AiPD: Autoinhibited Protein Database

Q0VDF9

Gene name	HSPA14 (HSP60, HSP70L1)
Protein name	Heat shock 70 kDa protein 14
Names	HSP70-like protein 1 , Heat shock protein HSP60 , Heat shock protein family A member 14
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51182
EC number
Protein Class

Descriptions

HSPA8 (or hsc70) is a heat shock cognate protein involved in many cellular processes. During recovery from stress, HSPA8, initially accumulating in the nucleoplasm for folding/refolding of proteins, transiently concentrates in nucleoli for nucleolar morphology and function restoration. The inhibitory region is positioned at one of the three domains of HSPA8 protein, which is the N-terminal ATPase domain, specifically in residues 263-287 of domain IIB. Under normal growth conditions, the constitutive nucleolar targeting function that is provided by residues 225-262 is diminished by the autoinhibitory element located in residues 263-287. When cells recover from stress, the autoinhibitory element is inactivated, and the constitutive nucleolar targeting function restores.

Autoinhibitory domains (AIDs)

261-285 (Autoinhibitory region) SS

Target domain	223-260 (Nucleolar targeting region)
Relief mechanism	Others
Assay

AID

261-285 (Autoinhibitory region)

Target domain

223-260 (Nucleolar targeting region)

Relief mechanism

Others (Cell stress recovery)

Assay

Accessory elements

No accessory elements

References

Bański P et al. (2010) "Nucleolar targeting of the chaperone hsc70 is regulated by stress, cell signaling, and a composite targeting signal which is controlled by autoinhibition", The Journal of biological chemistry, 285, 21858-67

Autoinhibited structure

Activated structure

1 structures for Q0VDF9

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q0VDF9-F1	Predicted				AlphaFoldDB

