AiPD: Autoinhibited Protein Database

Q13568

Gene name	IRF5
Protein name	Interferon regulatory factor 5
Names	IRF-5
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3663
EC number
Protein Class	INTERFERON REGULATORY FACTOR (PTHR11949)

Descriptions

Transcription factors of the interferon regulatory factor (IRF) family have been identified as critical mediators of early inflammatory gene transcription in infected cells. IRF-5 serves as a direct transducer of virus-mediated signaling. Deletion of C-terminal autoinhibitory region turns IRF5 into an active form.

Autoinhibitory domains (AIDs)

Target domain	10-123 (DNA-binding domain)
Relief mechanism	PTM
Assay	Deletion assay, Mutagenesis experiment

AID

449-499 (Autoinhibitory region)

Target domain

10-123 (DNA-binding domain)

Relief mechanism

PTM (Phosphorylation of Ser residues near autoinhibitory region)

Assay

Deletion assay, Mutagenesis experiment

Accessory elements

No accessory elements

References

Barnes BJ et al. (2002) "Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes", Molecular and cellular biology, 22, 5721-40

Autoinhibited structure

Activated structure

2 structures for Q13568

Entry ID	Method	Resolution	Chain	Position	Source
3DSH	X-ray	200 A	A	232-477	PDB
AF-Q13568-F1	Predicted				AlphaFoldDB

