AiPD: Autoinhibited Protein Database

Q13127

Gene name	REST (NRSF, XBR)
Protein name	RE1-silencing transcription factor
Names	Neural-restrictive silencer factor, X2 box repressor
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5978
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

827-901 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

827-901 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q13127

Entry ID	Method	Resolution	Chain	Position	Source
2CZY	NMR	-	B	43-57	PDB
6DU2	X-ray	250 A	C/D	858-869	PDB
6DU3	X-ray	258 A	C/D	858-869	PDB
AF-Q13127-F1	Predicted				AlphaFoldDB

901 variants for Q13127

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA357003184 RCV001294083 rs1342633562	80	G>R	Fibromatosis, gingival, 5 [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
RCV002553235 rs138686672 CA2932102 RCV001050838	141	P>R	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
VAR_076333	160	R>P	WT6; inhibits transcriptional repression activity [UniProt]	Yes	UniProt
RCV003163631 rs375735172 CA2932115 RCV001213984	176	H>R	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs869025311 RCV000207468	258	V>missing	Wilms tumor 6 [ClinVar]	Yes	ClinVar dbSNP
RCV001230375 rs869025310 RCV000207462	278	C>missing	Wilms tumor 6 [ClinVar]	Yes	ClinVar dbSNP
VAR_076334	290	N>Y	WT6; inhibits transcriptional repression activity [UniProt]	Yes	UniProt
VAR_076335 RCV000207458 rs869025312 CA351624	322	H>R	Wilms tumor 6 WT6; inhibits transcriptional repression activity [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
VAR_076336	412	H>Q	WT6 [UniProt]	Yes	UniProt
rs1553904077 CA357006327 RCV000516150 RCV000498225	437	L>*	Fibromatosis, gingival, 1 Fibromatosis, gingival, 5 Fibromatosis, gingival, 1 (gingf1) [ClinVar, Ensembl]	Yes	ClinGen ClinVar Ensembl dbSNP
VAR_079529	437	L>del	GINGF5 [UniProt]	Yes	UniProt
RCV001526813 RCV001212714 rs778247936 CA2932251	448	I>M	Wilms tumor 6 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV002254722 RCV001325863 CA2932295 rs754696564	547	V>L	Wilms tumor 6 [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
RCV001068521 RCV002554548 rs201530969 CA2932424	727	E>K	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
COSM3302227 rs139336427 RCV000922186 CA2932439 RCV002540995	750	S>T	skin Inborn genetic diseases [Cosmic, ClinVar]	Yes	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000515908 rs1553904346 RCV000498949	805	L>missing	Fibromatosis, gingival, 1 Fibromatosis, gingival, 5 [ClinVar]	Yes	ClinVar dbSNP
CA357008952 rs1553904378 RCV000624224	839	E>*	Variant assessed as Somatic; impact. Inborn genetic diseases [NCI-TCGA, ClinVar]	Yes	ClinGen ClinVar Ensembl NCI-TCGA dbSNP
RCV002563960 CA2932533 RCV001239828 rs748529871	894	L>F	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2932542 rs775073659 RCV001322230 RCV002546092	912	N>T	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000995854 rs1284461687 CA357009492	924	Q>*	Fibromatosis, gingival, 5 [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
rs1553904481 RCV000516014 RCV000497680 RCV001851328	958	N>missing	Fibromatosis, gingival, 1 Fibromatosis, gingival, 5 [ClinVar]	Yes	ClinVar dbSNP
RCV001055429 rs751959764 CA2932571 RCV002553354	958	N>T	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2932032 rs766627256	3	T>N		No	ClinGen ExAC gnomAD
rs1286387521 CA357002332	5	V>A		No	ClinGen gnomAD
CA357002333 rs1286387521	5	V>G		No	ClinGen gnomAD
rs1173516304 CA357002328	5	V>I		No	ClinGen gnomAD
TCGA novel	6	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA97629369 rs199666541	14	G>A		No	ClinGen Ensembl
CA357002388 CA357002387 rs1216190809	14	G>R		No	ClinGen gnomAD
CA97629372 rs1029986380	15	L>V		No	ClinGen TOPMed gnomAD
rs755279791 CA2932034	18	S>G		No	ClinGen ExAC gnomAD
rs1387715042 CA357002414	18	S>N		No	ClinGen Ensembl
rs147722706 CA97629377	20	G>A		No	ClinGen ESP
CA2932036 rs375511894	23	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA2932037 RCV001348285 rs777368920	24	M>V		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA97629383 rs894647864	25	A>D		No	ClinGen gnomAD
rs1178475745 CA357002529	25	A>S		No	ClinGen TOPMed gnomAD
CA97629386 rs948833888	29	D>N		No	ClinGen TOPMed
rs758725744 CA2932038	30	M>V		No	ClinGen ExAC TOPMed gnomAD
RCV001341699 rs967744114	31	Y>C		No	ClinVar dbSNP
CA2932039 rs778338685	31	Y>D		No	ClinGen ExAC gnomAD
CA97629391 rs967744114	31	Y>S		No	ClinGen TOPMed
rs1437046091 CA357002750	37	S>C		No	ClinGen gnomAD
rs776125562 CA2932042	38	K>Q		No	ClinGen ExAC gnomAD
rs1267572500 CA357002811	40	E>V		No	ClinGen TOPMed
CA2932044 rs769459656	42	A>G		No	ClinGen ExAC gnomAD
rs1388661460 CA357002837	42	A>T		No	ClinGen TOPMed gnomAD
rs1578485109 CA357002850	43	A>T		No	ClinGen Ensembl
CA2932045 rs775172840	47	I>L		No	ClinGen ExAC gnomAD
CA97629405 rs1014583225	48	M>I		No	ClinGen Ensembl
rs1381137665 CA357002934	48	M>L		No	ClinGen TOPMed gnomAD
TCGA novel	50	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932048 rs370180021	58	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA2932049 rs370180021	58	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA357003041 rs1206566572	59	N>S		No	ClinGen gnomAD
rs766523223 CA2932051	63	C>R		No	ClinGen ExAC gnomAD
CA2932053 rs755153452	65	Y>H		No	ClinGen ExAC gnomAD
rs1401967892 CA357003090	66	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA357003095 rs1331461971	67	V>L		No	ClinGen gnomAD
CA357003130 rs377080732	72	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs377080732 CA2932055	72	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1321193438 CA357003150	74	A>V		No	ClinGen gnomAD
TCGA novel	75	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357003161 rs1221861537	76	L>Q		No	ClinGen gnomAD
CA357003174 rs142504829	78	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA2932056 rs142504829	78	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1259814228 CA357003182	79	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs747481199 CA2932058	80	G>E		No	ClinGen ExAC gnomAD
CA2932060 rs545879908	81	D>E		No	ClinGen 1000Genomes ExAC gnomAD
rs745360783 CA2932061	82	N>S		No	ClinGen ExAC gnomAD
rs757097016 CA97629447	85	S>A		No	ClinGen Ensembl
rs757097016 CA97629445	85	S>T		No	ClinGen Ensembl
CA357003230 rs775123471	86	D>E		No	ClinGen ExAC gnomAD
RCV000818840 rs1578485326	89	E>missing		No	ClinVar dbSNP
CA2932064 rs796154475	89	E>G		No	ClinGen TOPMed gnomAD
CA2932066 rs748955783	90	G>R		No	ClinGen ExAC gnomAD
CA357003261 rs1477281855	91	E>K		No	ClinGen gnomAD
CA2932067 rs61748753 RCV000886566	92	G>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1044394452 CA97629460	93	L>P		No	ClinGen TOPMed gnomAD
CA97629463 rs909981105	95	E>K		No	ClinGen TOPMed
rs941391615 CA97629465	96	S>Y		No	ClinGen TOPMed
CA357003300 rs761757985	97	A>G		No	ClinGen ExAC TOPMed gnomAD
rs977427795 CA357003298	97	A>S		No	ClinGen TOPMed gnomAD
rs977427795 CA97629472	97	A>T		No	ClinGen TOPMed gnomAD
rs761757985 CA2932069	97	A>V		No	ClinGen ExAC TOPMed gnomAD
rs139840343 CA2932070	98	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1387367997 CA357003302	98	D>H		No	ClinGen gnomAD
rs1323149927 CA357003306	98	D>V		No	ClinGen gnomAD
CA2932072 rs141631518	99	I>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2932071 RCV001343405 rs141631518	99	I>T		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001051855 CA2932075 rs150412877	101	G>D		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs752906763 CA2932074	101	G>S		No	ClinGen ExAC gnomAD
CA2932077 rs751894476	103	P>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA357003337 rs1356441917	103	P>S		No	ClinGen gnomAD
rs1356441917 CA357003335	103	P>T		No	ClinGen gnomAD
TCGA novel	104	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757667930 CA2932078	104	H>P		No	ClinGen ExAC gnomAD
COSM1726171 rs781642150 CA2932079	105	G>V	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs755611815 CA2932081	106	L>P		No	ClinGen ExAC gnomAD
CA2932083 rs748907683	109	M>V		No	ClinGen ExAC gnomAD
TCGA novel	113	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357003444 rs1302497540	113	S>N		No	ClinGen gnomAD
TCGA novel	113	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs940245420 CA97629509	118	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1298973547 CA357003540	119	V>I		No	ClinGen gnomAD
CA2932087 rs772055621	120	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA2932088 rs773267428	121	P>R		No	ClinGen ExAC gnomAD
CA2932090 rs149829250 COSM587858 RCV000884953	123	P>A	lung [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs770225600 CA2932092	125	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1352164694 CA357003670	127	A>V		No	ClinGen TOPMed gnomAD
rs1288824485 CA357003684	128	S>L		No	ClinGen gnomAD
rs549796077 CA2932094	129	G>V		No	ClinGen ExAC TOPMed gnomAD
CA357003704 rs1225668240	130	A>G		No	ClinGen TOPMed
CA2932095 rs762162582	130	A>S		No	ClinGen ExAC gnomAD
CA357003709 rs1336567719	131	P>A		No	ClinGen gnomAD
CA2932097 rs750876253	132	D>G		No	ClinGen ExAC gnomAD
rs1424886471 CA357003733	133	I>V		No	ClinGen gnomAD
rs1366817450 CA357003767	135	S>N		No	ClinGen gnomAD
CA2932098 rs756621666	135	S>R		No	ClinGen ExAC gnomAD
rs374614406 CA2932100	138	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1358594587 CA357003814	138	K>R		No	ClinGen gnomAD
rs112115500 CA2932101	139	D>G		No	ClinGen ExAC gnomAD
TCGA novel	139	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1417692214 CA357003842	140	L>I		No	ClinGen TOPMed gnomAD
RCV001344821 rs1719881567	140	L>R		No	ClinVar dbSNP
CA357003843 rs1417692214	140	L>V		No	ClinGen TOPMed gnomAD
rs763563599 CA2932103	142	P>R		No	ClinGen ExAC TOPMed gnomAD
CA357003880 rs1428820816	143	E>K		No	ClinGen TOPMed
rs1401987985 CA357003906	144	T>I		No	ClinGen Ensembl
CA357003916 rs1184775327	145	P>R		No	ClinGen gnomAD
TCGA novel	147	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357003948 rs1310429913	147	A>V		No	ClinGen gnomAD
RCV001041844 rs1719882659	148	E>missing		No	ClinVar dbSNP
rs566521492 CA2932106	152	K>R		No	ClinGen 1000Genomes ExAC gnomAD
RCV001295758 rs1371092850 CA357004036	153	S>G		No	ClinGen ClinVar TOPMed dbSNP
CA357004042 rs370369213	153	S>I		No	ClinGen ESP TOPMed gnomAD
CA97629559 rs370369213	153	S>N		No	ClinGen ESP TOPMed gnomAD
rs771308736 CA2932108	154	S>L		No	ClinGen ExAC TOPMed gnomAD
rs771308736 CA2932107	154	S>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	155	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1483752957 CA357004111	160	R>C		No	ClinGen gnomAD
rs1200394143 CA357004112	160	R>H		No	ClinGen TOPMed gnomAD
rs1200394143 CA357004114	160	R>L		No	ClinGen TOPMed gnomAD
rs1434028396 CA357004136	163	P>L		No	ClinGen TOPMed
CA2932111 rs774426666	165	Q>R		No	ClinGen ExAC gnomAD
rs368110817 CA2932113	168	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1369643422 CA357004207	173	Q>R		No	ClinGen gnomAD
CA357004224 rs1178455302	175	V>A		No	ClinGen gnomAD
rs766763031 CA357004240	178	I>F		No	ClinGen ExAC gnomAD
CA2932116 rs766763031	178	I>V		No	ClinGen ExAC gnomAD
CA97629600 rs1031974892	179	R>T		No	ClinGen gnomAD
CA2932117 rs754431649	182	S>G		No	ClinGen ExAC gnomAD
CA357004280 rs1208006031	184	K>E		No	ClinGen TOPMed
CA357004288 rs1374252597	185	K>E		No	ClinGen gnomAD
CA2932119 rs764815520	186	F>L		No	ClinGen ExAC
CA2932120 rs752331309	186	F>S		No	ClinGen ExAC gnomAD
TCGA novel	188	V>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357004315 rs1346306429	189	E>K		No	ClinGen TOPMed
rs146236318 CA2932122	190	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757117156 CA2932124	192	A>T		No	ClinGen ExAC gnomAD
