Q13489

SS
Gene name
BIRC3 (API2, MIHC, RNF49)
Protein name
Baculoviral IAP repeat-containing protein 3
Names
EC 2.3.2.27 , Apoptosis inhibitor 2 , API2 , Cellular inhibitor of apoptosis 2 , C-IAP2 , IAP homolog C , Inhibitor of apoptosis protein 1 , hIAP-1 , hIAP1 , RING finger protein 49 , RING-type E3 ubiquitin transferase BIRC3 , TNFR2-TRAF-signaling complex protein 1
Species
Homo sapiens (Human)
KEGG Pathway
hsa:330
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

E3 ligases mediate the covalent attachment of ubiquitin to target proteins thereby enabling ubiquitin dependent signaling. Baculoviral IAP repeat-containing protein 2 (BIRC2) protein is an E3 ligase that modulates diverse biological processes such as cell survival, proliferation, and migration. Full-length BIRC2 fails to associate with E2, but CARD-deleted mutant BIRC2 readily interacts with E2. The CARD inhibits activation of BIRC2’s E3 activity by preventing RING dimerization, E2 binding, and E2 activation. In addition, BIRC2 lacking only the BIR3 domain readily associates with the E2, representing that the CARD and BIR3 domains are both required for inhibition of E3 activity of BIRC2.

Autoinhibitory domains (AIDs)

421-548 (CARD domain) SS

Target domain

557-602 (RING domain)

Relief mechanism

Ligand binding

Assay

253-324 (BIR3 domain) SS

Target domain

557-602 (RING domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q13489

Entry ID Method Resolution Chain Position Source
2UVL X-ray 191 A A/B 244-337 PDB
3EB5 X-ray 200 A A 536-604 PDB
3EB6 X-ray 340 A A 536-604 PDB
3M0A X-ray 261 A D 26-99 PDB
3M0D X-ray 280 A D 26-99 PDB
7NK0 X-ray 330 A D/E 26-102 PDB
AF-Q13489-F1 Predicted AlphaFoldDB

