AiPD: Autoinhibited Protein Database

Q13557

Gene name	CAMK2D (CAMKD)
Protein name	Calcium/calmodulin-dependent protein kinase type II subunit delta
Names	CaM kinase II subunit delta, CaMK-II subunit delta
Species	Homo sapiens (Human)
KEGG Pathway	hsa:817
EC number	2.7.11.17: Protein-serine/threonine kinases
Protein Class	SERINE/THREONINE-PROTEIN KINASE (PTHR24347)

Descriptions

CAMK2D is a Calcium/Calmodulin (CaM)-dependent kinase II (CaMKII) that plays as a molecular switch of cellular signaling by transmitting Ca2+ signals in humans. The C-terminal helix bound to the substrate-binding site causes autoinhibited CaMKII.

Autoinhibitory domains (AIDs)

Target domain	14-272 (Protein kinase domain)
Relief mechanism	Partner binding
Assay	Structural analysis

AID

283-291 (Autoinhibitory domain)

Target domain

14-272 (Protein kinase domain)

Relief mechanism

Partner binding (Ca2+-activated CaM binding)

Assay

Structural analysis

Accessory elements

156-179 (Activation loop from InterPro)

Target domain	14-272 (Protein kinase domain)
Relief mechanism
Assay

References

Rellos P et al. (2010) "Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation", PLoS biology, 8, e1000426

Autoinhibited structure

Activated structure

9 structures for Q13557

Entry ID	Method	Resolution	Chain	Position	Source
2VN9	X-ray	230 A	A/B	11-309	PDB
2W2C	X-ray	270 A	A/B/C/D/E/F/G/H/I/J/K/L/M/N	334-475	PDB
2WEL	X-ray	190 A	A	11-335	PDB
3GP2	X-ray	146 A	B	294-311	PDB
5VLO	X-ray	205 A	A/B	3-301	PDB
6AYW	X-ray	205 A	A/B	3-301	PDB
7ZRP	X-ray	265 A	B/D	294-315	PDB
7ZRQ	X-ray	168 A	B	294-315	PDB
AF-Q13557-F1	Predicted				AlphaFoldDB

