Q13555
Gene name |
CAMK2G (CAMK, CAMK-II, CAMKG) |
Protein name |
Calcium/calmodulin-dependent protein kinase type II subunit gamma |
Names |
CaM kinase II subunit gamma, CaMK-II subunit gamma |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:818 |
EC number |
2.7.11.17: Protein-serine/threonine kinases |
Protein Class |
SERINE/THREONINE-PROTEIN KINASE (PTHR24347) |
Descriptions
CAMK2G is a Calcium/Calmodulin (CaM)-dependent kinase II (CaMKII) that plays as a molecular switch of cellular signaling by transmitting Ca2+ signals in humans. The C-terminal helix bound to the substrate-binding site causes autoinhibited CaMKII.
Autoinhibitory domains (AIDs)
Target domain |
14-272 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
Structural analysis |
Accessory elements
156-179 (Activation loop from InterPro)
Target domain |
14-272 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Rellos P et al. (2010) "Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation", PLoS biology, 8, e1000426
- Morlot C et al. (2007) "Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3", Acta crystallographica. Section D, Biological crystallography, 63, 961-8
Autoinhibited structure
Activated structure
3 structures for Q13555
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2UX0 | X-ray | 246 A | A/B/C/D/E/F | 426-558 | PDB |
| 2V7O | X-ray | 225 A | A | 5-315 | PDB |
| AF-Q13555-F1 | Predicted | AlphaFoldDB |
No variants for Q13555
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q13555 | |||||
1 associated diseases with Q13555
[MIM: 618522]: Intellectual developmental disorder, autosomal dominant 59 (MRD59)
An autosomal dominant form of intellectual disability, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:23033978, ECO:0000269|PubMed:30184290}. Note=The disease may be caused by variants affecting the gene represented in this entry.
Without disease ID
- An autosomal dominant form of intellectual disability, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:23033978, ECO:0000269|PubMed:30184290}. Note=The disease may be caused by variants affecting the gene represented in this entry.
4 regional properties for Q13555
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 14 - 272 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 132 - 144 | IPR008271 |
| domain | Calcium/calmodulin-dependent protein kinase II, association-domain | 426 - 553 | IPR013543 |
| binding_site | Protein kinase, ATP binding site | 20 - 43 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.17 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | PTHR24347 | SERINE/THREONINE-PROTEIN KINASE |
| PANTHER Subfamily | PTHR24347:SF441 | CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA |
| PANTHER Protein Class |
non-receptor serine/threonine protein kinase
protein modifying enzyme |
|
| PANTHER Pathway Category |
Inflammation mediated by chemokine and cytokine signaling pathway CaMK Ionotropic glutamate receptor pathway CaMKII |
|
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| calcium- and calmodulin-dependent protein kinase complex | An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endocytic vesicle membrane | The lipid bilayer surrounding an endocytic vesicle. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| sarcoplasmic reticulum membrane | The lipid bilayer surrounding the sarcoplasmic reticulum. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium-dependent protein serine/threonine phosphatase activity | Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| calmodulin-dependent protein kinase activity | Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| insulin secretion | The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| regulation of calcium ion transport | Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of neuron projection development | Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| regulation of skeletal muscle adaptation | Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. |
40 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHJ9 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Bos taurus (Bovine) | SS |
| Q2HJF7 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Bos taurus (Bovine) | SS |
| Q5ZKI0 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II delta chain | Gallus gallus (Chicken) | SS |
| Q24210 | CASK | Peripheral plasma membrane protein CASK | Drosophila melanogaster (Fruit fly) | SS |
| Q00168 | CaMKII | Calcium/calmodulin-dependent protein kinase type II alpha chain | Drosophila melanogaster (Fruit fly) | SS |
