AiPD: Autoinhibited Protein Database

Q13131

Gene name	PRKAA1 (AMPK1)
Protein name	5'-AMP-activated protein kinase catalytic subunit alpha-1
Names	AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, Tau-protein kinase PRKAA1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5562
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class	MAP/MICROTUBULE AFFINITY-REGULATING KINASE (PTHR24346)

Descriptions

AMP-activated protein kinase (AMPK) acts as an energy sensor, being activated by metabolic stresses and regulating cellular metabolism. AMPK is a heterotrimer consisting of a catalytic alpha subunit and two regulatory subunits, beta and gamma. AMPK alpha subunit contains an autoinhibitory domain that inhibits the N-terminal kinase domain. Autoinhibitory region of AMPK alpha are not only responsible for kinase autoinhibition, but may also be responsible for full-length kinase degradation.

Autoinhibitory domains (AIDs)

Target domain	27-279 (Protein kinase domain)
Relief mechanism	Ligand binding
Assay	Deletion assay, Mutagenesis experiment

AID

313-335 (autoinhibitory region)

Target domain

27-279 (Protein kinase domain)

Relief mechanism

Ligand binding (AMP binding)

Assay

Deletion assay, Mutagenesis experiment

Accessory elements

167-189 (Activation loop from InterPro)

Target domain	27-279 (Protein kinase domain)
Relief mechanism
Assay

References

Pang T et al. (2007) "Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits", The Journal of biological chemistry, 282, 495-506

Hardie DG et al. (2012) "AMP-activated protein kinase: a target for drugs both ancient and modern", Chemistry & biology, 19, 1222-36

Li YY et al. (2013) "Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice", Toxicology and applied pharmacology, 273, 325-34

Oakhill JS et al. (2009) "Structure and function of AMP-activated protein kinase", Acta physiologica (Oxford, England), 196, 3-14

Pang T et al. (2008) "Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells", The Journal of biological chemistry, 283, 16051-60

Scott JW et al. (2014) "ATP sensitive bi-quinoline activator of the AMP-activated protein kinase", Biochemical and biophysical research communications, 443, 435-40

Autoinhibited structure

Activated structure

13 structures for Q13131

Entry ID	Method	Resolution	Chain	Position	Source
4RED	X-ray	295 A	A/B	22-362	PDB
4RER	X-ray	405 A	A	20-559	PDB
4REW	X-ray	458 A	A	20-559	PDB
5EZV	X-ray	299 A	A/C	359-401	PDB
6C9F	X-ray	292 A	A	22-559	PDB
6C9G	X-ray	270 A	A	22-559	PDB
6C9H	X-ray	265 A	A	22-559	PDB
6C9J	X-ray	305 A	A	22-559	PDB
7JHG	EM	347 A	A	22-559	PDB
7JHH	EM	392 A	A	22-559	PDB
7JIJ	X-ray	550 A	A	22-559	PDB
7M74	EM	393 A	A	22-559	PDB
AF-Q13131-F1	Predicted				AlphaFoldDB