321 variants for Q13568

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs761713287 CA4477384	5	I>T	No	ClinGen ExAC gnomAD
rs148928811 CA4477385	6	P>A	No	ClinGen ESP ExAC TOPMed gnomAD
rs1470509293 CA369228069	7	V>A	No	ClinGen gnomAD
CA4477386 rs750224674	10	T>P	No	ClinGen ExAC gnomAD
rs1326907688 CA369228138	10	T>S	No	ClinGen gnomAD
CA166227784 rs760492792	11	P>A	No	ClinGen ExAC gnomAD
rs200486000 CA166227793	11	P>L	No	ClinGen ExAC TOPMed gnomAD
CA4477389 rs200486000	11	P>Q	No	ClinGen ExAC TOPMed gnomAD
rs200486000 CA4477388	11	P>R	No	ClinGen ExAC TOPMed gnomAD
CA4477387 rs760492792	11	P>S	No	ClinGen ExAC gnomAD
rs752820843 CA4477393	12	P>L	No	ClinGen ExAC gnomAD
rs374100066 CA4477392	12	P>S	No	ClinGen ESP ExAC gnomAD
CA166227818 rs372781024	13	R>C	No	ClinGen TOPMed gnomAD
rs372781024 CA166227815	13	R>G	No	ClinGen TOPMed gnomAD
CA4477394 rs367931039	13	R>H	No	ClinGen ESP ExAC TOPMed gnomAD
rs367931039 CA369228224	13	R>P	No	ClinGen ESP ExAC TOPMed gnomAD
CA166227826 rs887623136	14	R>H	No	ClinGen TOPMed gnomAD
CA369228251 rs887623136	14	R>P	No	ClinGen TOPMed gnomAD
CA4477396 rs142800920	15	V>M	No	ClinGen ESP ExAC TOPMed gnomAD
CA369228303 rs1292749792	16	R>Q	No	ClinGen gnomAD
CA369228289 rs757578104	16	R>W	No	ClinGen ExAC gnomAD
CA369228443 rs1585294296	22	V>G	No	ClinGen Ensembl
rs1585294317 CA369228496	24	Q>P	No	ClinGen Ensembl
CA369228535 rs1276578665	25	V>A	No	ClinGen gnomAD
CA369228577 rs1585294348	27	S>T	No	ClinGen Ensembl
rs1181002220 CA369228596	28	C>R	No	ClinGen gnomAD
rs748883758 CA369228606	28	C>S	No	ClinGen ExAC TOPMed gnomAD
rs748883758 CA4477399	28	C>Y	No	ClinGen ExAC TOPMed gnomAD
rs1585294376 CA369228654	30	Y>H	No	ClinGen Ensembl
rs1030539169 CA166227852	35	W>C	No	ClinGen Ensembl
rs151211302 CA166227848	35	W>R	No	ClinGen ESP
CA369228858 rs1585294415	36	V>G	No	ClinGen Ensembl
rs773798984 CA4477401	36	V>I	No	ClinGen ExAC gnomAD
rs1322489944 CA369228880	37	N>D	No	ClinGen TOPMed gnomAD
CA369228912 rs140402357	37	N>K	No	ClinGen ESP ExAC TOPMed gnomAD
CA4477405 rs548286958 CA4477403	38	G>R	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs548286958 CA4477404	38	G>W	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1221498708 CA369228976	39	E>D	No	ClinGen gnomAD
CA4477406 rs780812353	40	K>N	No	ClinGen ExAC TOPMed gnomAD
rs777003579 CA4477407	41	K>Q	No	ClinGen ExAC TOPMed gnomAD
CA369229249 rs1454617138	47	W>*	No	ClinGen gnomAD
CA369229223 rs1334561980	47	W>*	No	ClinGen gnomAD
rs865918118 CA166227903	50	A>T	No	ClinGen Ensembl
CA166227913 rs558349156	56	S>R	No	ClinGen Ensembl
rs764541149 CA4477412	58	D>H	No	ClinGen ExAC gnomAD
CA4477414 rs371958768	59	G>R	No	ClinGen ESP ExAC TOPMed gnomAD
CA4477415 rs201487893	60	D>G	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA369229613 rs1444108237	61	N>D	No	ClinGen gnomAD
rs777397050 CA4477441	66	A>S	No	ClinGen ExAC gnomAD
CA4477442 rs746489290	70	E>K	No	ClinGen ExAC gnomAD
rs1161364866 CA369231526	74	Y>*	No	ClinGen gnomAD
CA4477445 rs745693125	76	E>K	No	ClinGen ExAC gnomAD
