Q11207
SS
Gene name |
PARP2 (APP, At4g02390, T14P8.19) |
Protein name |
Poly [ADP-ribose] polymerase 2 |
Names |
PARP-2 , EC 2.4.2.30 , NAD, + ADP-ribosyltransferase 2 , ADPRT-2 , Poly[ADP-ribose] synthase 2 , Protein ADP-ribosyltransferase PARP2 , EC 2.4.2.- |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G02390 |
EC number |
2.4.2.30: Pentosyltransferases |
Protein Class |
|
Descriptions
PARP2, also known as ARTD2, is an enzyme that becomes activated by DNA damage, specifically by 5′-phosphorylated DNA ends. It catalyzes poly-ADP-ribosylation, a post-translational modification involved in DNA repair processes. PARP2 plays a crucial role in DNA damage detection and repair, with its activity being essential for maintaining genomic stability and proper cellular function in response to genotoxic stress. In its inactive state, PARP2’s regulatory domain (RD) covers the active site, preventing substrate NAD+ binding. DNA damage recognition leads to RD unfolding and reorganization, enabling the enzyme to access and modify target macromolecules for ADP-ribosylation. The activation of PARP2 by DNA damage induces significant conformational changes in the enzyme, which relieve its autoinhibited state. This allows PARP2 to bind NAD+ and histone PARylation factor 1 (HPF1), altering its residue specificity during DNA repair.
Autoinhibitory domains (AIDs)
Target domain |
412-637 (ART domain) |
Relief mechanism |
Ligand binding, Others |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for Q11207
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| No available structures | |||||
67 variants for Q11207
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_1050114_A_G | 4 | K>R | No | 1000Genomes | |
| ENSVATH00454935 | 12 | L>S | No | 1000Genomes | |
| ENSVATH02622055 | 13 | K>Q | No | 1000Genomes | |
| ENSVATH02622056 | 22 | T>A | No | 1000Genomes | |
| ENSVATH00454938 | 24 | V>I | No | 1000Genomes | |
| tmp_4_1050180_C_T | 26 | A>V | No | 1000Genomes | |
| ENSVATH02622058 | 27 | V>A | No | 1000Genomes | |
| ENSVATH13882229 | 51 | R>I | No | 1000Genomes | |
| ENSVATH02622062 | 52 | N>D | No | 1000Genomes | |
| tmp_4_1050341_C_A | 54 | S>Y | No | 1000Genomes | |
| ENSVATH02622063 | 55 | N>D | No | 1000Genomes | |
| ENSVATH02622065 | 58 | Y>* | No | 1000Genomes | |
| ENSVATH02622064 | 58 | Y>D | No | 1000Genomes | |
| ENSVATH10534286 | 66 | I>S | No | 1000Genomes | |
| ENSVATH00454940 | 82 | I>S | No | 1000Genomes | |
| tmp_4_1050454_A_G | 92 | K>E | No | 1000Genomes | |
| ENSVATH06424120 | 98 | R>K | No | 1000Genomes | |
| ENSVATH06424120 | 98 | R>T | No | 1000Genomes | |
| ENSVATH06424121 | 108 | N>K | No | 1000Genomes | |
| ENSVATH02622067 | 111 | V>A | No | 1000Genomes | |
| tmp_4_1050613_G_A | 118 | D>N | No | 1000Genomes | |
| ENSVATH02622075 | 119 | E>G | No | 1000Genomes | |
| ENSVATH02622076 | 124 | N>D | No | 1000Genomes | |
| ENSVATH00454941 | 124 | N>S | No | 1000Genomes | |
| ENSVATH02622077 | 130 | E>D | No | 1000Genomes | |
| ENSVATH02622088 | 168 | V>I | No | 1000Genomes | |
| tmp_4_1050879_A_G | 176 | T>A | No | 1000Genomes | |
| ENSVATH02622090 | 187 | V>I | No | 1000Genomes | |
| ENSVATH02622095 | 199 | Y>F | No | 1000Genomes | |
| tmp_4_1051148_G_T | 205 | W>L | No | 1000Genomes | |
| ENSVATH02622096 | 221 | D>N | No | 1000Genomes | |
| ENSVATH06424130 | 225 | R>H | No | 1000Genomes | |
| tmp_4_1051252_A_T | 240 | N>Y | No | 1000Genomes | |
| tmp_4_1051282_C_T | 250 | P>S | No | 1000Genomes | |
| tmp_4_1051557_C_T | 276 | P>L | No | 1000Genomes | |
| tmp_4_1051604_C_G | 292 | R>G | No | 1000Genomes | |
| tmp_4_1051610_G_A | 294 | A>T | No | 1000Genomes | |
| ENSVATH06424139 | 295 | K>M | No | 1000Genomes | |
| tmp_4_1051625_C_T | 299 | L>F | No | 1000Genomes | |
| ENSVATH13882232 | 320 | L>V | No | 1000Genomes | |
| ENSVATH06424143 | 323 | G>S | No | 1000Genomes | |
| tmp_4_1051921_G_A | 326 | S>N | No | 1000Genomes | |
| ENSVATH00454949 | 328 | S>P | No | 1000Genomes | |
| tmp_4_1051938_A_G | 332 | K>E | No | 1000Genomes | |
| ENSVATH06424148 | 339 | R>G | No | 1000Genomes | |
| ENSVATH02622136 | 347 | Y>F | No | 1000Genomes | |
| ENSVATH10534373 | 361 | T>S | No | 1000Genomes | |
| ENSVATH00454952 | 376 | V>L | No | 1000Genomes | |
| tmp_4_1052557_T_G | 409 | L>V | No | 1000Genomes | |