271 variants for Q13131

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1033125825 CA359580432	2	R>C		No	ClinGen TOPMed gnomAD
CA359580433 rs1033125825	2	R>G		No	ClinGen TOPMed gnomAD
COSM1068168 COSM1068167 rs1426382824 CA359580429	2	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1426382824 CA359580426	2	R>L		No	ClinGen gnomAD
rs1033125825 CA117232237	2	R>S		No	ClinGen TOPMed gnomAD
rs1188565639 CA359580419	3	R>K		No	ClinGen gnomAD
rs1423481695 CA359580414	3	R>S		No	ClinGen gnomAD
rs1254288802 CA359580403	4	L>P		No	ClinGen gnomAD
CA3248651 rs773228528	5	S>R		No	ClinGen ExAC gnomAD
CA359580376 rs1286001321	6	S>F		No	ClinGen TOPMed gnomAD
rs551347552 CA3248650	7	W>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA117232218 rs939151107	7	W>R		No	ClinGen TOPMed gnomAD
CA359580326 rs1244459595	10	M>K		No	ClinGen gnomAD
CA117232215 VAR_058401 rs17855679	10	M>L		No	ClinGen UniProt Ensembl dbSNP
rs1244459595 CA359580324	10	M>T		No	ClinGen gnomAD
CA3248649 rs748031628	11	A>T		No	ClinGen ExAC gnomAD
rs867953599 CA117232211	11	A>V		No	ClinGen Ensembl
rs1382314545 CA359580301	12	T>I		No	ClinGen TOPMed gnomAD
CA359580259 rs1469720215	15	K>R		No	ClinGen TOPMed
COSM33502 rs928784854 VAR_035622 COSM1437563 CA117232187	16	Q>R	a breast cancer sample; somatic mutation large_intestine breast [UniProt, Cosmic]	No	ClinGen cosmic curated UniProt TOPMed dbSNP gnomAD
CA3248643 rs749919427	18	H>P		No	ClinGen ExAC TOPMed gnomAD
rs766987004 CA117232162	18	H>Q		No	ClinGen ExAC TOPMed gnomAD
COSM3784897 rs377040057 CA3248644 COSM3784896	18	H>Y	pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA3248641 rs199741192	20	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs753214385 CA3248640	22	V>M		No	ClinGen ExAC gnomAD
CA359580138 rs759922711	25	G>R		No	ClinGen ExAC gnomAD
rs759922711 CA3248638	25	G>S		No	ClinGen ExAC gnomAD
rs766616413 CA3248636	26	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA3248635 rs760844250	27	Y>C		No	ClinGen ExAC gnomAD
rs1209624022 CA359580098	28	I>F		No	ClinGen gnomAD
CA359580100 rs1209624022	28	I>V		No	ClinGen gnomAD
CA3248634 rs773317301	31	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1429046828 CA359580062	31	D>V		No	ClinGen gnomAD
rs773317301 CA359580067	31	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs772007686 CA3248633	32	T>M		No	ClinGen ExAC gnomAD
rs774220592 CA3248631	35	V>I		No	ClinGen ExAC gnomAD
rs1331613081 CA359580012	36	G>R		No	ClinGen gnomAD
rs1205168457 CA359578326	43	V>A		No	ClinGen gnomAD
rs1398359834 CA359579916	43	V>F		No	ClinGen TOPMed gnomAD
rs377206671 CA359578314	44	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs377206671 CA3248607	44	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs374595923 CA3248606	46	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA117215346 rs755206740	48	L>F		No	ClinGen Ensembl
CA359578239 rs1198171523	48	L>W		No	ClinGen gnomAD
CA3248605 rs780649839	49	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1176438429 CA359578193	50	G>R		No	ClinGen TOPMed
CA3248602 rs777461699	55	V>L		No	ClinGen ExAC gnomAD
rs930784916 CA117215266	59	N>S		No	ClinGen TOPMed
CA3248600 rs754248249	60	R>*		No	ClinGen ExAC
rs780617578 CA3248599	60	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1261017903 CA359578086	64	R>Q		No	ClinGen gnomAD
rs369977975 CA3248597	64	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA359578080 rs1412797330	65	S>I		No	ClinGen TOPMed gnomAD
CA359578078 rs1412797330	65	S>N		No	ClinGen TOPMed gnomAD
CA359578079 rs1412797330	65	S>T		No	ClinGen TOPMed gnomAD
rs762063813 CA3248595	68	V>M		No	ClinGen ExAC gnomAD
rs200927672 CA3248594	73	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764113006 CA3248593	73	R>H		No	ClinGen ExAC gnomAD
CA359578009 rs1185114438	76	I>V		No	ClinGen gnomAD
rs977171885 CA117215189	79	L>F		No	ClinGen Ensembl
rs1290622927 CA359577984	79	L>P		No	ClinGen TOPMed
CA117215173 rs377014464	84	H>Q		No	ClinGen ESP TOPMed gnomAD
rs879036617 CA117215169	87	I>M		No	ClinGen Ensembl
CA359577932 rs1228019406	87	I>V		No	ClinGen TOPMed