614 variants for Q13489

Variant ID(s) Position Change Description Diseaes Association Provenance
rs764638130 3 I>L No ExAC
TOPMed
gnomAD
rs1435803547 3 I>T No gnomAD
rs764638130 3 I>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs1050770403 4 V>A No TOPMed
gnomAD
rs376445512 4 V>I No ESP
TOPMed
gnomAD
rs376445512 4 V>L No ESP
TOPMed
gnomAD
TCGA novel 6 N>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1445029472 6 N>T No gnomAD
COSM259635 7 S>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1951061702 8 I>M No TOPMed
TCGA novel 9 F>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1369623604 9 F>V No gnomAD
rs1951061778 10 L>S No gnomAD
rs142523935 11 S>P No ESP
ExAC
TOPMed
gnomAD
rs2135784127 13 L>F No Ensembl
rs766043554 14 M>K No ExAC
TOPMed
gnomAD
rs766043554 14 M>T No ExAC
TOPMed
gnomAD
rs1951061872 14 M>V No TOPMed
rs1481000149 15 K>E No TOPMed
rs186307109 17 A>P No 1000Genomes
ExAC
TOPMed
gnomAD
rs186307109 17 A>S No 1000Genomes
ExAC
TOPMed
gnomAD
rs186307109 17 A>T No 1000Genomes
ExAC
TOPMed
gnomAD
rs1197601579 18 N>S No TOPMed
rs1238807475 19 T>M No gnomAD
rs1238807475 19 T>R No gnomAD
rs1339391963 21 E>G No gnomAD
rs370738985 25 D>N No ESP
ExAC
TOPMed
gnomAD
COSM1746003
rs370738985
 25 D>Y urinary_tract [Cosmic] No cosmic curated
ESP
ExAC
TOPMed
gnomAD
rs375640711 26 L>F No ESP
ExAC
TOPMed
gnomAD
rs2135784182 27 S>* No Ensembl
rs775814824 27 S>A No ExAC
gnomAD
rs761068492 28 C>S No ExAC
gnomAD
rs1438152538 32 R>* No gnomAD
rs1327480353 32 R>L No gnomAD
COSM4017239
rs2135784205
 33 M>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No Ensembl
NCI-TCGA Cosmic
COSM5655678 34 S>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1220112786 35 T>K No TOPMed
gnomAD
rs1220112786 35 T>M No TOPMed
gnomAD
rs1035350946 35 T>P No TOPMed
rs2135784220 37 S>F No Ensembl
rs1951062721 38 T>A No TOPMed
rs1294234452 39 F>L No TOPMed
rs2135784228 40 P>L No Ensembl
COSM1704480 40 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1565321648 41 A>G No Ensembl
rs777182261 41 A>S No ExAC
gnomAD
rs777182261 41 A>T No ExAC
gnomAD
rs1268151772 43 V>L No gnomAD
rs2135784245 44 P>L No Ensembl
rs1341226781 46 S>* No gnomAD
rs1379964530 46 S>P No TOPMed
gnomAD
rs1215021212 48 R>K No gnomAD
rs1951063148 49 S>R No Ensembl
rs1272544210 49 S>R No gnomAD
rs978016131 50 L>I No TOPMed
gnomAD
rs978016131 50 L>V No TOPMed
gnomAD
rs2135784263 52 R>C No Ensembl
rs762397304 52 R>H No ExAC
TOPMed
gnomAD
rs2135784271 53 A>T No Ensembl
rs1254995766 54 G>A No gnomAD
rs1254995766 54 G>D No gnomAD
TCGA novel 55 F>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs765765029 56 Y>C No ExAC
gnomAD
COSM3397353 57 Y>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs759088779 58 T>A No ExAC
gnomAD
rs759088779 58 T>S No ExAC
gnomAD
COSM4899955
rs1470578400
 59 G>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
TOPMed
gnomAD
rs2135784294 59 G>S No Ensembl
rs370995428 60 V>M No ESP
ExAC
TOPMed
gnomAD
rs1051348346 62 D>V No Ensembl
rs933852178 62 D>Y No Ensembl
rs1174684503 63 K>M No TOPMed
gnomAD
rs147902919 65 K>R No ESP
ExAC
TOPMed
gnomAD
rs147902919 65 K>T No ESP
ExAC
TOPMed
gnomAD
rs1565321701 68 C>R No Ensembl
rs1951063626 68 C>Y No Ensembl
rs753649715 69 C>R No ExAC
TOPMed
gnomAD
rs2135784332 69 C>Y No Ensembl
rs757252168 70 G>A No ExAC
gnomAD
rs2135784351 71 L>V No Ensembl
rs140520103 72 M>I No ESP
rs746013026 73 L>R No ExAC
gnomAD
rs1951063777 74 D>G No TOPMed
rs942391221 75 N>K No Ensembl
TCGA novel 75 N>T Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs924735278 76 W>L No gnomAD
rs2135784365 77 K>NT* No Ensembl
rs1431281475
COSM5147713
 77 K>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
gnomAD
rs1292563262 78 R>K No gnomAD
rs1332537125 78 R>S No gnomAD
rs1292563262 78 R>T No gnomAD
rs1951063947 79 G>E No TOPMed
rs1951064037 80 D>A No TOPMed
gnomAD
rs150392143 80 D>E No ESP
ExAC
TOPMed
gnomAD
rs2135784379 80 D>H No Ensembl
rs780321660 81 S>G No ExAC
TOPMed
gnomAD
rs1200982745 81 S>N No TOPMed
gnomAD
rs1200982745 81 S>T No TOPMed
gnomAD
TCGA novel 82 P>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs2135784395 83 T>I No Ensembl
TCGA novel 85 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1204767907 85 K>R No gnomAD
TCGA novel 85 K>S Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1259982097 86 H>Y No TOPMed
