Q13164
SS
Gene name |
MAPK7 (BMK1, ERK5, PRKM7) |
Protein name |
Mitogen-activated protein kinase 7 |
Names |
MAP kinase 7 , MAPK 7 , EC 2.7.11.24 , Big MAP kinase 1 , BMK-1 , Extracellular signal-regulated kinase 5 , ERK-5 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5598 |
EC number |
2.7.11.24: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
MAPK1 encodes Mitogen-activated protein kinase 1, and is involved in diverse cellular responses by phosphorylating cytoplasmic and nuclear proteins. Unlike other MAP kinases, MAPK1 activates via dual phosphorylation of Thr-186 and Tyr-193 within the activation lip, and mutations at Q105 alone were sufficient for autoactivation. Additionally, in the inactive form, L76, Q10 and I87 form a structural unit that restrains intramolecular autophosphorylation by preventing interactions between activation lip residues and the catalytic base (D149) needed for phosphoryl transfer. Mutations at L76, I87 and additionally S153 increased basal specific activity via autophosphorylation of Thr-186 and Tyr-193.
Autoinhibitory domains (AIDs)
Target domain |
55-347 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
199-226 (Activation loop from InterPro)
Target domain |
55-347 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Emrick MA et al. (2006) "The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity", Proceedings of the National Academy of Sciences of the United States of America, 103, 18101-6
- Emrick MA et al. (2001) "Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations", The Journal of biological chemistry, 276, 46469-79
Autoinhibited structure
Activated structure
14 structures for Q13164
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2Q8Y | X-ray | 200 A | B | 215-223 | PDB |
| 4B99 | X-ray | 280 A | A | 1-397 | PDB |
| 4IC7 | X-ray | 260 A | A/D | 1-431 | PDB |
| 4IC8 | X-ray | 280 A | A/B | 1-431 | PDB |
| 4ZSG | X-ray | 179 A | A | 47-393 | PDB |
| 4ZSJ | X-ray | 248 A | A | 50-393 | PDB |
| 4ZSL | X-ray | 225 A | A | 53-393 | PDB |
| 5BYY | X-ray | 279 A | A | 49-394 | PDB |
| 5BYZ | X-ray | 165 A | A | 48-395 | PDB |
| 5O7I | X-ray | 238 A | A | 46-402 | PDB |
| 6HKM | X-ray | 247 A | A | 49-395 | PDB |
| 6HKN | X-ray | 233 A | A | 54-393 | PDB |
| 7PUS | X-ray | 259 A | AAA | 46-402 | PDB |
| AF-Q13164-F1 | Predicted | AlphaFoldDB |
876 variants for Q13164
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
RCV000656381 rs147296805 |
296 | A>T | Scoliosis, isolated, susceptibility to, 1 [ClinVar] | Yes |
ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000656382 rs758163506 |
587 | P>L | Scoliosis, isolated, susceptibility to, 1 [ClinVar] | Yes |
ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs1555613564 RCV000656383 |
648 | P>L | Scoliosis, isolated, susceptibility to, 1 [ClinVar] | Yes |
ClinVar Ensembl dbSNP |
| rs1912354617 | 2 | A>V | No | Ensembl | |
| rs2152289496 | 4 | P>L | No | Ensembl | |
| rs1598109974 | 4 | P>S | No | Ensembl | |
| rs145510195 | 7 | E>K | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1326562849 | 8 | E>G | No | gnomAD | |
| rs531434532 | 8 | E>K | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs544657727 | 9 | D>E | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs759673722 | 10 | G>S | No |
ExAC TOPMed gnomAD |
|
| rs765309809 | 12 | D>N | No |
ExAC gnomAD |
|
| rs752946139 | 13 | G>R | No |
ExAC TOPMed gnomAD |
|
| rs1221813081 | 14 | S>F | No |
TOPMed gnomAD |
|
| rs555044170 | 15 | A>T | No |
ExAC gnomAD |
|
| rs1202397581 | 16 | E>K | No | gnomAD | |
| rs1437677714 | 17 | P>H | No | gnomAD | |
| rs1437677714 | 17 | P>L | No | gnomAD | |
| rs1248784382 | 17 | P>S | No |
TOPMed gnomAD |
|
| rs1248784382 | 17 | P>T | No |
TOPMed gnomAD |
|
| rs751958457 | 18 | P>H | No |
ExAC TOPMed gnomAD |
|
| rs751958457 | 18 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs1414891780 | 18 | P>S | No | gnomAD | |
| rs757695720 | 20 | P>H | No |
ExAC TOPMed gnomAD |
|
| rs757695720 | 20 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs983461334 | 20 | P>T | No | Ensembl | |
| rs1912364663 | 21 | V>A | No |
TOPMed gnomAD |
|
|
COSM559940 rs748692208 COSM6080405 |
21 | V>L | lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] | No |
cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD |
| rs374947186 | 23 | A>V | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs747827826 | 24 | E>D | No |
ExAC gnomAD |
|
| rs1912366216 | 25 | P>R | No | Ensembl | |
| rs1309749803 | 25 | P>S | No |
TOPMed gnomAD |
|
| rs567028407 | 26 | A>T | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs773113285 | 27 | H>D | No |
ExAC TOPMed gnomAD |
|
| rs773113285 | 27 | H>Y | No |
ExAC TOPMed gnomAD |
|
| rs944771923 | 28 | T>A | No | Ensembl | |
| rs944771923 | 28 | T>P | No | Ensembl | |
| rs1235673576 | 29 | A>G | No |
TOPMed gnomAD |
|
| rs1312858755 | 29 | A>T | No |
TOPMed gnomAD |
|
| rs1235673576 | 29 | A>V | No |
TOPMed gnomAD |
|
| rs546912846 | 31 | S>F | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs2152289637 | 31 | S>P | No | Ensembl | |
| rs776635073 | 32 | V>L | No |
ExAC gnomAD |
|
| rs932256706 | 35 | K>N | No |
TOPMed gnomAD |
|
| rs1044409528 | 37 | L>V | No |
TOPMed gnomAD |
|
| rs765379731 | 38 | A>S | No |
ExAC gnomAD |
|
| rs765379731 | 38 | A>T | No |
ExAC gnomAD |
|
| rs904098316 | 38 | A>V | No |
TOPMed gnomAD |
|
| rs1480613638 | 39 | L>Q | No | gnomAD | |
| rs1434459010 | 41 | K>E | No | gnomAD | |
| TCGA novel | 41 | K>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1372195010 | 43 | R>H | No | gnomAD | |
|
rs999628197 COSM343238 |
46 | D>N | lung [Cosmic] | No |
cosmic curated TOPMed gnomAD |
| rs999628197 | 46 | D>Y | No |
TOPMed gnomAD |
|
| rs751903543 | 48 | T>I | No |
ExAC TOPMed gnomAD |
|
| rs1912376162 | 48 | T>S | No | TOPMed | |
| rs1388640124 | 50 | D>E | No |
TOPMed gnomAD |
|
| rs767848284 | 53 | D>E | No |
ExAC gnomAD |
|
| rs1912378026 | 53 | D>V | No | TOPMed | |
| rs1364671960 | 54 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs754399677 | 57 | I>T | No |
ExAC TOPMed gnomAD |
|
| rs778545740 | 58 | I>M | No |
ExAC TOPMed gnomAD |
|
| rs1277132817 | 58 | I>T | No | gnomAD | |
| rs1222382102 | 59 | E>K | No | gnomAD | |
| rs1266586771 | 60 | T>A | No | gnomAD | |
| rs1418807987 | 60 | T>S | No | TOPMed | |
| rs371411625 | 61 | I>L | No |
ESP ExAC TOPMed gnomAD |
|
| rs371411625 | 61 | I>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs1260469705 | 64 | G>R | No | gnomAD | |
| rs1912382441 | 65 | A>V | No | TOPMed | |
| rs1912382986 | 68 | V>A | No | Ensembl | |
| rs1383137901 | 71 | S>F | No |
TOPMed gnomAD |
|
| rs770790042 | 72 | A>S | No |
ExAC gnomAD |
|
| rs1351599577 | 73 | R>C | No | gnomAD | |
| rs776381725 | 73 | R>H | No |
ExAC TOPMed gnomAD |
|
| rs745794753 | 74 | R>C | No |
ExAC TOPMed gnomAD |
|
| rs1388005122 | 74 | R>H | No | gnomAD | |
| rs1437912915 | 75 | R>C | No | Ensembl | |
| rs1271613921 | 75 | R>P | No |
TOPMed gnomAD |
|
| rs1381034115 | 76 | L>F | No | gnomAD | |
| rs1228158783 | 77 | T>A | No | gnomAD | |
| rs1912387366 | 77 | T>I | No | TOPMed | |
| rs763073942 | 78 | G>S | No |
ExAC gnomAD |
|
| rs1434928369 | 81 | V>A | No |
TOPMed gnomAD |
|
| rs1434928369 | 81 | V>E | No |
TOPMed gnomAD |
|
| rs914275176 | 81 | V>M | No | TOPMed | |
| rs756926506 | 82 | A>V | No |
ExAC gnomAD |
|
| rs1365858543 | 83 | I>V | No | gnomAD | |
| rs1301901552 | 90 | F>I | No | gnomAD | |
| rs780762020 | 91 | D>H | No |
ExAC TOPMed gnomAD |
|
| rs780762020 | 91 | D>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs1912488123 | 92 | V>M | No | Ensembl | |
| rs750172981 | 93 | V>M | No |
ExAC gnomAD |
|
| rs755904525 | 94 | T>I | No |
ExAC gnomAD |
|
| rs755904525 | 94 | T>S | No |
ExAC gnomAD |
|
| rs749248739 | 95 | N>S | No |
ExAC gnomAD |
|
| rs768633964 | 96 | A>G | No |
ExAC gnomAD |
|
| rs1471669078 | 97 | K>Q | No | TOPMed | |
| rs371649354 | 97 | K>R | No |
ESP ExAC TOPMed gnomAD |
|
