Q10I26
PR
Gene name |
EIF4A3B |
Protein name |
Eukaryotic initiation factor 4A-III homolog B |
Names |
OseIF4AIIIb, eIF-4A-III, eIF4A-III, DEAD-box ATP-dependent RNA helicase 34, OsRH34 |
Species |
Oryza sativa subsp japonica (Rice) |
KEGG Pathway |
osa:4333273 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q10I26
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q10I26-F1 | Predicted | AlphaFoldDB |
No variants for Q10I26
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q10I26 | |||||
No associated diseases with Q10I26
5 regional properties for Q10I26
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 178 - 186 | IPR000629 |
| domain | Helicase, C-terminal | 243 - 404 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 56 - 218 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 50 - 247 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 31 - 59 | IPR014014 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| mRNA transport | The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
25 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12099 | FAL1 | ATP-dependent RNA helicase FAL1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q2NL22 | EIF4A3 | Eukaryotic initiation factor 4A-III | Bos taurus (Bovine) | PR |
| Q3SZ65 | EIF4A2 | Eukaryotic initiation factor 4A-II | Bos taurus (Bovine) | PR |
| Q5ZM36 | EIF4A3 | Eukaryotic initiation factor 4A-III | Gallus gallus (Chicken) | PR |
| Q8JFP1 | EIF4A2 | Eukaryotic initiation factor 4A-II | Gallus gallus (Chicken) | PR |
| Q9VHS8 | CG7483 | Eukaryotic initiation factor 4A-III | Drosophila melanogaster (Fruit fly) | PR |
| P38919 | EIF4A3 | Eukaryotic initiation factor 4A-III | Homo sapiens (Human) | PR |
| Q91VC3 | Eif4a3 | Eukaryotic initiation factor 4A-III | Mus musculus (Mouse) | PR |
| A6M931 | EIF4A3 | Eukaryotic initiation factor 4A-III | Sus scrofa (Pig) | PR |
| Q3B8Q2 | Eif4a3 | Eukaryotic initiation factor 4A-III | Rattus norvegicus (Rat) | PR |
| Q5VNM3 | EIF4A3A | Eukaryotic initiation factor 4A-III homolog A | Oryza sativa subsp japonica (Rice) | PR |
| Q5QMN3 | Os01g0197200 | DEAD-box ATP-dependent RNA helicase 20 | Oryza sativa subsp japonica (Rice) | PR |
| Q5JK84 | AIP2 | DEAD-box ATP-dependent RNA helicase 15 | Oryza sativa subsp japonica (Rice) | PR |
| Q0E2Z7 | Os02g0201900 | DEAD-box ATP-dependent RNA helicase 41 | Oryza sativa subsp japonica (Rice) | PR |
| Q75HJ0 | PL10A | DEAD-box ATP-dependent RNA helicase 37 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6Z4K6 | PL10B | DEAD-box ATP-dependent RNA helicase 52B | Oryza sativa subsp. japonica (Rice) | SS |
| Q2R1M8 | Os11g0599500 | DEAD-box ATP-dependent RNA helicase 52C | Oryza sativa subsp. japonica (Rice) | SS |
| Q10RI7 | Os03g0158200 | DEAD-box ATP-dependent RNA helicase 38 | Oryza sativa subsp japonica (Rice) | PR |
| Q5Z6G5 | Os06g0697200 | DEAD-box ATP-dependent RNA helicase 35B | Oryza sativa subsp japonica (Rice) | PR |
| Q0JM17 | AIP1 | DEAD-box ATP-dependent RNA helicase 56 | Oryza sativa subsp japonica (Rice) | PR |
| Q5N7W4 | Os01g0911100 | DEAD-box ATP-dependent RNA helicase 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q0E3X4 | Os02g0150100 | DEAD-box ATP-dependent RNA helicase 35A | Oryza sativa subsp japonica (Rice) | PR |
| Q94A52 | EIF4A3 | Eukaryotic initiation factor 4A-III homolog | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B7ZTW1 | eif4a3 | Eukaryotic initiation factor 4A-III | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q7ZVA6 | eif4a3 | Eukaryotic initiation factor 4A-III | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAATTSRRG | PGAMDDENLT | FETSPGVEVI | SSFDQMGIRE | DLLRGIYAYG | FEKPSAIQQR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AVLPIISGRD | VIAQAQSGTG | KTSMISLSVC | QIVDTAVREV | QALILSPTRE | LAAQTERVML |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AIGDYINIQV | HACIGGKSIG | EDIRKLEHGV | HVVSGTPGRV | CDMIKRRTLR | TRAIKLLILD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EADEMLGRGF | KDQIYDVYRY | LPPELQVCLI | SATLPHEILE | MTSKFMTDPV | RILVKRDELT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LEGIKQFFVA | VEKEEWKFDT | LCDLYDTLTI | TQAVIFCNTK | RKVDWLTERM | RSNNFTVSAM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HGDMPQKERD | AIMGEFRSGA | TRVLITTDVW | ARGLDVQQVS | LVINYDLPNN | RELYIHRIGR |
| 370 | 380 | 390 | 400 | ||
| SGRFGRKGVA | INFVKKEDIR | ILRDIEQYYS | TQIDEMPMNV | ADLI |