CA357004357 rs1459464915	194	K>N		No	ClinGen TOPMed gnomAD
CA2932125 rs780987128	195	Q>R		No	ClinGen ExAC gnomAD
rs745876653 CA2932126 RCV001241448	198	A>V		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001053987 CA2932127 rs768565370	199	R>G		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA357004395 rs1193154231	200	E>G		No	ClinGen gnomAD
CA357004404 COSM98199 rs1309614313	201	S>F	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1432826392 CA357004409	202	G>A		No	ClinGen TOPMed
rs369789287 CA2932129	203	S>C		No	ClinGen ExAC TOPMed gnomAD
rs369789287 CA357004415	203	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1173681874 CA357004420	204	S>C		No	ClinGen gnomAD
rs981639576 CA97629646	205	T>A		No	ClinGen TOPMed gnomAD
rs773458977 CA2932131	205	T>I		No	ClinGen ExAC TOPMed gnomAD
rs981639576 CA357004423	205	T>P		No	ClinGen TOPMed gnomAD
CA97629648 rs373691787	206	A>S		No	ClinGen TOPMed
rs1441216415 CA357004458	210	D>G		No	ClinGen TOPMed
CA2932137 rs752278153	212	S>C		No	ClinGen ExAC TOPMed gnomAD
rs752278153 CA97629671	212	S>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	216	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932138 rs376611047	217	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2932139 rs763808902	217	R>H		No	ClinGen ExAC gnomAD
CA357004522 rs1346435228 COSM192719	220	R>C	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs751325926 CA2932140	220	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1578486222 CA357004535	222	G>C		No	ClinGen Ensembl
rs781057074 CA2932142	223	Y>*		No	ClinGen ExAC gnomAD
CA357004552 rs1223861498	224	N>K		No	ClinGen gnomAD
CA357004577 rs1488268000	228	Y>C		No	ClinGen gnomAD
rs1189295494 CA357004609	232	T>R		No	ClinGen gnomAD
CA357004633 rs1265108771	236	K>Q		No	ClinGen gnomAD
rs756112086 CA2932144	239	T>I		No	ClinGen ExAC gnomAD
CA357004664 rs1246760297	240	R>K		No	ClinGen gnomAD
CA357004674 rs1421379957	241	A>V		No	ClinGen gnomAD
CA97629688 rs368339850	243	D>E		No	ClinGen ESP TOPMed
CA357004685 rs1406655944	243	D>G		No	ClinGen gnomAD
rs1164834053 CA357004689	244	N>D		No	ClinGen TOPMed gnomAD
CA2932146 rs748191155	246	R>*		No	ClinGen ExAC gnomAD
rs772203091 CA2932147	246	R>Q		No	ClinGen ExAC
rs1314534661 CA357004707	247	V>I		No	ClinGen TOPMed gnomAD
CA357004721 rs1412642189	249	K>Q		No	ClinGen TOPMed
CA357004725 rs1456092970	249	K>R		No	ClinGen TOPMed gnomAD
CA357004760 rs1299598810	254	T>S		No	ClinGen gnomAD
rs1342789857 CA357004785	258	V>M		No	ClinGen gnomAD
rs1400922393 CA357004794	259	S>N		No	ClinGen gnomAD
CA2932148 rs777955335	260	E>G		No	ClinGen ExAC gnomAD
CA2932151 rs777083737	267	L>V		No	ClinGen ExAC gnomAD
CA357004872 rs1321159629	269	N>I		No	ClinGen gnomAD
TCGA novel	272	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932153 rs759911296	273	R>S		No	ClinGen ExAC gnomAD
rs1488530810 CA357004904	274	K>E		No	ClinGen gnomAD
TCGA novel	276	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763756962 CA2932156	277	T>R		No	ClinGen ExAC gnomAD
CA97629739 rs1037293261	280	K>N		No	ClinGen Ensembl
CA2932158 rs201400863	282	N>S		No	ClinGen ExAC TOPMed gnomAD
rs201400863 CA357004963	282	N>T		No	ClinGen ExAC TOPMed gnomAD
rs1014438653 CA97629746	283	Y>C		No	ClinGen TOPMed
rs767179173 CA2932159	283	Y>H		No	ClinGen ExAC gnomAD
CA2932160 rs750258882	285	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
RCV001313216 rs1160091901	286	D>E		No	ClinVar dbSNP
TCGA novel	289	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	291	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759671149 CA97629754	293	Q>*		No	ClinGen Ensembl
CA2932162 rs779959126	296	R>I		No	ClinGen ExAC TOPMed gnomAD
rs1277910638 CA357005162	302	R>P		No	ClinGen gnomAD
rs757320743 CA2932187	307	E>Q		No	ClinGen ExAC gnomAD
CA97632582 rs567456057	323	M>R		No	ClinGen ExAC TOPMed gnomAD
CA2932191 rs567456057	323	M>T		No	ClinGen ExAC TOPMed gnomAD
CA357005306 rs1173497088	323	M>V		No	ClinGen gnomAD
CA357005312 rs1468725438	324	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	325	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	326	H>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	326	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1191600909 CA357005611	333	K>N		No	ClinGen gnomAD
CA357005622 rs1560451153	335	D>N		No	ClinGen Ensembl
TCGA novel	339	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932211 rs780520222	339	Y>F		No	ClinGen ExAC gnomAD
rs1163187321 CA357005659	340	V>M		No	ClinGen gnomAD
CA2932212 rs749651610	341	A>S		No	ClinGen ExAC gnomAD
rs1560451173 CA357005672	342	S>A		No	ClinGen Ensembl
rs1578512879 CA357005714	348	T>P		No	ClinGen Ensembl
rs1419352292 CA357005722	349	R>C		No	ClinGen TOPMed
TCGA novel	355	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357005788 rs1298563122	358	P>L		No	ClinGen gnomAD
CA357005803 COSM1694423 rs1208548556	361	L>F	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
CA357005814 rs1429750659	362	N>T		No	ClinGen TOPMed gnomAD
CA357005838 rs139443175	365	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA357005836 rs1380492040	365	H>R		No	ClinGen TOPMed gnomAD
rs772625881 CA2932217	367	D>Y		No	ClinGen ExAC
CA97636299 rs77133253	368	Y>*		No	ClinGen Ensembl
rs1347262737 CA357005897	374	S>G		No	ClinGen TOPMed
CA97636302 rs997052671	383	H>Y		No	ClinGen Ensembl
rs776304738 CA2932220	388	Q>R		No	ClinGen ExAC gnomAD
CA2932221 rs150066390	390	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs775441291 CA2932223	393	V>L		No	ClinGen ExAC gnomAD
CA357006049 rs1383675520	395	D>E		No	ClinGen gnomAD
rs112873471 CA97636321	395	D>G		No	ClinGen Ensembl
rs762805457 CA2932224	395	D>N		No	ClinGen ExAC gnomAD
CA357006093 rs1159435321	402	C>R		No	ClinGen gnomAD
rs750555052 CA2932226	413	P>A		No	ClinGen ExAC TOPMed gnomAD
rs916067592 CA97636325	413	P>R		No	ClinGen TOPMed
CA97636329 rs1029140562	414	T>A		No	ClinGen gnomAD
CA2932227 rs756313952	414	T>I		No	ClinGen ExAC gnomAD
CA2932229 rs754183550	416	P>A		No	ClinGen ExAC TOPMed gnomAD
CA97636342 rs754183550	416	P>T		No	ClinGen ExAC TOPMed gnomAD
rs539110951 CA2932230	417	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2932231 rs539110951	417	N>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2932232 rs552744964	417	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA357006209 rs1578513163	419	T>A		No	ClinGen Ensembl
CA2932234 rs778391887	419	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1560451320 CA357006214	420	M>V		No	ClinGen Ensembl
CA357006245 rs1346305938	424	K>T		No	ClinGen TOPMed gnomAD
CA357006266 rs1179513496	427	L>Q		No	ClinGen gnomAD
CA2932239 rs769566447	428	K>E		No	ClinGen ExAC gnomAD
TCGA novel	428	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1378181425 CA357006287	430	T>N		No	ClinGen gnomAD
TCGA novel	430	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762902446 CA2932241	431	K>E		No	ClinGen ExAC gnomAD
CA2932242 rs768459194	432	K>T		No	ClinGen ExAC TOPMed gnomAD
rs774473417 CA2932243	433	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	433	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	434	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1370713548 CA357006312	434	E>G		No	ClinGen gnomAD
CA2932245 rs760836798	435	A>P		No	ClinGen ExAC gnomAD
rs760836798 CA2932244	435	A>T		No	ClinGen ExAC gnomAD
rs754044227 CA2932246	436	D>E		No	ClinGen ExAC gnomAD
rs1041043286 CA97636389	436	D>Y		No	ClinGen TOPMed
TCGA novel	437	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs569303832 CA2932247	437	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA2932248 rs765586309	438	P>H		No	ClinGen ExAC gnomAD
rs373407636 CA97636413	439	D>G		No	ClinGen ESP
CA357006349 rs1261755869	440	N>I		No	ClinGen gnomAD
TCGA novel	440	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932249 rs752980074	441	I>V		No	ClinGen ExAC gnomAD
rs1720897461 RCV001213709	442	T>A		No	ClinVar dbSNP
rs538429646 CA2932250	443	N>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	446	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA97636417 RCV001313302 rs764285600	448	I>T		No	ClinGen ClinVar TOPMed dbSNP gnomAD
RCV001053637 rs1720897736	448	I>V		No	ClinVar dbSNP
rs1560451450 CA357006426	451	T>R		No	ClinGen Ensembl
TCGA novel	452	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932252 rs555004124	452	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA2932253 rs756699542	453	I>V		No	ClinGen ExAC gnomAD
rs745483275 CA2932255	454	K>N		No	ClinGen ExAC TOPMed gnomAD
rs780685597 CA2932254	454	K>R		No	ClinGen ExAC gnomAD
rs967056074 CA97636430	456	D>G		No	ClinGen Ensembl
CA357006455 rs1330817652	456	D>N		No	ClinGen TOPMed gnomAD
rs1465746551 CA357006466	458	A>T		No	ClinGen gnomAD
CA357006479 rs1414044696	460	K>E		No	ClinGen TOPMed
CA357006499 rs1293688056	462	N>K		No	ClinGen gnomAD
CA2932259 rs768566876	462	N>T		No	ClinGen ExAC gnomAD
CA2932260 rs774421905 COSM1430334	466	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1215291953 CA357006546	469	E>G		No	ClinGen gnomAD
rs759708208 CA2932264	472	D>Y		No	ClinGen ExAC gnomAD
rs1241455829 CA357006584	475	K>E		No	ClinGen TOPMed
CA357006597 rs1189076248	476	E>V		No	ClinGen TOPMed
TCGA novel	478	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1292699206 CA357006611	478	K>T		No	ClinGen TOPMed gnomAD
rs753029340 CA2932266	479	P>A		No	ClinGen ExAC
CA357006621 rs763214077	480	S>P		No	ClinGen ExAC gnomAD
CA2932267 rs763214077	480	S>T		No	ClinGen ExAC gnomAD
CA2932270 rs757792826	485	V>A		No	ClinGen ExAC gnomAD
RCV000895645 rs575170084 CA2932269	485	V>M		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA357006668 rs1290857052	487	Q>P		No	ClinGen TOPMed
CA357006681 rs1165117154	489	T>S		No	ClinGen gnomAD
rs1230396425 CA357006698	492	T>S		No	ClinGen TOPMed
rs749881609 CA97636453	493	R>*		No	ClinGen ExAC TOPMed gnomAD
CA357006704 rs749881609	493	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2932273 rs755693790	493	R>Q		No	ClinGen ExAC gnomAD
CA357006710 rs1560451582	494	K>T		No	ClinGen Ensembl
TCGA novel	495	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357006722 rs1301654600	496	V>L		No	ClinGen gnomAD
CA2932274 rs779572079	497	T>A		No	ClinGen ExAC TOPMed gnomAD
COSM734047 CA357006743 rs1323370113	499	V>E	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
TCGA novel	499	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1439508558 CA357006780	504	V>M		No	ClinGen TOPMed
rs534211728 CA2932276	506	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs754749492 CA2932277	506	T>R		No	ClinGen ExAC
RCV001050392 rs1720904030	507	G>E		No	ClinVar dbSNP
rs1578513720 CA357006804	508	S>G		No	ClinGen Ensembl
rs201819290 CA2932278	509	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA357006828 rs1358952987	511	E>G		No	ClinGen gnomAD
TCGA novel	512	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1560451643 CA357006843	513	F>C		No	ClinGen Ensembl
RCV001244389 CA2932279 rs748046758	514	S>R		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2932280 rs772110771	516	T>I		No	ClinGen ExAC gnomAD
CA357006869 rs1447300108	517	K>E		No	ClinGen gnomAD
CA357006890 rs1451307650	519	S>R		No	ClinGen TOPMed
CA357006896 rs1578513787	520	K>R		No	ClinGen Ensembl
CA2932282 rs773320485	521	R>K		No	ClinGen ExAC gnomAD
CA357006910 rs1483986355	522	K>R		No	ClinGen gnomAD
rs1393178453 CA357006929	525	V>F		No	ClinGen TOPMed
CA97636478 rs74802679	526	D>A		No	ClinGen Ensembl
rs867012825 CA97636481	526	D>E		No	ClinGen Ensembl
rs1427457994 CA357006940	527	S>G		No	ClinGen TOPMed gnomAD
rs769974147 CA357006945	527	S>R		No	ClinGen ExAC gnomAD
rs1247527926 CA357006951	528	H>R		No	ClinGen TOPMed