507 variants for Q0VDF9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs866355401	2	A>V		No	TOPMed gnomAD
rs1833919160	3	A>S		No	gnomAD
rs1394810149	3	A>V		No	TOPMed gnomAD
rs1833919278	5	G>R		No	Ensembl
rs1281709143	6	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1833919377	7	H>N		No	TOPMed gnomAD
rs772691672	7	H>R		No	ExAC TOPMed gnomAD
rs1240083430	8	L>V		No	gnomAD
rs576845113	10	C>Y		No	1000Genomes ExAC TOPMed gnomAD
rs766902454	11	T>I		No	ExAC gnomAD
rs766902454	11	T>S		No	ExAC gnomAD
rs1478625806	12	S>P		No	TOPMed
rs1290121282	13	A>S		No	gnomAD
rs1290121282	13	A>T		No	gnomAD
rs1450740697	14	C>Y		No	gnomAD
rs1219100639	16	A>V		No	gnomAD
rs765298056	17	V>L		No	ExAC gnomAD
rs758533180	19	K>E		No	ExAC gnomAD
rs764014256	19	K>N		No	ExAC gnomAD
TCGA novel	20	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1440742188	21	G>V		No	gnomAD
rs767284734	22	R>Q		No	ExAC gnomAD
rs1348700868 COSM3741581	22	R>W	liver Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
rs545809443	23	A>G		No	1000Genomes ExAC gnomAD
rs945287117	23	A>T		No	Ensembl
rs1276826911 COSM3436123	24	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
rs1168895676	24	G>V		No	gnomAD
rs1833949756	28	N>S		No	gnomAD
rs1833949812	29	D>V		No	TOPMed
rs748995064	30	A>G		No	ExAC TOPMed gnomAD
rs748995064	30	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1335525552	31	G>S		No	TOPMed gnomAD
TCGA novel	32	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1400738130	34	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1208158945	35	T>S		No	Ensembl
rs1319782079	37	A>V		No	gnomAD
rs1340737341	38	V>F		No	gnomAD
rs747456551	40	A>D		No	ExAC TOPMed gnomAD
rs747456551	40	A>V		No	ExAC TOPMed gnomAD
rs377424149	45	E>A		No	ESP ExAC gnomAD
COSM916597	45	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs371168385	46	E>K		No	ESP ExAC TOPMed gnomAD
rs1833954008	47	I>F		No	Ensembl
TCGA novel	47	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1209608876	48	V>F		No	TOPMed gnomAD
rs1209608876	48	V>I		No	TOPMed gnomAD
rs1833954147	49	G>A		No	TOPMed
rs1421349866	50	L>F		No	gnomAD
COSM5958119 COSM5958118 rs780399435	51	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1833954280	52	A>P		No	TOPMed
rs1380273385	52	A>V		No	gnomAD
rs2131633749	55	S>C		No	Ensembl
rs749454461	58	R>G		No	ExAC gnomAD
rs893967656	60	I>T		No	TOPMed
rs774618877	62	N>D		No	ExAC gnomAD
rs1833954600 TCGA novel	63	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1458102102	63	T>I		No	gnomAD
rs1292670933	64	V>I		No	gnomAD
TCGA novel	68	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1427968618	70	I>L		No	TOPMed gnomAD
rs1833954772	71	L>P		No	TOPMed
rs1344094885	73	R>S		No	TOPMed gnomAD
rs1320804086	74	S>R		No	TOPMed
rs1833954986	74	S>T		No	TOPMed gnomAD
rs1834082892	76	S>N		No	gnomAD
rs763402880	78	P>T		No	ExAC TOPMed gnomAD
rs764455012	79	Q>*		No	ExAC gnomAD
rs751957518	80	A>T		No	ExAC gnomAD
rs1015031510	81	Q>E		No	Ensembl
rs375004850	84	I>M		No	ESP ExAC TOPMed gnomAD
rs374837716	85	A>E		No	ExAC TOPMed gnomAD
rs199859571	85	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
VAR_036347 rs374837716 COSM23329	85	A>V	Variant assessed as Somatic; MODERATE impact. breast a breast cancer sample; somatic mutation [NCI-TCGA, Cosmic, UniProt]	No	NCI-TCGA Cosmic cosmic curated UniProt ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs753738915	86	E>Q		No	ExAC gnomAD
COSM465481	88	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1415719311	89	C>F		No	TOPMed gnomAD
rs897268037	89	C>R		No	TOPMed gnomAD
rs1415719311	89	C>Y		No	TOPMed gnomAD
rs1834085083	91	V>A		No	Ensembl
rs768016540	91	V>I		No	ExAC gnomAD
