	ClinGen Ensembl
rs1380753153 CA409646030	248	L>M		No	ClinGen TOPMed gnomAD
CA9959677 rs775435329	249	A>V		No	ClinGen ExAC TOPMed gnomAD
rs771498785 CA9959676	250	L>Q		No	ClinGen ExAC gnomAD
CA317420119 rs148258053	251	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756868800 CA9959673	252	A>T		No	ClinGen ExAC TOPMed gnomAD
rs921418681 CA317420104	252	A>V		No	ClinGen TOPMed gnomAD
rs778094424 CA9959671	253	V>M		No	ClinGen ExAC TOPMed gnomAD
rs756711218 CA9959670	254	V>A		No	ClinGen ExAC gnomAD
rs753147867 CA9959669	255	S>T		No	ClinGen ExAC gnomAD
rs1194557374 CA409645933	255	S>Y		No	ClinGen TOPMed
rs755034061 CA409645922	256	V>L		No	ClinGen ExAC TOPMed gnomAD
rs755034061 CA9959667	256	V>M		No	ClinGen ExAC TOPMed gnomAD
CA9959665 rs766758186	257	G>A		No	ClinGen ExAC TOPMed gnomAD
CA409645868 rs1178659509	258	D>N		No	ClinGen TOPMed
rs1323195605 CA409645814	259	P>R		No	ClinGen gnomAD
rs370810132 CA9959663	259	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs760464024 CA9959661	260	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1189275777 CA409644205	262	I>V		No	ClinGen TOPMed
rs911987241 CA317419955	263	I>S		No	ClinGen TOPMed gnomAD
rs201712395 CA9959659	264	T>A		No	ClinGen ExAC gnomAD
rs149543998 CA9959658	264	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs149543998 CA409644167	264	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA409644104 rs1351898799	267	M>I		No	ClinGen gnomAD
rs986056991 CA317419913	267	M>V		No	ClinGen TOPMed
rs1336086959 CA409644082	268	A>V		No	ClinGen TOPMed
rs1209685896 CA409644045	270	G>D		No	ClinGen Ensembl
rs770625186 CA9959656	274	E>*		No	ClinGen ExAC gnomAD
rs748934769 CA9959655	277	R>C		No	ClinGen ExAC TOPMed gnomAD
CA317419906 rs748636967	277	R>H		No	ClinGen TOPMed gnomAD
CA317419905 rs748636967	277	R>L		No	ClinGen TOPMed gnomAD
rs1302188313 CA409642884	278	D>A		No	ClinGen gnomAD
CA9959654 rs770065818	278	D>H		No	ClinGen ExAC gnomAD
CA9959653 rs770065818	278	D>N		No	ClinGen ExAC gnomAD
CA317417604 rs376539060	280	D>N		No	ClinGen ESP TOPMed
rs781608510 CA9959631	281	E>K		No	ClinGen ExAC TOPMed gnomAD
CA317417591 rs1052546202	284	L>P		No	ClinGen TOPMed gnomAD
CA409642710 rs747527417	285	P>A		No	ClinGen ExAC gnomAD
CA9959629 rs747527417	285	P>S		No	ClinGen ExAC gnomAD
rs745905835 CA9959626	286	V>I		No	ClinGen ExAC TOPMed gnomAD
CA409642662 rs1378550327	287	S>L		No	ClinGen TOPMed gnomAD
rs751512181 CA409641289	293	A>P		No	ClinGen ExAC TOPMed gnomAD
rs751512181 CA409641287	293	A>S		No	ClinGen ExAC TOPMed gnomAD
CA9959620 rs751512181	293	A>T		No	ClinGen ExAC TOPMed gnomAD
rs766253414 CA9959619	293	A>V		No	ClinGen ExAC gnomAD
rs762479680 CA9959618	294	W>*		No	ClinGen ExAC gnomAD
rs1418281720 CA409641252	295	Q>*		No	ClinGen TOPMed
CA409641230 rs1426431185	296	V>A		No	ClinGen TOPMed
CA9959617 rs772688795	296	V>M		No	ClinGen ExAC gnomAD
rs764857884 CA9959616	298	E>D		No	ClinGen ExAC gnomAD
CA317417470 rs751128881	299	G>S		No	ClinGen Ensembl
rs1390603176 CA409641168	300	M>K		No	ClinGen TOPMed
CA409641170 rs1231901606	300	M>L		No	ClinGen gnomAD
rs1390603176 CA409641165	300	M>T		No	ClinGen TOPMed
rs1231901606 CA409641172	300	M>V		No	ClinGen gnomAD
rs776081884 CA9959614	305	S>L		No	ClinGen ExAC TOPMed gnomAD
rs747333280 CA9959612	308	Y>S		No	ClinGen ExAC gnomAD
CA409640987 rs1600932042	310	H>P		No	ClinGen Ensembl
rs757816269 CA9959609	311	R>Q		No	ClinGen ExAC gnomAD