RCV001213554 rs1720906927	528	H>Y		No	ClinVar dbSNP
CA357006959 rs1223990926	529	S>C		No	ClinGen TOPMed
CA357006972 rs1560451695	531	H>R		No	ClinGen Ensembl
CA2932285 rs141001113	532	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1034671158 CA357006984	533	P>H		No	ClinGen TOPMed
CA97636491 rs1034671158	533	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA2932286 rs763241761	537	E>A		No	ClinGen ExAC TOPMed gnomAD
CA97636495 rs950119056	537	E>K		No	ClinGen Ensembl
RCV000948276 CA2932287 rs61748754	539	S>P		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA357007032 rs1452216654	540	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1344692204 CA357007027	540	S>T		No	ClinGen gnomAD
rs762215943 CA2932289	543	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	544	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932290 rs767983452	544	K>R		No	ClinGen ExAC gnomAD
TCGA novel	545	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357007073 rs562997282	546	K>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2932293 rs765932585	546	K>N		No	ClinGen ExAC TOPMed gnomAD
RCV001069474 CA2932292 rs562997282	546	K>R		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA2932296 RCV001305378 rs148966683	547	V>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA357007076 rs754696564	547	V>I		No	ClinGen ExAC gnomAD
CA357007082 rs1578513979	548	E>A		No	ClinGen Ensembl
rs758332878 CA2932299	550	K>R		No	ClinGen ExAC TOPMed gnomAD
CA357007105 rs777556718 RCV001337405	551	S>C		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs777556718 CA2932300	551	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs374809419 CA2932301	552	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA357007111 rs1373563459	552	K>R		No	ClinGen TOPMed
CA2932302 rs769696285	553	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1233084710 CA357007122	554	N>D		No	ClinGen gnomAD
CA357007121 rs1233084710	554	N>H		No	ClinGen gnomAD
rs770372094 CA97636538	555	S>G		No	ClinGen Ensembl
CA2932304 rs749464692	560	K>E		No	ClinGen ExAC gnomAD
rs368950724 CA2932305	562	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
RCV001348097 rs1177703488	563	S>I		No	ClinVar dbSNP
CA357007188 rs1177703488	563	S>T		No	ClinGen gnomAD
CA2932306 rs774598378	568	N>D		No	ClinGen ExAC gnomAD
CA2932307 rs762164515	568	N>K		No	ClinGen ExAC gnomAD
CA2932308 rs541994823	569	K>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2932309 rs541994823	569	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA357007246 rs1369415378	571	Q>R		No	ClinGen gnomAD
rs561677801 CA2932310	572	N>H		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	573	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV001210246 TCGA novel rs1720913432	574	C>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinVar NCI-TCGA dbSNP
CA357007277 rs1484206596	575	M>I		No	ClinGen TOPMed
rs1206406732 CA357007272	575	M>V		No	ClinGen TOPMed
CA2932313 rs753362904	576	K>N		No	ClinGen ExAC TOPMed gnomAD
CA2932311 rs765754806	576	K>Q		No	ClinGen ExAC gnomAD
CA2932314 rs764975553	578	S>N		No	ClinGen ExAC gnomAD
CA357007294 rs1179161363	578	S>R		No	ClinGen gnomAD
CA357007299 rs1481592088	578	S>R		No	ClinGen gnomAD
rs1199978831	578	S>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA97636554 rs940282411	579	T>I		No	ClinGen TOPMed
CA357007308 rs1200855025	580	K>Q		No	ClinGen TOPMed gnomAD
rs752454165 CA2932315 RCV001312298	583	T>A		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs546657732 CA2932316	586	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1169703293 CA357007353	586	N>S		No	ClinGen gnomAD
rs777628511 CA2932317	587	K>T		No	ClinGen ExAC gnomAD
rs751413133 CA2932318	592	S>T		No	ClinGen ExAC gnomAD
rs1405313969 CA357007400	593	S>G		No	ClinGen TOPMed gnomAD
rs890164945 CA97636577	593	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA2932319 rs757241783	594	K>N		No	ClinGen ExAC gnomAD
rs1008600489 CA357007417	595	P>L		No	ClinGen TOPMed gnomAD
CA97636581 rs1008600489	595	P>R		No	ClinGen TOPMed gnomAD
rs372976455 CA2932322	596	P>L		No	ClinGen ESP ExAC gnomAD
rs749346190 CA2932321	596	P>S		No	ClinGen ExAC gnomAD
CA2932323 rs779100185	598	K>E		No	ClinGen ExAC gnomAD
CA97636592 rs901145804	599	E>G		No	ClinGen TOPMed gnomAD
rs748370783 CA2932324	600	P>A		No	ClinGen ExAC TOPMed gnomAD
rs772263163 CA2932325	600	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA357007448 rs1195906711	601	V>I		No	ClinGen gnomAD
rs773660811 CA2932326	604	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA357007480 rs1475091316	605	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1387308478 CA357007499	608	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA357007507 rs1578514334	609	D>A		No	ClinGen Ensembl
rs1302275759 CA357007514	610	P>S		No	ClinGen gnomAD
CA97636607 rs374180496	611	P>R		No	ClinGen Ensembl
CA357007525 rs1363425700	612	Q>*		No	ClinGen gnomAD
rs1401800389 CA357007529	612	Q>H		No	ClinGen gnomAD
rs771450067 CA2932328	613	M>K		No	ClinGen ExAC gnomAD
CA357007548 rs1224610611	615	P>L		No	ClinGen gnomAD
rs1285640601 CA357007553	616	A>T		No	ClinGen gnomAD
rs1471241534 CA357007568	618	T>R		No	ClinGen gnomAD
rs1359685376 CA357007571	619	E>A		No	ClinGen gnomAD
rs759114220 CA2932330	619	E>D		No	ClinGen ExAC gnomAD
CA97636613 rs1020026657	619	E>K		No	ClinGen Ensembl
rs142843754 CA2932331	620	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA357007585 rs1578514424	621	V>G		No	ClinGen Ensembl
CA2932334 rs763755642 COSM24350	622	Q>R	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA2932336 rs757050088	624	G>R		No	ClinGen ExAC
CA2932337 rs781173916	625	P>S		No	ClinGen ExAC gnomAD
CA2932339 VAR_029795 rs2228991	626	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs778973582 RCV001340513 CA2932340	627	Q>E		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1181615706 CA357007619	627	Q>R		No	ClinGen TOPMed
CA2932342 rs748334019	628	V>E		No	ClinGen ExAC gnomAD
CA2932341 rs748334019	628	V>G		No	ClinGen ExAC gnomAD
rs538702285 CA97636626	628	V>M		No	ClinGen Ensembl
rs777908846 CA2932343	629	E>G		No	ClinGen ExAC gnomAD
CA357007627 rs1383156613	629	E>K		No	ClinGen gnomAD
rs144905338 RCV001243115 CA2932344	630	P>L		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
COSM1430337 rs958664617 CA97636630	630	P>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA357007639 rs1338160539	631	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA97636635 rs202214963	632	P>L		No	ClinGen gnomAD
CA2932346 rs777213931	634	M>I		No	ClinGen ExAC TOPMed gnomAD
RCV001316501 rs1382836181 CA357007654	634	M>V		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA357007666 rs1312390036	635	E>G		No	ClinGen gnomAD
rs769381343 CA2932348	636	H>R		No	ClinGen ExAC TOPMed gnomAD
rs201189406 CA2932349	637	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762410337 CA2932350	637	A>V		No	ClinGen ExAC TOPMed gnomAD
CA357007687 rs1245071756	638	Q>H		No	ClinGen gnomAD
TCGA novel	640	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1461770315 CA357007716	642	A>G		No	ClinGen TOPMed gnomAD
CA357007717 RCV001315343 rs1461770315	642	A>V		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA2932352 rs763778581	643	Q>H		No	ClinGen ExAC
CA2932355 rs761661933 COSM1291932	645	R>Q	upper_aerodigestive_tract haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA2932354 RCV001045626 rs138773727	645	R>W		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs756063859 CA2932358	646	P>R		No	ClinGen ExAC TOPMed gnomAD
rs750298956 CA2932357	646	P>S		No	ClinGen ExAC TOPMed gnomAD
CA357007749 rs1560452115	648	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA2932359 rs569722591	648	P>S		No	ClinGen 1000Genomes TOPMed gnomAD
rs113122612 CA2932362 RCV000956215	649	D>G		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1560452139 CA357007763	650	E>D		No	ClinGen Ensembl
COSM1430338 RCV001324993 CA357007757 rs1334359309	650	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ClinVar NCI-TCGA dbSNP gnomAD
CA357007765 rs1375026161	651	P>T		No	ClinGen gnomAD
CA2932366 rs752754374	653	Q>R		No	ClinGen ExAC gnomAD
CA2932368 rs778054714	655	E>Q		No	ClinGen ExAC gnomAD
rs1237525823 CA357007801	656	V>L		No	ClinGen gnomAD
TCGA novel	657	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932370 rs548739943	657	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA2932369 rs548739943	657	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs746337844 CA2932372	658	Q>*		No	ClinGen ExAC gnomAD
CA2932373 rs568791076	658	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs748816108 CA2932375	659	E>K		No	ClinGen ExAC gnomAD
CA2932376 rs768115863	660	G>E		No	ClinGen ExAC TOPMed gnomAD
CA2932377 rs768115863	660	G>V		No	ClinGen ExAC TOPMed gnomAD
rs767247227 CA2932379	662	A>V		No	ClinGen ExAC gnomAD
rs1358568992 CA357007842	663	Q>R		No	ClinGen gnomAD
CA2932381 rs760516583	664	K>R		No	ClinGen ExAC gnomAD
rs1264491491 CA357007885	670	V>G		No	ClinGen TOPMed
COSM1642502 RCV000886788 rs145504954 CA2932385	670	V>M	stomach [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs138787075 CA2932386	671	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1285799630 CA357007900	672	P>L		No	ClinGen gnomAD
CA2932387 RCV001300634 rs556419593	673	A>V		No	ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD
CA357007907 rs1299328056	674	Q>E		No	ClinGen TOPMed gnomAD
CA97636780 rs908698864	675	M>T		No	ClinGen TOPMed
rs746211428 CA2932389	676	V>A		No	ClinGen ExAC TOPMed gnomAD
CA357007925 rs746211428	676	V>E		No	ClinGen ExAC TOPMed gnomAD
CA97636786 rs961944647	677	G>R		No	ClinGen TOPMed
CA357007930 rs1437359126	677	G>V		No	ClinGen TOPMed
CA2932391 rs367688230	678	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA2932390 rs367688230	678	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs768151863 CA357007966	683	A>D		No	ClinGen ExAC gnomAD
CA2932393 rs768151863	683	A>V		No	ClinGen ExAC gnomAD
CA357007974 rs1269579269	684	H>Q		No	ClinGen gnomAD
rs1720936153 RCV001040286	685	M>I		No	ClinVar dbSNP
rs778305540 CA2932394	685	M>V		No	ClinGen ExAC gnomAD
rs747793114 CA2932396	686	E>D		No	ClinGen ExAC TOPMed gnomAD
rs149486440 RCV001320823 CA2932397	689	P>S		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1169375776 CA357008008	690	P>A		No	ClinGen TOPMed gnomAD
CA357008012 rs1370978551	690	P>L		No	ClinGen gnomAD
RCV001351997 rs1169375776 CA357008009	690	P>S		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA2932399 rs770719504	691	M>L		No	ClinGen ExAC TOPMed gnomAD
CA2932400 rs776575945	691	M>T		No	ClinGen ExAC gnomAD
CA357008013 rs770719504	691	M>V		No	ClinGen ExAC TOPMed gnomAD
rs899168099 CA97636820	692	E>*		No	ClinGen TOPMed
VAR_029796 CA2932401 rs2227902	692	E>D		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs899168099 CA357008020	692	E>K		No	ClinGen TOPMed
rs1227375319 CA357008026 COSM1753790	693	T>P	urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
CA357008034 rs1292233494	694	A>S		No	ClinGen gnomAD
rs1299643587 CA357008040	695	Q>*		No	ClinGen TOPMed
RCV001340762 rs1299643587	695	Q>E		No	ClinVar dbSNP
rs141964506 CA2932402	696	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA2932404 rs780817845 COSM4005783	696	T>M	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed
rs1295173943 CA357008054	697	E>G		No	ClinGen gnomAD
rs572016877 CA2932407	698	V>G		No	ClinGen 1000Genomes ExAC gnomAD
rs202161415 CA2932406	698	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA2932408 rs756479154	699	A>T		No	ClinGen ExAC TOPMed gnomAD