rs768016540	91	V>L		No	ExAC gnomAD
rs773524564	92	I>T		No	ExAC TOPMed gnomAD
rs1834085240	94	K>N		No	TOPMed
rs1357397411	95	N>H		No	TOPMed gnomAD
COSM1347010 rs760011797	95	N>M	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs1261577294	99	R>*		No	TOPMed gnomAD
rs1261577294	99	R>G		No	TOPMed gnomAD
rs766422205	99	R>P		No	ExAC TOPMed gnomAD
rs766422205 COSM3414863	99	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs570960603	101	E>A		No	1000Genomes ExAC TOPMed gnomAD
rs201058008	102	I>L		No	1000Genomes ExAC TOPMed gnomAD
rs1044983161	102	I>T		No	TOPMed
rs201058008	102	I>V		No	1000Genomes ExAC TOPMed gnomAD
rs758140227	103	D>G		No	ExAC gnomAD
rs762136566	104	T>A		No	ExAC gnomAD
rs45567440	104	T>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs762136566	104	T>P		No	ExAC gnomAD
rs762136566	104	T>S		No	ExAC gnomAD
rs1834085827	105	G>R		No	TOPMed
rs372812746	106	E>K		No	ESP TOPMed
rs756876136	107	E>D		No	ExAC
rs1834085895	109	K>Q		No	Ensembl
COSM916599	110	F>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1834085923	110	F>I		No	TOPMed
rs750700184	111	V>I		No	Ensembl
rs745337056	112	N>K		No	ExAC TOPMed gnomAD
rs1391054423 COSM3436124	113	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1396526034	115	D>V		No	gnomAD
rs1834086137	117	A>T		No	gnomAD
rs111362845	118	R>G		No	Ensembl
rs375853738	118	R>T		No	ESP ExAC TOPMed gnomAD
rs2131640185	119	L>V		No	Ensembl
rs34106206	121	F>L		No	TOPMed
rs748692573	122	S>I		No	ExAC TOPMed gnomAD
rs748692573	122	S>N		No	ExAC TOPMed gnomAD
rs1451273008	124	M>V		No	TOPMed gnomAD
rs199812378	127	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1834093228	129	H>D		No	Ensembl
rs1834093258 TCGA novel	129	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
COSM427307	130	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1834093307	131	V>L		No	TOPMed gnomAD
rs569211037	134	S>A		No	1000Genomes ExAC TOPMed gnomAD
rs775563743	134	S>L		No	ExAC TOPMed gnomAD
rs1209810244	137	N>S		No	gnomAD
COSM1297122	138	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1255163101	138	D>V		No	gnomAD
rs1187003336	139	V>A		No	gnomAD
rs369169310	140	V>A		No	Ensembl
rs1834093756	141	I>S		No	Ensembl
COSM916600	142	T>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1261014357	144	P>L		No	gnomAD
rs751561981	146	D>H		No	ExAC gnomAD
rs1172123021	148	G>E		No	gnomAD
rs1434363003	148	G>R		No	gnomAD
rs1347291436	149	E>K		No	gnomAD
rs1554765917	151	Q>K		No	Ensembl
rs1564322061	151	Q>P		No	TOPMed
rs1564322061	151	Q>R		No	TOPMed
rs1432175348	153	N>K		No	TOPMed gnomAD
rs775839750 COSM4691340	153	N>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
TCGA novel	153	N>M	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs538018528	153	N>S		No	1000Genomes ExAC TOPMed gnomAD
rs538018528	153	N>T		No	1000Genomes ExAC TOPMed gnomAD
rs1288787537	153	N>Y		No	gnomAD
rs1564322071	155	L>V		No	Ensembl
TCGA novel	157	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1834106468	158	A>V		No	TOPMed
rs1400160436	160	R>S		No	TOPMed gnomAD
COSM916601	161	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs569279090	162	A>G		No	1000Genomes ExAC TOPMed gnomAD
rs1834106559	163	G>E		No	TOPMed gnomAD
rs1470644993	167	L>F		No	gnomAD
rs1834106586	167	L>S		No	TOPMed
rs570039143	168	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs538274140	168	R>Q		No	1000Genomes ExAC TOPMed gnomAD
rs1834106706	171	H>D		No	TOPMed
rs761810912	171	H>Q		No	ExAC TOPMed gnomAD
rs773045153	172	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs753596081	173	P>L		No	ExAC TOPMed gnomAD
rs766100141	173	P>S		No	ExAC gnomAD
rs1834106926	175	A>T		No	TOPMed