rs763787101 CA9959610	311	R>W		No	ClinGen ExAC gnomAD
CA9959608 rs757484266	312	D>H		No	ClinGen ExAC gnomAD
CA9959607 rs757484266	312	D>N		No	ClinGen ExAC gnomAD
rs749526666 CA9959606	314	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9959604 rs754789545	315	A>T		No	ClinGen ExAC TOPMed gnomAD
rs751314030 CA9959603	316	R>G		No	ClinGen ExAC gnomAD
rs758319981 CA9959601	318	I>T		No	ClinGen ExAC gnomAD
CA9959599 rs764809002	320	V>I		No	ClinGen ExAC gnomAD
CA409640839 rs1276990817	321	G>E		No	ClinGen gnomAD
CA9959597 rs146772563	321	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA409640823 rs1313313572	322	E>Q		No	ClinGen TOPMed
rs763802091 CA9959596	323	N>I		No	ClinGen ExAC TOPMed gnomAD
rs775971928 CA9959594	325	L>F		No	ClinGen ExAC gnomAD
CA409640720 rs1341534402	326	C>Y		No	ClinGen gnomAD
CA317417292 rs80316561	327	K>E		No	ClinGen Ensembl
rs746368719 CA9959592	328	V>A		No	ClinGen ExAC TOPMed gnomAD
CA9959593 rs772761303	328	V>I		No	ClinGen ExAC TOPMed gnomAD
CA9959589 rs150231299	332	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA9959583 rs779822271	337	I>T		No	ClinGen ExAC TOPMed gnomAD
CA9959584 rs369669438	337	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs182578992 CA9959552	339	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA9959551 rs374047717	340	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA9959548 rs763366099	341	V>I		No	ClinGen ExAC TOPMed gnomAD
rs763366099 CA9959549	341	V>L		No	ClinGen ExAC TOPMed gnomAD
CA409660473 rs1454869486	345	H>R		No	ClinGen gnomAD
CA9959547 rs773642785	346	D>N		No	ClinGen ExAC gnomAD
CA9959546 rs532466456	347	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1215736207 CA409660408	349	I>M		No	ClinGen gnomAD
CA9959541 rs768732889	351	Y>*		No	ClinGen ExAC gnomAD
CA9959542 rs776873617	351	Y>C		No	ClinGen ExAC gnomAD
rs565400172 CA409660364	353	W>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs565400172 CA317474829	353	W>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs1229917946 CA409660346	354	T>A		No	ClinGen gnomAD
rs774007573 CA9959539	354	T>M		No	ClinGen ExAC TOPMed gnomAD
CA409660335 rs1428515280	355	A>T		No	ClinGen gnomAD
rs1186607901 CA409660318	356	P>R		No	ClinGen TOPMed
rs777792665 CA9959536	356	P>S		No	ClinGen ExAC gnomAD
rs368430973 CA9959534	358	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA9959532 rs754564942	359	L>F		No	ClinGen ExAC gnomAD
rs543530283 CA9959531	361	R>*		No	ClinGen ExAC TOPMed gnomAD
rs766658804 CA9959530	361	R>Q		No	ClinGen ExAC gnomAD
CA317474782 rs1017638027	362	G>S		No	ClinGen TOPMed gnomAD
CA9959527 rs200055159	363	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs151098954 CA9959528	363	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA409660225 rs1307754404	364	Y>*		No	ClinGen gnomAD
rs1206826625 CA409660235	364	Y>H		No	ClinGen gnomAD
CA317474768 rs969596794	367	K>E		No	ClinGen Ensembl
CA317474756 rs140052862	369	D>N		No	ClinGen ESP TOPMed gnomAD
CA9959525 rs200554407	370	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409660164 rs1309678530	371	W>C		No	ClinGen gnomAD
CA317474750 rs1026355138	373	F>L		No	ClinGen gnomAD
CA9959524 rs764438690	375	I>V		No	ClinGen ExAC TOPMed
rs760799474 CA9959523	377	L>R		No	ClinGen ExAC gnomAD
CA9959522 rs201701939	378	H>R		No	ClinGen ExAC gnomAD
CA409660126 rs1340419170	378	H>Y		No	ClinGen TOPMed