rs775591029 CA4477447	78	V>M	No	ClinGen ExAC gnomAD
CA166229962 rs751739762	79	D>V	No	ClinGen Ensembl
CA369231704 rs1378246188	82	D>N	No	ClinGen TOPMed
CA4477450 rs774453718	83	P>L	No	ClinGen ExAC gnomAD
CA369231761 rs1214870597	84	A>T	No	ClinGen Ensembl
rs1307003258 CA369231836	86	W>*	No	ClinGen gnomAD
rs1334689817 CA369231842	86	W>C	No	ClinGen gnomAD
rs1436935701 CA369231918	93	A>T	No	ClinGen TOPMed
rs1299095250 CA369231957	97	S>T	No	ClinGen TOPMed gnomAD
rs750886286 CA4477453	98	R>Q	No	ClinGen ExAC gnomAD
rs761029569 CA4477454	99	D>N	No	ClinGen ExAC gnomAD
rs1458005638 CA369232021	101	R>C	No	ClinGen TOPMed
CA4477455 rs766706257	101	R>H	No	ClinGen ExAC TOPMed gnomAD
CA4477457 rs758112859	103	I>V	No	ClinGen ExAC TOPMed gnomAD
rs751140082 CA4477459	105	D>H	No	ClinGen ExAC gnomAD
CA4477463 rs769606450	108	R>Q	No	ClinGen ExAC gnomAD
rs745742459 CA4477462	108	R>W	No	ClinGen ExAC TOPMed gnomAD
rs779968332 CA369232189	110	M>K	No	ClinGen ExAC TOPMed gnomAD
rs779968332 CA4477464	110	M>R	No	ClinGen ExAC TOPMed gnomAD
CA369232173 rs1463424335	110	M>V	No	ClinGen gnomAD
rs749003004 CA4477465	114	P>L	No	ClinGen ExAC gnomAD
CA369232265 rs1395745193	114	P>S	No	ClinGen gnomAD
rs928578383 CA166230068	120	V>F	No	ClinGen TOPMed gnomAD
CA369232378 rs928578383	120	V>I	No	ClinGen TOPMed gnomAD
rs748258245 CA4477468	122	S>C	No	ClinGen ExAC gnomAD
CA4477470 rs773718383	123	N>S	No	ClinGen ExAC gnomAD
rs1321363449 CA369232462	124	G>S	No	ClinGen TOPMed
rs1480615573 CA369232471	124	G>V	No	ClinGen gnomAD
rs1342218209 CA369232479	125	P>L	No	ClinGen gnomAD
rs1196812486 CA369232497	127	P>S	No	ClinGen gnomAD
CA369232593 rs1487008870	130	S>Y	No	ClinGen gnomAD
rs1186878831 CA369232613	131	Q>L	No	ClinGen gnomAD
rs749129718 CA369232622	132	P>A	No	ClinGen ExAC gnomAD
rs749129718 CA4477483	132	P>S	No	ClinGen ExAC gnomAD
rs749129718 CA4477482	132	P>T	No	ClinGen ExAC gnomAD
rs779108354 CA4477484	133	P>S	No	ClinGen ExAC gnomAD
rs1429320460 CA369232672	135	D>Y	No	ClinGen TOPMed gnomAD
CA369232706 rs1452298748	137	S>A	No	ClinGen TOPMed
rs1173395501 CA369232712	137	S>F	No	ClinGen gnomAD
rs943756715 CA166230436	138	F>Y	No	ClinGen TOPMed
CA4477486 rs772266449	141	G>R	No	ClinGen ExAC gnomAD
CA369232823 rs1203783371	142	E>D	No	ClinGen gnomAD
CA4477488 rs773344520	143	E>G	No	ClinGen ExAC gnomAD
CA369232855 rs1161955438	144	E>A	No	ClinGen TOPMed
rs747040494 CA4477490	144	E>K	No	ClinGen ExAC gnomAD
CA166230453 rs371335617	147	E>D	No	ClinGen ESP TOPMed gnomAD
CA4477511 rs746421090	150	L>R	No	ClinGen ExAC TOPMed gnomAD
CA369235076 rs1159405444	150	L>V	No	ClinGen TOPMed gnomAD
CA369235204 rs770420647 CA4477512	153	M>I	No	ClinGen ExAC TOPMed gnomAD
CA369235307 rs1366590423	156	S>N	No	ClinGen gnomAD
CA4477514 rs763385119	158	S>R	No	ClinGen ExAC gnomAD
rs375199151 CA4477515	159	L>F	No	ClinGen ESP ExAC gnomAD
CA4477516 rs772699436	160	T>I	No	ClinGen ExAC gnomAD
CA4477560 rs370799034	164	K>N	No	ClinGen ESP ExAC TOPMed gnomAD
rs374213013 CA4477562	165	W>R	No	ClinGen ESP ExAC TOPMed gnomAD
rs764065524 CA4477567	166	P>L	No	ClinGen ExAC TOPMed gnomAD