rs769782415 CA3248590	89	K>T		No	ClinGen ExAC gnomAD
rs201964697 CA117213759	95	S>C		No	ClinGen TOPMed gnomAD
CA3248566 rs765077004	95	S>T		No	ClinGen ExAC gnomAD
rs945243312 CA117213755	100	I>N		No	ClinGen Ensembl
CA117213753 rs865932512	103	V>A		No	ClinGen gnomAD
rs759557332 CA3248565	105	E>*		No	ClinGen ExAC gnomAD
CA359577717 rs776543926	105	E>D		No	ClinGen ExAC gnomAD
rs913298651 CA117213735	106	Y>C		No	ClinGen Ensembl
rs368064778 CA117213728	109	G>A		No	ClinGen Ensembl
rs747608675 CA3248559	114	D>E		No	ClinGen ExAC gnomAD
rs747608675 CA3248560	114	D>E		No	ClinGen ExAC gnomAD
rs1427249658 CA359577592	115	Y>C		No	ClinGen gnomAD
rs773952820 CA3248558	119	N>S		No	ClinGen ExAC gnomAD
rs1195866028 CA359577049	123	D>G		No	ClinGen TOPMed gnomAD
rs1263050834 CA359577012	128	R>Q		No	ClinGen gnomAD
CA117211768 rs865929015	128	R>W		No	ClinGen gnomAD
CA359577007 rs1382671155	129	R>C		No	ClinGen gnomAD
rs375372236 CA3248514	129	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA3248511 rs768829085	132	Q>R		No	ClinGen ExAC gnomAD
CA117211744 rs975410782	135	L>V		No	ClinGen gnomAD
rs966217070 CA117211743	139	D>G		No	ClinGen TOPMed
rs966217070 CA359576942	139	D>V		No	ClinGen TOPMed
CA117211726 rs866433113	160	A>S		No	ClinGen Ensembl
rs1339790406 CA359576787	161	H>Y		No	ClinGen gnomAD
rs1388343363 CA359576774	162	M>I		No	ClinGen gnomAD
CA359576778 rs1296211909	162	M>T		No	ClinGen TOPMed gnomAD
CA117211714 rs75538611	162	M>V		No	ClinGen Ensembl
CA117211702 rs1004603226	169	F>S		No	ClinGen Ensembl
rs1472964330 CA359576404	174	M>V		No	ClinGen gnomAD
CA117210170 rs202230529	177	D>H		No	ClinGen Ensembl
CA3248492 rs780459093	180	F>L		No	ClinGen ExAC TOPMed gnomAD
rs918424548 CA117210146	189	N>S		No	ClinGen Ensembl
CA117210138 rs1046709838	195	V>I		No	ClinGen TOPMed gnomAD
CA3248461 rs753368761	208	I>L		No	ClinGen ExAC TOPMed gnomAD
CA359575526 rs1230232491	208	I>T		No	ClinGen gnomAD
CA117209063 rs972443048	216	Y>C		No	ClinGen Ensembl
rs1299322811 CA359575424	223	L>F		No	ClinGen gnomAD
CA3248456 rs763399194	224	P>R		No	ClinGen ExAC gnomAD
rs765521994 CA359575385	228	D>E		No	ClinGen ExAC TOPMed gnomAD
rs765521994 CA3248454	228	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1287731089 CA359575380	229	H>R		No	ClinGen TOPMed
rs373338557 CA3248453	232	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA359575362 rs1405608420	232	T>N		No	ClinGen TOPMed gnomAD
rs373338557 CA359575363	232	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA359575361 rs1405608420	232	T>S		No	ClinGen TOPMed gnomAD
CA117208998 rs999862425	233	L>P		No	ClinGen TOPMed
rs966382240 CA117208993	238	C>R		No	ClinGen TOPMed gnomAD
rs1478486576 CA359575300	241	I>F		No	ClinGen gnomAD
rs1268985916 CA359575293	242	F>V		No	ClinGen TOPMed
CA3248450 rs747116005	243	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs770875277 CA3248451	243	Y>H		No	ClinGen ExAC gnomAD
COSM4159873 COSM4159872 rs1248259974 CA359575234	250	P>H	thyroid [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1248259974 CA359575233	250	P>L		No	ClinGen TOPMed gnomAD
CA3248449 rs773074075	252	V>M		No	ClinGen ExAC gnomAD
CA3248448 rs772054123	259	M>T		No	ClinGen ExAC gnomAD
CA3248447 rs747908382	261	Q>H		No	ClinGen ExAC gnomAD
CA3248446 rs778730540	264	P>A		No	ClinGen ExAC gnomAD
CA117208964 rs959082384	265	M>L		No	ClinGen Ensembl
CA359575099 rs1360419421	270	I>T		No	ClinGen gnomAD
rs1214485166 CA359575102	270	I>V		No	ClinGen gnomAD
rs550046547 CA117208962	271	K>R		No	ClinGen 1000Genomes gnomAD
CA3248444 rs748853620	272	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1323447715 CA359575078	273	I>T		No	ClinGen gnomAD
rs1474740549 CA359575073	274	R>K		No	ClinGen TOPMed
CA3248425 rs774304395	276	H>R		No	ClinGen ExAC gnomAD
CA359574147 rs1251461243	279	F>L		No	ClinGen gnomAD
rs1176712168 CA359574128	281	Q>R		No	ClinGen gnomAD
rs1479685526 CA359574115	283	L>I		No	ClinGen gnomAD
rs1561166883 CA359574108	284	P>S		No	ClinGen Ensembl
CA3248421 rs769558593	287	L>V		No	ClinGen ExAC gnomAD
rs780896222 CA3248419	289	P>L		No	ClinGen ExAC gnomAD