rs1231108499 CA409660119	379	E>*		No	ClinGen TOPMed
rs572731155 CA9959521	380	M>T		No	ClinGen 1000Genomes ExAC gnomAD
rs552657815 CA9959519	382	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1255810927 CA409660084	383	R>S		No	ClinGen gnomAD
CA317474702 rs934046426	386	V>M		No	ClinGen TOPMed
rs773312243 CA9959518	387	P>S		No	ClinGen ExAC TOPMed gnomAD
rs550929351 CA317474694	389	P>L		No	ClinGen gnomAD
rs1329617425 CA409660030	390	G>D		No	ClinGen gnomAD
CA409660024 rs1600930839	391	M>K		No	ClinGen Ensembl
CA409659985 rs1287473998	396	A>D		No	ClinGen gnomAD
rs1467916171 CA409659981	397	F>L		No	ClinGen gnomAD
CA9959486 rs756175863	399	R>K		No	ClinGen ExAC gnomAD
CA9959485 rs752790189	400	V>L		No	ClinGen ExAC gnomAD
CA9959483 rs200692634	402	A>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs576420713 CA9959484	402	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs543091157 CA9959481	403	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1485895188 CA409659939	404	Y>H		No	ClinGen gnomAD
CA317474320 rs892610965	405	R>C		No	ClinGen TOPMed gnomAD
CA409659931 rs1433764079	405	R>H		No	ClinGen gnomAD
CA409659932 rs892610965	405	R>S		No	ClinGen TOPMed gnomAD
rs998303469 CA317474306	407	P>A		No	ClinGen TOPMed
CA317474302 rs965549112	407	P>L		No	ClinGen TOPMed
rs138646992 CA9959480	411	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA409659891 rs1600930782	411	E>G		No	ClinGen Ensembl
rs776465810 CA9959479	413	P>L		No	ClinGen ExAC TOPMed gnomAD
rs776465810 CA409659878	413	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1326299859 CA409659879	413	P>S		No	ClinGen gnomAD
CA9959477 rs554434901	414	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409659865 rs775054676	415	S>R		No	ClinGen ExAC TOPMed gnomAD
CA9959475 rs536469490	416	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1461047699 CA409659831	420	M>I		No	ClinGen gnomAD
CA409659825 rs778476657	421	L>P		No	ClinGen ExAC TOPMed gnomAD
CA9959473 rs778476657	421	L>R		No	ClinGen ExAC TOPMed gnomAD
CA409659803 rs1295221716	424	W>*		No	ClinGen TOPMed
rs1475523042 CA409659781	427	D>E		No	ClinGen gnomAD
rs374216534 CA9959472	427	D>N		No	ClinGen ExAC TOPMed gnomAD
rs144883780 CA409659769	429	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA317474252 rs902422650	429	E>G		No	ClinGen TOPMed
rs201157910 CA9959470	429	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409659757 rs1447760296	431	R>K		No	ClinGen TOPMed gnomAD
CA409659756 rs1447760296	431	R>T		No	ClinGen TOPMed gnomAD
CA409659751 rs538978244	432	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9959468 rs538978244	432	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409659742 rs1250333003	433	C>F		No	ClinGen TOPMed
rs370867449 CA317474206	435	K>N		No	ClinGen Ensembl
rs781417520 CA9959467	435	K>R		No	ClinGen ExAC gnomAD
CA9959466 rs56145017 VAR_041761	436	A>T		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
CA9959465 rs369157704	437	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs761742593 CA317474187	438	R>L		No	ClinGen ExAC TOPMed gnomAD
rs761742593 CA9959463	438	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs766668416 CA9959464	438	R>W		No	ClinGen ExAC TOPMed gnomAD
CA317474161 rs865792103	440	R>K		No	ClinGen Ensembl
rs865792103 CA317474180	440	R>M		No	ClinGen Ensembl
rs115907462 CA9959462	441	L>V		No	ClinGen 1000Genomes ExAC