213 variants for Q13557

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1594293623 CA357996833	5	T>S		No	ClinGen Ensembl
rs773637442 CA3053060	6	T>I		No	ClinGen ExAC gnomAD
rs770176711 CA3053059	7	C>R		No	ClinGen ExAC gnomAD
CA357996821 rs1594293303	7	C>S		No	ClinGen Ensembl
rs762107988 CA3053058	10	F>I		No	ClinGen ExAC TOPMed gnomAD
rs776873345 CA3053057	11	T>R		No	ClinGen ExAC
CA3053054 rs780266828	12	D>H		No	ClinGen ExAC gnomAD
CA357996792 rs780266828	12	D>N		No	ClinGen ExAC gnomAD
rs1344581184 CA357996780	13	E>G		No	ClinGen gnomAD
CA3053052 rs745786721	16	L>V		No	ClinGen ExAC TOPMed gnomAD
rs757024590 CA3053050	19	E>A		No	ClinGen ExAC gnomAD
rs866792403 CA104531290	24	A>T		No	ClinGen Ensembl
rs745952891 CA3053035	28	V>M		No	ClinGen ExAC gnomAD
CA104531289 rs866284270	31	C>F		No	ClinGen Ensembl
CA357996650 rs1270339685	31	C>R		No	ClinGen gnomAD
CA3053034 rs774300868	32	M>V		No	ClinGen ExAC gnomAD
CA3053033 rs770775266	35	P>L		No	ClinGen ExAC gnomAD
rs777541966 CA3053031	36	T>A		No	ClinGen ExAC TOPMed gnomAD
rs777541966 CA3053032	36	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1402972585 CA357996601	38	Q>R		No	ClinGen gnomAD
CA357996475 rs1477812682	54	D>E		No	ClinGen gnomAD
CA357996471 rs1424887030	55	H>Y		No	ClinGen TOPMed gnomAD
rs1313879323 CA357996408	64	I>L		No	ClinGen gnomAD
CA3053013 rs759589868	66	R>C		No	ClinGen ExAC gnomAD
rs1390583533 CA357996390	66	R>H		No	ClinGen TOPMed gnomAD
CA357996383 rs1561671882	67	L>R		No	ClinGen Ensembl
CA3052997 rs778447492	75	R>*		No	ClinGen ExAC gnomAD
COSM1426483 rs1382307916 CA357994313	75	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA104515116 rs749967571	77	H>Y		No	ClinGen gnomAD
CA3052996 rs756503673	78	D>G		No	ClinGen ExAC gnomAD
rs753112456 CA3052995	80	I>L		No	ClinGen ExAC gnomAD
rs767718280 CA3052994	81	S>A		No	ClinGen ExAC gnomAD
rs927276304 CA104515115	83	E>D		No	ClinGen TOPMed
rs1176557296 CA357995157	96	G>C		No	ClinGen gnomAD
CA357995079 rs1368549253	107	Y>S		No	ClinGen gnomAD
CA357995050 rs1191843295	111	A>T		No	ClinGen gnomAD
CA357995040 rs1341189956	112	D>G		No	ClinGen TOPMed
CA104508637 rs938950737	119	Q>H		No	ClinGen gnomAD
CA357994899 rs1243681757	120	I>V		No	ClinGen TOPMed
rs768312126 CA3052964	125	N>H		No	ClinGen ExAC TOPMed gnomAD
rs1033990185 CA104508634	131	G>D		No	ClinGen TOPMed
rs866393412 CA104508635	131	G>S		No	ClinGen Ensembl
CA357994786 rs1490201210	133	V>A		No	ClinGen TOPMed
rs774108754 CA3052918	142	L>*		No	ClinGen ExAC gnomAD
rs1189831286 CA357994015	144	L>*		No	ClinGen gnomAD
rs1560800061 CA357994009	145	A>G		No	ClinGen Ensembl
CA104507474 rs1045576763	145	A>P		No	ClinGen TOPMed
rs1300916212 CA357993964	152	A>S		No	ClinGen TOPMed
CA3052914 rs769258439	162	I>M		No	ClinGen ExAC gnomAD
CA3052915 rs772769979	162	I>T		No	ClinGen ExAC gnomAD
CA3052916 rs762312398	162	I>V		No	ClinGen ExAC gnomAD
rs1318492199 CA357993887	163	E>D		No	ClinGen gnomAD
CA357993867 rs1231440552 COSM1694853 COSM1694852	166	G>A	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
VAR_040602 rs35367671 CA3052912 RCV000898739	167	D>E		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs772371022 CA3052911	168	Q>L		No	ClinGen ExAC gnomAD
COSM1426482 rs979163662 CA104507473	170	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA3052909 rs779036954	171	W>R		No	ClinGen ExAC gnomAD
CA3052887 rs769880227	178	P>H		No	ClinGen ExAC
CA357996262 rs1460777755	182	S>C		No	ClinGen TOPMed
CA3052886 rs376527447	185	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA357996214 rs1377033850	189	D>V		No	ClinGen gnomAD
rs375039955 CA3052884	190	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1243820675 CA357996211	190	P>T		No	ClinGen TOPMed
rs754953102 CA3052883	191	Y>H		No	ClinGen ExAC gnomAD
rs1339963501 CA357996180	194	P>L		No	ClinGen gnomAD
CA357996170 rs1560757077	196	D>A		No	ClinGen Ensembl
rs917119793 CA104506932	197	M>L		No	ClinGen Ensembl
CA3052882 rs751618603	197	M>T		No	ClinGen ExAC TOPMed gnomAD
CA357996140 rs1398360773	200	C>Y		No	ClinGen gnomAD
CA357996119 rs1299184718	201	G>V		No	ClinGen gnomAD
CA357996110 rs1382493535	203	I>V		No	ClinGen gnomAD