| COSM559939 | 98 | R>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs748244394 | 98 | R>W | No |
ExAC TOPMed gnomAD |
|
| rs1248564982 | 100 | L>F | No | gnomAD | |
| rs1248564982 | 100 | L>V | No | gnomAD | |
| rs761055778 | 103 | L>P | No |
ExAC gnomAD |
|
| TCGA novel | 104 | K>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1912494969 | 104 | K>R | No | TOPMed | |
| TCGA novel | 106 | L>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1912495957 | 107 | K>T | No |
TOPMed gnomAD |
|
| rs151244032 | 108 | H>L | No |
ESP ExAC gnomAD |
|
| rs151244032 | 108 | H>P | No |
ESP ExAC gnomAD |
|
| rs765910850 | 111 | H>Y | No |
ExAC gnomAD |
|
| rs1273982658 | 112 | D>G | No | gnomAD | |
|
COSM472406 rs1342937620 |
112 | D>N | kidney [Cosmic] | No |
cosmic curated TOPMed gnomAD |
| rs1912498539 | 113 | N>T | No | gnomAD | |
|
rs147142467 COSM2798018 |
116 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA gnomAD |
| rs1912500427 | 117 | I>M | No | TOPMed | |
| rs755857429 | 118 | K>E | No |
ExAC TOPMed gnomAD |
|
| rs1598112528 | 120 | I>L | No | Ensembl | |
| rs753677940 | 122 | R>K | No |
ExAC TOPMed gnomAD |
|
| rs753677940 | 122 | R>M | No |
ExAC TOPMed gnomAD |
|
| rs778773876 | 123 | P>S | No |
ExAC TOPMed gnomAD |
|
| rs369748158 | 125 | V>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ESP ExAC NCI-TCGA TOPMed gnomAD |
| rs1912503560 | 126 | P>R | No | Ensembl | |
| rs771317953 | 127 | Y>C | No |
ExAC gnomAD |
|
| COSM1381425 | 128 | G>D | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1912504343 | 128 | G>S | No | gnomAD | |
| rs746288972 | 129 | E>D | No |
ExAC TOPMed gnomAD |
|
| rs1368255791 | 129 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| rs1165568184 | 131 | K>Q | No |
TOPMed gnomAD |
|
| rs759078562 | 135 | V>M | No |
ExAC TOPMed gnomAD |
|
| rs1912567711 | 136 | V>A | No |
TOPMed gnomAD |
|
| rs1912567491 | 136 | V>F | No | Ensembl | |
| rs1168762457 | 138 | D>Y | No | TOPMed | |
| rs1424993952 | 140 | M>R | No | gnomAD | |
| rs1457370499 | 141 | E>K | No | gnomAD | |
| rs762820642 | 143 | D>N | No |
ExAC gnomAD |
|
| COSM3969872 | 144 | L>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs138627525 | 146 | Q>* | No |
ESP TOPMed |
|
| rs1318867684 | 146 | Q>H | No |
TOPMed gnomAD |
|
| rs764051980 | 147 | I>V | No |
ExAC gnomAD |
|
| rs761932610 | 148 | I>V | No | ExAC | |
| rs767680810 | 149 | H>R | No |
ExAC gnomAD |
|
| rs1912571179 | 150 | S>T | No | Ensembl | |
| rs1481622271 | 151 | S>L | No | TOPMed | |
| rs1275661777 | 152 | Q>H | No | TOPMed | |
| rs1912571811 | 153 | P>A | No |
TOPMed gnomAD |
|
| rs1028749177 | 153 | P>L | No |
TOPMed gnomAD |
|
| rs780384541 | 156 | L>P | No |
ExAC gnomAD |
|
| rs755374629 | 159 | V>L | No |
ExAC TOPMed gnomAD |
|
| rs755374629 | 159 | V>M | No |
ExAC TOPMed gnomAD |
|
| rs748679283 | 160 | R>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs1299746199 | 160 | R>H | No |
TOPMed gnomAD |
|
| rs772605184 | 161 | Y>C | No |
ExAC gnomAD |
|
| rs1912574243 | 162 | F>S | No |
TOPMed gnomAD |
|
| COSM976383 | 163 | L>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1384572470 | 164 | Y>* | No | TOPMed | |
| rs1912574474 | 165 | Q>R | No |
TOPMed gnomAD |
|
|
rs1912575630 COSM976384 |
168 | R>Q | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated TOPMed |
| rs201284087 | 168 | R>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs745441493 | 169 | G>A | No |
ExAC TOPMed gnomAD |
|
| rs1368513680 | 169 | G>C | No |
TOPMed gnomAD |
|
| rs1912576297 | 170 | L>R | No | gnomAD | |
| rs769272709 | 170 | L>V | No |
ExAC TOPMed gnomAD |
|
| rs1369126434 | 172 | Y>* | No | gnomAD | |
| TCGA novel | 172 | Y>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs145405195 | 173 | M>I | No |
ESP ExAC TOPMed gnomAD |
|
| rs149300595 | 173 | M>V | No |
ESP ExAC |
|
| rs1912577998 | 174 | H>P | No | Ensembl | |
| rs1912577772 | 174 | H>Y | No | TOPMed | |
| rs774334323 | 175 | S>L | No |
ExAC gnomAD |
|
| rs774334323 | 175 | S>W | No |
ExAC gnomAD |
|
| TCGA novel | 176 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1912579038 | 177 | Q>E | No | Ensembl | |
| rs935890659 | 177 | Q>R | No | Ensembl | |
| rs1053803640 | 178 | V>D | No | Ensembl | |
| rs1053803640 | 178 | V>G | No | Ensembl | |
| rs1377453358 | 179 | I>N | No | gnomAD | |
| rs892436061 | 181 | R>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
|
COSM182408 rs773156619 |
181 | R>H | Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] | No |
cosmic curated ExAC NCI-TCGA gnomAD |
| rs1336270584 | 182 | D>N | No | gnomAD | |
| COSM4064604 | 183 | L>P | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs202122403 | 183 | L>V | No | Ensembl | |
| rs2152292290 | 186 | S>P | No | Ensembl | |
| rs755287381 | 192 | E>D | No |
ExAC gnomAD |
|
| rs2152292305 | 194 | C>W | No | Ensembl | |
| rs1235506220 | 195 | E>D | No | gnomAD | |
| rs1482844626 | 196 | L>F | No | gnomAD | |
| rs1912583394 | 198 | I>T | No | TOPMed | |
| rs142437840 | 201 | F>S | No | ESP | |
| rs1258769303 | 205 | R>C | No | TOPMed | |
| rs753124346 | 205 | R>H | No |
ExAC TOPMed gnomAD |
|
| rs753124346 | 205 | R>P | No |
ExAC TOPMed gnomAD |
|
| rs778264534 | 206 | G>V | No |
ExAC TOPMed gnomAD |
|
| rs1912586029 | 208 | C>S | No |
TOPMed gnomAD |
|
| rs1330660878 | 209 | T>P | No | TOPMed | |
| rs1465898155 | 210 | S>L | No | gnomAD | |
| COSM976386 | 211 | P>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs200671339 | 212 | A>T | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs376919837 | 214 | H>D | No |
ESP ExAC TOPMed gnomAD |
|
| rs953004960 | 214 | H>P | No | Ensembl | |
| rs376919837 | 214 | H>Y | No |
ESP ExAC TOPMed gnomAD |
|
| rs1912589192 | 216 | Y>* | No | Ensembl | |
| rs112890818 | 218 | M>T | No | Ensembl | |
| rs1912589853 | 219 | T>I | No | gnomAD | |
| rs2152292392 | 221 | Y>D | No | Ensembl | |
| TCGA novel | 223 | A>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| COSM4064605 | 223 | A>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| COSM3819008 | 224 | T>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs775325009 | 225 | R>H | No | Ensembl | |
| rs765499961 | 228 | R>C | No |
ExAC gnomAD |
|
| rs753001348 | 228 | R>H | No |
ExAC gnomAD |
|
| rs758766881 | 229 | A>V | No |
ExAC TOPMed gnomAD |
|
| rs1442224602 | 231 | E>K | No |
TOPMed gnomAD |
|
| rs752126084 | 232 | L>F | No |
ExAC gnomAD |
|
| rs2079437571 | 233 | M>I | No | TOPMed | |
| rs757750641 | 233 | M>L | No |
ExAC gnomAD |
|
| rs754667613 | 235 | S>F | No |
ExAC TOPMed gnomAD |
|
| rs748876612 | 235 | S>P | No |
ExAC gnomAD |
|
| rs976379277 | 236 | L>S | No | gnomAD | |
| rs1912596394 | 237 | H>R | No | Ensembl | |
| rs1158849118 | 237 | H>Y | No | gnomAD | |
| COSM3819009 | 239 | Y>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1428363713 | 240 | T>A | No | gnomAD | |
| rs1267994030 | 240 | T>I | No |
TOPMed gnomAD |
|
| rs747888959 | 241 | Q>H | No |
ExAC gnomAD |
|
| rs1598114253 | 243 | I>V | No | TOPMed | |
| rs371189451 | 245 | L>F | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs375465225 | 247 | S>C | No |
ESP TOPMed gnomAD |
|
| TCGA novel | 248 | V>A | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1912599368 | 252 | F>L | No | TOPMed | |
| rs1204309728 | 253 | G>V | No | gnomAD | |
| COSM976387 | 255 | M>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs925746978 | 257 | A>D | No |
TOPMed gnomAD |
|
| rs1275321758 | 257 | A>T | No | gnomAD | |
| rs925746978 | 257 | A>V | No |
TOPMed gnomAD |
|
| rs139385845 | 258 | R>Q | No |
ESP ExAC TOPMed gnomAD |
|
| rs759623746 | 258 | R>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
|
rs1455739978 COSM3402655 |
259 | R>C | Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated TOPMed gnomAD |
| rs1455739978 | 259 | R>G | No |
TOPMed gnomAD |
|
| rs563238549 | 259 | R>H | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1448090508 | 262 | F>L | No | gnomAD | |
| rs751906877 | 263 | P>L | No |
ExAC gnomAD |
|
| rs751906877 | 263 | P>Q | No |