gnomAD
rs1951064396 87 K>E No Ensembl
rs7930386 87 K>N No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1257297950 88 K>M No TOPMed
gnomAD
TCGA novel 89 L>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1951064563 90 Y>* No TOPMed
TCGA novel 90 Y>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1951064539 90 Y>H No gnomAD
rs748553156 91 P>R No ExAC
rs1167755679 93 C>F No gnomAD
rs1368477085 94 R>S No gnomAD
rs1951064710 94 R>T No gnomAD
rs1452514375 96 V>F No gnomAD
rs1452514375 96 V>I No gnomAD
rs1951064805 97 Q>R No TOPMed
gnomAD
TCGA novel 98 S>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs769968870 98 S>N No Ensembl
TCGA novel 98 S>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1951065082 102 V>D No TOPMed
gnomAD
rs922637067 102 V>F No TOPMed
gnomAD
rs1951065082 102 V>G No TOPMed
gnomAD
rs922637067 102 V>I No TOPMed
gnomAD
rs1323037598 104 N>K No TOPMed
rs1003047322 104 N>S No Ensembl
rs547723750 105 L>S No 1000Genomes
ExAC
TOPMed
gnomAD
rs759147879 107 A>T No ExAC
gnomAD
rs1951065251 108 T>I No TOPMed
rs1416464681 109 S>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs149102827 112 T>A No ESP
ExAC
TOPMed
gnomAD
rs1951065418 112 T>S No gnomAD
COSM1350355 115 S>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1951065453 115 S>F No gnomAD
rs1188255948 117 V>E No TOPMed
gnomAD
rs760407229 117 V>I No ExAC
TOPMed
gnomAD
COSM4017240 118 T>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 119 N>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs757121436 119 N>Y No ExAC
TOPMed
gnomAD
rs765259590 120 S>F No ExAC
TOPMed
gnomAD
rs765259590 120 S>Y No ExAC
TOPMed
gnomAD
COSM1561164
rs572690185
 123 S>L large_intestine [Cosmic] No cosmic curated
gnomAD
rs1393559808 123 S>T No TOPMed
rs750469359 125 L>F No ExAC
gnomAD
rs1173728754 126 P>L No TOPMed
gnomAD
rs1173728754 126 P>Q No TOPMed
gnomAD
rs758535139 127 G>S No ExAC
gnomAD
rs368897232 128 T>I No ESP
ExAC
TOPMed
gnomAD
rs368897232 128 T>R No ESP
ExAC
TOPMed
gnomAD
TCGA novel 130 N>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs147101958 130 N>T No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
TCGA novel 132 G>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs560628396 133 Y>F No 1000Genomes
ExAC
TOPMed
gnomAD
rs781386350 133 Y>H No ExAC
gnomAD
rs770192717 134 F>I No ExAC
gnomAD
rs200590873 135 R>C No 1000Genomes
ExAC
TOPMed
gnomAD
rs749825246 135 R>H No ExAC
TOPMed
gnomAD
rs1389638300 136 G>R No gnomAD
rs1951066290 137 S>F No Ensembl
rs775169948 137 S>T No ExAC
gnomAD
rs1438247839 138 Y>* No TOPMed
rs1183881756 138 Y>F No TOPMed
rs1241060537 141 S>C No gnomAD
COSM3442660 142 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1303042512 142 P>T No gnomAD
COSM4017241 143 S>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1951066503 143 S>P No TOPMed
gnomAD
rs1951066503 143 S>T No TOPMed
gnomAD
COSM4847220 145 P>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs761735307 146 V>A No ExAC
TOPMed
gnomAD
rs761735307 146 V>G No ExAC
TOPMed
gnomAD
rs1951066720 147 N>K No TOPMed
TCGA novel 148 S>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs986657671 148 S>Y No TOPMed
rs1785031981 149 R>G No TOPMed
gnomAD
COSM1297565 149 R>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1194596520 150 A>E No gnomAD
TCGA novel 153 D>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs750320348 154 F>S No ExAC
gnomAD
rs1392932947 155 S>F No gnomAD
rs758340219 155 S>P No ExAC
gnomAD
rs766408639 157 L>V No ExAC
TOPMed
gnomAD
rs141741107 158 M>V No ESP
ExAC
TOPMed
gnomAD
rs1951067133 159 R>G No TOPMed
rs755158444 159 R>S No ExAC
gnomAD
rs897653950 160 S>I No TOPMed
gnomAD
rs897653950 160 S>N No TOPMed
gnomAD
rs1389919038 161 S>A No Ensembl
rs1951067304 161 S>F No gnomAD
rs146254676 162 Y>* No ESP
ExAC
TOPMed
gnomAD
rs1951067454 163 H>Y No Ensembl
COSM922221 169 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 172 R>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1951067624 174 L>I No TOPMed
rs1951067624 174 L>V No TOPMed
rs749770154 175 T>I No ExAC
TOPMed
gnomAD
rs1951067777 176 F>V No TOPMed
rs771589672 178 T>A No ExAC
TOPMed
gnomAD
TCGA novel 180 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs746558818 180 P>T No ExAC
gnomAD