COSM4005784 rs374016428 CA2932409	700	Q>H	urinary_tract [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs111760333 CA2932411 RCV000956216	701	M>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2932410 rs540877198	701	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1485945984 COSM4135825 CA357008081	702	G>R	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
CA357008088 rs1371722247	703	P>A		No	ClinGen TOPMed
CA357008093 COSM1753791 rs1446119135	704	A>P	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1422035300 CA357008100	705	P>A		No	ClinGen TOPMed gnomAD
CA357008103 rs1163756753	705	P>R		No	ClinGen gnomAD
rs1422035300 CA357008101	705	P>S		No	ClinGen TOPMed gnomAD
TCGA novel	705	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357008120 rs1386263469	707	E>D		No	ClinGen gnomAD
rs1578515207 CA357008125	708	P>H		No	ClinGen Ensembl
CA2932415 rs771639346	709	A>P		No	ClinGen ExAC TOPMed gnomAD
CA357008132 rs1198920963	709	A>V		No	ClinGen TOPMed
CA2932416 rs777342086	710	Q>R		No	ClinGen ExAC gnomAD
rs1247969810 CA357008162	713	V>G		No	ClinGen TOPMed
rs746680187 CA2932417	714	A>S		No	ClinGen ExAC gnomAD
rs746680187 CA357008163	714	A>T		No	ClinGen ExAC gnomAD
CA2932418 rs770664440	714	A>V		No	ClinGen ExAC gnomAD
rs1024260073 CA97636865	716	V>A		No	ClinGen gnomAD
CA357008175 rs1204179439	716	V>I		No	ClinGen TOPMed
rs543390185 CA2932421	719	A>P		No	ClinGen 1000Genomes ExAC TOPMed
CA2932422 rs775554187	719	A>V		No	ClinGen ExAC gnomAD
CA97636875 rs1004072098	722	Q>E		No	ClinGen TOPMed
rs1208592065 CA357008236	725	Q>R		No	ClinGen TOPMed
rs750612169 CA2932425	728	P>R		No	ClinGen ExAC gnomAD
rs572960260 CA97636881	728	P>S		No	ClinGen gnomAD
CA357008260 rs1255538537	729	V>L		No	ClinGen TOPMed
COSM1294146 COSM734045 CA2932428 rs766722655	731	M>I	lung cervix [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
CA357008292 rs1333116508	733	L>P		No	ClinGen TOPMed
CA357008298 rs1286614883	734	S>F		No	ClinGen TOPMed
rs754117527 CA2932429	734	S>T		No	ClinGen ExAC gnomAD
CA2932431 rs528953101	735	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs141166149 CA2932430	735	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61754065 CA357008304	736	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61754065 CA2932432 RCV001354442 RCV000948680	736	P>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA97636908 rs568623889	738	E>Q		No	ClinGen 1000Genomes TOPMed
CA97636909 rs748898141	739	V>G		No	ClinGen TOPMed
CA357008344 rs1172721722	742	K>E		No	ClinGen TOPMed
rs757849649 CA2932433 RCV001299646	742	K>R		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000760805 rs777288773 CA357008351	743	E>*		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs777288773 CA2932434	743	E>K		No	ClinGen ExAC gnomAD
rs878887117 CA97636913	745	V>D		No	ClinGen Ensembl
CA97636911 rs775811215	745	V>L		No	ClinGen gnomAD
CA2932438 rs200745456	746	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs149964103 CA2932436	746	Q>K		No	ClinGen 1000Genomes TOPMed gnomAD
RCV000949906 rs770752350	746	Q>missing		No	ClinVar dbSNP
rs144031960 CA97636925	747	I>M		No	ClinGen TOPMed gnomAD
rs539480483 CA2932440	751	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA357008399 rs1446031877	751	P>S		No	ClinGen gnomAD
rs267600197 CA2932442	752	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs267600197 COSM24349 CA97636932	752	P>T	skin [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs369803397 RCV001224630	753	M>missing		No	ClinVar dbSNP
rs544207693 RCV001213261 CA97636942	753	M>I		No	ClinGen ClinVar 1000Genomes TOPMed dbSNP gnomAD
CA97636943 rs945526581	755	V>L		No	ClinGen Ensembl
rs1266500956 CA357008429	756	V>F		No	ClinGen TOPMed
rs1325154191 CA357008437	757	Q>R		No	ClinGen gnomAD
TCGA novel	758	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1203720039 CA357008449	759	E>K		No	ClinGen gnomAD
rs1016195062 CA97636959	760	P>R		No	ClinGen TOPMed gnomAD
CA2932446 rs775222659	760	P>S		No	ClinGen ExAC gnomAD
CA97636969 rs879137197	761	V>D		No	ClinGen Ensembl
rs1042548096 CA97636965	761	V>F		No	ClinGen TOPMed
VAR_029797 rs2227903 CA2932447	762	K>Q		No	ClinGen UniProt 1000Genomes ESP TOPMed dbSNP gnomAD
RCV001235982 rs775068300	762	K>missing		No	ClinVar dbSNP
CA357008477 rs1470681199	763	I>M		No	ClinGen gnomAD
rs555145007 CA2932449	763	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA357008488 rs1410394195	765	L>Q		No	ClinGen gnomAD
CA357008495 rs1181877521	766	S>C		No	ClinGen TOPMed gnomAD
CA357008496 rs1181877521	766	S>F		No	ClinGen TOPMed gnomAD
rs145232477 CA2932450	767	P>L		No	ClinGen ESP ExAC gnomAD
rs145232477 CA357008501	767	P>R		No	ClinGen ESP ExAC gnomAD
CA97636979 rs977418231	768	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA2932453 rs766485057	769	I>M		No	ClinGen ExAC TOPMed gnomAD
RCV001312545 CA2932452 rs574694774	769	I>V		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2932454 rs776981803	771	V>M		No	ClinGen ExAC gnomAD
CA357008525 rs1161315689	772	V>I		No	ClinGen TOPMed
CA2932455 rs199816806 RCV001323699	773	Q>R		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1342172031 CA357008552	775	E>D		No	ClinGen TOPMed gnomAD
CA2932456 rs765650440	775	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1189478455 CA357008548	775	E>Q		No	ClinGen TOPMed
rs61748756 CA2932457	776	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA357008555 rs1417816562	776	P>H		No	ClinGen gnomAD
RCV001058129 rs1417816562	776	P>L		No	ClinVar dbSNP
rs61748756 CA357008554	776	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA357008565 rs1438822320	778	Q>E		No	ClinGen gnomAD
CA2932460 rs751048298	778	Q>H		No	ClinGen ExAC gnomAD
CA2932459 rs146786246	778	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs756848835 CA2932461	779	M>I		No	ClinGen ExAC TOPMed
CA97637005 rs537388979	779	M>L		No	ClinGen TOPMed
CA97637002 rs537388979	779	M>V		No	ClinGen TOPMed
rs1059742 CA97637007	780	E>*		No	ClinGen Ensembl
RCV001229697 CA97637009 rs1015434923	780	E>D		No	ClinGen ClinVar dbSNP gnomAD
rs745537305 CA2932463	782	S>C		No	ClinGen ExAC gnomAD
CA97637018 rs370561076	783	P>L		No	ClinGen gnomAD
CA2932464 rs755806745 RCV001305547	783	P>S		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2932465 rs577847008	784	P>L		No	ClinGen 1000Genomes ExAC
rs946812694 CA97637022	785	M>I		No	ClinGen TOPMed
CA2932467 rs140408965	785	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs543071771 CA2932466	785	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs867079701 CA97637026	786	G>E		No	ClinGen TOPMed gnomAD
rs867079701 CA357008613	786	G>V		No	ClinGen TOPMed gnomAD
rs774475413 CA2932468	787	V>L		No	ClinGen ExAC gnomAD
rs1414206080 CA357008622	788	V>A		No	ClinGen TOPMed
CA2932469 rs747085895	790	K>E		No	ClinGen ExAC gnomAD
rs771051680 CA2932470	791	E>D		No	ClinGen ExAC gnomAD
CA97637036 rs923771558	791	E>K		No	ClinGen TOPMed
rs368741258 CA97637047	793	A>S		No	ClinGen ESP TOPMed
CA357008664 rs1449789511	794	Q>H		No	ClinGen gnomAD
CA2932473 VAR_029798 rs3796529	797	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs764572450 CA2932476	798	P>L		No	ClinGen ExAC gnomAD
rs763356980 CA2932475	798	P>S		No	ClinGen ExAC gnomAD
rs752126612 CA2932477	799	P>L		No	ClinGen ExAC gnomAD
CA2932478 rs140815829	800	P>S		No	ClinGen ESP ExAC TOPMed
rs1449982377 CA357008710	802	E>G		No	ClinGen gnomAD
CA97637075 rs895101219	803	P>S		No	ClinGen TOPMed gnomAD
CA357008719 rs1268132542	804	P>S		No	ClinGen TOPMed gnomAD
rs767066151 CA2932479	805	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1166872019 COSM3714931 CA357008728	805	L>R	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
rs767066151 CA2932480	805	L>V		No	ClinGen ExAC TOPMed gnomAD
CA2932481 rs755818796	806	H>N		No	ClinGen ExAC gnomAD
CA2932482 rs372216068	807	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs753660418 CA2932483	808	E>K		No	ClinGen ExAC gnomAD
rs1263966292 CA357008758	810	I>V		No	ClinGen TOPMed gnomAD
rs1211990605 CA357008768	811	S>C		No	ClinGen TOPMed
CA357008774 rs1388447579	812	K>R		No	ClinGen gnomAD
rs374822603 CA2932485	814	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA357008787 rs754874352	814	P>S		No	ClinGen ExAC gnomAD
CA2932484 rs754874352	814	P>T		No	ClinGen ExAC gnomAD
rs114282228 CA2932488	815	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1430340 CA2932489 rs745977591	817	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA357008806 rs1385520032	818	K>E		No	ClinGen gnomAD
rs148677477 CA357008819	819	D>E		No	ClinGen 1000Genomes ESP TOPMed gnomAD
CA357008824 rs1578516139	820	K>T		No	ClinGen Ensembl
RCV000677291 rs1553904359	822	E>missing		No	ClinVar dbSNP
rs978194547 CA97637134	825	N>D		No	ClinGen Ensembl
CA2932492 rs754996610	826	M>R		No	ClinGen ExAC TOPMed gnomAD
CA97637145 rs754996610	826	M>T		No	ClinGen ExAC TOPMed gnomAD
rs763298291 CA2932494	827	Q>H		No	ClinGen ExAC gnomAD
CA2932493 rs775747740	827	Q>R		No	ClinGen ExAC gnomAD
rs1207371267 CA357008882	828	S>N		No	ClinGen gnomAD
RCV001054651 CA2932495 rs146942863	829	E>G		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1169086243 CA357008887	829	E>K		No	ClinGen TOPMed
CA357008894 rs1421788780	830	R>G		No	ClinGen TOPMed
CA357008898 rs1578516206	830	R>M		No	ClinGen Ensembl
CA357008900 rs1464450663	830	R>S		No	ClinGen gnomAD
RCV001037851 rs774780252 CA2932496	831	A>S		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2932498 rs766894826	832	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs367963860 RCV001303688 CA2932497	832	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
CA357008909 rs1186549954	833	K>Q		No	ClinGen gnomAD
CA357008925 rs1455309474	835	Q>K		No	ClinGen gnomAD
TCGA novel	836	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866545099 CA97637186	837	L>P		No	ClinGen Ensembl
CA2932501 rs766112311	838	I>T		No	ClinGen ExAC gnomAD
CA2932504 rs778875167	839	E>D		No	ClinGen ExAC gnomAD
rs752540485 CA2932505	840	V>I		No	ClinGen ExAC gnomAD
TCGA novel	842	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932506 rs758327399	842	L>F		No	ClinGen ExAC gnomAD
rs564650387 CA2932507	843	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA357008989 rs1339003277	845	V>A		No	ClinGen TOPMed gnomAD
rs1312502963 CA357008987 RCV001348713	845	V>F		No	ClinGen ClinVar dbSNP gnomAD
rs181578247 CA2932508	847	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA357009000 rs1241820239	847	D>H		No	ClinGen gnomAD
CA357009013 rs1206868170	848	S>R		No	ClinGen TOPMed gnomAD
rs780183397 CA2932510	849	W>C		No	ClinGen ExAC TOPMed gnomAD
rs1275958087 CA357009019	849	W>L		No	ClinGen TOPMed
rs749525936 CA2932511	850	L>V		No	ClinGen ExAC TOPMed gnomAD
CA357009043 rs1182521923	853	E>G		No	ClinGen gnomAD
CA2932514 rs143324668 RCV000882604	853	E>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1411109400 CA357009048	854	S>G		No	ClinGen gnomAD
rs1471354248 CA357009062	856	S>G		No	ClinGen TOPMed gnomAD
rs1406128387 CA357009088	859	D>G		No	ClinGen gnomAD
CA2932516 rs773645911	860	L>H		No	ClinGen ExAC TOPMed gnomAD
CA97637217 rs868705266	860	L>I		No	ClinGen Ensembl
CA357009094 rs773645911	860	L>R		No	ClinGen ExAC TOPMed gnomAD
CA357009106 rs1300652443	862	P>L		No	ClinGen gnomAD
rs1400586734 CA357009111	863	P>R		No	ClinGen gnomAD
rs372493611 CA97637237	864	S>P		No	ClinGen ESP
rs374232811 CA2932520	866	P>A		No	ClinGen ESP ExAC gnomAD
rs753496340 CA357009138	868	P>L		No	ClinGen ExAC TOPMed gnomAD
rs753496340 CA2932521	868	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1174131327 CA357009136	868	P>S		No	ClinGen TOPMed
rs759296836 CA2932522	871	N>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	871	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765022916 CA2932523	874	E>K		No	ClinGen ExAC gnomAD