ExAC gnomAD |
|
| rs767970510 | 266 | N>H | No |
ExAC gnomAD |
|
| rs1912603318 | 266 | N>I | No | Ensembl | |
| rs201779270 | 267 | Y>C | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1912604075 | 268 | V>I | No |
TOPMed gnomAD |
|
| COSM1493856 | 269 | H>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1598114440 | 269 | H>P | No | Ensembl | |
| rs1327583863 | 274 | I>M | No | gnomAD | |
| rs752421327 | 275 | M>I | No |
ExAC gnomAD |
|
| TCGA novel | 275 | M>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1227331481 | 276 | M>L | No | gnomAD | |
| rs777595707 | 277 | V>A | No |
ExAC gnomAD |
|
| rs1912605724 | 277 | V>M | No | Ensembl | |
| rs1598114478 | 280 | T>P | No | Ensembl | |
| rs1226546740 | 281 | P>S | No | gnomAD | |
| rs770842877 | 283 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs1912607894 | 283 | P>S | No | Ensembl | |
| rs1463732963 | 285 | V>A | No | gnomAD | |
| rs745908158 | 285 | V>M | No |
ExAC TOPMed gnomAD |
|
| rs575867788 | 286 | I>L | No |
ExAC gnomAD |
|
|
rs763127489 COSM976388 |
288 | A>D | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD |
| rs368401668 | 288 | A>S | No |
ESP ExAC gnomAD |
|
| rs1409034650 | 291 | A>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs1912613015 | 292 | E>A | No | TOPMed | |
| rs1912613329 | 293 | R>W | No | TOPMed | |
| rs1598114547 | 294 | V>G | No | Ensembl | |
| rs1912613687 | 294 | V>L | No | Ensembl | |
| COSM976389 | 295 | R>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs762099766 | 295 | R>Q | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1912614529 | 295 | R>W | No | TOPMed | |
| rs147296805 | 296 | A>S | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1355194385 | 296 | A>V | No | TOPMed | |
| rs1433909436 | 298 | I>M | No | gnomAD | |
| rs764822262 | 298 | I>T | No |
ExAC gnomAD |
|
| rs1320907090 | 299 | Q>H | No | gnomAD | |
| rs565291709 | 300 | S>C | No |
1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 300 | S>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1283565243 | 303 | P>T | No |
TOPMed gnomAD |
|
| rs758067983 | 304 | R>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs777301615 | 304 | R>H | No |
ExAC gnomAD |
|
| rs777301615 | 304 | R>L | No |
ExAC gnomAD |
|
| rs1275161672 | 305 | Q>P | No | gnomAD | |
| rs1208364614 | 308 | P>S | No | gnomAD | |
| rs757029869 | 312 | V>A | No |
ExAC TOPMed gnomAD |
|
| rs751298326 | 312 | V>L | No |
ExAC gnomAD |
|
| rs1598114683 | 313 | Y>S | No | Ensembl | |
| rs1475836771 | 315 | G>A | No |
TOPMed gnomAD |
|
| rs745783396 | 315 | G>S | No |
ExAC gnomAD |
|
| rs866090979 | 316 | A>G | No | gnomAD | |
| rs866090979 | 316 | A>V | No | gnomAD | |
| rs1598114725 | 317 | D>A | No | Ensembl | |
| rs1598114725 | 317 | D>G | No | Ensembl | |
|
rs780101862 COSM6002489 |
317 | D>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD |
| rs370959187 | 318 | R>C | No |
ESP ExAC TOPMed gnomAD |
|
| rs370959187 | 318 | R>G | No |
ESP ExAC TOPMed gnomAD |
|
| rs202165382 | 318 | R>H | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs202165382 | 318 | R>L | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1430830787 | 319 | Q>L | No |
TOPMed gnomAD |
|
| rs748505375 | 320 | A>G | No |
ExAC gnomAD |
|
| rs773765852 | 325 | G>D | No | ExAC | |
|
COSM299750 rs761235886 |
326 | R>C | Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| rs761235886 | 326 | R>G | No |
ExAC TOPMed gnomAD |
|
|
COSM1214518 rs775129236 |
326 | R>H | ovary Variant assessed as Somatic; MODERATE impact. large_intestine [Cosmic, NCI-TCGA] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 327 | M>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1912625152 | 327 | M>V | No | gnomAD | |
| rs140853138 | 329 | R>C | No |
ESP ExAC TOPMed gnomAD |
|
| rs140853138 | 329 | R>G | No |
ESP ExAC TOPMed gnomAD |
|
| rs368014787 | 329 | R>H | No |
ESP ExAC TOPMed gnomAD |
|
| rs368014787 | 329 | R>L | No |
ESP ExAC TOPMed gnomAD |
|
| rs2152292724 | 332 | P>A | No | Ensembl | |
| rs564709382 | 334 | A>T | No |
ExAC TOPMed gnomAD |
|
|
rs756030990 COSM5549557 |
334 | A>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD |
| rs371930122 | 335 | R>C | No |
ESP ExAC TOPMed gnomAD |
|
|
COSM976390 rs1248980248 |
335 | R>H | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD |
| rs749325148 | 336 | I>M | No |
ExAC gnomAD |
|
|
rs1393472368 TCGA novel |
337 | S>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No |
NCI-TCGA Ensembl |
| rs1912628241 | 337 | S>P | No | Ensembl | |
| TCGA novel | 338 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| COSM3969873 | 338 | A>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs927355456 | 340 | A>V | No |
TOPMed gnomAD |
|
| rs779147478 | 341 | A>S | No |
ExAC gnomAD |
|
| rs1430614744 | 341 | A>V | No |
TOPMed gnomAD |
|
| COSM3515030 | 342 | L>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs985577604 | 343 | R>C | No |
TOPMed gnomAD |
|
| rs148933637 | 343 | R>H | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs148933637 | 343 | R>P | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs992784282 | 345 | P>T | No | TOPMed | |
| rs1268483719 | 346 | F>S | No | gnomAD | |
| rs1375851381 | 347 | L>V | No | gnomAD | |
| rs773710838 | 348 | A>G | No |
ExAC gnomAD |
|
| rs913267899 | 348 | A>S | No |
TOPMed gnomAD |
|
| TCGA novel | 348 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs773710838 | 348 | A>V | No |
ExAC gnomAD |
|
| rs1174501521 | 349 | K>E | No | gnomAD | |
| rs747439500 | 349 | K>N | No |
ExAC gnomAD |
|
| rs1377165158 | 349 | K>R | No | gnomAD | |
| rs1912633343 | 352 | D>G | No | Ensembl | |
| rs1477421604 | 352 | D>N | No |
TOPMed gnomAD |
|
| rs367652354 | 353 | P>L | No |
ESP ExAC TOPMed gnomAD |
|
| rs1250872576 | 355 | D>G | No | TOPMed | |
| rs1483174156 | 355 | D>N | No | TOPMed | |
| rs946057983 | 357 | P>R | No | TOPMed | |
| rs369699460 | 357 | P>S | No |
ESP ExAC |
|
| rs1313701692 | 359 | C>S | No |
TOPMed gnomAD |
|
| rs1313701692 | 359 | C>Y | No |
TOPMed gnomAD |
|
| rs767214222 | 360 | A>G | No |
ExAC TOPMed gnomAD |
|
| rs767214222 | 360 | A>V | No |
ExAC TOPMed gnomAD |
|
| rs750159595 | 361 | P>A | No |
ExAC TOPMed gnomAD |
|
| rs755910431 | 361 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs750159595 | 361 | P>S | No |
ExAC TOPMed gnomAD |
|
| rs1213604420 | 362 | P>A | No | gnomAD | |
| rs1170535036 | 362 | P>L | No |
TOPMed gnomAD |
|
| rs1170535036 | 362 | P>R | No |
TOPMed gnomAD |
|
| rs753742102 | 364 | D>E | No |
ExAC TOPMed gnomAD |
|
| rs1369004649 | 365 | F>L | No | gnomAD | |
| rs1195832565 | 366 | A>G | No | gnomAD | |
| rs1483026932 | 366 | A>T | No | gnomAD | |
| rs1912639348 | 367 | F>I | No | Ensembl | |
|
rs752892599 COSM1214519 |
369 | R>C | large_intestine [Cosmic] | No |
cosmic curated ExAC TOPMed gnomAD |
| rs752892599 | 369 | R>G | No |
ExAC TOPMed gnomAD |
|
|
COSM976391 rs371955456 |
369 | R>H | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
| rs371955456 | 369 | R>L | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1912641620 | 370 | E>K | No | TOPMed | |
| rs1413234043 | 371 | A>S | No |
TOPMed gnomAD |
|
| rs746329382 | 372 | L>V | No |
ExAC gnomAD |
|
| rs1462436464 | 373 | T>A | No | gnomAD | |
| rs770397600 | 373 | T>I | No |
ExAC TOPMed gnomAD |
|
| rs770397600 | 373 | T>S | No |
ExAC TOPMed gnomAD |
|
| rs369306861 | 374 | R>Q | No |
ESP ExAC TOPMed gnomAD |
|
| rs767185851 | 374 | R>W | No |
ExAC gnomAD |
|
| rs1912644609 | 375 | E>Q | No | TOPMed | |
| rs772884779 | 376 | R>H | No |
ExAC TOPMed gnomAD |
|
| rs772884779 | 376 | R>L | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 376 | R>missing | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs772799361 | 376 | R>C | No |
ExAC TOPMed gnomAD |
|
| rs200326974 | 377 | I>N | No | Ensembl | |
| rs1912646149 | 377 | I>V | No |
TOPMed gnomAD |
|
| rs2152292921 | 378 | K>T | No | 1000Genomes | |
| rs1598115250 | 379 | E>K | No | Ensembl | |
| rs1295905640 | 381 | I>T | No | gnomAD | |