rs1834106947	176	A>V		No	Ensembl
rs1588812067	178	L>P		No	Ensembl
rs146276897	179	A>T		No	ESP ExAC TOPMed gnomAD
rs868767840	180	Y>H		No	TOPMed gnomAD
rs781611125	181	G>R		No	ExAC gnomAD
rs1588812086	182	I>T		No	TOPMed
rs1010658254	184	Q>P		No	TOPMed gnomAD
rs746230499	185	D>E		No	ExAC gnomAD
rs1834107349	187	P>A		No	TOPMed
rs969243456	188	T>A		No	TOPMed gnomAD
rs756517663	188	T>I		No	ExAC TOPMed gnomAD
rs756517663	188	T>N		No	ExAC TOPMed gnomAD
rs1438572501	190	K>Q		No	gnomAD
rs1834114571	192	N>S		No	gnomAD
rs1834114544	192	N>Y		No	Ensembl
rs1834114599	194	L>F		No	gnomAD
rs2131641432	194	L>S		No	Ensembl
rs1834114653	195	V>G		No	gnomAD
rs759232023	195	V>L		No	ExAC TOPMed gnomAD
rs759232023	195	V>M		No	ExAC TOPMed gnomAD
rs937206558	197	K>N		No	Ensembl
rs1395075979	199	G>E		No	gnomAD
rs757916209	200	G>A		No	ExAC TOPMed gnomAD
TCGA novel rs1834114780	201	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs750947867	203	L>F		No	ExAC TOPMed gnomAD
rs148447352	204	S>P		No	ESP TOPMed
rs895816793	205	L>P		No	Ensembl
rs1478973733	205	L>V		No	TOPMed gnomAD
rs1214121089	206	S>I		No	TOPMed gnomAD
TCGA novel	206	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM6065698	207	V>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs115374281	207	V>I		No	1000Genomes TOPMed gnomAD
rs115374281	207	V>L		No	1000Genomes TOPMed gnomAD
rs1211982962	208	M>T		No	gnomAD
rs780398993	208	M>V		No	ExAC gnomAD
rs187571986	209	E>*		No	1000Genomes
rs1834115178	210	V>F		No	Ensembl
rs768579487	212	S>C		No	Ensembl
rs1441086428	212	S>I		No	gnomAD
rs1195923809	214	I>T		No	TOPMed gnomAD
rs1834115256	214	I>V		No	TOPMed gnomAD
rs1834115308	215	Y>C		No	TOPMed
rs779070180	216	R>Q		No	ExAC TOPMed gnomAD
rs115861078	216	R>W		No	1000Genomes ExAC gnomAD
rs748227134	217	V>G		No	ExAC gnomAD
rs934274719 COSM916602	218	L>I	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
rs934274719	218	L>V		No	TOPMed
rs1436228681	220	T>A		No	TOPMed gnomAD
rs767628389	220	T>I		No	ExAC gnomAD
rs572405668	222	T>A		No	1000Genomes ExAC TOPMed gnomAD
rs770782468	222	T>I		No	ExAC TOPMed gnomAD
rs1374311500	223	D>A		No	Ensembl
rs1327023691	223	D>H		No	TOPMed gnomAD
rs1327023691	223	D>N		No	TOPMed gnomAD
rs1227728423	224	D>Y		No	TOPMed
rs776584789	226	I>V		No	ExAC TOPMed gnomAD
rs1373419445	227	G>S		No	TOPMed gnomAD
rs1279940684	229	A>P		No	gnomAD
rs1054729671	230	H>P		No	TOPMed gnomAD
rs1834115973	232	T>A		No	TOPMed
COSM916603	233	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs759310450	234	T>I		No	ExAC TOPMed gnomAD
rs1198625500	236	A>G		No	Ensembl
rs1198625500	236	A>V		No	Ensembl
rs1834116123	237	Q>*		No	TOPMed
rs887168557	237	Q>H		No	gnomAD
rs1834116206	238	Y>C		No	TOPMed
rs769486646	238	Y>H		No	ExAC gnomAD
rs1834116259	240	A>V		No	Ensembl
rs762473100	244	Q>R		No	ExAC gnomAD
rs914856890	245	R>K		No	TOPMed gnomAD
rs1239053763	246	S>A		No	TOPMed
rs1183660133	246	S>Y		No	TOPMed gnomAD
rs974618055	247	F>L		No	Ensembl
rs1364127900	247	F>S		No	gnomAD
rs1834128237	248	K>T		No	gnomAD
rs1834128268	249	H>P		No	Ensembl
rs142604812	250	D>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs762514683	251	V>G		No	ExAC
rs1420018322	251	V>M		No	gnomAD
rs987270661	252	R>K		No	Ensembl
rs987270661	252	R>T		No	Ensembl
rs768093805	253	G>E		No	ExAC
rs912758788	254	N>D		No	gnomAD
rs150571516	254	N>K		No	ESP ExAC TOPMed gnomAD
rs1588813410	254	N>S		No	Ensembl
rs199663411	255	A>E		No	ExAC TOPMed gnomAD
rs199663411	255	A>G		No	ExAC TOPMed gnomAD
COSM212180 rs199663411	255	A>V	breast [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs201201285	256	R>*		No	ExAC TOPMed gnomAD
rs201201285	256	R>G		No	ExAC TOPMed gnomAD
