Q12099
PR
Gene name |
FAL1 (YDR021W, PZC399, YD9335.07) |
Protein name |
ATP-dependent RNA helicase FAL1 |
Names |
Translation initiation factor four A-like protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR021W |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q12099
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12099-F1 | Predicted | AlphaFoldDB |
6 variants for Q12099
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-487276 | 159 | K>R | No | SGRP | |
| s04-487335 | 179 | L>V | No | SGRP | |
| s04-487407 | 203 | V>L | No | SGRP | |
| s04-487539 | 247 | D>H | No | SGRP | |
| s04-487563 | 255 | T>A | No | SGRP | |
| s04-487954 | 385 | S>C | No | SGRP |
No associated diseases with Q12099
5 regional properties for Q12099
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 171 - 179 | IPR000629 |
| domain | Helicase, C-terminal | 238 - 399 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 48 - 214 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 42 - 242 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 23 - 51 | IPR014014 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| FAL1-SGD1 complex | A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| preribosome, small subunit precursor | A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of SSU-rRNA | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| RNA biosynthetic process | The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q07478 | SUB2 | ATP-dependent RNA helicase SUB2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P20447 | DBP3 | ATP-dependent RNA helicase DBP3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P23394 | PRP28 | Pre-mRNA-splicing ATP-dependent RNA helicase PRP28 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SZ65 | EIF4A2 | Eukaryotic initiation factor 4A-II | Bos taurus (Bovine) | PR |
| Q2NL22 | EIF4A3 | Eukaryotic initiation factor 4A-III | Bos taurus (Bovine) | PR |
| Q5ZM36 | EIF4A3 | Eukaryotic initiation factor 4A-III | Gallus gallus (Chicken) | PR |
| Q8JFP1 | EIF4A2 | Eukaryotic initiation factor 4A-II | Gallus gallus (Chicken) | PR |
| Q9VHS8 | CG7483 | Eukaryotic initiation factor 4A-III | Drosophila melanogaster (Fruit fly) | PR |
| P38919 | EIF4A3 | Eukaryotic initiation factor 4A-III | Homo sapiens (Human) | PR |
| Q91VC3 | Eif4a3 | Eukaryotic initiation factor 4A-III | Mus musculus (Mouse) | PR |
| A6M931 | EIF4A3 | Eukaryotic initiation factor 4A-III | Sus scrofa (Pig) | PR |
| Q3B8Q2 | Eif4a3 | Eukaryotic initiation factor 4A-III | Rattus norvegicus (Rat) | PR |
| Q10I26 | EIF4A3B | Eukaryotic initiation factor 4A-III homolog B | Oryza sativa subsp japonica (Rice) | PR |
| Q5VNM3 | EIF4A3A | Eukaryotic initiation factor 4A-III homolog A | Oryza sativa subsp japonica (Rice) | PR |
| Q94A52 | EIF4A3 | Eukaryotic initiation factor 4A-III homolog | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B7ZTW1 | eif4a3 | Eukaryotic initiation factor 4A-III | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q7ZVA6 | eif4a3 | Eukaryotic initiation factor 4A-III | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFDREEDQK | LKFKTSKKLK | VSSTFESMNL | KDDLLRGIYS | YGFEAPSSIQ | SRAITQIISG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDVIAQAQSG | TGKTATFTIG | LLQAIDLRKK | DLQALILSPT | RELASQIGQV | VKNLGDYMNV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NAFAITGGKT | LKDDLKKMQK | HGCQAVSGTP | GRVLDMIKKQ | MLQTRNVQML | VLDEADELLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ETLGFKQQIY | DIFAKLPKNC | QVVVVSATMN | KDILEVTRKF | MNDPVKILVK | RDEISLEGIK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QYVVNVDKEE | WKFDTLCDIY | DSLTITQCVI | FCNTKKKVDW | LSQRLIQSNF | AVVSMHGDMK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QEERDKVMND | FRTGHSRVLI | STDVWARGID | VQQVSLVINY | DLPEIIENYI | HRIGRSGRFG |
| 370 | 380 | 390 | |||
| RKGVAINFIT | KADLAKLREI | EKFYSIKINP | MPANFAELS |