| rs1175070137 | 382 | V>M | No | TOPMed | |
| rs1912647608 | 386 | E>Q | No | TOPMed | |
| rs1912648267 | 389 | H>D | No | TOPMed | |
| rs759390175 | 389 | H>R | No |
ExAC TOPMed gnomAD |
|
| rs1269880063 | 390 | A>V | No | gnomAD | |
| rs1253295436 | 391 | R>K | No |
TOPMed gnomAD |
|
| rs1253295436 | 391 | R>T | No |
TOPMed gnomAD |
|
|
rs752665090 COSM1679641 |
392 | R>C | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
cosmic curated ExAC TOPMed gnomAD |
| rs752665090 | 392 | R>G | No |
ExAC TOPMed gnomAD |
|
| rs758579521 | 392 | R>H | No |
ExAC TOPMed gnomAD |
|
| rs758579521 | 392 | R>L | No |
ExAC TOPMed gnomAD |
|
| rs1341098806 | 393 | E>K | No | gnomAD | |
| COSM4939459 | 395 | I>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1283964191 | 395 | I>T | No |
TOPMed gnomAD |
|
| rs1247194264 | 395 | I>V | No |
TOPMed gnomAD |
|
| rs200542703 | 396 | R>C | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs55733844 | 396 | R>H | No |
ExAC TOPMed gnomAD |
|
| rs1456499023 | 399 | I>N | No | gnomAD | |
| rs746301619 | 400 | R>C | No |
ExAC TOPMed gnomAD |
|
| rs746301619 | 400 | R>G | No |
ExAC TOPMed gnomAD |
|
| rs897457045 | 400 | R>H | No |
TOPMed gnomAD |
|
| rs897457045 | 400 | R>L | No |
TOPMed gnomAD |
|
| rs71369423 | 401 | F>L | No |
ExAC gnomAD |
|
| rs994526389 | 402 | Q>R | No |
TOPMed gnomAD |
|
| rs1912654649 | 403 | P>S | No | Ensembl | |
| rs998362441 | 404 | S>F | No | Ensembl | |
| rs747618741 | 406 | Q>R | No |
ExAC gnomAD |
|
| rs1273305442 | 408 | V>A | No | gnomAD | |
| rs1273305442 | 408 | V>G | No | gnomAD | |
| rs771594246 | 408 | V>M | No |
ExAC gnomAD |
|
| rs1181081896 | 409 | A>D | No | TOPMed | |
| rs201185415 | 410 | S>I | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs201185415 | 410 | S>N | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs772758502 | 410 | S>R | No |
ExAC TOPMed gnomAD |
|
| rs201185415 | 410 | S>T | No |
1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 411 | E>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs527796521 | 413 | G>D | No |
ExAC gnomAD |
|
| rs527796521 | 413 | G>V | No |
ExAC gnomAD |
|
| rs763030070 | 414 | C>S | No |
ExAC gnomAD |
|
| rs758886992 | 416 | D>A | No |
ExAC TOPMed gnomAD |
|
| rs758886992 | 416 | D>V | No |
ExAC TOPMed gnomAD |
|
| rs751755653 | 417 | V>F | No |
ExAC TOPMed gnomAD |
|
| rs751755653 | 417 | V>I | No |
ExAC TOPMed gnomAD |
|
| rs1418684799 | 418 | E>K | No | gnomAD | |
| rs2152293048 | 420 | P>R | No | Ensembl | |
| COSM4064609 | 420 | P>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1006551539 | 422 | P>S | No | Ensembl | |
| rs757539450 | 425 | P>S | No |
ExAC gnomAD |
|
| rs1598115569 | 428 | D>E | No | Ensembl | |
| rs369117342 | 428 | D>N | No |
ESP ExAC TOPMed gnomAD |
|
|
rs1428148784 COSM3515032 |
430 | A>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic NCI-TCGA gnomAD |
| rs1002425257 | 431 | M>V | No |
TOPMed gnomAD |
|
| rs373540639 | 432 | E>V | No |
ESP TOPMed gnomAD |
|
| rs200615471 | 433 | S>F | No |
1000Genomes ExAC gnomAD |
|
| rs1912662243 | 434 | P>L | No |
TOPMed gnomAD |
|
| rs377501164 | 434 | P>S | No |
ESP TOPMed gnomAD |
|
| rs764602331 | 437 | A>T | No | Ensembl | |
|
COSM3819010 rs749773496 |
438 | P>L | breast [Cosmic] | No |
cosmic curated ExAC TOPMed gnomAD |
| rs371136372 | 438 | P>S | No |
ESP ExAC |
|
| rs1912664346 | 439 | P>S | No | TOPMed | |
| rs913320458 | 440 | P>Q | No | TOPMed | |
| rs1912665848 | 441 | C>F | No | gnomAD | |
| rs1912665600 | 441 | C>R | No | Ensembl | |
| rs1456232919 | 442 | P>L | No | gnomAD | |
| rs967327863 | 443 | G>D | No |
TOPMed gnomAD |
|
| rs776354479 | 443 | G>R | No |
ExAC TOPMed gnomAD |
|
| rs776354479 | 443 | G>S | No |
ExAC TOPMed gnomAD |
|
| rs957127698 | 446 | P>L | No |
TOPMed gnomAD |
|
| rs764184576 | 446 | P>S | No |
ExAC gnomAD |
|
| rs1407472376 | 447 | D>G | No | gnomAD | |
| rs201374056 | 447 | D>N | No |
ExAC TOPMed gnomAD |
|
| rs201374056 | 447 | D>Y | No |
ExAC TOPMed gnomAD |
|
| rs761954426 | 448 | T>I | No |
ExAC TOPMed gnomAD |
|
| rs761954426 | 448 | T>N | No |
ExAC TOPMed gnomAD |
|
| rs1448783807 | 449 | I>T | No |
TOPMed gnomAD |
|
| rs767593957 | 450 | D>V | No |
ExAC gnomAD |
|
| rs1434635741 | 451 | L>V | No | gnomAD | |
| rs926179505 | 452 | T>I | No |
TOPMed gnomAD |
|
| rs1020100908 | 452 | T>S | No |
TOPMed gnomAD |
|
| rs756341504 | 453 | L>P | No |
ExAC gnomAD |
|
| rs1298906724 | 457 | P>L | No | gnomAD | |
| rs766699229 | 458 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs1344809050 | 458 | P>S | No | TOPMed | |
| rs1344809050 | 458 | P>T | No | TOPMed | |
| rs755467285 | 460 | S>N | No |
ExAC gnomAD |
|
| rs574431533 | 460 | S>R | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1303972126 | 464 | P>A | No | Ensembl | |
| rs756826269 | 464 | P>L | No |
ExAC gnomAD |
|
| rs780612902 | 465 | P>S | No |
ExAC TOPMed gnomAD |
|
| rs1174679086 | 468 | D>A | No | gnomAD | |
| rs1174679086 | 468 | D>G | No | gnomAD | |
| rs1454144226 | 468 | D>N | No | gnomAD | |
| rs1912676858 | 469 | G>C | No | Ensembl | |
| rs1912677200 | 470 | A>S | No | Ensembl | |
| TCGA novel | 470 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1319523470 | 470 | A>V | No | gnomAD | |
| rs927231540 | 474 | N>D | No | Ensembl | |
| rs769395341 | 474 | N>S | No |
ExAC gnomAD |
|
| rs1912678957 | 475 | T>I | No | Ensembl | |
| rs1912679338 | 476 | K>N | No | TOPMed | |
| COSM976393 | 477 | A>D | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1567921617 | 480 | K>R | No | Ensembl | |
| rs1428384185 | 481 | A>S | No |
TOPMed gnomAD |
|
| rs1372247110 | 485 | K>* | No | Ensembl | |
| rs1912681137 | 486 | S>F | No | Ensembl | |
| TCGA novel | 486 | S>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 488 | R>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs140977816 | 490 | R>G | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1354671217 | 490 | R>Q | No | gnomAD | |
| rs140977816 | 490 | R>W | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1178091344 | 491 | L>P | No | TOPMed | |
| rs1687454473 | 494 | G>D | No | TOPMed | |
| rs1174386297 | 496 | S>G | No | TOPMed | |
| rs1445678448 | 497 | A>T | No |
TOPMed gnomAD |
|
| rs192160574 | 497 | A>V | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1412347541 | 498 | P>S | No |
TOPMed gnomAD |
|
| rs748090158 | 501 | A>D | No |
ExAC gnomAD |
|
| rs748090158 | 501 | A>V | No |
ExAC gnomAD |
|
| rs1416546758 | 503 | E>D | No | gnomAD | |
| rs1461629892 | 504 | P>A | No |
TOPMed gnomAD |
|
| rs1461629892 | 504 | P>T | No |
TOPMed gnomAD |
|
| rs760687824 | 505 | R>Q | No |
ExAC TOPMed gnomAD |
|
| rs773329608 | 505 | R>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs1461250957 | 506 | K>N | No | TOPMed | |
| rs1399843610 | 507 | P>L | No |
TOPMed gnomAD |
|
| rs1567921853 | 508 | V>M | No | Ensembl | |
| rs1445748682 | 511 | Q>H | No | gnomAD | |
| rs1346827418 | 511 | Q>R | No |
TOPMed gnomAD |
|
| rs1912703714 | 512 | E>* | No | TOPMed | |
| rs1912703918 | 512 | E>G | No | TOPMed | |
|
rs541052326 COSM1721283 |
513 | R>C | NS Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] | No |
NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
| rs1234097307 | 513 | R>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs1348841149 | 514 | Q>* | No | gnomAD | |
| COSM976394 | 515 | R>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1912705557 | 515 | R>Q | No | Ensembl | |
| rs1204880959 | 515 | R>W | No | gnomAD | |
| rs1285402705 | 516 | E>* | No | gnomAD | |
| rs1567921921 | 517 | R>Q | No | TOPMed | |
| rs1209430056 | 517 | R>W | No |
TOPMed gnomAD |
|
| rs1333835323 | 518 | E>K | No | TOPMed | |
| rs1912707477 | 519 | E>Q | No | Ensembl | |
| rs1912707726 | 520 | K>R | No | gnomAD | |
| rs753067846 | 523 | R>K | No |
ExAC gnomAD |
|
| rs1158869204 | 524 | R>Q | No | gnomAD | |
| COSM5508887 | 524 | R>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs967463884 | 526 | E>G | No |
TOPMed gnomAD |
|