rs1232885076 CA357009185	875	E>*		No	ClinGen gnomAD
TCGA novel	880	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932524 rs200452180	882	L>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2932525 rs758185890	882	L>S		No	ClinGen ExAC gnomAD
CA357009240 rs1482052234	883	L>I		No	ClinGen gnomAD
CA357009250 rs1560453233	884	N>K		No	ClinGen Ensembl
rs144259100 CA2932527	885	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756127300 CA2932528	885	T>I		No	ClinGen ExAC gnomAD
CA357009261 rs1578516513	886	G>V		No	ClinGen Ensembl
TCGA novel	887	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932529 rs780130348	888	G>E		No	ClinGen ExAC gnomAD
rs749471105 CA97637284	893	P>A		No	ClinGen ExAC gnomAD
rs755158365 CA2932531	893	P>L		No	ClinGen ExAC gnomAD
rs749471105 CA2932530	893	P>S		No	ClinGen ExAC gnomAD
rs1305477281 CA357009319	895	Q>H		No	ClinGen TOPMed gnomAD
CA357009317 rs1238004515	895	Q>R		No	ClinGen Ensembl
CA2932535 rs371392326	897	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1430341 CA97637317 rs867829350	899	A>T	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs773713906 CA2932536	903	D>G		No	ClinGen ExAC gnomAD
CA357009368 rs1309512092	903	D>N		No	ClinGen gnomAD
CA357009380 rs1273658722	904	E>D		No	ClinGen gnomAD
rs747543922 CA2932537	905	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1351520978 CA357009384	905	S>N		No	ClinGen gnomAD
CA97637325 rs1037391182	907	P>R		No	ClinGen Ensembl
rs770528961 CA2932538	909	L>F		No	ClinGen ExAC gnomAD
RCV000937214 CA2932539 rs776254331	910	A>V		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs764969815 CA2932541	911	A>D		No	ClinGen ExAC gnomAD
rs759167194 CA2932540	911	A>T		No	ClinGen ExAC gnomAD
rs775073659 CA2932543	912	N>S		No	ClinGen ExAC TOPMed gnomAD
CA357009421 rs1226231366	912	N>Y		No	ClinGen TOPMed
rs763808162 CA2932544	914	N>D		No	ClinGen ExAC gnomAD
rs757216362 CA357009437	914	N>K		No	ClinGen ExAC TOPMed gnomAD
CA2932545 rs751463729	914	N>S		No	ClinGen ExAC TOPMed gnomAD
CA2932547 COSM1056342 rs372214552	915	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA2932548 rs753888665	916	S>Y		No	ClinGen ExAC gnomAD
CA2932549 rs374825536	918	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs777215075 CA97637350	918	H>Y		No	ClinGen Ensembl
rs1297121603 CA357009479	921	S>F		No	ClinGen TOPMed gnomAD
CA2932550 rs779188313	921	S>P		No	ClinGen ExAC TOPMed gnomAD
rs748320177 CA2932551	922	S>C		No	ClinGen ExAC TOPMed gnomAD
CA357009489 rs1247853778	923	G>E		No	ClinGen gnomAD
rs1284461687 CA357009491	924	Q>E		No	ClinGen gnomAD
CA357009495 rs1290561917	924	Q>R		No	ClinGen gnomAD
CA2932553 rs557500462	927	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA2932554 rs747423176 RCV001248568 COSM3409383	928	T>M	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs1244469586 CA357009531	929	P>L		No	ClinGen TOPMed
rs1245786650 CA357009538	930	E>D		No	ClinGen gnomAD
rs1448099045 CA357009542	931	G>S		No	ClinGen gnomAD
CA2932555 rs771546534	932	E>G		No	ClinGen ExAC TOPMed gnomAD
rs777335033 CA2932556	933	T>I		No	ClinGen ExAC gnomAD
CA2932558 rs769193151	934	L>S		No	ClinGen ExAC gnomAD
CA97637390 rs1048969204	935	N>S		No	ClinGen TOPMed
rs1347101010 CA357009576	936	G>V		No	ClinGen gnomAD
rs887450489 CA97637393	937	K>R		No	ClinGen TOPMed gnomAD
rs887450489 CA357009580	937	K>T		No	ClinGen TOPMed gnomAD
CA2932560 rs762533235 RCV001313088	938	H>R		No	ClinGen ClinVar ExAC dbSNP gnomAD
CA2932559 rs775148858	938	H>Y		No	ClinGen ExAC gnomAD
rs889882721 CA97637397	940	T>I		No	ClinGen TOPMed gnomAD
CA97637402 RCV001319263 rs61312656	942	S>G		No	ClinGen ClinVar Ensembl dbSNP
TCGA novel	942	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932563 rs761641120	943	I>V		No	ClinGen ExAC gnomAD
rs1309039210 CA357009624	944	V>I		No	ClinGen gnomAD
CA2932564 rs767425000	945	C>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	948	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA97637416 rs901618529	948	K>R		No	ClinGen TOPMed
rs1207531505 CA357009664	949	M>T		No	ClinGen gnomAD
CA2932565 rs199520565	951	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2932566 rs199520565	951	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000923812 CA2932568 rs148565623	952	D>G		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs765258656 CA2932567	952	D>Y		No	ClinGen ExAC gnomAD
CA2932569 rs758521937	953	Q>E		No	ClinGen ExAC gnomAD
CA357009688 rs758521937	953	Q>K		No	ClinGen ExAC gnomAD
rs958211796 CA97637436	956	R>G		No	ClinGen TOPMed gnomAD
TCGA novel	957	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357009720 rs1578516983	957	E>G		No	ClinGen Ensembl
CA2932572 rs757762660	962	I>M		No	ClinGen ExAC gnomAD
CA2932573 rs200509833	965	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2932574 rs746393027	965	T>R		No	ClinGen ExAC gnomAD
CA2932576 rs769297005	966	V>A		No	ClinGen ExAC gnomAD
CA2932575 rs769297005	966	V>G		No	ClinGen ExAC gnomAD
CA2932577 rs748869206	967	E>D		No	ClinGen ExAC gnomAD
rs1186198032 CA357009781	967	E>G		No	ClinGen TOPMed
CA357009795 rs1299865863	969	P>R		No	ClinGen gnomAD
CA2932580 RCV001347368 rs761587815	970	V>D		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs774044957 CA357009798	970	V>F		No	ClinGen ExAC TOPMed gnomAD
CA2932579 rs774044957	970	V>L		No	ClinGen ExAC TOPMed gnomAD
rs771856015 CA2932581	972	P>L		No	ClinGen ExAC gnomAD
TCGA novel	972	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1385254403 CA357009817	973	M>I		No	ClinGen gnomAD
rs773073831 CA2932582	973	M>V		No	ClinGen ExAC gnomAD
CA2932584 rs766383284	975	P>H		No	ClinGen ExAC TOPMed gnomAD
rs766383284 CA97637483	975	P>L		No	ClinGen ExAC TOPMed gnomAD
rs760563478 CA2932583	975	P>T		No	ClinGen ExAC gnomAD
TCGA novel	976	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932585 rs529390824	976	P>T		No	ClinGen ExAC TOPMed gnomAD
CA357009839 COSM3714933 rs1336617929	977	S>L	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
CA357009840 rs1483684662	978	A>S		No	ClinGen gnomAD
COSM108589 rs140574038 CA97637488	980	E>K	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
COSM247006 CA2932587 rs764218596	981	E>D	prostate [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
RCV001058230 CA2932586 rs763155357	981	E>Q		No	ClinGen ClinVar ExAC dbSNP gnomAD
CA2932589 rs200147565	982	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs200147565 CA2932588	982	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs781705605 CA2932590	982	R>H		No	ClinGen ExAC TOPMed gnomAD
rs781705605 CA357009870	982	R>L		No	ClinGen ExAC TOPMed gnomAD
CA357009871 rs1578517169	983	E>K		No	ClinGen Ensembl
CA97637502 rs144529300 COSM110398	986	S>F	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA357009908 rs1172312135	988	T>I		No	ClinGen gnomAD
rs145436917 CA97637509	988	T>P		No	ClinGen Ensembl
rs780658486 CA2932593	990	L>P		No	ClinGen ExAC gnomAD
CA357009930 rs1560453737	992	S>L		No	ClinGen Ensembl
rs748731008 CA2932594	993	P>L		No	ClinGen ExAC gnomAD
CA2932596 rs778468524	996	T>A		No	ClinGen ExAC gnomAD
CA357009957 rs1273927240	997	M>R		No	ClinGen gnomAD
CA2932597 rs373733071	997	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1720989281 RCV001296645	998	A>T		No	ClinVar dbSNP
CA2932598 rs771817079	998	A>V		No	ClinGen ExAC gnomAD
RCV001326110 rs1720989470	999	A>G		No	ClinVar dbSNP
rs772963466 CA2932599	1000	N>S		No	ClinGen ExAC gnomAD
CA2932601 rs770764679	1002	S>T		No	ClinGen ExAC gnomAD
TCGA novel	1002	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357009992 rs1205147847	1003	Q>K		No	ClinGen gnomAD
rs762874553 CA2932603	1003	Q>P		No	ClinGen ExAC gnomAD
rs1453449668 CA357009999	1004	E>*		No	ClinGen gnomAD
rs1578517302 CA357010008	1005	I>V		No	ClinGen Ensembl
CA2932605 rs764284810	1006	D>A		No	ClinGen ExAC gnomAD
CA97637552 rs775184173	1009	E>K		No	ClinGen Ensembl
rs1560453803 CA357010051	1011	I>V		No	ClinGen Ensembl
CA2932609 rs767890078	1014	H>Q		No	ClinGen ExAC gnomAD
rs1428868605 CA357010076	1014	H>R		No	ClinGen gnomAD
rs1368071244 CA357010088	1016	G>R		No	ClinGen TOPMed
CA2932610 rs750731942	1018	D>E		No	ClinGen ExAC gnomAD
CA357010110 rs1405828762	1019	L>V		No	ClinGen gnomAD
CA357010117 rs1167234532	1020	S>N		No	ClinGen TOPMed
CA2932611 rs756559394	1022	N>I		No	ClinGen ExAC TOPMed gnomAD
CA357010134 rs756559394	1022	N>S		No	ClinGen ExAC TOPMed gnomAD
CA97637560 rs916420522	1024	S>L		No	ClinGen TOPMed gnomAD
rs766787851 CA2932612	1026	G>D		No	ClinGen ExAC gnomAD
TCGA novel	1027	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2932614 rs559520154	1031	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs572949989 CA97637587	1033	H>P		No	ClinGen 1000Genomes
RCV001215115 rs572949989	1033	H>R		No	ClinVar dbSNP
CA357010219 rs1359116352	1035	A>T		No	ClinGen TOPMed gnomAD
rs777464251 CA2932620	1036	R>L		No	ClinGen ExAC TOPMed gnomAD
rs777464251 CA2932619	1036	R>P		No	ClinGen ExAC TOPMed gnomAD
CA2932618 rs777464251	1036	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2932617 rs201033957	1036	R>W	Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA357010231 rs1490774064	1037	P>L		No	ClinGen TOPMed
TCGA novel	1039	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369445358 CA97637598	1041	E>A		No	ClinGen Ensembl
CA2932622 rs745842034	1043	S>G		No	ClinGen ExAC gnomAD
CA357010280 rs1248852548	1045	K>E		No	ClinGen TOPMed gnomAD
CA357010279 rs1248852548	1045	K>Q		No	ClinGen TOPMed gnomAD
rs768815266 CA2932623	1045	K>R		No	ClinGen ExAC gnomAD
rs1251981173 CA357010290	1046	N>I		No	ClinGen TOPMed
TCGA novel	1046	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1204389518	1046	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV001306516 rs1251981173	1046	N>S		No	ClinVar dbSNP
CA357010304 rs1369937901	1048	K>R		No	ClinGen TOPMed gnomAD
CA2932625 rs762032850	1050	A>D		No	ClinGen ExAC TOPMed gnomAD
rs762032850 CA97637604	1050	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1306515151 CA357010333	1053	V>I		No	ClinGen TOPMed
rs1320856752 CA357010343	1054	K>R		No	ClinGen gnomAD
RCV001235209 CA2932630 rs201227059	1055	A>V		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1295869249 CA357010354	1056	A>D		No	ClinGen gnomAD
CA97637623 rs529281885	1056	A>S		No	ClinGen 1000Genomes
rs867254323 CA97637627	1057	K>E		No	ClinGen gnomAD
CA357010373 rs1464097351	1059	D>G		No	ClinGen TOPMed
CA2932633 rs752194030	1059	D>Y		No	ClinGen ExAC gnomAD
TCGA novel	1060	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1376768817 CA357010380	1060	F>Y		No	ClinGen TOPMed
CA2932634 rs757974590	1061	V>I		No	ClinGen ExAC gnomAD
TCGA novel	1064	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357010449 rs1268793336	1070	R>G		No	ClinGen gnomAD
CA357010460 rs1464637092	1071	K>R		No	ClinGen gnomAD
CA357010475 rs1176300291	1073	K>R		No	ClinGen TOPMed
rs746688243 CA2932636	1074	D>N		No	ClinGen ExAC gnomAD
rs1481192169 CA357010495	1076	S>G		No	ClinGen TOPMed
rs756954268 CA2932637	1077	K>R		No	ClinGen ExAC TOPMed gnomAD
rs116290363 CA2932638	1080	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1056348 rs745688107 CA2932639	1081	R>C	large_intestine endometrium Variant assessed as Somatic; 4.622e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA357010581 RCV001212116 rs1385129832	1088	Y>C		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA357010586 rs1410495744	1089	L>F		No	ClinGen TOPMed gnomAD
CA357010601 rs1304212419	1091	E>A		No	ClinGen TOPMed gnomAD
CA357010603 rs1304212419	1091	E>G		No	ClinGen TOPMed gnomAD
CA97637659 rs867564643	1091	E>K		No	ClinGen Ensembl
rs769830765 CA2932641	1092	A>S		No	ClinGen ExAC gnomAD
rs922903250 CA97637660	1095	G>E		No	ClinGen TOPMed