| O14936 | CASK | Peripheral plasma membrane protein CASK | Homo sapiens (Human) | EV |
| Q16816 | PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | Homo sapiens (Human) | PR |
| P15735 | PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform | Homo sapiens (Human) | PR |
| Q13554 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (Human) | EV |
| Q9UQM7 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (Human) | EV |
| Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Homo sapiens (Human) | EV |
| Q9H1R3 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Homo sapiens (Human) | EV |
| Q32MK0 | MYLK3 | Myosin light chain kinase 3 | Homo sapiens (Human) | SS |
| Q86YV6 | MYLK4 | Myosin light chain kinase family member 4 | Homo sapiens (Human) | SS |
| P11801 | PSKH1 | Serine/threonine-protein kinase H1 | Homo sapiens (Human) | SS |
| Q6P2M8 | PNCK | Calcium/calmodulin-dependent protein kinase type 1B | Homo sapiens (Human) | SS |
| Q96NX5 | CAMK1G | Calcium/calmodulin-dependent protein kinase type 1G | Homo sapiens (Human) | SS |
| Q8IU85 | CAMK1D | Calcium/calmodulin-dependent protein kinase type 1D | Homo sapiens (Human) | SS |
| Q8NCB2 | CAMKV | CaM kinase-like vesicle-associated protein | Homo sapiens (Human) | SS |
| Q14012 | CAMK1 | Calcium/calmodulin-dependent protein kinase type 1 | Homo sapiens (Human) | EV |
| O70589 | Cask | Peripheral plasma membrane protein CASK | Mus musculus (Mouse) | SS |
| P11798 | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Mus musculus (Mouse) | PR |
| Q6PHZ2 | Camk2d | Calcium/calmodulin-dependent protein kinase type II subunit delta | Mus musculus (Mouse) | SS |
| P28652 | Camk2b | Calcium/calmodulin-dependent protein kinase type II subunit beta | Mus musculus (Mouse) | SS |
| Q923T9 | Camk2g | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Mus musculus (Mouse) | SS |
| Q95266 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Sus scrofa (Pig) | SS |
| P15791 | Camk2d | Calcium/calmodulin-dependent protein kinase type II subunit delta | Rattus norvegicus (Rat) | SS |
| P11275 | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Rattus norvegicus (Rat) | PR |
| P11730 | Camk2g | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Rattus norvegicus (Rat) | SS |
| P54936 | lin-2 | Protein lin-2 | Caenorhabditis elegans | SS |
| O62305 | unc-43 | Calcium/calmodulin-dependent protein kinase type II | Caenorhabditis elegans | EV |
| Q9SSF8 | CPK30 | Calcium-dependent protein kinase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M9V8 | CPK10 | Calcium-dependent protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4I7 | CPK13 | Calcium-dependent protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIQ7 | CPK24 | Calcium-dependent protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93759 | GK-1 | Calcium-dependent protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NLQ6 | CPK32 | Calcium-dependent protein kinase 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38873 | CPK7 | Calcium-dependent protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6DGS3 | camk2d2 | Calcium/calmodulin-dependent protein kinase type II delta 2 chain | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6DEH3 | camk2d1 | Calcium/calmodulin-dependent protein kinase type II delta 1 chain | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATTATCTRF | TDDYQLFEEL | GKGAFSVVRR | CVKKTSTQEY | AAKIINTKKL | SARDHQKLER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EARICRLLKH | PNIVRLHDSI | SEEGFHYLVF | DLVTGGELFE | DIVAREYYSE | ADASHCIHQI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LESVNHIHQH | DIVHRDLKPE | NLLLASKCKG | AAVKLADFGL | AIEVQGEQQA | WFGFAGTPGY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSPEVLRKDP | YGKPVDIWAC | GVILYILLVG | YPPFWDEDQH | KLYQQIKAGA | YDFPSPEWDT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VTPEAKNLIN | QMLTINPAKR | ITADQALKHP | WVCQRSTVAS | MMHRQETVEC | LRKFNARRKL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KGAILTTMLV | SRNFSAAKSL | LNKKSDGGVK | KRKSSSSVHL | MPQSNNKNSL | VSPAQEPAPL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QTAMEPQTTV | VHNATDGIKG | STESCNTTTE | DEDLKGRVPE | GRSSRDRTAP | SAGMQPQPSL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CSSAMRKQEI | IKITEQLIEA | INNGDFEAYT | KICDPGLTSF | EPEALGNLVE | GMDFHKFYFE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NLLSKNSKPI | HTTILNPHVH | VIGEDAACIA | YIRLTQYIDG | QGRPRTSQSE | ETRVWHRRDG |
| 550 | |||||
| KWLNVHYHCS | GAPAAPLQ |