| rs1432779004 | 527 | R>* | No | gnomAD | |
| rs764518897 | 528 | A>T | No |
ExAC TOPMed gnomAD |
|
| rs1314877608 | 530 | E>K | No |
TOPMed gnomAD |
|
| rs1448176920 | 531 | R>Q | No | gnomAD | |
|
COSM1195768 rs1238623232 |
531 | R>W | lung [Cosmic] | No |
cosmic curated gnomAD |
| rs1912712045 | 532 | E>A | No | TOPMed | |
| rs1912712287 | 533 | K>E | No | Ensembl | |
| rs1280178355 | 534 | R>L | No |
TOPMed gnomAD |
|
| rs1280178355 | 534 | R>Q | No |
TOPMed gnomAD |
|
| rs753520515 | 534 | R>W | No |
ExAC gnomAD |
|
| VAR_046225 | 535 | R>H | No | UniProt | |
| rs754719194 | 535 | R>Q | No |
ExAC gnomAD |
|
| rs778765836 | 536 | Q>R | No |
ExAC gnomAD |
|
| rs1912714862 | 538 | R>G | No | gnomAD | |
| rs376025129 | 538 | R>Q | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 538 | R>W | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1912715610 | 539 | E>K | No | TOPMed | |
| rs1452397412 | 540 | R>* | No | gnomAD | |
| rs1172807778 | 540 | R>Q | No |
TOPMed gnomAD |
|
| rs1395572311 | 541 | K>N | No | gnomAD | |
| rs777580902 | 542 | E>K | No |
ExAC TOPMed gnomAD |
|
| rs777580902 | 542 | E>Q | No |
ExAC TOPMed gnomAD |
|
| rs953512321 | 543 | R>L | No |
TOPMed gnomAD |
|
|
rs953512321 COSM4129676 |
543 | R>Q | thyroid [Cosmic] | No |
cosmic curated TOPMed gnomAD |
|
rs1370617055 COSM976395 |
543 | R>W | Variant assessed as Somatic; MODERATE impact. large_intestine endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed |
| COSM4920923 | 544 | G>E | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs543850595 | 544 | G>R | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs944829775 | 544 | G>V | No |
TOPMed gnomAD |
|
| rs532138068 | 545 | A>T | No |
1000Genomes gnomAD |
|
| rs1912720874 | 545 | A>V | No | TOPMed | |
| rs759748015 | 546 | G>R | No | ExAC | |
| rs1912721885 | 547 | A>V | No |
TOPMed gnomAD |
|
| rs56388327 | 549 | G>A | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1348115164 | 549 | G>R | No |
TOPMed gnomAD |
|
|
VAR_042257 rs56388327 |
550 | G>A | No |
UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| rs1381713502 | 550 | G>D | No |
TOPMed gnomAD |
|
| rs1381713502 | 550 | G>V | No |
TOPMed gnomAD |
|
| rs144954037 | 551 | P>A | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1937263063 | 551 | P>L | No | Ensembl | |
|
rs144954037 RCV000957575 |
551 | P>S | No |
ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| rs1912724295 | 553 | T>A | No | Ensembl | |
| rs1338225085 | 555 | P>L | No |
TOPMed gnomAD |
|
| rs1195998458 | 556 | L>V | No | gnomAD | |
| rs1466884778 | 557 | A>V | No | gnomAD | |
| rs1912726346 | 560 | V>L | No | Ensembl | |
| rs1398961065 | 564 | N>S | No | Ensembl | |
| rs1912727465 | 566 | R>T | No | TOPMed | |
| rs1912729082 | 571 | R>H | No |
TOPMed gnomAD |
|
| COSM5520923 | 574 | R>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1191025186 | 574 | R>L | No |
TOPMed gnomAD |
|
| rs1191025186 | 574 | R>P | No |
TOPMed gnomAD |
|
| rs1191025186 | 574 | R>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs1912730069 | 576 | A>V | No | Ensembl | |
| rs374257511 | 577 | R>Q | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs764622447 | 577 | R>W | No |
ExAC TOPMed gnomAD |
|
| rs1598116923 | 578 | P>H | No | Ensembl | |
| rs1598116923 | 578 | P>L | No | Ensembl | |
|
rs377634607 COSM1214517 |
579 | A>T | large_intestine [Cosmic] | No |
cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
| rs1325633980 | 579 | A>V | No |
TOPMed gnomAD |
|
| rs753467532 | 581 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs753467532 | 581 | P>Q | No |
ExAC TOPMed gnomAD |
|
| rs971260506 | 582 | A>G | No | gnomAD | |
| rs971260506 | 582 | A>V | No | gnomAD | |
| rs1326382100 | 583 | L>F | No | gnomAD | |
| rs2152293680 | 583 | L>P | No | Ensembl | |
|
rs536758612 COSM3787282 |
585 | S>C | pancreas [Cosmic] | No |
cosmic curated 1000Genomes ExAC gnomAD |
| rs536758612 | 585 | S>F | No |
1000Genomes ExAC gnomAD |
|
| rs1040443509 | 588 | A>T | No | Ensembl | |
| rs1212748750 | 588 | A>V | No | gnomAD | |
| COSM6080404 | 589 | P>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
|
rs2233078 COSM94670 |
589 | P>S | lung [Cosmic] | No |
cosmic curated 1000Genomes ExAC TOPMed gnomAD |
| rs369539343 | 590 | A>P | No |
ESP ExAC TOPMed gnomAD |
|
| rs369539343 | 590 | A>S | No |
ESP ExAC TOPMed gnomAD |
|
| rs1260904487 | 591 | P>L | No | gnomAD | |
| rs566873291 | 592 | A>V | No |
ExAC gnomAD |
|
| rs903269432 | 593 | P>R | No | TOPMed | |
| rs745956343 | 593 | P>S | No |
ExAC gnomAD |
|
| rs1912742216 | 594 | T>A | No |
TOPMed gnomAD |
|
|
rs769933821 COSM1241414 |
594 | T>M | oesophagus [Cosmic] | No |
cosmic curated ExAC TOPMed gnomAD |
| rs769933821 | 594 | T>R | No |
ExAC TOPMed gnomAD |
|
| rs1332857077 | 595 | P>L | No |
TOPMed gnomAD |
|
| rs1912743332 | 596 | T>I | No | TOPMed | |
| rs1912745432 | 600 | V>G | No | Ensembl | |
| rs774819803 | 601 | Q>P | No |
ExAC gnomAD |
|
| rs1170893970 | 602 | P>A | No | gnomAD | |
| rs762406695 | 602 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs762406695 | 602 | P>R | No |
ExAC TOPMed gnomAD |
|
| rs1170893970 | 602 | P>S | No | gnomAD | |
| rs1567922557 | 604 | S>N | No | Ensembl | |
| rs918667483 | 604 | S>R | No |
TOPMed gnomAD |
|
|
COSM1302482 rs1384793471 |
605 | P>S | Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD |
| rs2152293782 | 606 | P>L | No | Ensembl | |
| rs1383283482 | 606 | P>S | No | gnomAD | |
| rs768198659 | 607 | P>L | No |
ExAC gnomAD |
|
| rs1353098422 | 608 | G>D | No | gnomAD | |
| rs1033515546 | 608 | G>S | No | TOPMed | |
| rs776225670 | 609 | P>L | No |
ExAC TOPMed gnomAD |
|
| COSM4942508 | 609 | P>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1042855 | 610 | V>I | No | Ensembl | |
| rs1042855 | 610 | V>L | No | Ensembl | |
| rs1293585565 | 611 | A>P | No | gnomAD | |
| rs138421126 | 611 | A>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs1438142410 | 612 | Q>R | No |
TOPMed gnomAD |
|
| rs1336531127 | 613 | P>L | No | gnomAD | |
| rs1912751602 | 614 | T>A | No | TOPMed | |
| rs764905455 | 615 | G>D | No |
ExAC TOPMed gnomAD |
|
| rs752319667 | 616 | P>A | No |
ExAC TOPMed gnomAD |
|
| rs149245489 | 616 | P>L | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs752319667 | 616 | P>S | No |
ExAC TOPMed gnomAD |
|
| rs372930872 | 618 | P>Q | No |
ESP ExAC TOPMed gnomAD |
|
| rs372930872 | 618 | P>R | No |
ESP ExAC TOPMed gnomAD |
|
| rs1484759429 | 619 | Q>* | No |
TOPMed gnomAD |
|
| rs1484759429 | 619 | Q>K | No |
TOPMed gnomAD |
|
| rs2152293839 | 620 | S>P | No | Ensembl | |
| rs1418800673 | 621 | A>P | No | gnomAD | |
| rs1418800673 | 621 | A>S | No | gnomAD | |
| rs1418800673 | 621 | A>T | No | gnomAD | |
| rs144440096 | 621 | A>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs1363645303 | 622 | G>D | No | gnomAD | |
| rs1300634630 | 624 | T>A | No | gnomAD | |
| rs780230210 | 624 | T>I | No |
ExAC gnomAD |
|
| rs749439203 | 625 | S>P | No |
ExAC gnomAD |
|
| rs377122950 | 626 | G>V | No |
ESP TOPMed gnomAD |
|
| TCGA novel | 628 | V>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs774843228 | 628 | V>L | No |
ExAC gnomAD |
|
| rs748539235 | 630 | Q>E | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 630 | Q>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs772642554 | 631 | P>A | No |
ExAC TOPMed gnomAD |
|
| rs201095735 | 631 | P>L | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs866948388 | 632 | A>T | No | Ensembl | |
|
rs1912758853 COSM976396 |
632 | A>V | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated Ensembl |
| TCGA novel | 633 | C>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1183830169 | 634 | P>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs1912759510 | 634 | P>S | No | TOPMed | |
| rs775109792 | 635 | P>H | No |
ExAC gnomAD |
|
| rs1484353112 | 635 | P>S | No | gnomAD | |
| rs1420106916 | 636 | P>A | No |
TOPMed gnomAD |
|
| rs762496317 | 636 | P>R | No |
ExAC gnomAD |
|
| rs1420106916 | 636 | P>S | No |