CA359574069 rs1354003048	290	E>Q		No	ClinGen gnomAD
rs535217762 CA3248418	291	D>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs542464918 CA3248416	294	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1414109649 CA359574003	299	I>T		No	ClinGen TOPMed gnomAD
CA3248414 rs754284731	301	D>H		No	ClinGen ExAC gnomAD
CA117207623 rs754284731	301	D>N		No	ClinGen ExAC gnomAD
rs766503818 CA3248413	303	A>V		No	ClinGen ExAC gnomAD
rs760937861 CA3248412	308	C>R		No	ClinGen ExAC gnomAD
CA359573938 rs1455034302	308	C>W		No	ClinGen TOPMed
CA359573932 rs1158613441	309	E>G		No	ClinGen gnomAD
rs958041636 CA117207597	314	S>A		No	ClinGen TOPMed
rs958041636 CA359573896	314	S>P		No	ClinGen TOPMed
CA117207589 rs772627284	318	V>I		No	ClinGen gnomAD
rs1255970170 CA359573862	319	L>V		No	ClinGen gnomAD
CA359573699 rs1579711633	338	I>M		No	ClinGen Ensembl
CA359573616 rs1259851932	345	M>T		No	ClinGen gnomAD
CA3248407 rs768701727	351	F>I		No	ClinGen ExAC gnomAD
rs775398537 CA3248405	352	Y>C		No	ClinGen ExAC gnomAD
rs769305521 CA3248404	354	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1400427220 CA359573434	355	T>A		No	ClinGen gnomAD
rs371800275 CA3248402	356	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA3248401 rs770495904	357	P>A		No	ClinGen ExAC gnomAD
CA359573353 rs1351762701	359	D>E		No	ClinGen gnomAD
rs1030169288 CA117207513	360	S>C		No	ClinGen TOPMed gnomAD
rs1030169288 CA359573332	360	S>Y		No	ClinGen TOPMed gnomAD
rs779274909 CA3248399	361	F>S		No	ClinGen ExAC gnomAD
rs1416393253 CA359573292	362	L>R		No	ClinGen gnomAD
CA359573301 rs1344489723	362	L>V		No	ClinGen TOPMed gnomAD
CA359573260 rs1196469993	364	D>G		No	ClinGen gnomAD
CA359573171 rs1261488694	368	T>I		No	ClinGen gnomAD
CA359573168 rs1489277086	369	R>Q		No	ClinGen gnomAD
rs570874680 CA3248397	369	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA359573162 rs1273370147	370	P>L		No	ClinGen TOPMed gnomAD
CA359573138 rs1331990523	373	E>D		No	ClinGen gnomAD
rs1212575008 CA359573144	373	E>Q		No	ClinGen gnomAD
CA117207500 rs369305280	374	R>K		No	ClinGen ESP TOPMed
rs780419077 CA3248396	375	V>G		No	ClinGen ExAC gnomAD
CA359573093 rs1561166384	381	E>*		No	ClinGen Ensembl
rs995813654 CA117207471	382	T>A		No	ClinGen Ensembl
rs1224388471 CA359573073	384	R>G		No	ClinGen TOPMed
CA117207459 COSM1437557 COSM1437558 rs866107019	386	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA359573056 COSM1437555 COSM1437556 rs1175516950	386	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA3248393 rs558686996	387	H>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs201118044 RCV000943351 CA3248394	387	H>R		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA359573045 rs1187435229	388	T>S		No	ClinGen TOPMed
CA3248391 rs141253847	391	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3248390 rs141253847	391	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1395301525 CA359572957	400	Q>H		No	ClinGen TOPMed
CA117207429 rs1055420381	401	G>C		No	ClinGen TOPMed gnomAD
CA359572956 rs1055420381	401	G>S		No	ClinGen TOPMed gnomAD
rs1321482842 CA359572952	401	G>V		No	ClinGen TOPMed
CA359572951 rs1349178291	402	V>I		No	ClinGen TOPMed
rs1049367137 CA117207425	405	A>V		No	ClinGen Ensembl
rs1372969872 CA359572866	413	S>R		No	ClinGen gnomAD
CA3248386 rs747861746	416	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs930517925 CA117207393	418	N>K		No	ClinGen TOPMed
CA3248383 rs770763740	422	A>T		No	ClinGen ExAC gnomAD
CA3248381 rs772818846	425	C>R		No	ClinGen ExAC TOPMed gnomAD
rs749762932 CA3248379	426	R>K		No	ClinGen ExAC gnomAD
CA359572764 rs1207503865	428	I>M		No	ClinGen TOPMed
CA359572769 rs1235199897	428	I>V		No	ClinGen gnomAD
CA359572757 rs1304524923	429	K>N		No	ClinGen gnomAD
RCV000892214 CA3248378 rs146544425	429	K>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs372372938 CA3248377	430	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA359572725 rs1391991049	434	E>K		No	ClinGen gnomAD
CA117207184 rs1052662585	440	P>L		No	ClinGen TOPMed
rs1389372463 CA359572668	440	P>S		No	ClinGen gnomAD