TCGA novel	259	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1329846460	260	K>R		No	gnomAD
rs758708366	262	T>M		No	ExAC TOPMed gnomAD
rs1295653434	263	N>D		No	gnomAD
rs1399912641	263	N>S		No	TOPMed gnomAD
rs1399912641	263	N>T		No	TOPMed gnomAD
rs751690069	264	S>G		No	ExAC TOPMed gnomAD
rs1264375330 COSM1210062	265	A>T	large_intestine [Cosmic]	No	cosmic curated TOPMed gnomAD
rs781256659	265	A>V		No	ExAC TOPMed gnomAD
rs368667443	266	E>K		No	ESP ExAC TOPMed gnomAD
rs114492585	267	V>A		No	1000Genomes ExAC TOPMed gnomAD
rs561618316	268	A>G		No	1000Genomes ExAC TOPMed gnomAD
rs561618316	268	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs372967532	270	H>R		No	ESP ExAC TOPMed gnomAD
rs1475505276	271	S>A		No	gnomAD
rs1475505276	271	S>P		No	gnomAD
COSM3985516	271	S>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	271	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1366766737	274	T>A		No	TOPMed gnomAD
rs375798936	274	T>I		No	ESP ExAC TOPMed gnomAD
rs375798936	274	T>S		No	ESP ExAC TOPMed gnomAD
rs1366766737	274	T>S		No	TOPMed gnomAD
rs773585592	275	L>M		No	ExAC gnomAD
COSM3436126	275	L>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1487539694	276	G>A		No	TOPMed
rs1408319743	277	S>R		No	gnomAD
rs1356608516	278	A>D		No	gnomAD
rs1356608516	278	A>G		No	gnomAD
rs1246273120	279	N>D		No	TOPMed gnomAD
rs147657350	279	N>S		No	ESP ExAC TOPMed gnomAD
rs147657350	279	N>T		No	ESP ExAC TOPMed gnomAD
rs1043320114	281	F>L		No	TOPMed
rs1311269238	283	D>E		No	gnomAD
rs1319390151	284	S>L		No	gnomAD
TCGA novel	286	Y>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM1347011 rs1251459753	286	Y>C	large_intestine [Cosmic]	No	cosmic curated gnomAD
rs775705611	288	G>A		No	ExAC TOPMed gnomAD
rs763481625	289	Q>H		No	ExAC TOPMed gnomAD
rs1218329351	291	F>C		No	TOPMed
rs1218329351	291	F>S		No	TOPMed
rs1485897518	293	C>S		No	gnomAD
rs764384875	293	C>Y		No	ExAC gnomAD
rs1564323339	294	N>H		No	gnomAD
rs1280630534	294	N>S		No	TOPMed
rs550460159	295	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs545262041	297	R>T		No	Ensembl
rs1832687838	299	R>K		No	TOPMed gnomAD
rs1832687886	301	E>D		No	gnomAD
rs772613538	301	E>K		No	ExAC gnomAD
rs770200908	303	L>F		No	ExAC gnomAD
rs776109779	306	P>A		No	ExAC TOPMed gnomAD
rs1438471420	306	P>Q		No	TOPMed gnomAD
rs776109779	306	P>S		No	ExAC TOPMed gnomAD
rs1832688104	307	L>F		No	Ensembl
rs1174415474	308	F>L		No	gnomAD
rs904011216	309	N>S		No	TOPMed gnomAD
rs764579068	311	C>F		No	ExAC TOPMed gnomAD
rs764579068	311	C>Y		No	ExAC TOPMed gnomAD
rs1214121307	315	I>M		No	gnomAD
rs762137167	315	I>T		No	ExAC gnomAD
rs774645059	315	I>V		No	ExAC gnomAD
rs1832688300	316	R>S		No	TOPMed
rs1387243531	317	G>R		No	TOPMed gnomAD
rs1235132938	318	L>R		No	TOPMed gnomAD
rs1338505107	319	L>F		No	TOPMed gnomAD
rs2131642746	322	N>S		No	Ensembl
rs1832689509	324	F>L		No	TOPMed
rs750461846	325	T>I		No	ExAC gnomAD
rs750461846	325	T>R		No	ExAC gnomAD
rs116239900	327	D>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs116239900	327	D>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs766204683	327	D>Y		No	ExAC gnomAD
rs1382851495	328	D>A		No	TOPMed gnomAD
rs2131642762	329	I>M		No	Ensembl
rs757973634	329	I>T		No	ExAC gnomAD
rs752290261	329	I>V		No	ExAC gnomAD
rs777550713	330	N>K		No	ExAC TOPMed gnomAD
rs1050249433	331	K>R		No	TOPMed gnomAD
rs751249348	332	V>I		No	ExAC TOPMed gnomAD
rs1832812762	333	V>I		No	Ensembl
rs745425981	335	C>S		No	ExAC TOPMed gnomAD
rs745425981	335	C>Y		No	ExAC TOPMed gnomAD
rs1564327042	336	G>A		No	gnomAD
rs1355921791	339	S>F		No	gnomAD
rs769277323 COSM1603243	340	R>*	Variant assessed as Somatic; HIGH impact. liver [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs769277323	340	R>G		No	ExAC TOPMed gnomAD