4 associated diseases with Q13127

[MIM: 616806]: Wilms tumor 6 (WT6)

A pediatric malignancy of kidney, and the most common childhood abdominal malignancy. It is caused by the uncontrolled multiplication of renal stem, stromal, and epithelial cells. {ECO:0000269|PubMed:26551668}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

[MIM: 617626]: Fibromatosis, gingival, 5 (GINGF5)

An autosomal dominant form of hereditary gingival fibromatosis, a rare condition characterized by a slow, progressive overgrowth of the gingiva. The excess gingival tissue can cover part of or the entire crown, and can result in diastemas, teeth displacement, or retention of primary or impacted teeth. {ECO:0000269|PubMed:28686854}. Note=The disease is caused by variants affecting the gene represented in this entry.

[MIM: 612431]: Deafness, autosomal dominant, 27 (DFNA27)

A form of non-syndromic deafness characterized by postlingual, progressive, moderate to profound sensorineural hearing loss. {ECO:0000269|PubMed:29961578}. Note=The disease may be caused by variants affecting the gene represented in this entry. An intronic variant that affects alternative splicing of REST and inactivation of REST repressor activity fully segregates with deafness in a 3-generation family. {ECO:0000269|PubMed:29961578}.

Without disease ID

A pediatric malignancy of kidney, and the most common childhood abdominal malignancy. It is caused by the uncontrolled multiplication of renal stem, stromal, and epithelial cells. {ECO:0000269|PubMed:26551668}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
An autosomal dominant form of hereditary gingival fibromatosis, a rare condition characterized by a slow, progressive overgrowth of the gingiva. The excess gingival tissue can cover part of or the entire crown, and can result in diastemas, teeth displacement, or retention of primary or impacted teeth. {ECO:0000269|PubMed:28686854}. Note=The disease is caused by variants affecting the gene represented in this entry.
A form of non-syndromic deafness characterized by postlingual, progressive, moderate to profound sensorineural hearing loss. {ECO:0000269|PubMed:29961578}. Note=The disease may be caused by variants affecting the gene represented in this entry. An intronic variant that affects alternative splicing of REST and inactivation of REST repressor activity fully segregates with deafness in a 3-generation family. {ECO:0000269|PubMed:29961578}.

9 regional properties for Q13127

Type	Name	Position	InterPro Accession
domain	Zinc finger C2H2-type	159 - 186	IPR013087-1
domain	Zinc finger C2H2-type	216 - 238	IPR013087-2
domain	Zinc finger C2H2-type	248 - 270	IPR013087-3
domain	Zinc finger C2H2-type	276 - 303	IPR013087-4
domain	Zinc finger C2H2-type	304 - 331	IPR013087-5
domain	Zinc finger C2H2-type	332 - 360	IPR013087-6
domain	Zinc finger C2H2-type	361 - 388	IPR013087-7
domain	Zinc finger C2H2-type	389 - 412	IPR013087-8
domain	Zinc finger C2H2-type	1060 - 1082	IPR013087-9

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Colocalizes with ZFP90 in the nucleus (By similarity) In response to hypoxia, there is a more pronounced increase in levels in the nucleus as compared to the cytoplasm (PubMed:27531581) In aging neurons, increased levels in the nucleus as compared to the cytoplasm (PubMed:24670762, PubMed:30684677)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription repressor complex	A protein complex that possesses activity that prevents or downregulates transcription.