rs1406356639 CA409659684	443	S>R		No	ClinGen TOPMed
rs763997422 CA9959461	445	T>A		No	ClinGen ExAC gnomAD
rs1456419388 CA409659668	446	S>G		No	ClinGen TOPMed
CA317474145 rs374160715	448	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs767032287 CA9959458	448	E>D		No	ClinGen ExAC gnomAD
rs374160715 CA9959459	448	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1300419422 CA409659642	449	N>K		No	ClinGen TOPMed
rs61736385 CA9959457	450	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs61736385 CA409659636	450	P>R		No	ClinGen ESP ExAC TOPMed gnomAD

No associated diseases with Q13882

7 regional properties for Q13882

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	14 - 267	IPR000719
domain	POLO box domain	668 - 711	IPR000959
active_site	Tyrosine-protein kinase, active site	134 - 146	IPR008266
binding_site	Protein kinase, ATP binding site	20 - 43	IPR017441
domain	Plk4, C-terminal polo-box domain	655 - 736	IPR033696
domain	Plk4, second cryptic polo-box domain	496 - 600	IPR033698
domain	Plk4, first cryptic polo-box domain	379 - 496	IPR033699

Functions

		Description
EC Number	2.7.10.2	Protein-tyrosine kinases
Subcellular Localization	Cytoplasm Nucleus Cell projection, ruffle Membrane	Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate
PANTHER Family	PTHR24418	TYROSINE-PROTEIN KINASE
PANTHER Subfamily	PTHR24418:SF265	PROTEIN-TYROSINE KINASE 6
PANTHER Protein Class	non-receptor tyrosine protein kinase
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of cytoplasmic side of plasma membrane	The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ruffle	Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
non-membrane spanning protein tyrosine kinase activity	Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

16 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cellular response to retinoic acid	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
ERBB2 signaling pathway	The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
intestinal epithelial cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine.
negative regulation of growth	Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
negative regulation of protein tyrosine kinase activity	Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity.
positive regulation of cell cycle	Any process that activates or increases the rate or extent of progression through the cell cycle.
positive regulation of epidermal growth factor receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
positive regulation of neuron projection development	Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of tyrosine phosphorylation of STAT protein	Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
transmembrane receptor protein tyrosine kinase signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
tyrosine phosphorylation of STAT protein	The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

90 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A0JNB0	FYN	Tyrosine-protein kinase Fyn	Bos taurus (Bovine)	SS
Q0VBZ0	CSK	Tyrosine-protein kinase CSK	Bos taurus (Bovine)	SS
Q3ZC95	BTK	Tyrosine-protein kinase	Bos taurus (Bovine)	EV SS
P42683	LCK	Proto-oncogene tyrosine-protein kinase LCK	Gallus gallus (Chicken)	SS
P41239	CSK	Tyrosine-protein kinase CSK	Gallus gallus (Chicken)	SS