TCGA novel 182 T>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 185 S>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs769568651 185 S>T No ExAC
TOPMed
gnomAD
rs1469494339 186 P>S No gnomAD
rs2135784650 187 T>A No Ensembl
rs1274252278 187 T>I No TOPMed
gnomAD
rs1274252278 187 T>R No TOPMed
gnomAD
rs1951068525 188 D>G No TOPMed
rs147996132 188 D>H No ESP
ExAC
TOPMed
gnomAD
rs147996132 188 D>N No ESP
ExAC
TOPMed
gnomAD
rs566770230 190 A>V No 1000Genomes
ExAC
TOPMed
gnomAD
rs1951068796 191 K>E No Ensembl
rs1951068828 192 A>T No Ensembl
rs1466182381 196 Y>H No gnomAD
rs759714681 197 I>V No ExAC
TOPMed
gnomAD
rs1438790963 198 G>A No gnomAD
rs1438790963 198 G>E No gnomAD
rs1951067576 198 G>Y No Ensembl
rs767508008 199 P>A No ExAC
gnomAD
rs1361678151 200 G>A No TOPMed
gnomAD
rs1361678151 200 G>E No TOPMed
gnomAD
COSM1676385 201 D>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs752896863 202 R>S No ExAC
TOPMed
gnomAD
rs1237634037 203 V>A No Ensembl
rs1951069332 204 A>V No TOPMed
gnomAD
rs756320829 205 C>F No ExAC
gnomAD
rs778148792 205 C>W No ExAC
gnomAD
rs76109257 207 A>S No ExAC
gnomAD
rs76109257 207 A>T No ExAC
gnomAD
rs1344380953 208 C>R No TOPMed
gnomAD
rs959725789 209 G>D No Ensembl
rs757809452 209 G>R No ExAC
TOPMed
gnomAD
rs757809452 209 G>S No ExAC
TOPMed
gnomAD
rs779632081 212 L>F No ExAC
gnomAD
COSM5147714 212 L>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1951069650 214 N>S No Ensembl
COSM1731948
rs768158423
 217 P>L NS Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
gnomAD
rs768158423 217 P>R No ExAC
gnomAD
rs747799588 220 N>S No ExAC
TOPMed
gnomAD
rs1055928157 222 M>I No Ensembl
rs1474805083 222 M>V No TOPMed
gnomAD
rs769356523 227 R>G No ExAC
TOPMed
gnomAD
rs369162016 228 H>N No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs369162016 228 H>Y No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs770838087 230 P>S No ExAC
gnomAD
rs1320326385 233 P>A No TOPMed
rs1320326385 233 P>S No TOPMed
rs768016837 234 F>L No ExAC
TOPMed
gnomAD
rs767593360 235 I>T No 1000Genomes
ExAC
TOPMed
gnomAD
rs1951070210 236 E>D No Ensembl
rs752740710 237 N>K No ExAC
gnomAD
rs141682743 238 Q>E No ESP
ExAC
TOPMed
gnomAD
rs764452461 239 L>P No ExAC
gnomAD
rs764452461 239 L>R No ExAC
gnomAD
rs2095311901 240 Q>R No TOPMed
rs150502736 241 D>A No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs150502736 241 D>G No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1021677759 244 R>G No TOPMed
gnomAD
rs765714914 244 R>K No ExAC
gnomAD
rs747731925 245 Y>* No ExAC
gnomAD
rs750897944 246 T>R No ExAC
gnomAD
TCGA novel 247 V>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1260062391 247 V>I No TOPMed
gnomAD
rs1951070527 248 S>A No Ensembl
COSM73837
rs373514370
 248 S>C ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No NCI-TCGA Cosmic
cosmic curated
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1243376162 249 N>D No TOPMed
gnomAD
rs1951070669 249 N>K No TOPMed
rs747649672 249 N>S No ExAC
gnomAD
rs755783862 250 L>V No ExAC
TOPMed
gnomAD
rs777456061 251 S>G No ExAC
gnomAD
rs755873313 252 M>L No Ensembl
rs1407377931 254 T>A No gnomAD
rs967841484 255 H>Q No Ensembl
rs1951070917 255 H>R No Ensembl
rs571701272 255 H>Y No 1000Genomes
ExAC
gnomAD
rs770645813 256 A>V No ExAC
gnomAD
rs774161644 257 A>S No ExAC
TOPMed
gnomAD
COSM4017242 258 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1951071030 258 R>L No TOPMed
rs2135784831 258 R>S No Ensembl
rs1951071056 260 K>E No gnomAD
VAR_021069
rs2276113
 260 K>R No UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
TCGA novel 262 F>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs771950433 263 F>L No ExAC
TOPMed
gnomAD
rs775611041 264 N>I No ExAC
TOPMed
gnomAD
rs1370541388 265 W>C No gnomAD
rs760734130 265 W>R No ExAC
gnomAD
rs201026275 266 P>R No ExAC
TOPMed
gnomAD
rs377560709 266 P>S No ESP
ExAC
TOPMed
gnomAD
rs1951071366 267 S>F No Ensembl
rs1231858204 268 S>I No gnomAD
rs1431652592 269 V>G No TOPMed
rs753471138 269 V>I No gnomAD
rs1203749799 270 L>P No gnomAD
rs370712639 272 N>D No ESP
TOPMed
gnomAD
rs1456555442 273 P>L No gnomAD
rs201739570 273 P>T No 1000Genomes
COSM279163
rs1951071731
 278 S>R large_intestine [Cosmic] No cosmic curated
Ensembl
COSM279163
rs1180732396
 278 S>R Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
gnomAD
rs1050193516 278 S>T No Ensembl
rs1288469434 279 A>E No Ensembl
rs1288469434 279 A>V No Ensembl