CA4477569 rs761623021	167	P>L	No	ClinGen ExAC gnomAD
CA369236474 rs1332385774	168	T>A	No	ClinGen TOPMed
CA166231083 rs566635242	170	Q>R	No	ClinGen 1000Genomes TOPMed
rs767661654 CA4477577	171	P>L	No	ClinGen ExAC gnomAD
RCV000947069 rs60344245	175	R>missing	No	ClinVar dbSNP
rs113806178 CA369236677	175	R>L	No	ClinGen 1000Genomes TOPMed gnomAD
rs113806178 CA4477582	175	R>Q	No	ClinGen 1000Genomes TOPMed gnomAD
CA369236672 rs1175572430	175	R>W	No	ClinGen TOPMed gnomAD
CA4477585 rs750603767	176	P>L	No	ClinGen ExAC TOPMed gnomAD
rs1467003035 CA369236706	177	P>H	No	ClinGen TOPMed
CA369236716 rs1252861392	178	T>A	No	ClinGen TOPMed
rs1284336147 CA369236743	181	P>L	No	ClinGen gnomAD
CA4477593 rs753962224	183	T>I	No	ClinGen ExAC TOPMed
rs2935017 CA166231173	185	Q>R	No	ClinGen TOPMed
CA4477594 rs367880963	186	P>L	No	ClinGen ESP ExAC TOPMed gnomAD
rs1266698537 CA369236767	186	P>T	No	ClinGen gnomAD
rs1364599747 CA369236774	187	P>S	No	ClinGen gnomAD
rs371725551 CA4477598	188	V>L	No	ClinGen ESP ExAC TOPMed gnomAD
CA4477597 rs371725551	188	V>M	No	ClinGen ESP ExAC TOPMed gnomAD
CA369236797 rs1010959827	191	G>A	No	ClinGen TOPMed gnomAD
CA166231198 rs1010959827	191	G>V	No	ClinGen TOPMed gnomAD
CA4477599 rs201659973	192	P>L	No	ClinGen ESP ExAC TOPMed gnomAD
rs1292846432 CA369236800	192	P>S	No	ClinGen gnomAD
CA369236807 rs1375617948	193	P>L	No	ClinGen gnomAD
CA4477600 rs201243166	193	P>S	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4477601 rs368724832	194	A>S	No	ClinGen ESP ExAC gnomAD
rs1362066496 CA369236817	195	P>L	No	ClinGen gnomAD
rs748777671 CA4477602	195	P>S	No	ClinGen ExAC gnomAD
CA369236821 rs1408977255	196	D>A	No	ClinGen TOPMed
CA369236818 rs1396921221	196	D>N	No	ClinGen TOPMed
CA369236826 rs1265344093	197	P>T	No	ClinGen gnomAD
rs372467866 CA4477603	198	S>G	No	ClinGen ESP ExAC TOPMed gnomAD
rs1197619100 CA369236835	198	S>T	No	ClinGen gnomAD
CA369236841 rs1238880986	199	P>S	No	ClinGen gnomAD
CA369236854 rs556267493	201	A>G	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA369236851 rs1177039921	201	A>T	No	ClinGen gnomAD
rs556267493 CA4477604	201	A>V	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4477606 rs767281005	202	P>L	No	ClinGen ExAC gnomAD
CA4477605 rs761515288	202	P>S	No	ClinGen ExAC TOPMed gnomAD
CA369236860 rs1366631451	203	P>A	No	ClinGen gnomAD
rs1366631451 CA369236861	203	P>S	No	ClinGen gnomAD
rs200860703 CA4477607	204	P>A	No	ClinGen ESP ExAC TOPMed gnomAD
rs1398955976 CA369236869	204	P>L	No	ClinGen gnomAD
rs200860703 CA369236865	204	P>T	No	ClinGen ESP ExAC TOPMed gnomAD
CA369236870 rs1444053978	205	G>S	No	ClinGen gnomAD
rs1468801017 CA369236882	206	N>K	No	ClinGen TOPMed
rs1585306955 CA369236880	206	N>T	No	ClinGen Ensembl
CA369236884 rs1338265590	207	P>T	No	ClinGen gnomAD
rs761045410 CA4477608	209	G>D	No	ClinGen ExAC gnomAD
CA369236923 rs368258981	212	E>D	No	ClinGen ESP ExAC TOPMed gnomAD
CA4477610 rs754018091	213	L>I	No	ClinGen ExAC gnomAD
rs765669086 CA4477612	217	V>I	No	ClinGen ExAC TOPMed gnomAD
