Q0WNY5
PR
Gene name |
WAKL18 (At4g31110, F6E21.30) |
Protein name |
Wall-associated receptor kinase-like 18 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G31110 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
596-620 (Activation loop from InterPro)
Target domain |
453-728 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q0WNY5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0WNY5-F1 | Predicted | AlphaFoldDB |
87 variants for Q0WNY5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02946681 | 3 | N>Y | No | 1000Genomes | |
| ENSVATH12329164 | 4 | E>Q | No | 1000Genomes | |
| ENSVATH02946683 | 5 | S>N | No | 1000Genomes | |
| ENSVATH02946685 | 16 | M>K | No | 1000Genomes | |
| ENSVATH00546284 | 31 | R>W | No | 1000Genomes | |
| ENSVATH06806282 | 32 | E>* | No | 1000Genomes | |
| tmp_4_15127357_G_A | 34 | G>E | No | 1000Genomes | |
| ENSVATH00546285 | 37 | S>A | No | 1000Genomes | |
| ENSVATH00546287 | 49 | C>Y | No | 1000Genomes | |
| ENSVATH02946687 | 69 | L>F | No | 1000Genomes | |
| ENSVATH02946688 | 72 | F>L | No | 1000Genomes | |
| ENSVATH06806284 | 76 | E>K | No | 1000Genomes | |
| ENSVATH02946690 | 84 | S>T | No | 1000Genomes | |
| ENSVATH02946691 | 86 | D>E | No | 1000Genomes | |
| ENSVATH02946692 | 88 | H>Y | No | 1000Genomes | |
| ENSVATH02946694 | 92 | E>A | No | 1000Genomes | |
| ENSVATH02946693 | 92 | E>Q | No | 1000Genomes | |
| ENSVATH06806286 | 93 | V>I | No | 1000Genomes | |
| ENSVATH02946695 | 95 | D>N | No | 1000Genomes | |
| ENSVATH06806287 | 129 | M>V | No | 1000Genomes | |
| ENSVATH02946698 | 140 | R>S | No | 1000Genomes | |
| ENSVATH02946699 | 141 | S>T | No | 1000Genomes | |
| ENSVATH02946701 | 147 | A>V | No | 1000Genomes | |
| ENSVATH12329230 | 158 | I>L | No | 1000Genomes | |
| ENSVATH02946703 | 161 | K>E | No | 1000Genomes | |
| ENSVATH00546290 | 170 | N>D | No | 1000Genomes | |
| ENSVATH02946705 | 179 | S>N | No | 1000Genomes | |
| ENSVATH02946706 | 185 | A>T | No | 1000Genomes | |
| ENSVATH02946707 | 186 | G>R | No | 1000Genomes | |
| ENSVATH00546291 | 196 | Q>H | No | 1000Genomes | |
| ENSVATH02946708 | 196 | Q>K | No | 1000Genomes | |
| ENSVATH02946709 | 198 | Q>E | No | 1000Genomes | |
| ENSVATH02946710 | 201 | P>S | No | 1000Genomes | |
| ENSVATH09505604 | 202 | E>A | No | 1000Genomes | |
| ENSVATH09505603 | 202 | E>K | No | 1000Genomes | |
| ENSVATH02946711 | 204 | I>T | No | 1000Genomes | |
| ENSVATH02946712 | 205 | A>P | No | 1000Genomes | |
| ENSVATH02946713 | 205 | A>V | No | 1000Genomes | |
| ENSVATH02946715 | 208 | T>K | No | 1000Genomes | |
| ENSVATH00546292 | 213 | I>N | No | 1000Genomes | |
| ENSVATH02946716 | 232 | T>S | No | 1000Genomes | |
| ENSVATH02946717 | 234 | N>S | No | 1000Genomes | |
| ENSVATH02946719 | 235 | N>T | No | 1000Genomes | |
| tmp_4_15127988_G_C | 244 | E>D | No | 1000Genomes | |
| ENSVATH00546294 | 246 | T>I | No | 1000Genomes | |
| ENSVATH02946720 | 250 | F>I | No | 1000Genomes | |
| ENSVATH06806289 | 251 | L>V | No | 1000Genomes | |
| ENSVATH00546296 | 256 | Y>S | No | 1000Genomes | |
| ENSVATH12329232 | 262 | T>I | No | 1000Genomes | |
| ENSVATH02946722 | 264 | T>S | No | 1000Genomes | |
| ENSVATH00546297 | 284 | S>G | No | 1000Genomes | |
| ENSVATH06806291 | 284 | S>N | No | 1000Genomes | |
