Q10GB1
Gene name |
NEK1 |
Protein name |
Serine/threonine-protein kinase Nek1 |
Names |
NimA-related protein kinase 1, OsNek1 |
Species |
Oryza sativa subsp japonica (Rice) |
KEGG Pathway |
osa:4333522 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
146-168 (Activation loop from InterPro)
Target domain |
4-258 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q10GB1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q10GB1-F1 | Predicted | AlphaFoldDB |
No variants for Q10GB1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q10GB1 | |||||
No associated diseases with Q10GB1
5 regional properties for Q10GB1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 188 - 196 | IPR000629 |
| domain | Helicase, C-terminal | 253 - 414 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 66 - 227 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 60 - 257 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 41 - 69 | IPR014014 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P22209 | KIN3 | Serine/threonine-protein kinase KIN3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q6P3R8 | NEK5 | Serine/threonine-protein kinase Nek5 | Homo sapiens (Human) | PR |
| Q8NE28 | STKLD1 | Serine/threonine kinase-like domain-containing protein STKLD1 | Homo sapiens (Human) | PR |
| P51957 | NEK4 | Serine/threonine-protein kinase Nek4 | Homo sapiens (Human) | PR |
| P51955 | NEK2 | Serine/threonine-protein kinase Nek2 | Homo sapiens (Human) | EV |
| Q8K1R7 | Nek9 | Serine/threonine-protein kinase Nek9 | Mus musculus (Mouse) | SS |
| Q7TSC3 | Nek5 | Serine/threonine-protein kinase Nek5 | Mus musculus (Mouse) | PR |
| O35942 | Nek2 | Serine/threonine-protein kinase Nek2 | Mus musculus (Mouse) | PR |
| Q6ZEZ5 | NEK3 | Serine/threonine-protein kinase Nek3 | Oryza sativa subsp japonica (Rice) | PR |
| Q19469 | sad-1 | Serine/threonine kinase SAD-1 | Caenorhabditis elegans | SS |
| Q9LT35 | NEK6 | Serine/threonine-protein kinase Nek6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RXT4 | NEK4 | Serine/threonine-protein kinase Nek4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SLI2 | NEK1 | Serine/threonine-protein kinase Nek1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEQYEVLEQI | GKGAFGSALL | VRHKVEKKKY | VLKKIRLARQ | TDRTRRSAHQ | EMQLIATVRN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PFIVEYKDSW | VEKGCYVCII | IGYCEGGDMA | EAIKRATGDH | FSEEKLCKWL | VQLLMALDYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HANHILHRDV | KCSNIFLTRD | QSIRLGDFGL | AKILTSDDLA | SSVVGTPSYM | CPELLADIPY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTKSDIWSLG | CCIYEMTALR | PAFKAFDMQA | LISKITKSIV | SPLPTRYSGA | FRGLIKSMLR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSPEHRPSAA | ELLKHPHLQP | YVLQVHLKSS | PARNIIPSHQ | SPIDKVKKMT | FPTESMCRSK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GRRNSLGNER | IVTFSKPSPE | RKFTSSIQSI | KDYSTTRSVK | DLSIDVSLVE | EVSSKTTFTT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RTSSIVKTPK | RTPSKTITTP | QLEPPKVSYN | RVNRSELLSR | TPVNRSARVI | RRASLPLPLP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SSETPKRGVS | SISILEQLES | PDVSVNSPRI | DRIAEFPLAS | SEDPPFLKLH | GRRSPTPTPQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HCVIDQSITK | DKCMVEAFHI | IDVDDDDGRS | DSSSGRNNAA | AAASSRAGSS | ESTRQRRFDT |
| 550 | 560 | 570 | 580 | 590 | |
| SSYQQRAEAL | EGLLEFSAQL | LQQERYDELG | VLLKPFGPEK | VSPRETAIWL | TKSFKETGL |