P00523	SRC	Proto-oncogene tyrosine-protein kinase Src	Gallus gallus (Chicken)	EV
Q02977	YRK	Proto-oncogene tyrosine-protein kinase Yrk	Gallus gallus (Chicken)	SS
Q8JH64	BTK	Tyrosine-protein kinase BTK	Gallus gallus (Chicken)	SS
P09324	YES1	Tyrosine-protein kinase Yes	Gallus gallus (Chicken)	SS
Q05876	FYN	Tyrosine-protein kinase Fyn	Gallus gallus (Chicken)	SS
Q75R65	JAK2	Tyrosine-protein kinase JAK2	Gallus gallus (Chicken)	SS
Q24592	hop	Tyrosine-protein kinase hopscotch	Drosophila melanogaster (Fruit fly)	PR
Q9V9J3	Src42A	Tyrosine-protein kinase Src42A	Drosophila melanogaster (Fruit fly)	SS
P00528	Src64B	Tyrosine-protein kinase Src64B	Drosophila melanogaster (Fruit fly)	SS
P08630	Btk	Tyrosine-protein kinase Btk	Drosophila melanogaster (Fruit fly)	SS
P23458	JAK1	Tyrosine-protein kinase JAK1	Homo sapiens (Human)	SS
O60674	JAK2	Tyrosine-protein kinase JAK2	Homo sapiens (Human)	EV
P52333	JAK3	Tyrosine-protein kinase JAK3	Homo sapiens (Human)	SS
P29597	TYK2	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (Human)	EV
P43405	SYK	Tyrosine-protein kinase SYK	Homo sapiens (Human)	EV
P43403	ZAP70	Tyrosine-protein kinase ZAP-70	Homo sapiens (Human)	EV
P09769	FGR	Tyrosine-protein kinase Fgr	Homo sapiens (Human)	SS
P07948	LYN	Tyrosine-protein kinase Lyn	Homo sapiens (Human)	SS
P06241	FYN	Tyrosine-protein kinase Fyn	Homo sapiens (Human)	SS
P12931	SRC	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (Human)	EV
P06239	LCK	Tyrosine-protein kinase Lck	Homo sapiens (Human)	EV
P51451	BLK	Tyrosine-protein kinase Blk	Homo sapiens (Human)	SS
P08631	HCK	Tyrosine-protein kinase HCK	Homo sapiens (Human)	EV
P07947	YES1	Tyrosine-protein kinase Yes	Homo sapiens (Human)	SS
P42685	FRK	Tyrosine-protein kinase FRK	Homo sapiens (Human)	EV
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Homo sapiens (Human)	EV
Q06187	BTK	Tyrosine-protein kinase BTK	Homo sapiens (Human)	EV
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (Human)	SS
P42680	TEC	Tyrosine-protein kinase Tec	Homo sapiens (Human)	SS
P42679	MATK	Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (Human)	SS
P41240	CSK	Tyrosine-protein kinase CSK	Homo sapiens (Human)	SS
Q14289	PTK2B	Protein-tyrosine kinase 2-beta	Homo sapiens (Human)	PR
Q05397	PTK2	Focal adhesion kinase 1	Homo sapiens (Human)	EV
Q13470	TNK1	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (Human)	PR
Q07912	TNK2	Activated CDC42 kinase 1	Homo sapiens (Human)	EV
P16591	FER	Tyrosine-protein kinase Fer	Homo sapiens (Human)	PR
Q6J9G0	STYK1	Tyrosine-protein kinase STYK1	Homo sapiens (Human)	PR
P42684	ABL2	Tyrosine-protein kinase ABL2	Homo sapiens (Human)	SS
P00519	ABL1	Tyrosine-protein kinase ABL1	Homo sapiens (Human)	EV
Q9R117	Tyk2	Non-receptor tyrosine-protein kinase TYK2	Mus musculus (Mouse)	SS
P08103	Hck	Tyrosine-protein kinase HCK	Mus musculus (Mouse)	SS
P16277	Blk	Tyrosine-protein kinase Blk	Mus musculus (Mouse)	SS
Q62270	Srms	Tyrosine-protein kinase Srms	Mus musculus (Mouse)	SS
P05480	Src	Proto-oncogene tyrosine-protein kinase Src	Mus musculus (Mouse)	EV
P14234	Fgr	Tyrosine-protein kinase Fgr	Mus musculus (Mouse)	SS
P35991	Btk	Tyrosine-protein kinase BTK	Mus musculus (Mouse)	EV
P41241	Csk	Tyrosine-protein kinase CSK	Mus musculus (Mouse)	EV
P25911	Lyn	Tyrosine-protein kinase Lyn	Mus musculus (Mouse)	EV
Q62137	Jak3	Tyrosine-protein kinase JAK3	Mus musculus (Mouse)	SS
Q62120	Jak2	Tyrosine-protein kinase JAK2	Mus musculus (Mouse)	EV