CA369236949 rs765669086	217	V>L	No	ClinGen ExAC TOPMed gnomAD
CA166231293 rs866348379	219	E>*	No	ClinGen Ensembl
CA4477613 rs753191121	219	E>D	No	ClinGen ExAC gnomAD
CA369236966 rs1253823650	220	P>T	No	ClinGen gnomAD
rs904357361 CA166231297	223	L>P	No	ClinGen TOPMed gnomAD
rs1221511791 CA369236987	224	P>A	No	ClinGen TOPMed
CA369236988 rs1221511791	224	P>S	No	ClinGen TOPMed
rs1585307135 CA369236993	225	A>T	No	ClinGen Ensembl
rs145868185 CA4477614	225	A>V	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369237000 rs1284381208	226	S>G	No	ClinGen TOPMed
CA369237013 rs1406341251	228	P>S	No	ClinGen gnomAD
CA369237011 rs1406341251	228	P>T	No	ClinGen gnomAD
CA4477618 rs779635934	229	P>L	No	ClinGen ExAC TOPMed gnomAD
rs554490940 CA4477617	229	P>T	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4477619 rs748782161	230	A>G	No	ClinGen ExAC TOPMed gnomAD
CA369237021 rs1307388841	230	A>T	No	ClinGen Ensembl
CA369237024 rs748782161	230	A>V	No	ClinGen ExAC TOPMed gnomAD
rs1279366922 CA369237029	231	G>D	No	ClinGen gnomAD
CA369237038 rs1265090041	232	E>D	No	ClinGen gnomAD
rs778726588 CA4477621	232	E>K	No	ClinGen ExAC gnomAD
rs1027912590 CA166231338	233	Q>E	No	ClinGen gnomAD
rs748171902 CA4477622	236	P>S	No	ClinGen ExAC gnomAD
rs760523827 CA4477625	242	P>H	No	ClinGen ExAC gnomAD
rs572647299 CA4477626	243	H>N	No	ClinGen 1000Genomes ExAC gnomAD
CA369237205 rs1476834253	244	M>I	No	ClinGen gnomAD
rs965400346 CA166231396	244	M>V	No	ClinGen TOPMed gnomAD
rs776950755 CA369237238	247	L>V	No	ClinGen ExAC TOPMed gnomAD
rs1308209829 CA369237354	250	L>P	No	ClinGen gnomAD
rs772184409 CA4477643	253	K>N	No	ClinGen ExAC gnomAD
rs747580155 CA4477642	253	K>R	No	ClinGen ExAC gnomAD
CA369237467 rs1266492925	257	R>W	No	ClinGen gnomAD
rs1409303747 CA369237479	258	G>R	No	ClinGen TOPMed
rs538018492 CA166231648	259	R>L	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs538018492 CA4477644	259	R>Q	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1457899008 CA369237514	260	P>L	No	ClinGen TOPMed gnomAD
CA166231664 rs770794321	262	R>L	No	ClinGen ExAC gnomAD
CA4477646 rs770794321	262	R>Q	No	ClinGen ExAC gnomAD
rs746828797 CA4477645	262	R>W	No	ClinGen ExAC gnomAD
rs984670222 CA166231681	266	I>N	No	ClinGen TOPMed
CA4477648 rs149233628	268	N>K	No	ClinGen ESP ExAC TOPMed gnomAD
rs1418754603 CA369237682	270	H>L	No	ClinGen gnomAD
CA369237687 rs1405306619	270	H>Q	No	ClinGen gnomAD
rs769876611 CA4477649	270	H>Y	No	ClinGen ExAC gnomAD
rs775692797 CA4477650	273	R>L	No	ClinGen ExAC gnomAD
rs764619615 CA4477652	278	Q>P	No	ClinGen ExAC gnomAD
rs751999369 CA4477653	279	L>M	No	ClinGen ExAC TOPMed gnomAD
rs1226564674 CA369237827	281	A>D	No	ClinGen gnomAD
rs767924203 CA166231774	283	Q>H	No	ClinGen ExAC TOPMed gnomAD
CA369237861 rs1264251096	284	E>A	No	ClinGen TOPMed
rs1365703320 CA369237855	284	E>K	No	ClinGen TOPMed gnomAD
rs1197502142 CA369237878	285	Q>H	No	ClinGen gnomAD
rs1585308306 CA369237890	286	V>G	No	ClinGen Ensembl
CA4477657 rs750746175	286	V>M	No	ClinGen ExAC gnomAD
rs1423596481 CA369237964	292	I>K	No	ClinGen gnomAD
