Q12469
Gene name |
SKM1 (YOL113W, HRA655) |
Protein name |
Serine/threonine-protein kinase SKM1 |
Names |
Protein kinase 75490 D |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOL113W |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
524-547 (Activation loop from InterPro)
Target domain |
360-639 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q12469
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12469-F1 | Predicted | AlphaFoldDB |
12 variants for Q12469
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-105097 | 258 | I>V | No | SGRP | |
| s15-105232 | 303 | S>A | No | SGRP | |
| s15-105242 | 306 | R>K | No | SGRP | |
| s15-105283 | 320 | H>Y | No | SGRP | |
| s15-105291 | 322 | S>R | No | SGRP | |
| s15-105680 | 452 | M>T | No | SGRP | |
| s15-105728 | 468 | A>V | No | SGRP | |
| s15-105737 | 471 | N>S | No | SGRP | |
| s15-105996 | 557 | K>N | No | SGRP | |
| s15-106151 | 609 | S>C | No | SGRP | |
| s15-106156 | 611 | Q>E | No | SGRP | |
| s15-106264 | 647 | Q>E | No | SGRP |
No associated diseases with Q12469
5 regional properties for Q12469
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CRIB domain | 123 - 179 | IPR000095 |
| domain | Protein kinase domain | 360 - 639 | IPR000719 |
| domain | Pleckstrin homology domain | 3 - 120 | IPR001849 |
| active_site | Serine/threonine-protein kinase, active site | 503 - 515 | IPR008271 |
| domain | p21 activated kinase binding domain | 121 - 165 | IPR033923 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of MAPK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. |
| septum digestion after cytokinesis | The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. |
| sterol import | The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
22 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q08E52 | PAK1 | Serine/threonine-protein kinase PAK 1 | Bos taurus (Bovine) | SS |
| Q7YQL4 | PAK3 | Serine/threonine-protein kinase PAK 3 | Pan troglodytes (Chimpanzee) | SS |
| Q9VXE5 | mbt | Serine/threonine-protein kinase PAK mbt | Drosophila melanogaster (Fruit fly) | PR |
| Q9NQU5 | PAK6 | Serine/threonine-protein kinase PAK 6 | Homo sapiens (Human) | EV |
| Q9P286 | PAK5 | Serine/threonine-protein kinase PAK 5 | Homo sapiens (Human) | EV |
| O96013 | PAK4 | Serine/threonine-protein kinase PAK 4 | Homo sapiens (Human) | EV |
| Q13177 | PAK2 | Serine/threonine-protein kinase PAK 2 | Homo sapiens (Human) | EV |
| O75914 | PAK3 | Serine/threonine-protein kinase PAK 3 | Homo sapiens (Human) | SS |
| Q13153 | PAK1 | Serine/threonine-protein kinase PAK 1 | Homo sapiens (Human) | EV |
| Q3ULB5 | Pak6 | Serine/threonine-protein kinase PAK 6 | Mus musculus (Mouse) | PR |
| Q8C015 | Pak5 | Serine/threonine-protein kinase PAK 5 | Mus musculus (Mouse) | SS |
| Q8BTW9 | Pak4 | Serine/threonine-protein kinase PAK 4 | Mus musculus (Mouse) | PR |
| Q8CIN4 | Pak2 | Serine/threonine-protein kinase PAK 2 | Mus musculus (Mouse) | SS |
| Q61036 | Pak3 | Serine/threonine-protein kinase PAK 3 | Mus musculus (Mouse) | SS |
| O88643 | Pak1 | Serine/threonine-protein kinase PAK 1 | Mus musculus (Mouse) | SS |
| D4A280 | Pak5 | Serine/threonine-protein kinase PAK 5 | Rattus norvegicus (Rat) | SS |
| Q64303 | Pak2 | Serine/threonine-protein kinase PAK 2 | Rattus norvegicus (Rat) | SS |
| Q62829 | Pak3 | Serine/threonine-protein kinase PAK 3 | Rattus norvegicus (Rat) | SS |
| P35465 | Pak1 | Serine/threonine-protein kinase PAK 1 | Rattus norvegicus (Rat) | SS |
| G5EFU0 | pak-2 | Serine/threonine-protein kinase pak-2 | Caenorhabditis elegans | PR |
| G5EGQ3 | max-2 | Serine/threonine-protein kinase max-2 | Caenorhabditis elegans | SS |
| Q17850 | pak-1 | Serine/threonine-protein kinase pak-1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKGVKKEGWI | SYKVDGLFSF | LWQKRYLVLN | DSYLAFYKSD | KCNEEPVLSV | PLTSITNVSR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IQLKQNCFEI | LRATDQKENI | SPINSYFYES | NSKRSIFIST | RTERDLHGWL | DAIFAKCPLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGVSSPTNFT | HKVHVGFDPK | VGNFVGVPDS | WAKLLQTSEI | TYDDWNRNSK | AVIKALQFYE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DYNGLDTMQF | NDHLNTSLDL | KPLKSPTRYI | INKRTNSIKR | SVSRTLRKGK | TDSILPVYQS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELKPFPRPSD | DDYKFTNIED | NKVREEGRVH | VSKESTADSQ | TKQLGKKEQK | VIQSHLRRHD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NNSTFRPHRL | APSAPATKNH | DSKTKWHKED | LLELKNNDDS | NEIIMKMKTV | AIDVNPRPYF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QLVEKAGQGA | SGAVYLSKRI | KLPQENDPRF | LKSHCHRVVG | ERVAIKQIRL | SEQPKKQLIM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NELLVMNDSR | QENIVNFLEA | YIIDDEELWV | IMEYMEGGCL | TDILDAVARS | NTGEHSSPLN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ENQMAYIVKE | TCQGLKFLHN | KKIIHRDIKS | DNILLNSQGL | VKITDFGFCV | ELTEKRSKRA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TMVGTPYWMA | PEIVNQKGYD | EKVDVWSLGI | MLIEMIEGEP | PYLNEDPLKA | LYLIANNGSP |
| 610 | 620 | 630 | 640 | 650 | |
| KLRHPESVSK | QTKQFLDACL | QVNVESRASV | RKLLTFEFLS | MACSPEQLKV | SLKWH |