Q0WUG6

PR
Gene name
SBT6.1
Protein name
Subtilisin-like protease SBT6.1
Names
Site-1 protease, AtS1P, Subtilase subfamily 6 member 1, AtSBT6.1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G19660
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-200 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0WUG6

Entry ID Method Resolution Chain Position Source
AF-Q0WUG6-F1 Predicted AlphaFoldDB

64 variants for Q0WUG6

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_6646409_G_A 4 L>F No 1000Genomes
tmp_5_6646405_C_T 5 G>E No 1000Genomes
ENSVATH06997281 15 C>Y No 1000Genomes
ENSVATH06997280 18 V>I No 1000Genomes
ENSVATH06997278 27 W>G No 1000Genomes
ENSVATH06997277 28 L>F No 1000Genomes
tmp_5_6646333_C_T 29 R>H No 1000Genomes
ENSVATH06997275 42 P>Q No 1000Genomes
ENSVATH06997276 42 P>T No 1000Genomes
tmp_5_6646290_C_G 43 E>D No 1000Genomes
ENSVATH06997274 49 E>D No 1000Genomes
tmp_5_6646273_T_A 49 E>V No 1000Genomes
ENSVATH06997273 52 N>T No 1000Genomes
ENSVATH00632711 55 K>R No 1000Genomes
ENSVATH10865939 56 T>N No 1000Genomes
ENSVATH06997271 67 P>R No 1000Genomes
tmp_5_6646204_C_A 72 R>L No 1000Genomes
tmp_5_6646138_G_T 94 T>K No 1000Genomes
tmp_5_6646134_C_A 95 K>N No 1000Genomes
ENSVATH00632709 101 G>A No 1000Genomes
ENSVATH06997269 155 M>R No 1000Genomes
tmp_5_6645895_T_A 175 N>I No 1000Genomes
tmp_5_6645720_A_T 190 M>K No 1000Genomes
tmp_5_6645037_C_T 278 V>I No 1000Genomes
ENSVATH10865881 295 D>E No 1000Genomes
tmp_5_6644986_C_A 295 D>Y No 1000Genomes
tmp_5_6644784_G_A 321 T>I No 1000Genomes
tmp_5_6644462_C_T 392 D>N No 1000Genomes
ENSVATH14097805 412 S>R No 1000Genomes
ENSVATH06997235 423 V>A No 1000Genomes
tmp_5_6644103_G_T 477 H>N No 1000Genomes
ENSVATH10865876 489 Y>C No 1000Genomes
tmp_5_6644016_C_T 506 G>R No 1000Genomes
tmp_5_6643916_C_T 539 G>E No 1000Genomes
ENSVATH03081790 549 P>L No 1000Genomes
ENSVATH06997220 557 G>S No 1000Genomes
tmp_5_6643845_T_A 563 M>L No 1000Genomes
ENSVATH06997218 590 S>P No 1000Genomes
tmp_5_6643748_G_T 595 P>H No 1000Genomes
ENSVATH03081789 613 P>S No 1000Genomes
tmp_5_6643689_C_A 615 A>S No 1000Genomes
ENSVATH06997216 684 Q>E No 1000Genomes
ENSVATH06997216 684 Q>K No 1000Genomes
tmp_5_6643412_T_G 707 D>A No 1000Genomes
tmp_5_6643398_T_A 712 T>S No 1000Genomes
ENSVATH03081788 718 V>M No 1000Genomes
tmp_5_6643202_T_C 777 D>G No 1000Genomes
tmp_5_6643160_C_T 791 R>Q No 1000Genomes
tmp_5_6643148_C_A 795 G>V No 1000Genomes
ENSVATH00632699 821 S>A No 1000Genomes
ENSVATH03081785 823 E>K No 1000Genomes
ENSVATH03081784 823 E>V No 1000Genomes
tmp_5_6642881_T_A 852 M>L No 1000Genomes
ENSVATH06997210 899 T>P No 1000Genomes
tmp_5_6642716_A_T 907 S>T No 1000Genomes
ENSVATH06997208 935 R>K No 1000Genomes
ENSVATH10865822 939 R>H No 1000Genomes
ENSVATH00632695 955 F>L No 1000Genomes
tmp_5_6642565_A_G 957 V>A No 1000Genomes
ENSVATH03081783 959 S>N No 1000Genomes
ENSVATH00632694 960 K>T No 1000Genomes
ENSVATH06997206 967 S>L No 1000Genomes
tmp_5_6642494_A_T 981 S>T No 1000Genomes
tmp_5_6642327_G_C 1009 A>G No 1000Genomes