| ENSVATH06806292 | 284 | S>R | No | 1000Genomes | |
| ENSVATH06806293 | 286 | R>I | No | 1000Genomes | |
| ENSVATH02946723 | 286 | R>S | No | 1000Genomes | |
| ENSVATH06806294 | 298 | D>H | No | 1000Genomes | |
| ENSVATH06806295 | 318 | T>I | No | 1000Genomes | |
| ENSVATH12329233 | 324 | Y>F | No | 1000Genomes | |
| ENSVATH02946724 | 325 | A>T | No | 1000Genomes | |
| ENSVATH02946725 | 329 | C>F | No | 1000Genomes | |
| ENSVATH00546299 | 342 | G>E | No | 1000Genomes | |
| tmp_4_15128280_G_A | 342 | G>R | No | 1000Genomes | |
| tmp_4_15128475_C_T | 359 | T>I | No | 1000Genomes | |
| ENSVATH00546300 | 360 | E>D | No | 1000Genomes | |
| ENSVATH14319086 | 370 | R>H | No | 1000Genomes | |
| tmp_4_15128517_G_A | 373 | R>H | No | 1000Genomes | |
| ENSVATH02946739 | 401 | K>M | No | 1000Genomes | |
| ENSVATH12329308 | 404 | I>V | No | 1000Genomes | |
| ENSVATH06806299 | 425 | L>R | No | 1000Genomes | |
| ENSVATH06806300 | 431 | R>K | No | 1000Genomes | |
| tmp_4_15128852_A_C | 452 | N>H | No | 1000Genomes | |
| tmp_4_15129125_T_G | 543 | S>A | No | 1000Genomes | |
| ENSVATH06806302 | 548 | M>L | No | 1000Genomes | |
| tmp_4_15129143_T_A | 549 | L>I | No | 1000Genomes | |
| tmp_4_15129180_C_T | 561 | A>V | No | 1000Genomes | |
| tmp_4_15129183_G_A | 562 | G>E | No | 1000Genomes | |
| tmp_4_15129206_T_G | 570 | S>A | No | 1000Genomes | |
| tmp_4_15129213_C_G | 572 | S>C | No | 1000Genomes | |
| ENSVATH02946752 | 628 | Q>R | No | 1000Genomes | |
| ENSVATH02946757 | 648 | L>I | No | 1000Genomes | |
| tmp_4_15129443_A_C | 649 | I>L | No | 1000Genomes | |
| ENSVATH12329309 | 684 | I>T | No | 1000Genomes | |
| ENSVATH00546301 | 714 | K>N | No | 1000Genomes | |
| ENSVATH14319092 | 727 | R>K | No | 1000Genomes | |
| ENSVATH12329310 | 729 | C>F | No | 1000Genomes | |
| tmp_4_15129712_T_G | 738 | H>Q | No | 1000Genomes | |
| tmp_4_15129807_C_G | 770 | A>G | No | 1000Genomes |
No associated diseases with Q0WNY5
6 regional properties for Q0WNY5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 453 - 728 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 456 - 725 | IPR001245 |
| active_site | Serine/threonine-protein kinase, active site | 575 - 587 | IPR008271 |
| domain | Wall-associated receptor kinase | 207 - 315 | IPR013695 |
| conserved_site | EGF-like calcium-binding, conserved site | 345 - 371 | IPR018097 |
| domain | Wall-associated receptor kinase, galacturonan-binding domain | 29 - 83 | IPR025287 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| polysaccharide binding | Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
59 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| Q9Y616 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | Homo sapiens (Human) | PR |
| P53667 | LIMK1 | LIM domain kinase 1 | Homo sapiens (Human) | PR |
| P53671 | LIMK2 | LIM domain kinase 2 | Homo sapiens (Human) | PR |
| P06213 | INSR | Insulin receptor | Homo sapiens (Human) | EV |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P00533 | EGFR | Epidermal growth factor receptor | Homo sapiens (Human) | EV |
| Q15303 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | Homo sapiens (Human) | SS |
| P04626 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (Human) | SS |
| P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | Homo sapiens (Human) | SS |