9 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
identical protein binding	Binding to an identical protein or proteins.
metal ion binding	Binding to a metal ion.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II core promoter sequence-specific DNA binding	Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
RNA polymerase II-specific DNA-binding transcription factor binding	Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

44 GO annotations of biological process

Name	Definition
auditory receptor cell stereocilium organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.
cardiac muscle cell myoblast differentiation	The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.
cellular response to electrical stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
cellular response to glucocorticoid stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
cellular response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
detection of mechanical stimulus involved in sensory perception of sound	The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.
hematopoietic progenitor cell differentiation	The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
histone H4 deacetylation	The modification of histone H4 by the removal of one or more acetyl groups.
modification of synaptic structure	Any process that modifies the structure/morphology of a synapse.
negative regulation by host of viral transcription	Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription.
negative regulation of aldosterone biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.
negative regulation of amniotic stem cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation.
negative regulation of calcium ion-dependent exocytosis	Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of cortisol biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process.
negative regulation of dense core granule biogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of insulin secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
negative regulation of mesenchymal stem cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell differentiation.
negative regulation of miRNA transcription	Any process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription.
negative regulation of neurogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
negative regulation of neuron differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
negative regulation of oxidative stress-induced neuron death	Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of transcription regulatory region DNA binding	Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.
neuromuscular process controlling balance	Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
neuronal stem cell population maintenance	Any process in by an organism or tissue maintains a population of neuronal stem cells.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of neuron differentiation	Any process that activates or increases the frequency, rate or extent of neuron differentiation.
positive regulation of oxidative stress-induced neuron death	Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death.
positive regulation of stem cell population maintenance	Any process that activates or increases the frequency, rate or extent of stem cell population maintenance.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of alternative mRNA splicing, via spliceosome	Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of osteoblast differentiation	Any process that modulates the frequency, rate or extent of osteoblast differentiation.
regulation of oxidative stress-induced neuron death	Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death.
response to hypoxia	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to ischemia	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
somatic stem cell population maintenance	Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.