rs1433191043 CA359572640 COSM1068155	444	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs747211627 CA3248354	444	R>H		No	ClinGen ExAC gnomAD
rs747211627 CA3248355	444	R>L		No	ClinGen ExAC gnomAD
rs747211627 CA359572639	444	R>P		No	ClinGen ExAC gnomAD
CA359572631 rs1444272285	446	R>*		No	ClinGen TOPMed
CA3248353 rs370544157	446	R>Q		No	ClinGen ESP ExAC gnomAD
rs1361573994 CA359572609	449	N>S		No	ClinGen gnomAD
rs778987497 CA3248352	450	P>A		No	ClinGen ExAC TOPMed gnomAD
rs778987497 CA3248351	450	P>S		No	ClinGen ExAC TOPMed gnomAD
CA3248350 rs778987497	450	P>T		No	ClinGen ExAC TOPMed gnomAD
rs753662810 CA3248348	452	T>I		No	ClinGen ExAC gnomAD
CA359572590 rs1208526937	453	S>G		No	ClinGen gnomAD
CA359572573 rs1357593691	455	Y>C		No	ClinGen TOPMed gnomAD
CA117207107 rs979993957	457	K>N		No	ClinGen TOPMed gnomAD
CA359572562 rs1489129414	457	K>Q		No	ClinGen gnomAD
rs766237840 CA3248347	457	K>R		No	ClinGen ExAC gnomAD
rs1193269441 CA359572539	460	L>V		No	ClinGen TOPMed
CA359572533 rs1561165666	461	Q>*		No	ClinGen Ensembl
CA359572519 rs1350147490	463	Y>H		No	ClinGen gnomAD
CA359572495 rs1178543256	466	D>A		No	ClinGen TOPMed gnomAD
CA359572474 rs1433777150	469	T>A		No	ClinGen gnomAD
rs1235170260 CA359572466	470	Y>S		No	ClinGen gnomAD
rs767134351 CA3248344	474	F>I		No	ClinGen ExAC gnomAD
CA117207090 rs879302536	475	R>C		No	ClinGen gnomAD
CA3248343 rs761385811	475	R>H		No	ClinGen ExAC TOPMed gnomAD
CA359572434 rs761385811	475	R>P		No	ClinGen ExAC TOPMed gnomAD
rs773894144 CA3248342	477	I>S		No	ClinGen ExAC TOPMed gnomAD
CA3248341 rs770267711	478	D>V		No	ClinGen ExAC gnomAD
CA3248318 rs371307629	484	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3248319 rs371307629	484	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748330955 CA3248317	486	S>L		No	ClinGen ExAC gnomAD
CA3248316 rs774720365	489	A>P		No	ClinGen ExAC gnomAD
CA3248314 rs749439577	490	T>A		No	ClinGen ExAC TOPMed gnomAD
CA3248313 rs780136282	491	P>S		No	ClinGen ExAC gnomAD
CA3248312 rs756048705	493	R>T		No	ClinGen ExAC TOPMed gnomAD
rs377722592 CA3248311	494	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1271858075 CA359572220	499	N>S		No	ClinGen gnomAD
rs373496949 CA3248309	500	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs369722345 CA117206228	501	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs369722345 CA3248308	501	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs369722345 CA117206232	501	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA359572179 rs1369698439	502	S>C		No	ClinGen gnomAD
rs1249689552 CA359572117	506	S>R		No	ClinGen TOPMed
CA359572089 rs1230030619	508	S>L		No	ClinGen gnomAD
CA3248306 rs373650446	511	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA3248305 rs200834318	513	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA117206190 rs924546469	517	S>A		No	ClinGen Ensembl
CA359571868 rs1198216596	521	L>F		No	ClinGen TOPMed
rs1408060601 CA359571845	522	T>I		No	ClinGen gnomAD
CA359571782 rs1314323666	526	T>N		No	ClinGen gnomAD
CA3248301 rs759783859	528	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1394656931 CA359571714	530	S>F		No	ClinGen gnomAD
rs767733105 CA3248300	531	S>F		No	ClinGen ExAC gnomAD
rs79215941 CA117206168	533	V>A		No	ClinGen Ensembl
CA359571662 rs1461908786	534	D>V		No	ClinGen TOPMed
CA117206163 rs368455500	537	P>L		No	ClinGen TOPMed gnomAD
CA359571602 rs1436516797	538	R>K		No	ClinGen gnomAD
rs537660683 CA3248297	539	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs537660683 CA3248298	539	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA359571536 rs1346729889	542	H>N		No	ClinGen gnomAD
CA3248296 rs749349784	542	H>R		No	ClinGen ExAC gnomAD
rs769941751 CA3248294	544	I>T		No	ClinGen ExAC gnomAD
CA359571487 rs1341286749	544	I>V		No	ClinGen TOPMed
CA3248293 rs745757450	545	E>G		No	ClinGen ExAC gnomAD
rs774750291 CA3248291	549	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1561164246 CA359571396	549	M>K		No	ClinGen Ensembl
CA359571349 rs1377155034	551	A>V		No	ClinGen gnomAD
CA3248290 rs756983376	555	K>N		No	ClinGen ExAC gnomAD
rs1293501358 CA359570014	557	L>V		No	ClinGen TOPMed