rs1470903630 280 G>R No TOPMed
TCGA novel 281 F>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1381204334 283 Y>S No gnomAD
rs766775968 285 G>D No ExAC
TOPMed
gnomAD
rs766775968 285 G>V No ExAC
TOPMed
gnomAD
rs894701627 286 N>S No Ensembl
rs1325194761 288 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
rs1951073077 289 D>G No TOPMed
rs2135785013 291 K>R No 1000Genomes
rs1951073108 293 F>V No Ensembl
rs760066891 294 C>Y No ExAC
TOPMed
gnomAD
rs200850963 296 D>G No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
COSM4017243 297 G>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1356057510 300 R>K No TOPMed
gnomAD
rs1219202535 301 C>G No gnomAD
rs1408985207 306 D>N No TOPMed
gnomAD
rs1951073398 309 W>C No TOPMed
rs1565322147 309 W>R No Ensembl
rs1951073423 311 Q>E No Ensembl
rs2135785046 311 Q>H No Ensembl
rs1951073446 311 Q>R No Ensembl
rs1951073480 312 H>R No TOPMed
TCGA novel 313 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1416796624 315 W>L No TOPMed
gnomAD
rs1164889210 318 R>G No TOPMed
gnomAD
rs1257880413 320 E>K No TOPMed
rs1482653478 321 Y>C No TOPMed
rs373892386 322 L>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs771233410 323 I>R No ExAC
TOPMed
gnomAD
rs771233410 323 I>T No ExAC
TOPMed
gnomAD
rs1951102781 324 R>T No Ensembl
rs1423980533 327 G>E No gnomAD
rs899691911 328 Q>* No TOPMed
gnomAD
TCGA novel 328 Q>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs147320536 328 Q>R No ESP
TOPMed
rs775905642 329 E>A No TOPMed
gnomAD
rs775905642 329 E>G No TOPMed
gnomAD
rs1951102916 329 E>K No Ensembl
TCGA novel 330 F>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs746893155 331 I>T No ExAC
TOPMed
gnomAD
rs200082566 332 R>C No ESP
ExAC
TOPMed
gnomAD
rs764613103 332 R>H No ExAC
TOPMed
gnomAD
rs141069802 334 V>I No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1365915992 336 A>D No gnomAD
rs1365915992 336 A>V No gnomAD
rs1411725535 337 S>R No TOPMed
gnomAD
rs1951103289 337 S>R No Ensembl
rs921649894 337 S>T No TOPMed
rs766098781 338 Y>H No ExAC
TOPMed
gnomAD
rs766098781 338 Y>N No ExAC
TOPMed
gnomAD
rs540273624 339 P>H No 1000Genomes
ExAC
TOPMed
gnomAD
rs540273624 339 P>R No 1000Genomes
ExAC
TOPMed
gnomAD
rs1951103398 339 P>S No TOPMed
gnomAD
rs1340397338 340 H>N No gnomAD
rs1340397338 340 H>Y No gnomAD
rs754759697 343 E>K No ExAC
TOPMed
gnomAD
rs754759697 343 E>Q No ExAC
TOPMed
gnomAD
rs1951103625 344 Q>R No Ensembl
rs757305247 346 L>V No ExAC
gnomAD
rs1481844237 347 S>F No TOPMed
gnomAD
rs372905086 350 D>G No ESP
ExAC
gnomAD
rs997430245 350 D>N No Ensembl
rs997430245 350 D>Y No Ensembl
rs1306041646 352 P>Q No TOPMed
rs758642472 353 G>R No ExAC
gnomAD
rs953349466 354 D>E No TOPMed
gnomAD
COSM922222 354 D>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1951112345 355 E>D No Ensembl
rs555493036 356 N>K No 1000Genomes
ExAC
TOPMed
gnomAD
rs1392996629 357 A>T No TOPMed
rs1951112426 358 E>Q No Ensembl
rs747444965 358 E>V No ExAC
gnomAD
rs868604617 360 S>L No Ensembl
rs769041751 360 S>P No ExAC
TOPMed
gnomAD
rs377252240 361 I>V No ESP
ExAC
TOPMed
gnomAD
rs755300733 362 I>T No ExAC
TOPMed
gnomAD
rs144815282 364 F>S No ESP
ExAC
gnomAD
COSM3868270
rs1951132148
 365 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TOPMed
gnomAD
rs1237671522 366 P>L No gnomAD
COSM685797
rs748637898
 368 E>K lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs770469557 369 D>H No ExAC
gnomAD
rs770469557 369 D>N No ExAC
gnomAD
rs1034908456 369 D>V No TOPMed
rs770469557 369 D>Y No ExAC
gnomAD
rs745436136 370 H>R No ExAC
gnomAD
rs1005862733 371 S>T No TOPMed
rs771836966 372 E>G No ExAC
gnomAD
rs373338711 374 A>S No ESP
TOPMed
gnomAD
rs373338711 374 A>T No ESP
TOPMed
gnomAD
rs1463583457 375 I>V No TOPMed
rs768458534 377 M>R No ExAC
TOPMed
gnomAD
rs768458534 377 M>T No ExAC
TOPMed
gnomAD
rs760250405 377 M>V No ExAC
TOPMed
gnomAD
rs1951132617 378 N>S No gnomAD
rs776315214 379 T>A No ExAC
gnomAD
rs761718383 379 T>I No ExAC
TOPMed
gnomAD
rs544163875 381 V>A No 1000Genomes
rs2135789033 382 I>V No Ensembl
rs145818257 384 A>V No ESP
ExAC
TOPMed
gnomAD
rs750500487 385 A>S No ExAC
TOPMed
gnomAD
rs750500487 385 A>T No ExAC
TOPMed
gnomAD
rs12222256 386 V>L No 1000Genomes
ExAC
TOPMed
gnomAD
VAR_049536
rs12222256
 386 V>M No UniProt
1000Genomes
ExAC
TOPMed
dbSNP
gnomAD
rs755173347 388 M>I No ExAC