rs867010473 CA104505561	210	G>R		No	ClinGen Ensembl
rs774010373 CA104505560	216	D>E		No	ClinGen Ensembl
rs1194833939 CA357996010	218	D>N		No	ClinGen Ensembl
CA3052866 rs748439471	228	A>T		No	ClinGen ExAC gnomAD
CA104505559 rs1053265334	232	D>G		No	ClinGen Ensembl
rs1472705615 CA357995908	232	D>N		No	ClinGen TOPMed
rs755579133 CA3052830	238	W>*		No	ClinGen ExAC gnomAD
CA104505359 rs868073161	243	P>S		No	ClinGen Ensembl
rs1441650850 CA357995793	247	D>Y		No	ClinGen gnomAD
CA3052828 rs767115074	250	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1590524312 CA357995728	256	N>T		No	ClinGen Ensembl
CA357995714 rs1187470839	258	A>D		No	ClinGen gnomAD
rs1441193312 CA357995701	260	R>C		No	ClinGen gnomAD
rs954113235 CA104505358	265	E>G		No	ClinGen TOPMed
CA3052827 rs199910718	266	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA357995665 rs1443501806	266	A>T		No	ClinGen TOPMed
CA357995659 rs369679944	267	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs377215305 CA3052823	271	W>C		No	ClinGen ESP ExAC gnomAD
CA357995588 rs1318349233	275	R>C		No	ClinGen gnomAD
rs777349770 CA3052812	282	M>I		No	ClinGen ExAC gnomAD
rs1227223871 CA357995534	283	H>Y		No	ClinGen gnomAD
rs780537393 CA3052809	293	K>R		No	ClinGen ExAC gnomAD
rs779267272 CA104505250	300	L>Q		No	ClinGen Ensembl
rs1590480879 RCV001001324 CA357995363	305	L>S		No	ClinGen ClinVar Ensembl dbSNP
rs779507600 CA3052786	311	T>A		No	ClinGen ExAC gnomAD
rs71604981 CA104505209	313	N>D		No	ClinGen Ensembl
CA3052785 rs757823700	313	N>S		No	ClinGen ExAC gnomAD
CA3052760 rs780889115	318	K>R		No	ClinGen ExAC gnomAD
rs1207731980 CA357995259	319	S>G		No	ClinGen gnomAD
rs1349725547 CA357995222	324	P>S		No	ClinGen gnomAD
rs755225383 CA3052758	325	D>G		No	ClinGen ExAC TOPMed gnomAD
CA3052757 rs374130979	327	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA357994292 rs1232293562	329	E>V		No	ClinGen gnomAD
rs766833343 CA3052658	331	T>I		No	ClinGen ExAC gnomAD
CA357994246 rs1305019887	332	E>D		No	ClinGen TOPMed gnomAD
rs1227337431 CA357994199	336	T>A		No	ClinGen TOPMed
CA357994175 rs1391362677	338	I>V		No	ClinGen gnomAD
CA357994159 rs1290119810	339	E>*		No	ClinGen TOPMed
CA3052656 rs773592122	340	D>E		No	ClinGen ExAC gnomAD
rs769955321 CA3052655	341	E>G		No	ClinGen ExAC gnomAD
rs1443424119 CA357994100	343	V>M		No	ClinGen gnomAD
rs776654102 CA3052653	344	K>R		No	ClinGen ExAC
rs1311905399 CA357994072	345	A>T		No	ClinGen gnomAD
rs1194393580 CA357928498	346	R>Q		No	ClinGen TOPMed
rs1487106510 CA357928475	348	Q>K		No	ClinGen gnomAD
rs370943563 CA3052641	353	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs750608072 CA103847285	358	I>M		No	ClinGen ExAC TOPMed gnomAD
rs765571056 CA3052638	359	E>D		No	ClinGen ExAC gnomAD
CA3052637 rs762186336	360	A>V		No	ClinGen ExAC gnomAD
rs199963971 CA3052636	361	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA357928282 rs1216261957	362	N>S		No	ClinGen gnomAD
rs768824734 CA3052635	363	N>S		No	ClinGen ExAC gnomAD
rs1318461939 CA357928246	365	D>Y		No	ClinGen gnomAD
rs760511898 CA3052634	366	F>L		No	ClinGen ExAC gnomAD
rs142412040 CA103847262	368	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs771719573 CA3052632	368	A>P		No	ClinGen ExAC gnomAD
rs142412040 CA3052631	368	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA3052630 rs564198114	370	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA357927523 rs1375036612	372	I>N		No	ClinGen gnomAD
rs139199077 CA3052612	376	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1251205904 CA357927386	384	A>G		No	ClinGen gnomAD
rs1397984871 CA357927363	386	G>D		No	ClinGen TOPMed
CA357927352 rs1277331745	387	N>S		No	ClinGen TOPMed
rs1455515647 CA357927332	389	V>L		No	ClinGen gnomAD
CA3052610 rs770752204	392	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1589664714 CA357927300	392	M>V		No	ClinGen Ensembl
CA3052609 rs748916709	396	R>*		No	ClinGen ExAC TOPMed gnomAD
CA103845527 rs987657983	396	R>Q		No	ClinGen TOPMed
rs1276366541 CA357927227	397	F>V		No	ClinGen TOPMed
CA3052608 rs772949010	399	F>S		No	ClinGen ExAC gnomAD
CA3052596 rs764377560	405	K>R		No	ClinGen ExAC TOPMed gnomAD
rs756086512 CA3052595	406	S>N		No	ClinGen ExAC gnomAD