No associated diseases with Q13131

6 regional properties for Q13131

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	27 - 279	IPR000719
active_site	Serine/threonine-protein kinase, active site	146 - 158	IPR008271
binding_site	Protein kinase, ATP binding site	33 - 56	IPR017441
domain	PRKAA1, UBA-like autoinhibitory domain	296 - 360	IPR028797
domain	AMPK, C-terminal adenylate sensor domain	406 - 480	IPR032270
domain	5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal	404 - 557	IPR039137

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Nucleus	In response to stress, recruited by p53/TP53 to specific promoters
PANTHER Family	PTHR24346	MAP/MICROTUBULE AFFINITY-REGULATING KINASE
PANTHER Subfamily	PTHR24346:SF82	SERINE_THREONINE-PROTEIN KINASE MARK-A-RELATED
PANTHER Protein Class	non-receptor serine/threonine protein kinase protein modifying enzyme
PANTHER Pathway Category	p53 pathway by glucose deprivation AMPK

10 GO annotations of cellular component

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleotide-activated protein kinase complex	A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

16 GO annotations of molecular function

Name	Definition
[acetyl-CoA carboxylase] kinase activity	Catalysis of the reaction: ATP
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity	+Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP.
AMP-activated protein kinase activity	Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cAMP-dependent protein kinase activity	cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone serine kinase activity	Catalysis of the transfer of a phosphate group to a serine residue of a histone.
metal ion binding	Binding to a metal ion.
protein C-terminus binding	Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein-containing complex binding	Binding to a macromolecular complex.
tau protein binding	Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
tau-protein kinase activity	Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.

63 GO annotations of biological process

Name	Definition
autophagy	The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
bile acid and bile salt transport	The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
bile acid signaling pathway	The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
CAMKK-AMPK signaling cascade	The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
cellular response to calcium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
cellular response to ethanol	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
cellular response to glucose starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
cellular response to glucose stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
cellular response to hydrogen peroxide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
cellular response to hypoxia	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
cellular response to nutrient levels	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
cellular response to organonitrogen compound	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
cellular response to oxidative stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
cellular response to prostaglandin E stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
cellular response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
cholesterol biosynthetic process	The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
cold acclimation	Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
energy homeostasis	Any process involved in the balance between food intake (energy input) and energy expenditure.
fatty acid biosynthetic process	The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
fatty acid homeostasis	Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.
fatty acid oxidation	The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
glucose homeostasis	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
glucose metabolic process	The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipid biosynthetic process	The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
motor behavior	The specific neuromuscular movement of a single organism in response to external or internal stimuli.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of glucosylceramide biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.
negative regulation of hepatocyte apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process.
negative regulation of insulin receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
negative regulation of lipid catabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
negative regulation of TOR signaling	Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
negative regulation of tubulin deacetylation	Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.
neuron cellular homeostasis	The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
positive regulation of autophagy	Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cholesterol biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of glycolytic process	Any process that activates or increases the frequency, rate or extent of glycolysis.
positive regulation of mitochondrial transcription	Any process that activates or increases the frequency, rate or extent of transcription occuring in the mitochondrion.
positive regulation of peptidyl-lysine acetylation	Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation.
positive regulation of protein localization	Any process that activates or increases the frequency, rate or extent of a protein localization.
positive regulation of protein targeting to mitochondrion	Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
positive regulation of skeletal muscle tissue development	Any process that activates, maintains or increases the rate of skeletal muscle tissue development.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of bile acid secretion	Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.
regulation of circadian rhythm	Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
regulation of microtubule cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
regulation of peptidyl-serine phosphorylation	Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.
regulation of stress granule assembly	Any process that modulates the rate, frequency or extent of stress granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
regulation of vesicle-mediated transport	Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
response to 17alpha-ethynylestradiol	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus.
response to activity	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
response to caffeine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
response to camptothecin	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus.
response to gamma radiation	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
response to hypoxia	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to UV	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
rhythmic process	Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