TOPMed gnomAD |
|
| rs1912764313 | 637 | G>D | No | gnomAD | |
| rs763816343 | 637 | G>S | No |
ExAC gnomAD |
|
| rs1912765026 | 638 | P>L | No | TOPMed | |
| rs371008501 | 639 | A>P | No |
ESP ExAC gnomAD |
|
| rs1297300361 | 640 | P>H | No |
TOPMed gnomAD |
|
| rs1439529086 | 640 | P>S | No |
TOPMed gnomAD |
|
| rs767392187 | 641 | H>P | No |
ExAC gnomAD |
|
| rs1478318422 | 641 | H>Q | No |
TOPMed gnomAD |
|
| rs767392187 | 641 | H>R | No |
ExAC gnomAD |
|
| rs1912767853 | 642 | P>R | No | Ensembl | |
| rs1912767625 | 642 | P>S | No | TOPMed | |
| rs1373144676 | 643 | T>A | No | 1000Genomes | |
| rs1912768621 | 643 | T>N | No | Ensembl | |
| rs1373144676 | 643 | T>P | No | 1000Genomes | |
| rs554667705 | 644 | G>A | No |
1000Genomes ExAC gnomAD |
|
| rs554667705 | 644 | G>V | No |
1000Genomes ExAC gnomAD |
|
| rs754008504 | 645 | P>L | No |
ExAC gnomAD |
|
| rs779993745 | 645 | P>S | No |
ExAC TOPMed gnomAD |
|
| rs755099667 | 646 | P>L | No |
ExAC gnomAD |
|
| rs779283737 | 647 | G>R | No |
ExAC TOPMed gnomAD |
|
| rs779283737 | 647 | G>W | No |
ExAC TOPMed gnomAD |
|
| rs1912771259 | 649 | I>L | No | Ensembl | |
| rs748486443 | 649 | I>L | No |
ExAC gnomAD |
|
| rs2152293984 | 649 | I>N | No | Ensembl | |
| rs748486443 | 649 | I>V | No |
ExAC gnomAD |
|
| rs1912771828 | 650 | P>T | No | gnomAD | |
| rs1912772062 | 651 | V>F | No | TOPMed | |
| rs1912772272 | 652 | P>L | No | TOPMed | |
| rs144078337 | 653 | A>S | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs144078337 COSM182409 |
653 | A>T | Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] | No |
cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
| rs749056959 | 653 | A>V | No |
ExAC TOPMed gnomAD |
|
| rs1194846616 | 654 | P>S | No | gnomAD | |
| rs1912773804 | 655 | P>S | No | Ensembl | |
| rs1426634336 | 656 | Q>E | No | gnomAD | |
| rs1598117788 | 656 | Q>P | No | Ensembl | |
| rs868484052 | 657 | I>T | No | Ensembl | |
| rs1407051865 | 658 | A>G | No |
TOPMed gnomAD |
|
| rs1407051865 | 658 | A>V | No |
TOPMed gnomAD |
|
| rs1598117811 | 659 | T>A | No | TOPMed | |
| rs1473634693 | 659 | T>I | No | TOPMed | |
| rs1598117811 | 659 | T>P | No | TOPMed | |
| rs1912775761 | 661 | T>A | No | Ensembl | |
| rs200536560 | 661 | T>I | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1042293921 | 662 | S>R | No |
TOPMed gnomAD |
|
| rs374391055 | 663 | L>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs774014133 | 664 | L>P | No |
ExAC gnomAD |
|
| rs761499978 | 665 | A>T | No |
ExAC gnomAD |
|
| rs199558212 | 666 | A>T | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1912778102 | 666 | A>V | No | TOPMed | |
| rs1912778543 | 667 | Q>R | No | Ensembl | |
| rs201426673 | 669 | L>F | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1318849147 | 670 | V>G | No | gnomAD | |
| rs766353128 | 671 | P>Q | No |
ExAC gnomAD |
|
| rs868484799 | 671 | P>S | No | Ensembl | |
| rs1271624191 | 672 | P>L | No | gnomAD | |
| rs1271624191 | 672 | P>R | No | gnomAD | |
| rs755118879 | 673 | P>A | No |
ExAC gnomAD |
|
| rs755118879 | 673 | P>S | No |
ExAC gnomAD |
|
| rs199788725 | 674 | G>R | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs372317367 | 678 | S>C | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs372317367 | 678 | S>F | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs2152294092 | 678 | S>P | No | Ensembl | |
| rs958886505 | 679 | S>G | No |
TOPMed gnomAD |
|
| rs1007543565 | 680 | T>I | No |
TOPMed gnomAD |
|
| rs1912782369 | 681 | P>R | No | Ensembl | |
| rs1325318771 | 682 | G>* | No | gnomAD | |
| rs1343298964 | 682 | G>A | No | gnomAD | |
| rs1325318771 | 682 | G>R | No | gnomAD | |
| rs1430000167 | 683 | V>F | No | gnomAD | |
| rs1598118060 | 683 | V>G | No | Ensembl | |
| rs1430000167 | 683 | V>I | No | gnomAD | |
| rs1453770827 | 684 | L>M | No | TOPMed | |
| rs1269665066 | 685 | P>L | No |
TOPMed gnomAD |
|
| rs2152294147 | 687 | F>I | No | Ensembl | |
| rs781736991 | 687 | F>L | No |
ExAC TOPMed gnomAD |
|
| rs1291612994 | 689 | P>R | No | gnomAD | |
| rs1229180120 | 690 | G>C | No |
TOPMed gnomAD |
|
| rs1567923265 | 690 | G>D | No | Ensembl | |
| rs1229180120 | 690 | G>S | No |
TOPMed gnomAD |
|
| rs768130772 | 692 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs1445761606 | 692 | P>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| rs747794000 | 693 | P>L | No |
ExAC TOPMed gnomAD |
|
| rs1185194418 | 694 | P>L | No |
TOPMed gnomAD |
|
| TCGA novel | 694 | P>Q | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1472927069 | 695 | D>H | No | gnomAD | |
| rs1472927069 | 695 | D>N | No | gnomAD | |
| rs367852843 | 696 | A>G | No |
ESP TOPMed |
|
| rs972699681 | 696 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| COSM3515034 | 696 | A>V | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
|
COSM48547 rs138826180 |
697 | G>R | lung [Cosmic] | No |
cosmic curated 1000Genomes ExAC TOPMed gnomAD |
| rs138826180 | 697 | G>W | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1344951488 | 698 | G>E | No | TOPMed | |
| rs1912790405 | 699 | A>P | No |
TOPMed gnomAD |
|
| rs1912790405 | 699 | A>T | No |
TOPMed gnomAD |
|
| rs1311175261 | 699 | A>V | No | gnomAD | |
| rs201210264 | 700 | P>L | No |
ESP ExAC TOPMed gnomAD |
|
| rs1449093912 | 701 | Q>H | No | gnomAD | |
| rs1344670697 | 701 | Q>R | No |
TOPMed gnomAD |
|
| rs765380529 | 703 | S>P | No |
ExAC gnomAD |
|
| rs752895556 | 704 | M>L | No |
ExAC TOPMed gnomAD |
|
| rs752895556 | 704 | M>V | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 705 | S>P | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1912792483 | 706 | E>K | No | TOPMed | |
| rs1912793546 | 708 | P>L | No | gnomAD | |
| rs1356467898 | 708 | P>S | No |
TOPMed gnomAD |
|
| rs751828560 | 709 | D>E | No |
ExAC gnomAD |
|
| rs2152294237 | 709 | D>H | No | Ensembl | |
| rs1912795273 | 710 | V>A | No | Ensembl | |
| rs757659396 | 710 | V>I | No |
ExAC TOPMed gnomAD |
|
| rs781457886 | 711 | N>S | No |
ExAC TOPMed gnomAD |
|
| rs1912795937 | 712 | L>H | No | Ensembl | |
| rs756681013 | 714 | T>I | No |
ExAC TOPMed gnomAD |
|
| rs942949367 | 716 | Q>E | No | Ensembl | |
| rs1159031112 | 716 | Q>H | No | gnomAD | |
| COSM976397 | 717 | L>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1170995982 | 718 | S>Y | No | TOPMed | |
| rs1912797037 | 719 | K>R | No | TOPMed | |
| rs1432810167 | 720 | S>L | No | gnomAD | |
| rs1663251276 | 722 | V>M | No | TOPMed | |
| rs750809881 | 724 | D>V | No |
ExAC TOPMed gnomAD |
|
| rs1912838413 | 724 | D>Y | No |
TOPMed gnomAD |
|
| rs140944584 | 725 | P>H | No |
ESP ExAC |
|
| rs756554617 | 725 | P>S | No |
ExAC gnomAD |
|
| rs1567923967 | 726 | L>M | No | Ensembl | |
| rs747618662 | 726 | L>P | No |
ExAC gnomAD |
|
| rs777199570 | 728 | P>A | No |
ExAC TOPMed gnomAD |
|
| rs1373150000 | 728 | P>L | No | Ensembl | |
| rs777199570 | 728 | P>T | No |
ExAC TOPMed gnomAD |
|
| rs1912841690 | 729 | V>G | No | Ensembl | |
| rs746645223 | 730 | F>L | No |
ExAC TOPMed gnomAD |
|
| rs1212849334 | 730 | F>Y | No | gnomAD | |
| rs1201024711 | 732 | G>D | No | gnomAD | |
| rs1912842992 | 734 | P>L | No | gnomAD | |
| COSM1302483 | 738 | G>E | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1477618468 | 739 | A>S | No | gnomAD | |
| rs781032290 | 742 | G>S | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 744 | G>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs2152294705 | 745 | F>L | No | Ensembl | |
| rs1598119578 | 749 | E>G | No | Ensembl | |
| rs1912844871 | 749 | E>K | No |
TOPMed gnomAD |
|
| rs1389084223 | 753 | Q>* | No | gnomAD | |
| rs769810486 | 755 | F>L | No |
ExAC TOPMed gnomAD |
|
| rs775587740 | 756 | D>H | No |
ExAC TOPMed gnomAD |
|
| rs775587740 | 756 | D>N | No |
ExAC TOPMed gnomAD |
|
| rs1269656380 | 758 | G>S | No |
TOPMed gnomAD |
|
| rs35099302 | 759 | V>L | No |
ESP ExAC TOPMed gnomAD |
|
| rs35099302 | 759 | V>M | No |
ESP ExAC TOPMed gnomAD |
|
| rs1367373679 | 760 | A>V | No | gnomAD | |
| rs1232408243 | 761 | D>G | No | gnomAD | |