rs996049356 COSM916605	340	R>Q	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
rs779599589	342	P>Q		No	ExAC TOPMed gnomAD
rs779599589	342	P>R		No	ExAC TOPMed gnomAD
rs1307205561	342	P>S		No	gnomAD
rs748438676	343	K>N		No	ExAC gnomAD
rs1272895518	343	K>R		No	TOPMed gnomAD
rs1272895518	343	K>T		No	TOPMed gnomAD
TCGA novel	344	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs748373740	345	Q>*		No	Ensembl
COSM1474514	345	Q>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	345	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1832813738	346	Q>L		No	TOPMed
rs1355708576	347	L>V		No	TOPMed gnomAD
rs1832813809	348	I>T		No	TOPMed gnomAD
rs1832813862	349	K>R		No	Ensembl
TCGA novel	350	D>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1275302626	350	D>G		No	gnomAD
rs1343161885	351	L>F		No	TOPMed gnomAD
rs1343161885	351	L>V		No	TOPMed gnomAD
rs1486881247	352	F>C		No	gnomAD
rs1832814006	352	F>L		No	gnomAD
rs773263888	352	F>L		No	ExAC gnomAD
rs760955481	353	P>A		No	ExAC TOPMed gnomAD
rs770859059	353	P>L		No	ExAC gnomAD
rs1472138976	354	A>D		No	gnomAD
rs1271694851	354	A>P		No	TOPMed
rs776681220	355	V>A		No	ExAC gnomAD
rs1200891995	356	E>K		No	TOPMed
rs1832814195	358	L>V		No	TOPMed
rs1430035996	359	N>H		No	gnomAD
rs2131649765	359	N>S		No	Ensembl
rs1249336217	361	I>M		No	TOPMed
rs1368442928	361	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1832814330	363	P>R		No	Ensembl
rs1436417127	363	P>S		No	gnomAD
rs1334735270	364	D>N		No	gnomAD
rs376813616	369	I>T		No	ESP ExAC TOPMed gnomAD
rs1832814431	369	I>V		No	Ensembl
rs1366157735	371	A>T		No	gnomAD
rs370665194	372	A>S		No	ESP ExAC TOPMed gnomAD
rs762612115	373	I>T		No	ExAC TOPMed gnomAD
rs953104203	373	I>V		No	TOPMed
rs890396916	375	A>S		No	TOPMed gnomAD
rs890396916	375	A>T		No	TOPMed gnomAD
rs2131649814	376	G>R		No	Ensembl
rs1278463418	379	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1207364404	380	G>W		No	TOPMed gnomAD
rs1249307493	381	K>R		No	TOPMed gnomAD
TCGA novel	384	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1020598375	386	V>L		No	TOPMed gnomAD
rs1455369927	387	E>K		No	gnomAD
TCGA novel	388	D>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1172961831	388	D>G		No	gnomAD
rs1172961831	388	D>V		No	gnomAD
rs1408033023	389	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs149016758	391	M>T		No	ESP ExAC TOPMed gnomAD
rs755731523	391	M>V		No	ExAC gnomAD
rs1400506292	392	I>M		No	TOPMed
rs1832815271	393	E>A		No	gnomAD
rs1373484467	394	C>F		No	TOPMed gnomAD
rs1832815401	397	R>K		No	TOPMed gnomAD
rs201767789	398	D>E		No	ESP ExAC TOPMed gnomAD
TCGA novel	400	L>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs747392032	400	L>S		No	ExAC gnomAD
rs1432023924	401	V>D		No	TOPMed
rs1269380616	401	V>I		No	gnomAD
rs751141664	403	G>A		No	ExAC TOPMed gnomAD
rs1296074019	403	G>S		No	TOPMed
rs751141664	403	G>V		No	ExAC TOPMed gnomAD
rs187027693	404	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs187027693	404	V>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs757669772	406	E>K		No	ExAC gnomAD
rs757669772	406	E>Q		No	ExAC gnomAD
rs1832819752	407	S>A		No	gnomAD
rs1177115994	407	S>L		No	TOPMed gnomAD
rs781346954	410	S>N		No	ExAC TOPMed gnomAD
rs781346954	410	S>T		No	ExAC TOPMed gnomAD
rs1388849825	413	T>I		No	gnomAD
rs369198567	414	V>L		No	ESP ExAC TOPMed gnomAD
COSM916606	418	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1832819931	419	G>V		No	TOPMed
rs1408509193	420	T>S		No	gnomAD
rs1481042460	422	L>S		No	TOPMed
rs768603582	425	R>G		No	ExAC gnomAD
