Q0ZAQ8
PR
Gene name |
PPARD (NR1C2, PPARB) |
Protein name |
Peroxisome proliferator-activated receptor delta |
Names |
PPAR-delta, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta |
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:481756 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0ZAQ8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0ZAQ8-F1 | Predicted | AlphaFoldDB |
No variants for Q0ZAQ8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q0ZAQ8 | |||||
No associated diseases with Q0ZAQ8
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor binding | Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. |
| linoleic acid binding | Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid. |
| lipid binding | Binding to a lipid. |
| nuclear receptor activity | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| transcription coactivator binding | Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
| zinc ion binding | Binding to a zinc ion (Zn). |
35 GO annotations of biological process
| Name | Definition |
|---|---|
| adipose tissue development | The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. |
| apoptotic signaling pathway | The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. |
| axon ensheathment | Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cell-substrate adhesion | The attachment of a cell to the underlying substrate via adhesion molecules. |
| cellular response to hypoxia | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| embryo implantation | Attachment of the blastocyst to the uterine lining. |
| fat cell proliferation | The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. |
| fatty acid beta-oxidation | A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
| fatty acid metabolic process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
| fatty acid transport | The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
| hormone-mediated signaling pathway | The series of molecular signals mediated by the detection of a hormone. |
| keratinocyte migration | The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another. |
| keratinocyte proliferation | The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. |
| negative regulation of cholesterol storage | Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| negative regulation of epithelial cell proliferation | Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. |
| negative regulation of inflammatory response | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. |
| negative regulation of miRNA transcription | Any process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription. |
| negative regulation of myoblast differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| phosphatidylinositol 3-kinase signaling | A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. |
| placenta development | The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of fat cell proliferation | Any process that activates or increases the rate or extent of fat cell proliferation. |
| positive regulation of fatty acid metabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of myoblast proliferation | Any process that activates or increases the frequency, rate or extent of myoblast proliferation. |
| positive regulation of phosphatidylinositol 3-kinase signaling | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. |
| positive regulation of skeletal muscle tissue regeneration | Any process that activates or increase the rate of skeletal muscle regeneration. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of fat cell differentiation | Any process that modulates the frequency, rate or extent of adipocyte differentiation. |
| regulation of lipid metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. |
| regulation of skeletal muscle satellite cell proliferation | Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation. |
| response to lipid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. |
| wound healing | The series of events that restore integrity to a damaged tissue, following an injury. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEQPPGEAAE | VREEEEKKEV | AEAEGAPELN | GGPERSLPSS | SYTDLSRSSS | PPSLLDQLQM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGDGASCGSL | NMECRVCGDK | ASGFHYGVHA | CEGCKGFFRR | TIRMKLEYEK | CERICKIQKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NRNKCQYCRF | QKCVALGMSH | NAIRFGRMPE | AEKRKLVAGL | TANEGTQHNP | QVADLKAFSK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HIYNAYLKNF | NMTKKKARGI | LTGKASHTAP | FVIHDIETLW | QAEKGLVWKQ | LVNGLPPYKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ISVHVFYRCQ | CTTVETVREL | TEFAKSIPSF | SNLFLNDQVT | LLKYGVHEAI | FAMLASIVNK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DGLLVANGTG | FVTREFLRSL | RKPFSDIIEP | KFEFAVKFNA | LELDDSDLAL | FIAAIILCGD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RPGLINVPQV | EAIQDTILRA | LEFHLQANHP | YAQYLFPKLL | QKMADLRQLV | TEHAQMMQRI |
| 430 | 440 | ||||
| KKTETETSLH | PLLQEIYKDM | Y |