72 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q02066		Abscisic acid-inducible protein kinase	Triticum aestivum (Wheat)	PR
P06782	SNF1	Carbon catabolite-derepressing protein kinase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	EV
Q5GLH2	TRIB2	Tribbles homolog 2	Bos taurus (Bovine)	SS
Q0VCE3	TRIB3	Tribbles homolog 3	Bos taurus (Bovine)	SS
Q3SZW1	TSSK1B	Testis-specific serine/threonine-protein kinase 1	Bos taurus (Bovine)	PR
Q92519	TRIB2	Tribbles homolog 2	Homo sapiens (Human)	SS
Q96RU7	TRIB3	Tribbles homolog 3	Homo sapiens (Human)	PR
Q96RU8	TRIB1	Tribbles homolog 1	Homo sapiens (Human)	EV
Q15831	STK11	Serine/threonine-protein kinase STK11	Homo sapiens (Human)	PR
Q96RG2	PASK	PAS domain-containing serine/threonine-protein kinase	Homo sapiens (Human)	EV
O14757	CHEK1	Serine/threonine-protein kinase Chk1	Homo sapiens (Human)	EV
Q8IWQ3	BRSK2	Serine/threonine-protein kinase BRSK2	Homo sapiens (Human)	PR
Q8TDC3	BRSK1	Serine/threonine-protein kinase BRSK1	Homo sapiens (Human)	SS
Q14680	MELK	Maternal embryonic leucine zipper kinase	Homo sapiens (Human)	EV
P57059	SIK1	Serine/threonine-protein kinase SIK1	Homo sapiens (Human)	PR
Q9NRH2	SNRK	SNF-related serine/threonine-protein kinase	Homo sapiens (Human)	SS
Q9BXA7	TSSK1B	Testis-specific serine/threonine-protein kinase 1	Homo sapiens (Human)	PR
O60285	NUAK1	NUAK family SNF1-like kinase 1	Homo sapiens (Human)	PR
P54646	PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (Human)	EV
Q8K4K3	Trib2	Tribbles homolog 2	Mus musculus (Mouse)	SS
Q61241	Tssk1b	Testis-specific serine/threonine-protein kinase 1	Mus musculus (Mouse)	PR
Q8K4K2	Trib3	Tribbles homolog 3	Mus musculus (Mouse)	SS
O54863	Tssk2	Testis-specific serine/threonine-protein kinase 2	Mus musculus (Mouse)	PR
Q8K4K4	Trib1	Tribbles homolog 1	Mus musculus (Mouse)	SS
Q61846	Melk	Maternal embryonic leucine zipper kinase	Mus musculus (Mouse)	PR
Q8BRK8	Prkaa2	5'-AMP-activated protein kinase catalytic subunit alpha-2	Mus musculus (Mouse)	SS
Q5EG47	Prkaa1	5'-AMP-activated protein kinase catalytic subunit alpha-1	Mus musculus (Mouse)	SS
Q28948	PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2	Sus scrofa (Pig)	SS
Q09136	PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1	Sus scrofa (Pig)	SS
Q9WTQ6	Trib3	Tribbles homolog 3	Rattus norvegicus (Rat)	SS
Q09137	Prkaa2	5'-AMP-activated protein kinase catalytic subunit alpha-2	Rattus norvegicus (Rat)	EV
P54645	Prkaa1	5'-AMP-activated protein kinase catalytic subunit alpha-1	Rattus norvegicus (Rat)	EV
Q5QNM6	CIPK13	Putative CBL-interacting protein kinase 13	Oryza sativa subsp japonica (Rice)	PR
Q5JLQ9	CIPK30	CBL-interacting protein kinase 30	Oryza sativa subsp japonica (Rice)	PR
Q5N942	SAPK4	Serine/threonine-protein kinase SAPK4	Oryza sativa subsp japonica (Rice)	PR
Q852Q0	OSK3	Serine/threonine protein kinase OSK3	Oryza sativa subsp. japonica (Rice)	SS
Q75LR7	SAPK1	Serine/threonine-protein kinase SAPK1	Oryza sativa subsp japonica (Rice)	PR
Q75H77	SAPK10	Serine/threonine-protein kinase SAPK10	Oryza sativa subsp japonica (Rice)	PR
Q7Y0B9	SAPK8	Serine/threonine-protein kinase SAPK8	Oryza sativa subsp japonica (Rice)	PR
Q7XQP4	SAPK7	Serine/threonine-protein kinase SAPK7	Oryza sativa subsp japonica (Rice)	PR
Q0D4J7	SAPK2	Serine/threonine-protein kinase SAPK2	Oryza sativa subsp japonica (Rice)	PR
Q6ERS4	CIPK16	CBL-interacting protein kinase 16	Oryza sativa subsp japonica (Rice)	PR
P0C5D6	SAPK3	Serine/threonine-protein kinase SAPK3	Oryza sativa subsp japonica (Rice)	PR
Q75V57	SAPK9	Serine/threonine-protein kinase SAPK9	Oryza sativa subsp japonica (Rice)	PR
Q8LIG4	CIPK3	CBL-interacting protein kinase 3	Oryza sativa subsp japonica (Rice)	PR
Q852Q1	OSK4	Serine/threonine protein kinase OSK4	Oryza sativa subsp. japonica (Rice)	SS
Q852Q2	OSK1	Serine/threonine protein kinase OSK1	Oryza sativa subsp. japonica (Rice)	SS
Q6ZLP5	CIPK23	CBL-interacting protein kinase 23	Oryza sativa subsp japonica (Rice)	PR
Q2RAX3	CIPK33	CBL-interacting protein kinase 33	Oryza sativa subsp japonica (Rice)	PR
Q2QY53	CIPK32	CBL-interacting protein kinase 32	Oryza sativa subsp japonica (Rice)	PR
Q21017	kin-29	Serine/threonine-protein kinase kin-29	Caenorhabditis elegans	SS
Q95ZQ4	aak-2	5'-AMP-activated protein kinase catalytic subunit alpha-2	Caenorhabditis elegans	SS
P45894	aak-1	5'-AMP-activated protein kinase catalytic subunit alpha-1	Caenorhabditis elegans	SS
P43291	SRK2A	Serine/threonine-protein kinase SRK2A	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C958	SRK2B	Serine/threonine-protein kinase SRK2B	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M9E9	SRK2C	Serine/threonine-protein kinase SRK2C	Arabidopsis thaliana (Mouse-ear cress)	PR
O64812	SRK2J	Serine/threonine-protein kinase SRK2J	Arabidopsis thaliana (Mouse-ear cress)	PR
Q2V452	CIPK3	CBL-interacting serine/threonine-protein kinase 3	Arabidopsis thaliana (Mouse-ear cress)	SS
O22971	CIPK13	CBL-interacting serine/threonine-protein kinase 13	Arabidopsis thaliana (Mouse-ear cress)	PR
Q39192	SRK2D	Serine/threonine-protein kinase SRK2D	Arabidopsis thaliana (Mouse-ear cress)	PR
O65554	CIPK6	CBL-interacting serine/threonine-protein kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q940H6	SRK2E	Serine/threonine-protein kinase SRK2E	Arabidopsis thaliana (Mouse-ear cress)	PR
P43292	SRK2G	Serine/threonine-protein kinase SRK2G	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FJ54	CIPK20	CBL-interacting serine/threonine-protein kinase 20	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FFP9	SRK2H	Serine/threonine-protein kinase SRK2H	Arabidopsis thaliana (Mouse-ear cress)	PR
Q39193	SRK2I	Serine/threonine-protein kinase SRK2I	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94CG0	CIPK21	CBL-interacting serine/threonine-protein kinase 21	Arabidopsis thaliana (Mouse-ear cress)	PR
Q93VD3	CIPK23	CBL-interacting serine/threonine-protein kinase 23	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LDI3	CIPK24	CBL-interacting serine/threonine-protein kinase 24	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FLZ3	KIN12	SNF1-related protein kinase catalytic subunit alpha KIN12	Arabidopsis thaliana (Mouse-ear cress)	SS
P92958	KIN11	SNF1-related protein kinase catalytic subunit alpha KIN11	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38997	KIN10	SNF1-related protein kinase catalytic subunit alpha KIN10	Arabidopsis thaliana (Mouse-ear cress)	SS