rs369860646	425	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs369860646	425	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs374572266	426	R>S		No	ESP ExAC TOPMed gnomAD
rs1832820151	427	Q>P		No	gnomAD
rs200075818	428	H>N		No	1000Genomes ExAC gnomAD
rs1264272761	429	T>I		No	TOPMed gnomAD
rs1179904191	432	A>V		No	gnomAD
rs1832820383	433	P>R		No	Ensembl
rs759009106	434	G>R		No	ExAC TOPMed gnomAD
rs764642871	435	S>I		No	ExAC TOPMed gnomAD
TCGA novel	436	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs377330806	436	I>V		No	ESP TOPMed gnomAD
rs752031347	437	S>P		No	ExAC gnomAD
rs563548129	438	S>P		No	1000Genomes
rs1832820544	439	V>M		No	Ensembl
rs1027944219	440	C>F		No	TOPMed gnomAD
rs1027944219	440	C>S		No	TOPMed gnomAD
TCGA novel	444	Y>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1311027869	444	Y>C		No	Ensembl
rs757580253	445	E>Q		No	ExAC gnomAD
rs750590411	446	S>F		No	ExAC gnomAD
rs1832820782	446	S>T		No	TOPMed
COSM3790649 rs1305107822	447	D>H	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1396049993	448	G>R		No	gnomAD
rs780176240	448	G>V		No	ExAC gnomAD
rs1832820935	449	K>R		No	TOPMed
rs879001514	450	N>Y		No	Ensembl
rs767819289	451	S>C		No	Ensembl
rs985901985	452	A>T		No	Ensembl
rs1338231869	453	K>T		No	TOPMed gnomAD
rs750958050	455	E>D		No	ExAC TOPMed gnomAD
rs201930086	456	T>A		No	ExAC TOPMed gnomAD
rs1832821127	457	K>E		No	TOPMed
rs763846408	457	K>N		No	Ensembl
rs778868386	458	F>S		No	ExAC gnomAD
rs944591423	459	A>G		No	1000Genomes
COSM916607	459	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs944591423 COSM916608	459	A>V	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes NCI-TCGA
rs370514399	462	V>I		No	ESP ExAC TOPMed gnomAD
rs1373988657	463	L>F		No	TOPMed
rs1373988657	463	L>V		No	TOPMed
rs1281307886	464	Q>H		No	TOPMed gnomAD
rs373637596	466	L>S		No	ESP TOPMed
rs776308282	467	D>H		No	ExAC gnomAD
rs2131654587	468	K>*		No	Ensembl
COSM3806831	470	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1439989042	470	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs1588823428	471	N>S		No	Ensembl
rs769292701 COSM181509	474	R>C	Variant assessed as Somatic; MODERATE impact. large_intestine breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1386071128	474	R>H		No	TOPMed gnomAD
rs918261015	475	D>V		No	TOPMed gnomAD
rs2131654608	475	D>Y		No	Ensembl
rs762485831	478	A>V		No	ExAC gnomAD
rs1229032792	479	V>G		No	gnomAD
rs1267624520	480	L>V		No	gnomAD
rs1420151288	481	T>I		No	TOPMed
rs1588823457	483	K>E		No	Ensembl
rs1588823457	483	K>Q		No	Ensembl
rs767985534	484	R>T		No	ExAC gnomAD
rs1422915338	485	D>N		No	gnomAD
rs527307117	486	G>A		No	1000Genomes ExAC gnomAD
COSM427308	486	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1372160347	487	S>C		No	gnomAD
rs1230295005	487	S>T		No	TOPMed
rs188294142	489	H>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1003029235	490	V>M		No	TOPMed gnomAD
rs1352701159	491	T>A		No	gnomAD
TCGA novel	494	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs773638875	495	Q>E		No	ExAC TOPMed gnomAD
rs1832854822	495	Q>H		No	Ensembl
rs773638875	495	Q>K		No	ExAC TOPMed gnomAD
rs1284886387	496	E>A		No	gnomAD
rs1441743093	496	E>D		No	TOPMed gnomAD
rs567192550	498	G>R		No	1000Genomes ExAC gnomAD
rs766966072	500	C>R		No	ExAC gnomAD
rs2131655813	501	E>G		No	Ensembl
rs1832854926	503	I>M		No	TOPMed gnomAD
rs1351757445	504	S>C		No	TOPMed
rs1351757445	504	S>F		No	TOPMed
TCGA novel	505	I>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1832855015	505	I>T		No	Ensembl
rs141304912	505	I>V		No	1000Genomes ExAC gnomAD
rs759985609	506	E>V		No	ExAC TOPMed gnomAD
rs1443838300	507	I>T		No	TOPMed gnomAD
rs1832855103	507	I>V		No	TOPMed