gnomAD
rs1238990244 388 M>K No TOPMed
gnomAD
rs1257429618 391 S>N No TOPMed
gnomAD
TCGA novel 392 R>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs923662883 393 S>N No Ensembl
rs1456464212 394 L>V No TOPMed
TCGA novel 396 K>missing Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM6067024 400 Q>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
RCV000953293
rs17881197
VAR_021070
 401 R>K No ClinVar
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs559399763 403 I>L No 1000Genomes
ExAC
gnomAD
rs1425711656 403 I>T No gnomAD
rs559399763 403 I>V No 1000Genomes
ExAC
gnomAD
rs1951133753 405 A>G No Ensembl
TCGA novel 405 A>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1951133839 406 T>P No Ensembl
rs749826929 408 E>D No ExAC
TOPMed
gnomAD
rs1193655352 408 E>K No gnomAD
rs1478543681 410 Y>C No TOPMed
gnomAD
rs201361356 411 R>K No 1000Genomes
ExAC
TOPMed
gnomAD
rs1951134221 412 L>R No Ensembl
rs1242006697 414 N>S No TOPMed
rs947413657 415 D>E No TOPMed
gnomAD
rs1951134365 416 L>F No Ensembl
rs779461718 417 V>E No ExAC
TOPMed
gnomAD
rs779461718 417 V>G No ExAC
TOPMed
gnomAD
rs1330209632 417 V>L No TOPMed
gnomAD
COSM685796 419 D>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1565324041 420 L>V No Ensembl
rs1392177670 421 L>R No TOPMed
rs1295816034 422 N>D No TOPMed
rs369562282 422 N>S No ESP
ExAC
TOPMed
gnomAD
rs898645561 423 A>V No gnomAD
rs748006743 425 D>Y No ExAC
gnomAD
rs769710195 427 I>K No ExAC
gnomAD
rs1951134967 427 I>L No TOPMed
rs551049741 432 R>G No 1000Genomes
ExAC
TOPMed
gnomAD
rs994266696 432 R>K No Ensembl
rs1025701599 433 E>A No Ensembl
rs151072309 433 E>D No ESP
ExAC
TOPMed
gnomAD
rs1951135205 433 E>K No TOPMed
rs766428761 434 R>K No ExAC
gnomAD
rs774340936 435 A>T No ExAC
gnomAD
rs767698113 438 E>D No ExAC
gnomAD
rs753096055 439 K>* No ExAC
gnomAD
rs753096055 439 K>E No ExAC
gnomAD
rs571142895 439 K>R No 1000Genomes
ExAC
TOPMed
gnomAD
rs571142895 439 K>T No 1000Genomes
ExAC
TOPMed
gnomAD
rs1591523739 441 S>P No Ensembl
TCGA novel 442 N>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 443 D>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM466204 443 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs764505569 444 L>S No ExAC
gnomAD
COSM922224 444 L>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1395199228 446 L>S No TOPMed
gnomAD
rs754305891 447 I>T No ExAC
gnomAD
rs759842920 448 R>P No ExAC
TOPMed
gnomAD
rs759842920
COSM171761
 448 R>Q Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs757753179 448 R>W No ExAC
TOPMed
gnomAD
TCGA novel 449 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1394418106 449 K>R No gnomAD
TCGA novel 451 R>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1338809240 451 R>S No gnomAD
rs1383751307 452 M>L No gnomAD
rs754391604 453 A>G No ExAC
TOPMed
gnomAD
rs751069462 453 A>S No ExAC
gnomAD
rs910399438 454 L>F No Ensembl
COSM922225 456 Q>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1356362773 457 H>N No gnomAD
rs1356362773 457 H>Y No gnomAD
rs1951191941 459 T>N No Ensembl
rs1342231567 461 V>I No gnomAD
rs1201621698 462 I>L No gnomAD
rs777510978 464 I>V No ExAC
gnomAD
rs897547684 466 D>A No TOPMed
gnomAD
rs1239776617 466 D>E No TOPMed
gnomAD
rs897547684 466 D>G No TOPMed
gnomAD
rs1037418239 466 D>H No Ensembl
rs1591525814 467 S>G No Ensembl
rs377413987 467 S>N No ESP
ExAC
TOPMed
gnomAD
rs377413987 467 S>T No ESP
ExAC
TOPMed
gnomAD
rs1951192513 471 A>S No TOPMed
rs1184660231 472 G>E No TOPMed
COSM294168
rs145025961
 472 G>R Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs993209498 473 I>V No Ensembl
rs1046482558 475 N>T No Ensembl
rs760957345 477 Q>K No ExAC
gnomAD
rs200653824 477 Q>R No Ensembl
rs200833305 478 E>Q No 1000Genomes
gnomAD
rs1951193049 479 H>D No Ensembl
rs1490151855 479 H>R No gnomAD
rs1483497360 480 D>G No TOPMed
gnomAD
COSM6067023 480 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1483497360 480 D>V No TOPMed
gnomAD
rs1951193126 480 D>Y No Ensembl
rs202087665 481 V>F No TOPMed
gnomAD
COSM3985860 481 V>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs202087665 481 V>I No TOPMed
gnomAD
rs1951193327 482 I>T No Ensembl
rs1197249795 483 K>E No gnomAD
rs1265911746 483 K>R No TOPMed
gnomAD
rs1301041094 484 Q>R No TOPMed
gnomAD
rs1329812731 486 T>A No TOPMed
gnomAD
rs1951193621 487 Q>E No gnomAD