rs1175575808 CA357926039	407	N>S		No	ClinGen gnomAD
rs1478369761 CA357926023	408	K>T		No	ClinGen gnomAD
rs934041904 CA103844686	409	P>S		No	ClinGen TOPMed
CA357926001 rs1180200020	410	I>T		No	ClinGen gnomAD
CA3052594 rs752806656	410	I>V		No	ClinGen ExAC gnomAD
CA357925994 rs1370316745	411	H>Y		No	ClinGen TOPMed
CA3052593 rs767559122	412	T>A		No	ClinGen ExAC gnomAD
CA103844676 rs189007324	414	I>T		No	ClinGen 1000Genomes
CA357925917 rs1252973457	416	N>K		No	ClinGen gnomAD
CA357925906 rs1589630639	417	P>R		No	ClinGen Ensembl
CA103844667 rs774320839	418	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA357925894 rs1485120688	418	H>R		No	ClinGen gnomAD
rs759437393 CA3052592	418	H>Y		No	ClinGen ExAC gnomAD
CA3052590 rs766113663	419	V>I		No	ClinGen ExAC gnomAD
CA357925858 rs1345028205	420	H>Q		No	ClinGen gnomAD
rs1262058128 CA357925864	420	H>R		No	ClinGen gnomAD
CA3052589 rs762742010	421	L>V		No	ClinGen ExAC TOPMed gnomAD
rs772683148 CA3052588	422	V>I		No	ClinGen ExAC gnomAD
CA3052585 rs146612481	424	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA103844645 rs1055781843	427	A>T		No	ClinGen Ensembl
CA357925768 rs1415113015	428	C>Y		No	ClinGen gnomAD
CA357925755 rs1384271133	429	I>V		No	ClinGen gnomAD
CA357925731 rs1157396785	431	Y>C		No	ClinGen gnomAD
CA357925658 rs1589629538	437	Y>H		No	ClinGen Ensembl
rs1311458122 CA357925607	440	G>S		No	ClinGen TOPMed
CA357925594 rs1471439605	441	S>C		No	ClinGen gnomAD
CA357925592 rs1413207475	441	S>N		No	ClinGen gnomAD
rs746331862 CA3052583	443	M>K		No	ClinGen ExAC gnomAD
rs182748214 CA3052581	445	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA3052582 rs779599382	445	K>R		No	ClinGen ExAC gnomAD
CA3052580 rs749672940	447	M>R		No	ClinGen ExAC gnomAD
CA103844624 rs547989734	447	M>V		No	ClinGen TOPMed
CA103844609 rs938779568	453	R>C		No	ClinGen TOPMed gnomAD
rs1331106251 CA357925322	453	R>H		No	ClinGen gnomAD
CA103844606 rs527830719	454	V>M		No	ClinGen Ensembl
rs756352922 CA3052578	456	H>L		No	ClinGen ExAC TOPMed gnomAD
rs776889531 CA103844596	457	R>C		No	ClinGen Ensembl
rs369980399 CA3052577	457	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs146226572 CA3052575	458	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs771227612 CA3052576	458	R>W		No	ClinGen ExAC gnomAD
CA3052574 rs751432544	459	D>V		No	ClinGen ExAC gnomAD
CA357925199 rs1325999107	460	G>R		No	ClinGen gnomAD
rs992470602 CA103844582	461	K>R		No	ClinGen TOPMed gnomAD
rs747409017 CA103844579	462	W>*		No	ClinGen Ensembl
rs1053668 VAR_028196 CA103844576	463	Q>E		No	ClinGen UniProt Ensembl dbSNP
rs1259562371 CA357925079	465	V>I		No	ClinGen TOPMed
CA357925032 rs1445421360	467	F>S		No	ClinGen TOPMed
rs199603492 CA3052572	469	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA3052571 rs141725310	469	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA357924987 rs141725310	469	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3052569 rs761508441	473	P>S		No	ClinGen ExAC gnomAD
CA3052568 rs776173852	474	T>A		No	ClinGen ExAC gnomAD
rs1465831185 CA357924902	476	P>H		No	ClinGen gnomAD
CA3052549 rs753479517	479	P>L		No	ClinGen ExAC TOPMed gnomAD
CA3052548 rs763847621	482	I>V		No	ClinGen ExAC gnomAD
rs760458481 CA3052547	484	N>D		No	ClinGen ExAC TOPMed gnomAD
CA3052546 rs775133200	484	N>K		No	ClinGen ExAC gnomAD
rs763492401 CA3052544	485	G>A		No	ClinGen ExAC TOPMed gnomAD
rs763492401 CA103843954	485	G>E		No	ClinGen ExAC TOPMed gnomAD
rs771745152 CA3052545	485	G>W		No	ClinGen ExAC TOPMed gnomAD
rs1394365225 CA357924573	486	K>R		No	ClinGen TOPMed
rs969953638 CA103843948	487	E>G		No	ClinGen TOPMed gnomAD
rs781596266 CA3052540	492	G>D		No	ClinGen ExAC TOPMed gnomAD
rs35765784 CA3052537 VAR_040603	493	T>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs35765784 CA357924462	493	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3052538 rs35765784	493	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778724654 CA3052534	496	W>*		No	ClinGen ExAC gnomAD
rs750338554 CA3052535	496	W>R		No	ClinGen ExAC gnomAD
rs757014510 CA3052533	497	Q>K		No	ClinGen ExAC gnomAD
CA103843910 rs777310167	497	Q>R		No	ClinGen Ensembl

