Q13625

EV
Gene name
TP53BP2 (ASPP2, BBP)
Protein name
Apoptosis-stimulating of p53 protein 2
Names
Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51, Tumor suppressor p53-binding protein 2, 53BP2, p53-binding protein 2, p53BP2
Species
Homo sapiens (Human)
KEGG Pathway
hsa:7159
EC number
Protein Class
APOPTOSIS-STIMULATING OF P53 PROTEIN (PTHR24131)

Descriptions

ASPP2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response. The C terminus of ASPP2 contains ankyrin (Ank) repeats and a SH3 domain, which mediate its interactions with numerous partner proteins such as p53, NFkappaB, and Bcl2. ASPP2 also contains a proline-rich domain, which interacts with the Ank and SH3 domains for autoinhibition.

Autoinhibitory domains (AIDs)

693-901 (Proline-rich domain) EV

Target domain

919-1119 (Ank-SH3 domains)

Relief mechanism

Assay

Deletion assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q13625

Entry ID Method Resolution Chain Position Source
1YCS X-ray 220 A B 892-1126 PDB
2UWQ NMR - A 1-83 PDB
4A63 X-ray 227 A B/D/F/H/J/L 892-1128 PDB
4IRV X-ray 204 A E/F/G/H 726-782 PDB
6GHM X-ray 215 A C/D 920-1128 PDB
6HKP X-ray 190 A S 970-992 PDB
AF-Q13625-F1 Predicted AlphaFoldDB

No variants for Q13625

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q13625

No associated diseases with Q13625

2 regional properties for Q13625

Type Name Position InterPro Accession
domain Sec7 domain 54 - 243 IPR000904
domain Pleckstrin homology domain 259 - 378 IPR001849

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, perinuclear region
  • Nucleus
  • Predominantly found in the perinuclear region
  • Some small fraction is nuclear
  • Sequester in the cytoplasm on overexpression of DDX42
PANTHER Family PTHR24131 APOPTOSIS-STIMULATING OF P53 PROTEIN
PANTHER Subfamily PTHR24131:SF8 APOPTOSIS-STIMULATING OF P53 PROTEIN 2
PANTHER Protein Class protein-binding activity modulator
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

4 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
NF-kappaB binding Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
p53 binding Binding to one of the p53 family of proteins.
SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

5 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
intrinsic apoptotic signaling pathway by p53 class mediator The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
negative regulation of cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
positive regulation of execution phase of apoptosis Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8CG79 Tp53bp2 Apoptosis-stimulating of p53 protein 2 Mus musculus (Mouse) SS
10 20 30 40 50 60
MMPMFLTVYL SNNEQHFTEV PVTPETICRD VVDLCKEPGE SDCHLAEVWC GSERPVADNE
70 80 90 100 110 120
RMFDVLQRFG SQRNEVRFFL RHERPPGRDI VSGPRSQDPS LKRNGVKVPG EYRRKENGVN
130 140 150 160 170 180
SPRMDLTLAE LQEMASRQQQ QIEAQQQLLA TKEQRLKFLK QQDQRQQQQV AEQEKLKRLK
190 200 210 220 230 240
EIAENQEAKL KKVRALKGHV EQKRLSNGKL VEEIEQMNNL FQQKQRELVL AVSKVEELTR
250 260 270 280 290 300
QLEMLKNGRI DSHHDNQSAV AELDRLYKEL QLRNKLNQEQ NAKLQQQREC LNKRNSEVAV
310 320 330 340 350 360
MDKRVNELRD RLWKKKAALQ QKENLPVSSD GNLPQQAASA PSRVAAVGPY IQSSTMPRMP
370 380 390 400 410 420
SRPELLVKPA LPDGSLVIQA SEGPMKIQTL PNMRSGAASQ TKGSKIHPVG PDWSPSNADL
430 440 450 460 470 480
FPSQGSASVP QSTGNALDQV DDGEVPLREK EKKVRPFSMF DAVDQSNAPP SFGTLRKNQS
490 500 510 520 530 540
SEDILRDAQV ANKNVAKVPP PVPTKPKQIN LPYFGQTNQP PSDIKPDGSS QQLSTVVPSM
550 560 570 580 590 600
GTKPKPAGQQ PRVLLSPSIP SVGQDQTLSP GSKQESPPAA AVRPFTPQPS KDTLLPPFRK
610 620 630 640 650 660
PQTVAASSIY SMYTQQQAPG KNFQQAVQSA LTKTHTRGPH FSSVYGKPVI AAAQNQQQHP
670 680 690 700 710 720
ENIYSNSQGK PGSPEPETEP VSSVQENHEN ERIPRPLSPT KLLPFLSNPY RNQSDADLEA
730 740 750 760 770 780
LRKKLSNAPR PLKKRSSITE PEGPNGPNIQ KLLYQRTTIA AMETISVPSY PSKSASVTAS
790 800 810 820 830 840
SESPVEIQNP YLHVEPEKEV VSLVPESLSP EDVGNASTEN SDMPAPSPGL DYEPEGVPDN
850 860 870 880 890 900
SPNLQNNPEE PNPEAPHVLD VYLEEYPPYP PPPYPSGEPE GPGEDSVSMR PPEITGQVSL
910 920 930 940 950 960
PPGKRTNLRK TGSERIAHGM RVKFNPLALL LDSSLEGEFD LVQRIIYEVD DPSLPNDEGI
970 980 990 1000 1010 1020
TALHNAVCAG HTEIVKFLVQ FGVNVNAADS DGWTPLHCAA SCNNVQVCKF LVESGAAVFA
1030 1040 1050 1060 1070 1080
MTYSDMQTAA DKCEEMEEGY TQCSQFLYGV QEKMGIMNKG VIYALWDYEP QNDDELPMKE
1090 1100 1110 1120
GDCMTIIHRE DEDEIEWWWA RLNDKEGYVP RNLLGLYPRI KPRQRSLA