rs762144986 487 Q>P No ExAC
gnomAD
rs200008391 488 T>K No TOPMed
gnomAD
COSM168408
rs200008391
 488 T>M Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No cosmic curated
NCI-TCGA
TOPMed
gnomAD
rs1591525882 491 Q>P No TOPMed
rs1591525882 491 Q>R No TOPMed
rs763551333 492 A>V No ExAC
gnomAD
rs1159354646 493 R>G No gnomAD
rs199509362 494 E>K No 1000Genomes
ExAC
gnomAD
rs1410111207 495 L>Q No TOPMed
rs752241001 496 I>M No ExAC
TOPMed
gnomAD
rs1480768971 496 I>T No gnomAD
rs373311655 497 D>G No ESP
ExAC
TOPMed
gnomAD
rs1951194042 497 D>Y No Ensembl
rs138752976 498 T>M No ESP
ExAC
TOPMed
gnomAD
TCGA novel 498 T>N Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1951194102 498 T>P No TOPMed
rs1951194203 500 L>F No TOPMed
rs753540410 501 V>E No ExAC
gnomAD
rs756933731 503 G>E No ExAC
gnomAD
rs778798841 505 I>F No ExAC
gnomAD
rs77165340 506 A>P No ExAC
gnomAD
rs1164390031 506 A>V No TOPMed
rs1951194437 507 A>V No Ensembl
rs1350859397 508 T>I No gnomAD
rs747155453 508 T>S No ExAC
gnomAD
rs1407277844 509 V>A No gnomAD
rs767629005 509 V>L No Ensembl
rs1951194626 511 R>I No Ensembl
rs370069893 512 N>S No ESP
ExAC
TOPMed
gnomAD
rs370069893 512 N>T No ESP
ExAC
TOPMed
gnomAD
rs776938400 513 S>C No ExAC
TOPMed
gnomAD
rs776938400 513 S>F No ExAC
TOPMed
gnomAD
COSM1474943 514 L>A Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1473044401 514 L>R No TOPMed
gnomAD
rs2135792641 518 E>D No Ensembl
rs1216201125 518 E>K No TOPMed
gnomAD
rs1297142999 518 E>V No gnomAD
rs1453451870 519 A>P No TOPMed
gnomAD
rs1453451870 519 A>T No TOPMed
gnomAD
rs773670994 522 Y>H No ExAC
gnomAD
rs1951195337 523 E>D No TOPMed
rs763335184 523 E>K No ExAC
gnomAD
rs1223093283
TCGA novel
 524 H>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
rs998326954 528 Q>R No Ensembl
TCGA novel 529 Q>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs749715948 530 D>H No ExAC
TOPMed
gnomAD
rs749715948 530 D>Y No ExAC
TOPMed
gnomAD
rs771295858 531 I>V No ExAC
TOPMed
gnomAD
rs1380092376 533 Y>C No TOPMed
gnomAD
rs1483351317 535 P>T No gnomAD
COSM69820 536 T>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1161998779 537 E>D No gnomAD
COSM3442664 537 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs760065153 538 D>G No ExAC
gnomAD
rs1300591134 539 V>A No TOPMed
gnomAD
rs1951201072 539 V>I No TOPMed
rs1951202663 541 D>V No TOPMed
rs1330336027 543 P>A No gnomAD
rs1330336027 543 P>S No gnomAD
rs1951202845 544 V>A No TOPMed
rs1444050077 544 V>M No gnomAD
rs1565325906 548 L>V No gnomAD
COSM685795
rs373651361
 549 R>Q lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
TOPMed
gnomAD
rs145399165 549 R>W No ESP
ExAC
TOPMed
gnomAD
rs1295346849 552 Q>K No TOPMed
gnomAD
rs1441559680 553 E>D No TOPMed
gnomAD
rs149475723 556 T>I No ESP
ExAC
TOPMed
gnomAD
rs774719063 557 C>* No ExAC
gnomAD
rs1436314841 557 C>Y No gnomAD
rs1233821588 558 K>R No gnomAD
rs1951203458 559 V>A No Ensembl
rs1477953478 561 M>I No TOPMed
gnomAD
rs1951203517 561 M>T No TOPMed
rs1951203496 561 M>V No gnomAD
TCGA novel
rs1951203589
 563 K>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
COSM1350362 564 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs746351416 565 V>A No ExAC
gnomAD
rs772607176 567 I>T No ExAC
gnomAD
rs1157973692 567 I>V No TOPMed
gnomAD
rs1480499410 568 V>A No gnomAD
rs200093408 569 F>L No 1000Genomes
ExAC
gnomAD
rs1169373239 569 F>L No TOPMed
gnomAD
rs1411306598 571 P>L No TOPMed
gnomAD
rs1411306598 571 P>R No TOPMed
gnomAD
COSM3442665 571 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1349146692 573 G>S No TOPMed
gnomAD
TCGA novel 574 H>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1193650949 577 V>I No TOPMed
gnomAD
rs1951204018 579 K>Q No gnomAD
rs1304922616 580 D>N No gnomAD
rs1304922616 580 D>Y No gnomAD
rs761445277 581 C>W No ExAC
gnomAD
COSM1739751
rs1951204079
 581 C>Y NS [Cosmic] No cosmic curated
Ensembl
rs1224146569 585 L>* No gnomAD
rs1951204167 586 R>T No Ensembl
rs1277681875 589 P>A No gnomAD
COSM3442666 592 R>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs202122377 594 T>I No 1000Genomes
gnomAD
rs1951204333 595 I>L No TOPMed
rs1951204333 595 I>V No TOPMed
rs1951204407 597 G>D No TOPMed
rs762729326 600 R>H No ExAC
TOPMed
gnomAD
rs762729326 600 R>P No ExAC
TOPMed
gnomAD
rs766231708 601 T>A No ExAC
gnomAD
rs761837224 605 S>= No ESP
ExAC
TOPMed
gnomAD