| rs767647117 | 762 | G>E | No |
ExAC gnomAD |
|
| rs762081000 | 762 | G>R | No |
ExAC TOPMed gnomAD |
|
| rs762081000 | 762 | G>W | No |
ExAC TOPMed gnomAD |
|
|
rs576915447 COSM1709998 |
763 | P>S | skin [Cosmic] | No |
cosmic curated 1000Genomes ExAC TOPMed gnomAD |
| rs891169262 | 765 | D>N | No | Ensembl | |
| rs1259730709 | 765 | D>V | No | gnomAD | |
| TCGA novel | 766 | G>= | Variant assessed as Somatic; LOW impact. [NCI-TCGA] | No | NCI-TCGA |
| rs967628894 | 768 | A>S | No |
TOPMed gnomAD |
|
| rs761803437 | 770 | S>A | No |
ExAC TOPMed gnomAD |
|
| rs761803437 | 770 | S>P | No |
ExAC TOPMed gnomAD |
|
| rs772298224 | 771 | A>G | No |
ExAC gnomAD |
|
| rs772298224 | 771 | A>V | No |
ExAC gnomAD |
|
| rs766701364 | 773 | L>V | No |
ExAC gnomAD |
|
| TCGA novel | 774 | S>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 775 | A>Q | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1912864780 | 775 | A>S | No | TOPMed | |
| rs1463655473 | 776 | S>F | No | TOPMed | |
| rs765681181 | 778 | L>F | No |
ExAC gnomAD |
|
| rs765681181 | 778 | L>I | No |
ExAC gnomAD |
|
| rs1912867326 | 779 | A>D | No | TOPMed | |
| rs1373131082 | 783 | E>A | No |
TOPMed gnomAD |
|
| rs756737208 | 783 | E>K | No |
ExAC TOPMed gnomAD |
|
| rs756737208 | 783 | E>Q | No |
ExAC TOPMed gnomAD |
|
| rs1465225171 | 784 | G>V | No | gnomAD | |
| rs780896247 | 785 | H>Q | No | ExAC | |
| rs200495874 | 785 | H>R | No | Ensembl | |
| rs750066421 | 786 | G>A | No |
ExAC gnomAD |
|
| COSM4064611 | 786 | G>D | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs779980288 | 787 | M>I | No | ExAC | |
| rs755895662 | 787 | M>L | No |
ExAC gnomAD |
|
| rs1024668610 | 787 | M>T | No | TOPMed | |
| rs755895662 | 787 | M>V | No |
ExAC gnomAD |
|
| rs556753840 | 788 | N>D | No | TOPMed | |
| rs202149646 | 788 | N>T | No |
ExAC gnomAD |
|
| rs1308292534 | 789 | P>L | No | gnomAD | |
| COSM3889414 | 789 | P>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs977727265 | 791 | D>N | No |
TOPMed gnomAD |
|
| rs1288248712 | 792 | I>T | No | gnomAD | |
| rs1176675847 | 793 | E>D | No | TOPMed | |
| rs139282653 | 793 | E>Q | No |
ESP ExAC TOPMed |
|
| rs748210824 | 794 | S>C | No |
ExAC gnomAD |
|
| rs747229896 | 797 | R>C | No |
ExAC TOPMed gnomAD |
|
| rs747229896 | 797 | R>G | No |
ExAC TOPMed gnomAD |
|
| rs541783142 | 797 | R>H | No |
1000Genomes TOPMed gnomAD |
|
| rs1912874638 | 801 | M>K | No | Ensembl | |
| rs1440810042 | 801 | M>V | No |
TOPMed gnomAD |
|
| rs1777862769 | 802 | D>V | No | Ensembl | |
| COSM1324119 | 803 | S>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1598120284 | 804 | P>L | No | Ensembl | |
| rs757807560 | 805 | M>V | No |
ExAC TOPMed gnomAD |
|
| rs138168947 | 808 | A>G | No | 1000Genomes | |
| rs915682482 | 811 | P>S | No |
TOPMed gnomAD |
|
| COSM705956 | 812 | D>Y | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| TCGA novel | 813 | L>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs530556354 | 813 | L>P | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1400848783 | 814 | Q>* | No | gnomAD | |
| COSM4932458 | 814 | Q>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs77296467 | 817 | P>G | No | gnomAD | |
| rs1448889210 | 817 | P>R | No | gnomAD | |
| rs767773020 | 817 | P>S | No |
ExAC TOPMed gnomAD |
No associated diseases with Q13164
4 regional properties for Q13164
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 55 - 347 | IPR000719 |
| conserved_site | Mitogen-activated protein (MAP) kinase, conserved site | 90 - 194 | IPR003527 |
| active_site | Serine/threonine-protein kinase, active site | 178 - 190 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 61 - 85 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.24 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| enzyme inhibitor activity | Binds to and stops, prevents or reduces the activity of an enzyme. |
| MAP kinase activity | Catalysis of the reaction |
| mitogen-activated protein kinase binding | Binding to a mitogen-activated protein kinase. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
23 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP). |
| calcineurin-NFAT signaling cascade | Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). |
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cellular response to growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. |
| cellular response to hydrogen peroxide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| cellular response to laminar fluid shear stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. |
| cellular response to transforming growth factor beta stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers |
| negative regulation of calcineurin-NFAT signaling cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade. |
| negative regulation of endothelial cell apoptotic process | Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. |
| negative regulation of heterotypic cell-cell adhesion | Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion. |
| negative regulation of inflammatory response | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. |
| negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. |
| negative regulation of response to cytokine stimulus | Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus. |
| negative regulation of smooth muscle cell apoptotic process | Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of protein metabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of angiogenesis | Any process that modulates the frequency, rate or extent of angiogenesis. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
93 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41808 | SMK1 | Sporulation-specific mitogen-activated protein kinase SMK1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q00772 | SLT2 | Mitogen-activated protein kinase SLT2/MPK1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3T0N5 | MAPK13 | Mitogen-activated protein kinase 13 | Bos taurus (Bovine) | SS |
| P46196 | MAPK1 | Mitogen-activated protein kinase 1 | Bos taurus (Bovine) | SS |
| A5PKJ4 | MAPK7 | Mitogen-activated protein kinase 7 | Bos taurus (Bovine) | SS |
| Q5F3W3 | MAPK6 | Mitogen-activated protein kinase 6 | Gallus gallus (Chicken) | SS |
| Q95NE7 | MAPK14 | Mitogen-activated protein kinase 14 | Pan troglodytes (Chimpanzee) | SS |
| Q9N272 | MAPK13 | Mitogen-activated protein kinase 13 | Pan troglodytes (Chimpanzee) | SS |
| Q9W354 | Erk7 | Extracellular signal-regulated kinase 7 | Drosophila melanogaster (Fruit fly) | SS |
| O61443 | p38b | Mitogen-activated protein kinase p38b | Drosophila melanogaster (Fruit fly) | SS |
| O62618 | p38a | Mitogen-activated protein kinase p38a | Drosophila melanogaster (Fruit fly) | SS |
| P83100 | p38c | Putative mitogen-activated protein kinase 14C | Drosophila melanogaster (Fruit fly) | SS |
| P40417 | rl | Mitogen-activated protein kinase ERK-A | Drosophila melanogaster (Fruit fly) | SS |
| P20794 | MAK | Serine/threonine-protein kinase MAK | Homo sapiens (Human) | PR |
| Q9UQ07 | MOK | MAPK/MAK/MRK overlapping kinase | Homo sapiens (Human) | PR |
| Q8TD08 | MAPK15 | Mitogen-activated protein kinase 15 | Homo sapiens (Human) | SS |
| P45984 | MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens (Human) | SS |
| P45983 | MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens (Human) | EV |
| P53779 | MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens (Human) | EV |
| Q9UBE8 | NLK | Serine/threonine-protein kinase NLK | Homo sapiens (Human) | SS |
| P27361 | MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens (Human) | SS |
| P28482 | MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens (Human) | EV |
| P31152 | MAPK4 | Mitogen-activated protein kinase 4 | Homo sapiens (Human) | SS |
| Q16659 | MAPK6 | Mitogen-activated protein kinase 6 | Homo sapiens (Human) | SS |
| P53778 | MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens (Human) | SS |