| tmp_4_1052689_A_G | 422 | N>D | No | 1000Genomes | |
| ENSVATH06424174 | 431 | D>N | No | 1000Genomes | |
| ENSVATH06424178 | 469 | A>T | No | 1000Genomes | |
| tmp_4_1052942_G_C | 470 | D>H | No | 1000Genomes | |
| ENSVATH10534442 | 474 | Q>L | No | 1000Genomes | |
| tmp_4_1053233_G_A | 502 | R>Q | No | 1000Genomes | |
| tmp_4_1053242_C_T | 505 | P>L | No | 1000Genomes | |
| tmp_4_1053329_C_T | 534 | A>V | No | 1000Genomes | |
| ENSVATH02622175 | 535 | N>S | No | 1000Genomes | |
| tmp_4_1053334_A_C | 536 | T>P | No | 1000Genomes | |
| tmp_4_1053337_G_T | 537 | G>C | No | 1000Genomes | |
| tmp_4_1053340_G_A | 538 | A>T | No | 1000Genomes | |
| ENSVATH06424187 | 546 | C>S | No | 1000Genomes | |
| ENSVATH13882285 | 568 | P>L | No | 1000Genomes | |
| tmp_4_1053743_G_C | 595 | V>L | No | 1000Genomes | |
| ENSVATH06424193 | 614 | E>G | No | 1000Genomes | |
| tmp_4_1053903_T_A,C | 619 | N>K | No | 1000Genomes | |
| ENSVATH00454964 | 625 | M>T | No | 1000Genomes |
No associated diseases with Q11207
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.2.30 | Pentosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| NAD+ ADP-ribosyltransferase activity | Catalysis of the reaction |
| NAD+-protein ADP-ribosyltransferase activity | Catalysis of the reaction |
| nucleotidyltransferase activity | Catalysis of the transfer of a nucleotidyl group to a reactant. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA ADP-ribosylation | The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA. |
| double-strand break repair via nonhomologous end joining | The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. |
| protein poly-ADP-ribosylation | The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P18493 | PARP1 | Poly [ADP-ribose] polymerase 1 | Bos taurus (Bovine) | SS |
| P26446 | PARP1 | Poly [ADP-ribose] polymerase 1 | Gallus gallus (Chicken) | SS |
| P35875 | Parp | Poly [ADP-ribose] polymerase | Drosophila melanogaster (Fruit fly) | SS |
| P09874 | PARP1 | Poly [ADP-ribose] polymerase 1 | Homo sapiens (Human) | SS |
| Q9UGN5 | PARP2 | Poly [ADP-ribose] polymerase 2 | Homo sapiens (Human) | EV |
| Q9Y6F1 | PARP3 | Protein mono-ADP-ribosyltransferase PARP3 | Homo sapiens (Human) | PR |
| O50017 | PARP2 | Poly [ADP-ribose] polymerase 2 | Zea mays (Maize) | SS |
| P11103 | Parp1 | Poly [ADP-ribose] polymerase 1 | Mus musculus (Mouse) | SS |
| O88554 | Parp2 | Poly [ADP-ribose] polymerase 2 | Mus musculus (Mouse) | SS |
| P27008 | Parp1 | Poly [ADP-ribose] polymerase 1 | Rattus norvegicus (Rat) | SS |
| Q0JMY1 | PARP2-B | Poly [ADP-ribose] polymerase 2-B | Oryza sativa subsp. japonica (Rice) | SS |
| Q5Z8Q9 | PARP2-A | Poly [ADP-ribose] polymerase 2-A | Oryza sativa subsp. japonica (Rice) | SS |
| Q9ZP54 | PARP1 | Poly [ADP-ribose] polymerase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5RHR0 | parp1 | Poly [ADP-ribose] polymerase 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANKLKVDEL | RLKLAERGLS | TTGVKAVLVE | RLEEAIAEDT | KKEESKSKRK | RNSSNDTYES |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NKLIAIGEFR | GMIVKELREE | AIKRGLDTTG | TKKDLLERLC | NDANNVSNAP | VKSSNGTDEA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EDDNNGFEEE | KKEEKIVTAT | KKGAAVLDQW | IPDEIKSQYH | VLQRGDDVYD | AILNQTNVRD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NNNKFFVLQV | LESDSKKTYM | VYTRWGRVGV | KGQSKLDGPY | DSWDRAIEIF | TNKFNDKTKN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YWSDRKEFIP | HPKSYTWLEM | DYGKEENDSP | VNNDIPSSSS | EVKPEQSKLD | TRVAKFISLI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CNVSMMAQHM | MEIGYNANKL | PLGKISKSTI | SKGYEVLKRI | SEVIDRYDRT | RLEELSGEFY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVIPHDFGFK | KMSQFVIDTP | QKLKQKIEMV | EALGEIELAT | KLLSVDPGLQ | DDPLYYHYQQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LNCGLTPVGN | DSEEFSMVAN | YMENTHAKTH | SGYTVEIAQL | FRASRAVEAD | RFQQFSSSKN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RMLLWHGSRL | TNWAGILSQG | LRIAPPEAPV | TGYMFGKGVY | FADMFSKSAN | YCYANTGAND |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GVLLLCEVAL | GDMNELLYSD | YNADNLPPGK | LSTKGVGKTA | PNPSEAQTLE | DGVVVPLGKP |
| 610 | 620 | 630 | |||
| VERSCSKGML | LYNEYIVYNV | EQIKMRYVIQ | VKFNYKH |