| Q8K4B2 | Irak3 | Interleukin-1 receptor-associated kinase 3 | Mus musculus (Mouse) | PR |
| Q8CFA1 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Mus musculus (Mouse) | PR |
| O54785 | Limk2 | LIM domain kinase 2 | Mus musculus (Mouse) | PR |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q4QQS0 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Rattus norvegicus (Rat) | PR |
| Q9ASQ5 | CRCK3 | Calmodulin-binding receptor-like cytoplasmic kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCZ4 | FER | Receptor-like protein kinase FERONIA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYN6 | At3g56050 | Probable inactive receptor-like protein kinase At3g56050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTC0 | PBL19 | Probable serine/threonine-protein kinase PBL19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIL7 | CRCK1 | Calmodulin-binding receptor-like cytoplasmic kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7X8C5 | WAKL2 | Wall-associated receptor kinase-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9S9M2 | WAKL4 | Wall-associated receptor kinase-like 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9L5 | WAKL9 | Wall-associated receptor kinase-like 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYA3 | WAKL10 | Wall-associated receptor kinase-like 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M092 | WAKL17 | Wall-associated receptor kinase-like 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8X3 | fgfr3 | Fibroblast growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNESTNCSF | FLNLFMLLLL | LIFYSADACQ | RECGGISIPY | PFGIGKDCCL | EKYYEIECRN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TTSRKLVPLL | SFINKEVVSI | SLPSADSHFA | YEVSDQERHE | SFGLVRVKFP | ITSAGCFNDG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KESGGGSKMN | FTGSPFFIDR | SNSLIAAGCN | SKVSLMYIKP | KMVGCELSCN | TSKDSYSNSI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PFVEAGCSSN | VLPYSQDQGC | PEEIAEETGC | NGIGCCQASL | PNEPQQVIGI | RTENNDGNST |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TKVECTVSAF | LTDEIYALPK | ATKTEHLLAK | RYATVSLGWV | IQTSNRSFLD | SLALACKDRE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DYRNTTNLER | KCTCGRITIS | ETSYANCGCT | YGYTGNPYVL | NGCKDIDECK | VKFEYCGKTE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TCVNFEGGYR | CVRDKTKAIM | IGAGTGFGVL | VLVGGLWWLR | KFLIKRRITK | RKKKFFKRNG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GLLLLQELNT | REGYVEKTRV | FNSRELEKAT | ENFSENRVLG | HGGQGTVYKG | MLVDGRTVAV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KKSKVIDEDK | LQEFINEVVI | LSQINHRHVV | KLLGCCLETE | VPMLVYEFII | NGNLFKHIHE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EESDDYTMLW | GMRLRIAVDI | AGALSYLHSS | ASSPIYHRDI | KSTNILLDEK | YRAKVADFGT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SRSVTIDQTH | WTTVISGTVG | YVDPEYYQSS | QYTEKSDVYS | FGVILAELIT | GDKPVIMVQN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TQEIVALAEH | FRVAMKEKRL | TDIIDARIRN | DCKPEQVMAV | AKVAMKCLSS | KGKKRPNMRE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VFTELERICT | SPEDSQVHNR | IDEEEEEEEE | EEEVVTTINR | GDSWSISVTA | PALSIVASSP |
| 790 | |||||
| SSDVEPLFPR | LTW |