| O15264 | MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens (Human) | SS |
| Q15759 | MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens (Human) | SS |
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens (Human) | SS |
| Q9Z1B7 | Mapk13 | Mitogen-activated protein kinase 13 | Mus musculus (Mouse) | SS |
| P47811 | Mapk14 | Mitogen-activated protein kinase 14 | Mus musculus (Mouse) | SS |
| Q61532 | Mapk6 | Mitogen-activated protein kinase 6 | Mus musculus (Mouse) | SS |
| Q63844 | Mapk3 | Mitogen-activated protein kinase 3 | Mus musculus (Mouse) | SS |
| P63085 | Mapk1 | Mitogen-activated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q9WUI1 | Mapk11 | Mitogen-activated protein kinase 11 | Mus musculus (Mouse) | SS |
| O08911 | Mapk12 | Mitogen-activated protein kinase 12 | Mus musculus (Mouse) | SS |
| Q80Y86 | Mapk15 | Mitogen-activated protein kinase 15 | Mus musculus (Mouse) | SS |
| Q6P5G0 | Mapk4 | Mitogen-activated protein kinase 4 | Mus musculus (Mouse) | SS |
| Q9WVS8 | Mapk7 | Mitogen-activated protein kinase 7 | Mus musculus (Mouse) | SS |
| P70618 | Mapk14 | Mitogen-activated protein kinase 14 | Rattus norvegicus (Rat) | SS |
| Q9WTY9 | Mapk13 | Mitogen-activated protein kinase 13 | Rattus norvegicus (Rat) | SS |
| P63086 | Mapk1 | Mitogen-activated protein kinase 1 | Rattus norvegicus (Rat) | SS |
| Q9Z2A6 | Mapk15 | Mitogen-activated protein kinase 15 | Rattus norvegicus (Rat) | SS |
| P27704 | Mapk6 | Mitogen-activated protein kinase 6 | Rattus norvegicus (Rat) | SS |
| P21708 | Mapk3 | Mitogen-activated protein kinase 3 | Rattus norvegicus (Rat) | SS |
| Q63538 | Mapk12 | Mitogen-activated protein kinase 12 | Rattus norvegicus (Rat) | SS |
| Q63454 | Mapk4 | Mitogen-activated protein kinase 4 | Rattus norvegicus (Rat) | SS |
| P0C865 | Mapk7 | Mitogen-activated protein kinase 7 | Rattus norvegicus (Rat) | SS |
| Q10N20 | MPK5 | Mitogen-activated protein kinase 5 | Oryza sativa subsp. japonica (Rice) | SS |
| Q84UI5 | MPK1 | Mitogen-activated protein kinase 1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5J4W4 | MPK2 | Mitogen-activated protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q336X9 | MPK6 | Mitogen-activated protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5ZCI1 | MPK10 | Mitogen-activated protein kinase 10 | Oryza sativa subsp. japonica (Rice) | SS |
| Q75KK8 | MPK14 | Mitogen-activated protein kinase 14 | Oryza sativa subsp. japonica (Rice) | SS |
| Q53N72 | MPK15 | Mitogen-activated protein kinase 15 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6L5F7 | MPK17 | Mitogen-activated protein kinase 17 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5VP69 | MPK16 | Mitogen-activated protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6Z437 | MPK3 | Mitogen-activated protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5Z859 | MPK4 | Mitogen-activated protein kinase 4 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5VN19 | MPK11 | Mitogen-activated protein kinase 11 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5Z9J0 | MPK12 | Mitogen-activated protein kinase 12 | Oryza sativa subsp. japonica (Rice) | SS |
| Q0E459 | MPK13 | Mitogen-activated protein kinase 13 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5SN53 | MPK8 | Mitogen-activated protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q67C40 | MPK7 | Mitogen-activated protein kinase 7 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6L5D4 | MPK9 | Mitogen-activated protein kinase 9 | Oryza sativa subsp japonica (Rice) | PR |
| Q17446 | pmk-1 | Mitogen-activated protein kinase pmk-1 | Caenorhabditis elegans | SS |
| Q11179 | mapk-15 | Mitogen-activated protein kinase 15 | Caenorhabditis elegans | SS |
| Q8MXI4 | pmk-2 | Mitogen-activated protein kinase pmk-2 | Caenorhabditis elegans | SS |
| P39745 | mpk-1 | Mitogen-activated protein kinase mpk-1 | Caenorhabditis elegans | SS |
| O44514 | pmk-3 | Mitogen-activated protein kinase pmk-3 | Caenorhabditis elegans | PR |
| G5EBT1 | sma-5 | Mitogen-activated protein kinase sma-5 | Caenorhabditis elegans | SS |
| Q9LMM5 | MPK11 | Mitogen-activated protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LQQ9 | MPK13 | Mitogen-activated protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39026 | MPK6 | Mitogen-activated protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GYQ5 | MPK12 | Mitogen-activated protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39023 | MPK3 | Mitogen-activated protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M1Z5 | MPK10 | Mitogen-activated protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39024 | MPK4 | Mitogen-activated protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39025 | MPK5 | Mitogen-activated protein kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C5C0 | MPK18 | Mitogen-activated protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LUC3 | MPK19 | Mitogen-activated protein kinase 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SJG9 | MPK20 | Mitogen-activated protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8W4J2 | MPK16 | Mitogen-activated protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LM33 | MPK8 | Mitogen-activated protein kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84M93 | MPK17 | Mitogen-activated protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23236 | MPK14 | Mitogen-activated protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39027 | MPK7 | Mitogen-activated protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39022 | MPK2 | Mitogen-activated protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39021 | MPK1 | Mitogen-activated protein kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C9U4 | MPK15 | Mitogen-activated protein kinase 15 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LV37 | MPK9 | Mitogen-activated protein kinase 9 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O42376 | mapk12 | Mitogen-activated protein kinase 12 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DGE1 | mapk14b | Mitogen-activated protein kinase 14B | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DGE2 | mapk14a | Mitogen-activated protein kinase 14A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEPLKEEDG | EDGSAEPPGP | VKAEPAHTAA | SVAAKNLALL | KARSFDVTFD | VGDEYEIIET |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IGNGAYGVVS | SARRRLTGQQ | VAIKKIPNAF | DVVTNAKRTL | RELKILKHFK | HDNIIAIKDI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LRPTVPYGEF | KSVYVVLDLM | ESDLHQIIHS | SQPLTLEHVR | YFLYQLLRGL | KYMHSAQVIH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDLKPSNLLV | NENCELKIGD | FGMARGLCTS | PAEHQYFMTE | YVATRWYRAP | ELMLSLHEYT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QAIDLWSVGC | IFGEMLARRQ | LFPGKNYVHQ | LQLIMMVLGT | PSPAVIQAVG | AERVRAYIQS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LPPRQPVPWE | TVYPGADRQA | LSLLGRMLRF | EPSARISAAA | ALRHPFLAKY | HDPDDEPDCA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PPFDFAFDRE | ALTRERIKEA | IVAEIEDFHA | RREGIRQQIR | FQPSLQPVAS | EPGCPDVEMP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SPWAPSGDCA | MESPPPAPPP | CPGPAPDTID | LTLQPPPPVS | EPAPPKKDGA | ISDNTKAALK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AALLKSLRSR | LRDGPSAPLE | APEPRKPVTA | QERQREREEK | RRRRQERAKE | REKRRQERER |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KERGAGASGG | PSTDPLAGLV | LSDNDRSLLE | RWTRMARPAA | PALTSVPAPA | PAPTPTPTPV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QPTSPPPGPV | AQPTGPQPQS | AGSTSGPVPQ | PACPPPGPAP | HPTGPPGPIP | VPAPPQIATS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TSLLAAQSLV | PPPGLPGSST | PGVLPYFPPG | LPPPDAGGAP | QSSMSESPDV | NLVTQQLSKS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QVEDPLPPVF | SGTPKGSGAG | YGVGFDLEEF | LNQSFDMGVA | DGPQDGQADS | ASLSASLLAD |
| 790 | 800 | 810 | |||
| WLEGHGMNPA | DIESLQREIQ | MDSPMLLADL | PDLQDP |