rs754695057 CA4477658	293	S>I	No	ClinGen ExAC gnomAD
rs1472734719 CA369237998	295	E>K	No	ClinGen gnomAD
CA369238016 rs1321467367	296	Q>E	No	ClinGen TOPMed
CA4477661 rs757940206	298	R>C	No	ClinGen ExAC gnomAD
rs144448991 CA4477662	298	R>H	No	ClinGen ESP ExAC TOPMed gnomAD
rs745628783 CA4477666	304	D>G	No	ClinGen ExAC TOPMed gnomAD
rs781081333 CA4477665	304	D>N	No	ClinGen ExAC TOPMed gnomAD
CA4477668 rs775538341	309	K>R	No	ClinGen ExAC gnomAD
rs368255860 CA4477669	311	R>H	No	ClinGen ESP ExAC TOPMed gnomAD
rs866301843 CA166231820	311	R>S	No	ClinGen Ensembl
CA369238235 rs1467820609	312	F>C	No	ClinGen TOPMed
rs1279982666 CA369238265	314	T>M	No	ClinGen gnomAD
rs1159471524 CA369238284	316	Q>*	No	ClinGen TOPMed
rs1053330362 CA166231833	319	D>N	No	ClinGen TOPMed gnomAD
rs1325165297 CA369238332	320	V>F	No	ClinGen TOPMed gnomAD
CA166231838 rs777216993	323	R>C	No	ClinGen gnomAD
rs762371242 CA4477672	324	G>R	No	ClinGen ExAC gnomAD
CA369238418 rs1265972336	330	Q>L	No	ClinGen gnomAD
CA369238428 rs1243979492	331	G>S	No	ClinGen gnomAD
CA369238464 rs1244343589	333	D>G	No	ClinGen TOPMed
CA4477675 rs767365191	338	R>C	No	ClinGen ExAC TOPMed gnomAD
CA4477677 rs752223694	338	R>H	No	ClinGen ExAC gnomAD
CA4477676 rs767365191	338	R>S	No	ClinGen ExAC TOPMed gnomAD
CA369238599 rs1563078240	342	C>Y	No	ClinGen Ensembl
CA369238671 rs1484834772	345	F>Y	No	ClinGen TOPMed gnomAD
CA166231880 rs944583782	346	W>R	No	ClinGen TOPMed
rs556983422 CA166231889	347	S>N	No	ClinGen gnomAD
CA369238794 rs1383231055	350	C>F	No	ClinGen TOPMed
CA369238874 rs1412540759	354	H>L	No	ClinGen gnomAD
CA4477680 rs751082848	355	D>E	No	ClinGen ExAC TOPMed gnomAD
CA4477681 rs757314255	360	P>S	No	ClinGen ExAC TOPMed gnomAD
rs745711094 CA4477683	363	R>Q	No	ClinGen ExAC TOPMed gnomAD
rs780339569 CA4477685	365	V>G	No	ClinGen ExAC gnomAD
CA369239241 rs1209164836	370	F>L	No	ClinGen gnomAD
CA369239339 rs1216544451	373	E>V	No	ClinGen gnomAD
CA369239439 rs1439528024	377	N>S	No	ClinGen TOPMed
rs766593500 CA4477694	380	I>T	No	ClinGen ExAC TOPMed gnomAD
rs763816650 CA4477697	383	Q>K	No	ClinGen ExAC gnomAD
rs1296163261 CA369239618	384	K>Q	No	ClinGen TOPMed
CA4477698 rs751137748	386	Q>H	No	ClinGen ExAC
CA4477699 rs761192295	387	T>A	No	ClinGen ExAC gnomAD
CA4477700 rs554813398	389	T>I	No	ClinGen 1000Genomes ExAC gnomAD
rs750273513 CA4477701	390	P>L	No	ClinGen ExAC gnomAD
CA369239697 rs1458362719	390	P>S	No	ClinGen gnomAD
rs1387973474 CA369239717	391	P>L	No	ClinGen TOPMed gnomAD
rs1448410615 CA369239723	392	P>A	No	ClinGen gnomAD
rs993891504 CA166232083	392	P>H	No	ClinGen Ensembl
rs756068460 CA369239749 CA369239747	393	F>L	No	ClinGen ExAC TOPMed gnomAD
CA369239760 rs1424905278	394	E>K	No	ClinGen TOPMed
rs576256045 CA4477705	396	F>I	No	ClinGen 1000Genomes ExAC gnomAD
CA166232103 rs866806873	400	G>E	No	ClinGen Ensembl
rs369114262 CA4477706	406	R>C	No	ClinGen ESP ExAC TOPMed gnomAD
CA4477707 rs201569154	406	R>H	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1382042040 CA369240025	408	P>S	No	ClinGen gnomAD
CA4477709 rs771977004	409	R>*	No	ClinGen ExAC gnomAD