No associated diseases with Q0WUG6

4 regional properties for Q0WUG6

Type Name Position InterPro Accession
domain Peptidase S8/S53 domain 204 - 453 IPR000209
active_site Peptidase S8, subtilisin, His-active site 243 - 253 IPR022398
active_site Peptidase S8, subtilisin, Ser-active site 407 - 417 IPR023828
domain Site-1 peptidase catalytic domain 197 - 453 IPR034185

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

3 GO annotations of biological process

Name Definition
hyperosmotic response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
hyperosmotic salinity response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q14703 MBTPS1 Membrane-bound transcription factor site-1 protease Homo sapiens (Human) PR
Q9WTZ2 Mbtps1 Membrane-bound transcription factor site-1 protease Mus musculus (Mouse) PR
Q9WTZ3 Mbtps1 Membrane-bound transcription factor site-1 protease Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MKVLGEASSY PYRSCIIVVF LSVSLFWLRP STYHPQQQNL NPENVTRLES ENETKTNYII
70 80 90 100 110 120
RFKQYKPAKD HRIYLESKVR SGGWGWIERI NPATKYPTDF GVLWIEESGK EAVVGEIERL
130 140 150 160 170 180
EMVKDVNVEF KYQRVLLGGS FPDGKKRPGK IFTSMSFEEG TESSPMADTS NTTLNWSRHL
190 200 210 220 230 240
LAQKTQVTSM FGADHLWKKG YTGAKVKMAI FDTGIRADHP HFRKIKERTN WTNEDTLNDN
250 260 270 280 290 300
LGHGTFVAGV IAGRNPECLG FASDTEIYAF RVFTDAQVSY TSWFLDAFNY AIATDMDVLN
310 320 330 340 350 360
LSIGGPDYLD LPFVEKVWEI TASNIIMVSA IGNDGPLYGT LNNPADQSDV IGVGGIDNDD
370 380 390 400 410 420
HIASFSSRGM STWELPHGYG RVKPDVVAYG RDIMGSKIST GCKSLSGTSV ASPVVAGIVC
430 440 450 460 470 480
LLVSVIPEAR RKDLLNPASM KQALVEGAAK LSGPNMYEQG AGRVDLLESY EILKSYHPRA
490 500 510 520 530 540
SIFPSILDYN DCPYSWPFCR QPLYAGAMPI IFNTTILNGM GVIGYIESPP TWHPANEEGN
550 560 570 580 590 600
LLSIHFKYPD VIWPWTGYLA LHMQIKEEGA QFTGEIEGNV TVKVYSPPAS GESGPRRSTC
610 620 630 640 650 660
SLQLKLKVIP TPPRAKRILW DQFHSIKYPP GYIPRDSLDV RNDILDWHGD HLHTNFHIMY
670 680 690 700 710 720
NMLRDAGYYI ETLGSPLTCF DAQQYGTLLM VDLEDDYFPE EIEKLRDDVI NTGLGLVVFA
730 740 750 760 770 780
EWYNVDTMVK MRFFDDNTRS WWTPVTGGAN IPALNNLLAS FGIAFGDKIL NGDFSIDGEQ
790 800 810 820 830 840
SRYASGTNIV RFPAGGFLHT FPLLDSSESG ATQNLLLTEA SKEDPAVLGL LEIGEGRVGV
850 860 870 880 890 900
YGDSNCLDSS HMVTNCYWLL KKMLDFSSSN IKDPVLFSKF AKRYSPVIID EKQLPSRRTD
910 920 930 940 950 960
VNFSTYSSVI GKELICESDS RFEVWGTKGY NLHVRGRNRR LPGYHGIDLG RGLNFTVESK
970 980 990 1000 1010 1020
RPTRWRSAKE GGELSSSRSK SLGGLFNRDE IDMPFLVPTR WIVLAGVVAS GVLVLLSIWR
1030
IRQKRGRRRR ASGSNRLA