177 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q08DS3	OSR1	Protein odd-skipped-related 1	Bos taurus (Bovine)	PR
Q2VWH6	FEZF2	Fez family zinc finger protein 2	Bos taurus (Bovine)	PR
A6QNZ0	ZSCAN26	Zinc finger and SCAN domain-containing protein 26	Bos taurus (Bovine)	PR
A7MBI1	ZFP69	Zinc finger protein 69 homolog	Bos taurus (Bovine)	PR
Q08705	CTCF	Transcriptional repressor CTCF	Gallus gallus (Chicken)	PR
O42409	GFI1B	Zinc finger protein Gfi-1b	Gallus gallus (Chicken)	PR
A2T6W2	ZNF449	Zinc finger protein 449	Pan troglodytes (Chimpanzee)	PR
Q9U405	grau	Transcription factor grauzone	Drosophila melanogaster (Fruit fly)	PR
Q7K0S9	sug	Zinc finger protein GLIS2 homolog	Drosophila melanogaster (Fruit fly)	PR
P20385	Cf2	Chorion transcription factor Cf2	Drosophila melanogaster (Fruit fly)	PR
Q86P48	ATbp	AT-rich binding protein	Drosophila melanogaster (Fruit fly)	PR
P28698	MZF1	Myeloid zinc finger 1	Homo sapiens (Human)	PR
O14978	ZNF263	Zinc finger protein 263	Homo sapiens (Human)	PR
O60304	ZNF500	Zinc finger protein 500	Homo sapiens (Human)	PR
P08151	GLI1	Zinc finger protein GLI1	Homo sapiens (Human)	PR
Q9UFB7	ZBTB47	Zinc finger and BTB domain-containing protein 47	Homo sapiens (Human)	PR
P18146	EGR1	Early growth response protein 1	Homo sapiens (Human)	PR
Q9Y5W3	KLF2	Krueppel-like factor 2	Homo sapiens (Human)	PR
Q9UNY5	ZNF232	Zinc finger protein 232	Homo sapiens (Human)	PR
Q96SZ4	ZSCAN10	Zinc finger and SCAN domain-containing protein 10	Homo sapiens (Human)	PR
P17028	ZNF24	Zinc finger protein 24	Homo sapiens (Human)	PR
P57682	KLF3	Krueppel-like factor 3	Homo sapiens (Human)	PR
P25490	YY1	Transcriptional repressor protein YY1	Homo sapiens (Human)	SS
O43296	ZNF264	Zinc finger protein 264	Homo sapiens (Human)	PR
P49711	CTCF	Transcriptional repressor CTCF	Homo sapiens (Human)	PR
Q9NQX1	PRDM5	PR domain zinc finger protein 5	Homo sapiens (Human)	PR
Q9HBE1	PATZ1	POZ-, AT hook-, and zinc finger-containing protein 1	Homo sapiens (Human)	PR
Q8TAX0	OSR1	Protein odd-skipped-related 1	Homo sapiens (Human)	PR
Q9UL58	ZNF215	Zinc finger protein 215	Homo sapiens (Human)	PR
Q8TBJ5	FEZF2	Fez family zinc finger protein 2	Homo sapiens (Human)	PR
Q96SR6	ZNF382	Zinc finger protein 382	Homo sapiens (Human)	PR
Q96IT1	ZNF496	Zinc finger protein 496	Homo sapiens (Human)	PR
Q96N95	ZNF396	Zinc finger protein 396	Homo sapiens (Human)	PR
Q9ULJ3	ZBTB21	Zinc finger and BTB domain-containing protein 21	Homo sapiens (Human)	PR
O75840	KLF7	Krueppel-like factor 7	Homo sapiens (Human)	PR
Q9H9D4	ZNF408	Zinc finger protein 408	Homo sapiens (Human)	PR
Q8IZM8	ZNF654	Zinc finger protein 654	Homo sapiens (Human)	PR
Q14526	HIC1	Hypermethylated in cancer 1 protein	Homo sapiens (Human)	PR
P17022	ZNF18	Zinc finger protein 18	Homo sapiens (Human)	PR
Q86XF7	ZNF575	Zinc finger protein 575	Homo sapiens (Human)	PR
Q06889	EGR3	Early growth response protein 3	Homo sapiens (Human)	PR
Q8NAM6	ZSCAN4	Zinc finger and SCAN domain-containing protein 4	Homo sapiens (Human)	PR
Q08ER8	ZNF543	Zinc finger protein 543	Homo sapiens (Human)	PR
P17029	ZKSCAN1	Zinc finger protein with KRAB and SCAN domains 1	Homo sapiens (Human)	PR
Q8N680	ZBTB2	Zinc finger and BTB domain-containing protein 2	Homo sapiens (Human)	PR
O95625	ZBTB11	Zinc finger and BTB domain-containing protein 11	Homo sapiens (Human)	PR
Q9NPC7	MYNN	Myoneurin	Homo sapiens (Human)	PR
Q96BV0	ZNF775	Zinc finger protein 775	Homo sapiens (Human)	PR
Q8NF99	ZNF397	Zinc finger protein 397	Homo sapiens (Human)	PR
Q63HK3	ZKSCAN2	Zinc finger protein with KRAB and SCAN domains 2	Homo sapiens (Human)	PR
Q5FWF6	ZNF789	Zinc finger protein 789	Homo sapiens (Human)	PR
Q15776	ZKSCAN8	Zinc finger protein with KRAB and SCAN domains 8	Homo sapiens (Human)	PR
Q53GI3	ZNF394	Zinc finger protein 394	Homo sapiens (Human)	PR
O95125	ZNF202	Zinc finger protein 202	Homo sapiens (Human)	PR
Q05516	ZBTB16	Zinc finger and BTB domain-containing protein 16	Homo sapiens (Human)	PR
Q9H116	GZF1	GDNF-inducible zinc finger protein 1	Homo sapiens (Human)	PR
Q8N0Y2	ZNF444	Zinc finger protein 444	Homo sapiens (Human)	PR
Q6P9G9	ZNF449	Zinc finger protein 449	Homo sapiens (Human)	PR
Q8IW36	ZNF695	Zinc finger protein 695	Homo sapiens (Human)	PR
Q5VTD9	GFI1B	Zinc finger protein Gfi-1b	Homo sapiens (Human)	PR
Q6PG37	ZNF790	Zinc finger protein 790	Homo sapiens (Human)	PR
Q9Y2D9	ZNF652	Zinc finger protein 652	Homo sapiens (Human)	PR
Q5TC79	ZBTB37	Zinc finger and BTB domain-containing protein 37	Homo sapiens (Human)	PR
Q9Y4E5	ZNF451	E3 SUMO-protein ligase ZNF451	Homo sapiens (Human)	PR
Q8ND82	ZNF280C	Zinc finger protein 280C	Homo sapiens (Human)	PR
Q49AA0	ZFP69	Zinc finger protein 69 homolog	Homo sapiens (Human)	PR
O43298	ZBTB43	Zinc finger and BTB domain-containing protein 43	Homo sapiens (Human)	PR
Q9Y330	ZBTB12	Zinc finger and BTB domain-containing protein 12	Homo sapiens (Human)	PR
Q13105	ZBTB17	Zinc finger and BTB domain-containing protein 17	Homo sapiens (Human)	PR
P51508	ZNF81	Zinc finger protein 81	Homo sapiens (Human)	PR
Q5JNZ3	ZNF311	Zinc finger protein 311	Homo sapiens (Human)	PR
Q9BRR0	ZKSCAN3	Zinc finger protein with KRAB and SCAN domains 3	Homo sapiens (Human)	PR
Q969J2	ZKSCAN4	Zinc finger protein with KRAB and SCAN domains 4	Homo sapiens (Human)	PR
P49910	ZNF165	Zinc finger protein 165	Homo sapiens (Human)	PR
Q9Y4X4	KLF12	Krueppel-like factor 12	Homo sapiens (Human)	PR
P10074	ZBTB48	Telomere zinc finger-associated protein	Homo sapiens (Human)	PR
P17010	ZFX	Zinc finger X-chromosomal protein	Homo sapiens (Human)	PR
Q9H5H4	ZNF768	Zinc finger protein 768	Homo sapiens (Human)	PR
Q6NSZ9	ZSCAN25	Zinc finger and SCAN domain-containing protein 25	Homo sapiens (Human)	PR
Q9Y2L8	ZKSCAN5	Zinc finger protein with KRAB and SCAN domains 5	Homo sapiens (Human)	PR
Q86UZ6	ZBTB46	Zinc finger and BTB domain-containing protein 46	Homo sapiens (Human)	PR
Q9NX65	ZSCAN32	Zinc finger and SCAN domain-containing protein 32	Homo sapiens (Human)	PR
O14771	ZNF213	Zinc finger protein 213	Homo sapiens (Human)	PR
Q8IWY8	ZSCAN29	Zinc finger and SCAN domain-containing protein 29	Homo sapiens (Human)	PR
Q8NCP5	ZBTB44	Zinc finger and BTB domain-containing protein 44	Homo sapiens (Human)	PR
P41182	BCL6	B-cell lymphoma 6 protein	Homo sapiens (Human)	PR
Q9NQX0	PRDM6	Putative histone-lysine N-methyltransferase PRDM6	Homo sapiens (Human)	PR
Q9BU19	ZNF692	Zinc finger protein 692	Homo sapiens (Human)	PR
Q08AG5	ZNF844	Zinc finger protein 844	Homo sapiens (Human)	PR
Q6R2W3	ZBED9	SCAN domain-containing protein 3	Homo sapiens (Human)	PR
P98182	ZNF200	Zinc finger protein 200	Homo sapiens (Human)	PR
Q9UK11	ZNF223	Zinc finger protein 223	Homo sapiens (Human)	PR
O15156	ZBTB7B	Zinc finger and BTB domain-containing protein 7B	Homo sapiens (Human)	PR
Q6ZMS7	ZNF783	Zinc finger protein 783	Homo sapiens (Human)	PR
P59923	ZNF445	Zinc finger protein 445	Homo sapiens (Human)	PR
Q8N859	ZNF713	Zinc finger protein 713	Homo sapiens (Human)	PR
Q99612	KLF6	Krueppel-like factor 6	Homo sapiens (Human)	PR
Q8TD17	ZNF398	Zinc finger protein 398	Homo sapiens (Human)	PR
P52739	ZNF131	Zinc finger protein 131	Homo sapiens (Human)	PR
A6NGD5	ZSCAN5C	Zinc finger and SCAN domain-containing protein 5C	Homo sapiens (Human)	PR
Q05215	EGR4	Early growth response protein 4	Homo sapiens (Human)	PR
Q7Z398	ZNF550	Zinc finger protein 550	Homo sapiens (Human)	PR
Q9Y2K1	ZBTB1	Zinc finger and BTB domain-containing protein 1	Homo sapiens (Human)	PR
Q96N20	ZNF75A	Zinc finger protein 75A	Homo sapiens (Human)	PR
A6NJL1	ZSCAN5B	Zinc finger and SCAN domain-containing protein 5B	Homo sapiens (Human)	PR
A1YPR0	ZBTB7C	Zinc finger and BTB domain-containing protein 7C	Homo sapiens (Human)	PR
Q9NWS9	ZNF446	Zinc finger protein 446	Homo sapiens (Human)	PR
P24278	ZBTB25	Zinc finger and BTB domain-containing protein 25	Homo sapiens (Human)	PR
Q96N38	ZNF714	Zinc finger protein 714	Homo sapiens (Human)	PR
Q86YH2	ZNF280B	Zinc finger protein 280B	Homo sapiens (Human)	PR
Q9NTW7	ZFP64	Zinc finger protein 64	Homo sapiens (Human)	PR
Q9NQV6	PRDM10	PR domain zinc finger protein 10	Homo sapiens (Human)	PR
O08584	Klf6	Krueppel-like factor 6	Mus musculus (Mouse)	PR
Q61164	Ctcf	Transcriptional repressor CTCF	Mus musculus (Mouse)	PR
Q810A1	Znf18	Zinc finger protein 18	Mus musculus (Mouse)	PR
Q8BGS3	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Mus musculus (Mouse)	PR
Q00899	Yy1	Transcriptional repressor protein YY1	Mus musculus (Mouse)	PR
P41183	Bcl6	B-cell lymphoma 6 protein homolog	Mus musculus (Mouse)	PR
Q9DAI4	Zbtb43	Zinc finger and BTB domain-containing protein 43	Mus musculus (Mouse)	PR
O70237	Gfi1b	Zinc finger protein Gfi-1b	Mus musculus (Mouse)	PR
Q99KZ6	Znf639	Zinc finger protein 639	Mus musculus (Mouse)	PR
Q9Z1D9	Znf394	Zinc finger protein 394	Mus musculus (Mouse)	PR
Q9CXE0	Prdm5	PR domain zinc finger protein 5	Mus musculus (Mouse)	PR
P43300	Egr3	Early growth response protein 3	Mus musculus (Mouse)	PR
Q9DAU9	Znf654	Zinc finger protein 654	Mus musculus (Mouse)	PR
Q9R1Y5	Hic1	Hypermethylated in cancer 1 protein	Mus musculus (Mouse)	PR
Q8R0T2	Znf768	Zinc finger protein 768	Mus musculus (Mouse)	PR
Q9WVG7	Osr1	Protein odd-skipped-related 1	Mus musculus (Mouse)	PR
Q8BI73	Znf775	Zinc finger protein 775	Mus musculus (Mouse)	PR
Q8VCZ7	Zbtb7c	Zinc finger and BTB domain-containing protein 7C	Mus musculus (Mouse)	PR
Q91VN1	Znf24	Zinc finger protein 24	Mus musculus (Mouse)	PR
Q9DB38	Znf580	Zinc finger protein 580	Mus musculus (Mouse)	PR
A7KBS4	Zscan4d	Zinc finger and SCAN domain containing protein 4D	Mus musculus (Mouse)	PR
Q91VW9	Zkscan3	Zinc finger protein with KRAB and SCAN domains 3	Mus musculus (Mouse)	PR
P10925	Zfy1	Zinc finger Y-chromosomal protein 1	Mus musculus (Mouse)	PR
P08046	Egr1	Early growth response protein 1	Mus musculus (Mouse)	PR
Q3TTC2	Yy2	Transcription factor YY2	Mus musculus (Mouse)	PR
Q3UTQ7	Prdm10	PR domain zinc finger protein 10	Mus musculus (Mouse)	PR
Q6P3Y5	Znf280c	Zinc finger protein 280C	Mus musculus (Mouse)	PR
Q9ERU3	Znf22	Zinc finger protein 22	Mus musculus (Mouse)	PR
Q9Z1D8	Zkscan5	Zinc finger protein with KRAB and SCAN domains 5	Mus musculus (Mouse)	PR
Q8BID6	Zbtb46	Zinc finger and BTB domain-containing protein 46	Mus musculus (Mouse)	PR
P17012	Zfx	Zinc finger X-chromosomal protein	Mus musculus (Mouse)	PR
Q9WUK6	Zbtb18	Zinc finger and BTB domain-containing protein 18	Mus musculus (Mouse)	PR
O35738	Klf12	Krueppel-like factor 12	Mus musculus (Mouse)	PR
B2RXC5	Znf382	Zinc finger protein 382	Mus musculus (Mouse)	PR
O08900	Ikzf3	Zinc finger protein Aiolos	Mus musculus (Mouse)	PR
Q5DU09	Znf652	Zinc finger protein 652	Mus musculus (Mouse)	PR
Q5RJ54	Zscan26	Zinc finger and SCAN domain-containing protein 26	Mus musculus (Mouse)	PR
Q8BLM0	Klf8	Krueppel-like factor 8	Mus musculus (Mouse)	PR
Q99JB0	Klf7	Krueppel-like factor 7	Mus musculus (Mouse)	PR
Q8R0A2	Zbtb44	Zinc finger and BTB domain-containing protein 44	Mus musculus (Mouse)	PR
P20662	Zfy2	Zinc finger Y-chromosomal protein 2	Mus musculus (Mouse)	PR
Q80VJ6	Zscan4c	Zinc finger and SCAN domain containing protein 4C	Mus musculus (Mouse)	PR
Q3URS2	Zscan4f	Zinc finger and SCAN domain containing protein 4F	Mus musculus (Mouse)	PR
Q60980	Klf3	Krueppel-like factor 3	Mus musculus (Mouse)	PR
Q8K3J5	Znf131	Zinc finger protein 131	Mus musculus (Mouse)	PR
Q8VIG1	Rest	RE1-silencing transcription factor	Mus musculus (Mouse)	PR
Q9Z2K3	Znf394	Zinc finger protein 394	Rattus norvegicus (Rat)	PR
Q642B9	Znf18	Zinc finger protein 18	Rattus norvegicus (Rat)	PR
B0K011	Osr1	Protein odd-skipped-related 1	Rattus norvegicus (Rat)	PR
D3ZUU2	Gzf1	GDNF-inducible zinc finger protein 1	Rattus norvegicus (Rat)	PR
B1WBU4	Zbtb8a	Zinc finger and BTB domain-containing protein 8A	Rattus norvegicus (Rat)	PR
Q7TNK3	Znf24	Zinc finger protein 24	Rattus norvegicus (Rat)	PR
O35819	Klf6	Krueppel-like factor 6	Rattus norvegicus (Rat)	PR
Q9R1D1	Ctcf	Transcriptional repressor CTCF	Rattus norvegicus (Rat)	PR
P43301	Egr3	Early growth response protein 3	Rattus norvegicus (Rat)	PR
P08154	Egr1	Early growth response protein 1	Rattus norvegicus (Rat)	PR
A0JPL0	Znf382	Zinc finger protein 382	Rattus norvegicus (Rat)	PR
Q4KLI1	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Rattus norvegicus (Rat)	PR
A1L1J6	Znf652	Zinc finger protein 652	Rattus norvegicus (Rat)	PR
Q9SHD0	ZAT4	Zinc finger protein ZAT4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0P4X6	zbtb44	Zinc finger and BTB domain-containing protein 44	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A4II20	egr1	Early growth response protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6P882	zbtb8a.2	Zinc finger and BTB domain-containing protein 8A.2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q567C6	znf367	Zinc finger protein 367	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
A7Y7X5	znf711	Zinc finger protein 711	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MATQVMGQSS	GGGGLFTSSG	NIGMALPNDM	YDLHDLSKAE	LAAPQLIMLA	NVALTGEVNG
70	80	90	100	110	120
SCCDYLVGEE	RQMAELMPVG	DNNFSDSEEG	EGLEESADIK	GEPHGLENME	LRSLELSVVE
130	140	150	160	170	180
PQPVFEASGA	PDIYSSNKDL	PPETPGAEDK	GKSSKTKPFR	CKPCQYEAES	EEQFVHHIRV
190	200	210	220	230	240
HSAKKFFVEE	SAEKQAKARE	SGSSTAEEGD	FSKGPIRCDR	CGYNTNRYDH	YTAHLKHHTR
250	260	270	280	290	300
AGDNERVYKC	IICTYTTVSE	YHWRKHLRNH	FPRKVYTCGK	CNYFSDRKNN	YVQHVRTHTG
310	320	330	340	350	360
ERPYKCELCP	YSSSQKTHLT	RHMRTHSGEK	PFKCDQCSYV	ASNQHEVTRH	ARQVHNGPKP
370	380	390	400	410	420
LNCPHCDYKT	ADRSNFKKHV	ELHVNPRQFN	CPVCDYAASK	KCNLQYHFKS	KHPTCPNKTM
430	440	450	460	470	480
DVSKVKLKKT	KKREADLPDN	ITNEKTEIEQ	TKIKGDVAGK	KNEKSVKAEK	RDVSKEKKPS
490	500	510	520	530	540
NNVSVIQVTT	RTRKSVTEVK	EMDVHTGSNS	EKFSKTKKSK	RKLEVDSHSL	HGPVNDEESS
550	560	570	580	590	600
TKKKKKVESK	SKNNSQEVPK	GDSKVEENKK	QNTCMKKSTK	KKTLKNKSSK	KSSKPPQKEP
610	620	630	640	650	660
VEKGSAQMDP	PQMGPAPTEA	VQKGPVQVEP	PPPMEHAQME	GAQIRPAPDE	PVQMEVVQEG
670	680	690	700	710	720
PAQKELLPPV	EPAQMVGAQI	VLAHMELPPP	METAQTEVAQ	MGPAPMEPAQ	MEVAQVESAP
730	740	750	760	770	780
MQVVQKEPVQ	MELSPPMEVV	QKEPVQIELS	PPMEVVQKEP	VKIELSPPIE	VVQKEPVQME
790	800	810	820	830	840
LSPPMGVVQK	EPAQREPPPP	REPPLHMEPI	SKKPPLRKDK	KEKSNMQSER	ARKEQVLIEV
850	860	870	880	890	900
GLVPVKDSWL	LKESVSTEDL	SPPSPPLPKE	NLREEASGDQ	KLLNTGEGNK	EAPLQKVGAE
910	920	930	940	950	960
EADESLPGLA	ANINESTHIS	SSGQNLNTPE	GETLNGKHQT	DSIVCEMKMD	TDQNTRENLT
970	980	990	1000	1010	1020
GINSTVEEPV	SPMLPPSAVE	EREAVSKTAL	ASPPATMAAN	ESQEIDEDEG	IHSHEGSDLS
1030	1040	1050	1060	1070	1080
DNMSEGSDDS	GLHGARPVPQ	ESSRKNAKEA	LAVKAAKGDF	VCIFCDRSFR	KGKDYSKHLN
1090
RHLVNVYYLE	EAAQGQE