Q12086
Gene name |
DIN7 (DIN3, YDR263C, YD9320B.02C) |
Protein name |
DNA damage-inducible protein DIN7 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR263C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q12086
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12086-F1 | Predicted | AlphaFoldDB |
8 variants for Q12086
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-994734 | 266 | S>T | No | SGRP | |
| s04-994510 | 341 | V>I | No | SGRP | |
| s04-994468 | 355 | M>V | No | SGRP | |
| s04-994410 | 374 | V>A | No | SGRP | |
| s04-994411 | 374 | V>I | No | SGRP | |
| s04-994338 | 398 | V>A | No | SGRP | |
| s04-994339 | 398 | V>M | No | SGRP | |
| s04-994269 | 421 | A>E | No | SGRP |
No associated diseases with Q12086
6 regional properties for Q12086
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | XPG, N-terminal | 1 - 99 | IPR006085 |
| domain | XPG-I domain | 138 - 227 | IPR006086 |
| conserved_site | Helix-hairpin-helix motif, class 2 | 214 - 247 | IPR008918 |
| conserved_site | XPG conserved site | 71 - 85 | IPR019974-1 |
| conserved_site | XPG conserved site | 141 - 155 | IPR019974-2 |
| domain | Exonuclease 1-like, PIN-like domain | 1 - 202 | IPR044752 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5'-3' exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. |
| 5'-flap endonuclease activity | Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| metal ion binding | Binding to a metal ion. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA double-strand break processing | The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. |
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40028 | YEN1 | Holliday junction resolvase YEN1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9UQ84 | EXO1 | Exonuclease 1 | Homo sapiens (Human) | EV |
| Q9QZ11 | Exo1 | Exonuclease 1 | Mus musculus (Mouse) | SS |
| Q803U7 | exo1 | Exonuclease 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGIPGLLPQL | KRIQKQVSLK | KYMYQTLAID | GYAWLHRASC | ACAFELVMNK | PTNKYLQFFI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KRLQLLKRLK | IKPYIVFDGD | SLFVKNHTET | RRRKKRLENE | MIAKKLWSAG | NRYNAMEYFQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KSVDITPEMA | KCIIDYCKLH | SIPYIVAPFE | ADPQMVYLEK | MGLIQGIISE | DSDLLVFGCK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TLITKLNDQG | KALEISKDDF | SALPENFPLG | ELSEQQFRNL | VCLAGCDYTS | GIWKVGVVTA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MKIVKRYSEM | KDILIQIERT | EKLCFSKAFK | QQVEFANYAF | QYQRVFCPLS | NQITTLNNIP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KAVTNSHAEI | IKIMKCIGSV | VERGSGVRKD | VINTKNIDHK | VHEMIAKGEL | HPVDMASKLI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NRERKLKARK | LFKVGLLGGE | SNSFNKKVEQ | PLVDTQDVLS | ERENSLDNKN | ASSIYMTSPA |
| AISGTVPSIF |