CA4477710 rs565075578	409	R>Q	No	ClinGen 1000Genomes ExAC gnomAD
CA369240048 rs1450583194	410	E>K	No	ClinGen TOPMed gnomAD
CA369240051 rs1450583194	410	E>Q	No	ClinGen TOPMed gnomAD
CA4477711 rs747537470	411	K>R	No	ClinGen ExAC gnomAD
rs777185406 CA4477713	412	K>Q	No	ClinGen ExAC TOPMed gnomAD
CA369240153 rs1585309647	414	I>M	No	ClinGen Ensembl
CA369240146 rs1366684252	414	I>T	No	ClinGen gnomAD
rs774084347 CA4477716	416	V>E	No	ClinGen ExAC gnomAD
rs960473207 CA166232156	417	Q>*	No	ClinGen TOPMed gnomAD
rs1277928197 CA369240401	418	V>M	No	ClinGen gnomAD
CA369240419 rs1489207255	419	V>M	No	ClinGen gnomAD
CA369240447 rs1217274308	421	V>I	No	ClinGen gnomAD
rs1262448956 CA369240468	422	A>E	No	ClinGen gnomAD
CA4477737 rs775986353	424	R>*	No	ClinGen ExAC TOPMed gnomAD
rs1192495423 CA369240495	424	R>Q	No	ClinGen gnomAD
rs547434560 CA4477738	429	M>L	No	ClinGen 1000Genomes ExAC gnomAD
CA4477739 rs547434560	429	M>V	No	ClinGen 1000Genomes ExAC gnomAD
rs760179831 CA4477741	435	S>F	No	ClinGen ExAC gnomAD
CA166232420 rs921773705	436	W>C	No	ClinGen TOPMed gnomAD
rs1233004578 CA369240762	441	I>T	No	ClinGen Ensembl
rs766331114 CA4477742	441	I>V	No	ClinGen ExAC gnomAD
rs1368490077 CA369240771	442	R>G	No	ClinGen TOPMed gnomAD
rs199556554 CA4477744	442	R>Q	No	ClinGen 1000Genomes ExAC gnomAD
CA369240772 rs1368490077	442	R>W	No	ClinGen TOPMed gnomAD
rs112815033 CA166232436	450	L>P	No	ClinGen Ensembl
CA4477747 rs201822184	453	R>C	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4477748 rs200918740	453	R>H	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA369240955 rs200918740	453	R>L	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751622444 CA4477749	454	M>T	No	ClinGen ExAC gnomAD
rs1441920448 CA369241025	462	H>L	No	ClinGen gnomAD
rs1239660357 CA369241024	462	H>Y	No	ClinGen gnomAD
rs781768972 CA4477751	464	I>F	No	ClinGen ExAC gnomAD
rs1407817094 CA369241056	466	Q>P	No	ClinGen gnomAD
rs1471165643 CA369241068	468	Q>*	No	ClinGen gnomAD
CA369241084 rs1166950093	470	R>Q	No	ClinGen TOPMed gnomAD
CA4477752 rs537292247	470	R>W	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4477753 rs146164429	473	P>T	No	ClinGen ESP ExAC TOPMed gnomAD
rs780602210 CA4477754	474	V>M	No	ClinGen ExAC TOPMed gnomAD
CA4477755 rs749639613	475	A>D	No	ClinGen ExAC gnomAD
CA369241142 rs1447512794	476	Q>E	No	ClinGen TOPMed
CA369241146 rs1563079290	476	Q>L	No	ClinGen Ensembl
CA369241185 rs1289917787	478	P>L	No	ClinGen gnomAD
CA4477757 rs772876537	478	P>S	No	ClinGen ExAC gnomAD
rs1320573560 CA369241196	479	P>L	No	ClinGen gnomAD
rs746504982 CA4477759	483	L>F	No	ClinGen ExAC gnomAD
rs1232692954 CA369241290	486	G>A	No	ClinGen gnomAD
RCV000970179 rs145965576 CA4477761	486	G>S	No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1380599805 CA369241388	490	W>*	No	ClinGen TOPMed
CA166232500 rs976049209	493	H>P	No	ClinGen Ensembl
rs1415206663 CA369241472	493	H>Y	No	ClinGen gnomAD
CA369241549 rs1460981740	496	G>V	No	ClinGen gnomAD
rs759535681 CA4477763	497	M>T	No	ClinGen ExAC gnomAD