P06240	Lck	Proto-oncogene tyrosine-protein kinase LCK	Mus musculus (Mouse)	SS
P24604	Tec	Tyrosine-protein kinase Tec	Mus musculus (Mouse)	SS
Q04736	Yes1	Tyrosine-protein kinase Yes	Mus musculus (Mouse)	SS
P39688	Fyn	Tyrosine-protein kinase Fyn	Mus musculus (Mouse)	SS
P52332	Jak1	Tyrosine-protein kinase JAK1	Mus musculus (Mouse)	SS
Q03526	Itk	Tyrosine-protein kinase ITK/TSK	Mus musculus (Mouse)	SS
P41242	Matk	Megakaryocyte-associated tyrosine-protein kinase	Mus musculus (Mouse)	SS
Q922K9	Frk	Tyrosine-protein kinase FRK	Mus musculus (Mouse)	SS
Q64434	Ptk6	Protein-tyrosine kinase 6	Mus musculus (Mouse)	SS
A1Y2K1	FYN	Tyrosine-protein kinase Fyn	Sus scrofa (Pig)	SS
O19064	JAK2	Tyrosine-protein kinase JAK2	Sus scrofa (Pig)	SS
Q62662	Frk	Tyrosine-protein kinase FRK	Rattus norvegicus (Rat)	SS
Q62844	Fyn	Tyrosine-protein kinase Fyn	Rattus norvegicus (Rat)	SS
Q07014	Lyn	Tyrosine-protein kinase Lyn	Rattus norvegicus (Rat)	SS
P50545	Hck	Tyrosine-protein kinase HCK	Rattus norvegicus (Rat)	SS
Q9WUD9	Src	Proto-oncogene tyrosine-protein kinase Src	Rattus norvegicus (Rat)	SS
Q01621	Lck	Proto-oncogene tyrosine-protein kinase LCK	Rattus norvegicus (Rat)	SS
Q6P6U0	Fgr	Tyrosine-protein kinase Fgr	Rattus norvegicus (Rat)	SS
Q62689	Jak2	Tyrosine-protein kinase JAK2	Rattus norvegicus (Rat)	SS
Q63272	Jak3	Tyrosine-protein kinase JAK3	Rattus norvegicus (Rat)	SS
P32577	Csk	Tyrosine-protein kinase CSK	Rattus norvegicus (Rat)	SS
P41243	Matk	Megakaryocyte-associated tyrosine-protein kinase	Rattus norvegicus (Rat)	SS
F1LM93	Yes1	Tyrosine-protein kinase Yes	Rattus norvegicus (Rat)	SS
O45539	src-2	Tyrosine protein-kinase src-2	Caenorhabditis elegans	SS
G5ECJ6	csk-1	Tyrosine-protein kinase csk-1	Caenorhabditis elegans	SS
G5EE56	src-1	Tyrosine protein-kinase src-1	Caenorhabditis elegans	SS
F4JTP5	STY46	Serine/threonine-protein kinase STY46	Arabidopsis thaliana (Mouse-ear cress)	PR
O22558	STY8	Serine/threonine-protein kinase STY8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q2MHE4	HT1	Serine/threonine/tyrosine-protein kinase HT1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8RWL6	STY17	Serine/threonine-protein kinase STY17	Arabidopsis thaliana (Mouse-ear cress)	PR
A1A5H8	yes1	Tyrosine-protein kinase yes	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
F1RDG9	fynb	Tyrosine-protein kinase fynb	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
O12990	jak1	Tyrosine-protein kinase JAK1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q1JPZ3	src	Proto-oncogene tyrosine-protein kinase Src	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q6EWH2	fyna	Tyrosine-protein kinase fyna	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MVSRDQAHLG	PKYVGLWDFK	SRTDEELSFR	AGDVFHVARK	EEQWWWATLL	DEAGGAVAQG
70	80	90	100	110	120
YVPHNYLAER	ETVESEPWFF	GCISRSEAVR	RLQAEGNATG	AFLIRVSEKP	SADYVLSVRD
130	140	150	160	170	180
TQAVRHYKIW	RRAGGRLHLN	EAVSFLSLPE	LVNYHRAQSL	SHGLRLAAPC	RKHEPEPLPH
190	200	210	220	230	240
WDDWERPREE	FTLCRKLGSG	YFGEVFEGLW	KDRVQVAIKV	ISRDNLLHQQ	MLQSEIQAMK
250	260	270	280	290	300
KLRHKHILAL	YAVVSVGDPV	YIITELMAKG	SLLELLRDSD	EKVLPVSELL	DIAWQVAEGM
310	320	330	340	350	360
CYLESQNYIH	RDLAARNILV	GENTLCKVGD	FGLARLIKED	VYLSHDHNIP	YKWTAPEALS
370	380	390	400	410	420
RGHYSTKSDV	WSFGILLHEM	FSRGQVPYPG	MSNHEAFLRV	DAGYRMPCPL	ECPPSVHKLM
430	440	450
LTCWCRDPEQ	RPCFKALRER	LSSFTSYENP	T