No associated diseases with Q13557

2 regional properties for Q13557

Type	Name	Position	InterPro Accession
domain	ABC1 atypical kinase-like domain	297 - 536	IPR004147
domain	ADCK3-like domain	292 - 542	IPR034646

Functions

		Description
EC Number	2.7.11.17	Protein-serine/threonine kinases
Subcellular Localization	Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family	PTHR24347	SERINE/THREONINE-PROTEIN KINASE
PANTHER Subfamily	PTHR24347:SF365	CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA
PANTHER Protein Class	non-receptor serine/threonine protein kinase protein modifying enzyme
PANTHER Pathway Category	Inflammation mediated by chemokine and cytokine signaling pathway CaMK Ionotropic glutamate receptor pathway CaMKII

10 GO annotations of cellular component

Name	Definition
calcium- and calmodulin-dependent protein kinase complex	An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endocytic vesicle membrane	The lipid bilayer surrounding an endocytic vesicle.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
sarcolemma	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
sarcoplasmic reticulum membrane	The lipid bilayer surrounding the sarcoplasmic reticulum.

11 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein kinase activity	Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
identical protein binding	Binding to an identical protein or proteins.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
sodium channel inhibitor activity	Binds to and stops, prevents, or reduces the activity of a sodium channel.
titin binding	Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
transmembrane transporter binding	Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

29 GO annotations of biological process

Name	Definition
cardiac muscle cell contraction	The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell.
cellular response to calcium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
endoplasmic reticulum calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.
negative regulation of sodium ion transmembrane transport	Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport.
negative regulation of sodium ion transmembrane transporter activity	Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of cardiac muscle cell apoptotic process	Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
positive regulation of cardiac muscle hypertrophy	Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
regulation of cardiac muscle cell action potential	Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
regulation of cardiac muscle cell action potential involved in regulation of contraction	Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction.
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
regulation of cell communication by electrical coupling	Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.
regulation of cell communication by electrical coupling involved in cardiac conduction	Any process that modulates the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction.
regulation of cell growth	Any process that modulates the frequency, rate, extent or direction of cell growth.
regulation of cellular localization	Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
regulation of heart contraction	Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
regulation of heart rate by cardiac conduction	A cardiac conduction process that modulates the frequency or rate of heart contraction.
regulation of histone deacetylase activity	Any process that modulates the frequency, rate or extent of histone deacetylase activity.
regulation of membrane depolarization	Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.
regulation of relaxation of cardiac muscle	Any process that modulates the frequency, rate or extent of relaxation of cardiac muscle.
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
regulation of ryanodine-sensitive calcium-release channel activity	Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
regulation of the force of heart contraction	Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
relaxation of cardiac muscle	The process in which the extent of cardiac muscle contraction is reduced.