No associated diseases with Q13568

4 regional properties for Q13568

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	186 - 448	IPR000719
domain	AGC-kinase, C-terminal	449 - 528	IPR000961
domain	RGS domain	52 - 171	IPR016137
binding_site	Protein kinase, ATP binding site	192 - 224	IPR017441

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus
PANTHER Family	PTHR11949	INTERFERON REGULATORY FACTOR
PANTHER Subfamily	PTHR11949:SF10	INTERFERON REGULATORY FACTOR 5
PANTHER Protein Class	DNA-binding transcription factor helix-turn-helix transcription factor winged helix/forkhead transcription factor
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name	Definition
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
identical protein binding	Binding to an identical protein or proteins.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding	Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

16 GO annotations of biological process

Name	Definition
cellular response to virus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
cytokine-mediated signaling pathway	The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
immune system process	Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of cytokine production involved in immune response	Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.
positive regulation of interferon-alpha production	Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
positive regulation of interferon-beta production	Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
positive regulation of interleukin-12 production	Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of type I interferon production	Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to muramyl dipeptide	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
response to peptidoglycan	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q58DJ0	IRF5	Interferon regulatory factor 5	Bos taurus (Bovine)	SS
Q00978	IRF9	Interferon regulatory factor 9	Homo sapiens (Human)	PR
Q15306	IRF4	Interferon regulatory factor 4	Homo sapiens (Human)	SS
Q14653	IRF3	Interferon regulatory factor 3	Homo sapiens (Human)	EV
Q92985	IRF7	Interferon regulatory factor 7	Homo sapiens (Human)	EV
Q02556	IRF8	Interferon regulatory factor 8	Homo sapiens (Human)	PR
P56477	Irf5	Interferon regulatory factor 5	Mus musculus (Mouse)	SS

10	20	30	40	50	60
MNQSIPVAPT	PPRRVRLKPW	LVAQVNSCQY	PGLQWVNGEK	KLFCIPWRHA	TRHGPSQDGD
70	80	90	100	110	120
NTIFKAWAKE	TGKYTEGVDE	ADPAKWKANL	RCALNKSRDF	RLIYDGPRDM	PPQPYKIYEV
130	140	150	160	170	180
CSNGPAPTDS	QPPEDYSFGA	GEEEEEEEEL	QRMLPSLSLT	EDVKWPPTLQ	PPTLRPPTLQ
190	200	210	220	230	240
PPTLQPPVVL	GPPAPDPSPL	APPPGNPAGF	RELLSEVLEP	GPLPASLPPA	GEQLLPDLLI
250	260	270	280	290	300
SPHMLPLTDL	EIKFQYRGRP	PRALTISNPH	GCRLFYSQLE	ATQEQVELFG	PISLEQVRFP
310	320	330	340	350	360
SPEDIPSDKQ	RFYTNQLLDV	LDRGLILQLQ	GQDLYAIRLC	QCKVFWSGPC	ASAHDSCPNP
370	380	390	400	410	420
IQREVKTKLF	SLEHFLNELI	LFQKGQTNTP	PPFEIFFCFG	EEWPDRKPRE	KKLITVQVVP
430	440	450	460	470	480
VAARLLLEMF	SGELSWSADS	IRLQISNPDL	KDRMVEQFKE	LHHIWQSQQR	LQPVAQAPPG
490
AGLGVGQGPW	PMHPAGMQ