10	20	30	40	50	60
MRRLSSWRKM	ATAEKQKHDG	RVKIGHYILG	DTLGVGTFGK	VKVGKHELTG	HKVAVKILNR
70	80	90	100	110	120
QKIRSLDVVG	KIRREIQNLK	LFRHPHIIKL	YQVISTPSDI	FMVMEYVSGG	ELFDYICKNG
130	140	150	160	170	180
RLDEKESRRL	FQQILSGVDY	CHRHMVVHRD	LKPENVLLDA	HMNAKIADFG	LSNMMSDGEF
190	200	210	220	230	240
LRTSCGSPNY	AAPEVISGRL	YAGPEVDIWS	SGVILYALLC	GTLPFDDDHV	PTLFKKICDG
250	260	270	280	290	300
IFYTPQYLNP	SVISLLKHML	QVDPMKRATI	KDIREHEWFK	QDLPKYLFPE	DPSYSSTMID
310	320	330	340	350	360
DEALKEVCEK	FECSEEEVLS	CLYNRNHQDP	LAVAYHLIID	NRRIMNEAKD	FYLATSPPDS
370	380	390	400	410	420
FLDDHHLTRP	HPERVPFLVA	ETPRARHTLD	ELNPQKSKHQ	GVRKAKWHLG	IRSQSRPNDI
430	440	450	460	470	480
MAEVCRAIKQ	LDYEWKVVNP	YYLRVRRKNP	VTSTYSKMSL	QLYQVDSRTY	LLDFRSIDDE
490	500	510	520	530	540
ITEAKSGTAT	PQRSGSVSNY	RSCQRSDSDA	EAQGKSSEVS	LTSSVTSLDS	SPVDLTPRPG
550
SHTIEFFEMC	ANLIKILAQ