No associated diseases with Q13489

2 regional properties for Q13489

Type Name Position InterPro Accession
domain Protein kinase domain 221 - 479 IPR000719
active_site Serine/threonine-protein kinase, active site 345 - 357 IPR008271

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

6 GO annotations of molecular function

Name Definition
cysteine-type endopeptidase inhibitor activity involved in apoptotic process Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
metal ion binding Binding to a metal ion.
protein-containing complex binding Binding to a macromolecular complex.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

19 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
canonical NF-kappaB signal transduction The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of necroptotic process Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
non-canonical NF-kappaB signal transduction The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
positive regulation of canonical NF-kappaB signal transduction Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of protein ubiquitination Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
regulation of cysteine-type endopeptidase activity Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity.
regulation of inflammatory response Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
regulation of innate immune response Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
regulation of necroptotic process Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway.
regulation of RIG-I signaling pathway Any process that modulates the frequency, rate or extent of the RIG-I signaling pathway.
regulation of toll-like receptor signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
tumor necrosis factor-mediated signaling pathway The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q90660 ITA Inhibitor of apoptosis protein Gallus gallus (Chicken) SS
A1E2V0 BIRC3 Baculoviral IAP repeat-containing protein 3 Canis lupus familiaris (Dog) (Canis familiaris) SS
Q13490 BIRC2 Baculoviral IAP repeat-containing protein 2 Homo sapiens (Human) EV
Q96P09 BIRC8 Baculoviral IAP repeat-containing protein 8 Homo sapiens (Human) PR
Q62210 Birc2 Baculoviral IAP repeat-containing protein 2 Mus musculus (Mouse) SS
O08863 Birc3 Baculoviral IAP repeat-containing protein 3 Mus musculus (Mouse) SS
O62640 PIAP Putative inhibitor of apoptosis Sus scrofa (Pig) SS
10 20 30 40 50 60
MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL ARAGFYYTGV
70 80 90 100 110 120
NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN SVNNLEATSQ PTFPSSVTNS
130 140 150 160 170 180
THSLLPGTEN SGYFRGSYSN SPSNPVNSRA NQDFSALMRS SYHCAMNNEN ARLLTFQTWP
190 200 210 220 230 240
LTFLSPTDLA KAGFYYIGPG DRVACFACGG KLSNWEPKDN AMSEHLRHFP KCPFIENQLQ
250 260 270 280 290 300
DTSRYTVSNL SMQTHAARFK TFFNWPSSVL VNPEQLASAG FYYVGNSDDV KCFCCDGGLR
310 320 330 340 350 360
CWESGDDPWV QHAKWFPRCE YLIRIKGQEF IRQVQASYPH LLEQLLSTSD SPGDENAESS
370 380 390 400 410 420
IIHFEPGEDH SEDAIMMNTP VINAAVEMGF SRSLVKQTVQ RKILATGENY RLVNDLVLDL
430 440 450 460 470 480
LNAEDEIREE ERERATEEKE SNDLLLIRKN RMALFQHLTC VIPILDSLLT AGIINEQEHD
490 500 510 520 530 540
VIKQKTQTSL QARELIDTIL VKGNIAATVF RNSLQEAEAV LYEHLFVQQD IKYIPTEDVS
550 560 570 580 590 600
DLPVEEQLRR LQEERTCKVC MDKEVSIVFI PCGHLVVCKD CAPSLRKCPI CRSTIKGTVR
TFLS