40 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3MHJ9	CAMK2B	Calcium/calmodulin-dependent protein kinase type II subunit beta	Bos taurus (Bovine)	SS
Q2HJF7	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Bos taurus (Bovine)	SS
Q5ZKI0	CAMK2D	Calcium/calmodulin-dependent protein kinase type II delta chain	Gallus gallus (Chicken)	SS
Q24210	CASK	Peripheral plasma membrane protein CASK	Drosophila melanogaster (Fruit fly)	SS
Q00168	CaMKII	Calcium/calmodulin-dependent protein kinase type II alpha chain	Drosophila melanogaster (Fruit fly)	SS
O14936	CASK	Peripheral plasma membrane protein CASK	Homo sapiens (Human)	EV
Q16816	PHKG1	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (Human)	PR
P15735	PHKG2	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (Human)	PR
Q13554	CAMK2B	Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (Human)	EV
Q9UQM7	CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (Human)	EV
Q13555	CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (Human)	EV
Q9H1R3	MYLK2	Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (Human)	EV
Q32MK0	MYLK3	Myosin light chain kinase 3	Homo sapiens (Human)	SS
Q86YV6	MYLK4	Myosin light chain kinase family member 4	Homo sapiens (Human)	SS
P11801	PSKH1	Serine/threonine-protein kinase H1	Homo sapiens (Human)	SS
Q6P2M8	PNCK	Calcium/calmodulin-dependent protein kinase type 1B	Homo sapiens (Human)	SS
Q96NX5	CAMK1G	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (Human)	SS
Q8IU85	CAMK1D	Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (Human)	SS
Q8NCB2	CAMKV	CaM kinase-like vesicle-associated protein	Homo sapiens (Human)	SS
Q14012	CAMK1	Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (Human)	EV
O70589	Cask	Peripheral plasma membrane protein CASK	Mus musculus (Mouse)	SS
P11798	Camk2a	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Mus musculus (Mouse)	PR
P28652	Camk2b	Calcium/calmodulin-dependent protein kinase type II subunit beta	Mus musculus (Mouse)	SS
Q923T9	Camk2g	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Mus musculus (Mouse)	SS
Q6PHZ2	Camk2d	Calcium/calmodulin-dependent protein kinase type II subunit delta	Mus musculus (Mouse)	SS
Q95266	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Sus scrofa (Pig)	SS
P11275	Camk2a	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Rattus norvegicus (Rat)	PR
P11730	Camk2g	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Rattus norvegicus (Rat)	SS
P15791	Camk2d	Calcium/calmodulin-dependent protein kinase type II subunit delta	Rattus norvegicus (Rat)	SS
P54936	lin-2	Protein lin-2	Caenorhabditis elegans	SS
O62305	unc-43	Calcium/calmodulin-dependent protein kinase type II	Caenorhabditis elegans	EV
Q9SSF8	CPK30	Calcium-dependent protein kinase 30	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M9V8	CPK10	Calcium-dependent protein kinase 10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8W4I7	CPK13	Calcium-dependent protein kinase 13	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SIQ7	CPK24	Calcium-dependent protein kinase 24	Arabidopsis thaliana (Mouse-ear cress)	PR
P93759	GK-1	Calcium-dependent protein kinase 14	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6NLQ6	CPK32	Calcium-dependent protein kinase 32	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38873	CPK7	Calcium-dependent protein kinase 7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6DEH3	camk2d1	Calcium/calmodulin-dependent protein kinase type II delta 1 chain	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q6DGS3	camk2d2	Calcium/calmodulin-dependent protein kinase type II delta 2 chain	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MASTTTCTRF	TDEYQLFEEL	GKGAFSVVRR	CMKIPTGQEY	AAKIINTKKL	SARDHQKLER
70	80	90	100	110	120
EARICRLLKH	PNIVRLHDSI	SEEGFHYLVF	DLVTGGELFE	DIVAREYYSE	ADASHCIQQI
130	140	150	160	170	180
LESVNHCHLN	GIVHRDLKPE	NLLLASKSKG	AAVKLADFGL	AIEVQGDQQA	WFGFAGTPGY
190	200	210	220	230	240
LSPEVLRKDP	YGKPVDMWAC	GVILYILLVG	YPPFWDEDQH	RLYQQIKAGA	YDFPSPEWDT
250	260	270	280	290	300
VTPEAKDLIN	KMLTINPAKR	ITASEALKHP	WICQRSTVAS	MMHRQETVDC	LKKFNARRKL
310	320	330	340	350	360
KGAILTTMLA	TRNFSAAKSL	LKKPDGVKES	TESSNTTIED	EDVKARKQEI	IKVTEQLIEA
370	380	390	400	410	420
INNGDFEAYT	KICDPGLTAF	EPEALGNLVE	GMDFHRFYFE	NALSKSNKPI	HTIILNPHVH
430	440	450	460	470	480
LVGDDAACIA	YIRLTQYMDG	SGMPKTMQSE	ETRVWHRRDG	KWQNVHFHRS	GSPTVPIKPP
490
CIPNGKENFS	GGTSLWQNI