No associated diseases with Q0VDF9

3 regional properties for Q0VDF9

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	49 - 350	IPR000719
conserved_site	Mitogen-activated protein (MAP) kinase, conserved site	84 - 187	IPR003527
binding_site	Protein kinase, ATP binding site	55 - 79	IPR017441

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ribosome	An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction
ATP-dependent protein folding chaperone	Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
heat shock protein binding	Binding to a heat shock protein, a protein synthesized or activated in response to heat shock.
protein folding chaperone	Binding to a protein or a protein-containing complex to assist the protein folding process.

3 GO annotations of biological process

Name	Definition
'de novo' cotranslational protein folding	The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.
chaperone cofactor-dependent protein refolding	The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.
protein refolding	The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.

57 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P19120	HSPA8	Heat shock cognate 71 kDa protein	Bos taurus (Bovine)	SS
Q27975	HSPA1A	Heat shock 70 kDa protein 1A	Bos taurus (Bovine)	SS
P0CB32	HSPA1L	Heat shock 70 kDa protein 1-like	Bos taurus (Bovine)	SS
Q2YDD0	HSPA14	Heat shock 70 kDa protein 14	Bos taurus (Bovine)	SS
O73885	HSPA8	Heat shock cognate 71 kDa protein	Gallus gallus (Chicken)	SS
P08106		Heat shock 70 kDa protein	Gallus gallus (Chicken)	SS
E1C2P3	HSPA14	Heat shock 70 kDa protein 14	Gallus gallus (Chicken)	SS
P77319	hscC	Chaperone protein HscC	Escherichia coli (strain K12)	PR
P0A6Y8	dnaK	Chaperone protein DnaK	Escherichia coli (strain K12)	SS
P29843	Hsc70-1	Heat shock 70 kDa protein cognate 1	Drosophila melanogaster (Fruit fly)	SS
P02825	Hsp70Ab	Major heat shock 70 kDa protein Ab	Drosophila melanogaster (Fruit fly)	SS
P82910	Hsp70Aa	Major heat shock 70 kDa protein Aa	Drosophila melanogaster (Fruit fly)	SS
Q9VG58	Hsp70Bbb	Major heat shock 70 kDa protein Bbb	Drosophila melanogaster (Fruit fly)	SS
Q9BIR7	Hsp70Bc	Major heat shock 70 kDa protein Bc	Drosophila melanogaster (Fruit fly)	SS
Q8INI8	Hsp70Ba	Major heat shock 70 kDa protein Ba	Drosophila melanogaster (Fruit fly)	SS
Q9BIS2	Hsp70Bb	Major heat shock 70 kDa protein Bb	Drosophila melanogaster (Fruit fly)	SS
P11146	Hsc70-2	Heat shock 70 kDa protein cognate 2	Drosophila melanogaster (Fruit fly)	SS
P11147	Hsc70-4	Heat shock 70 kDa protein cognate 4	Drosophila melanogaster (Fruit fly)	SS
O97125	Hsp68	Heat shock protein 68	Drosophila melanogaster (Fruit fly)	SS
Q96MM6	HSPA12B	Heat shock 70 kDa protein 12B	Homo sapiens (Human)	PR
O43301	HSPA12A	Heat shock 70 kDa protein 12A	Homo sapiens (Human)	PR
P0DMV9	HSPA1B	Heat shock 70 kDa protein 1B	Homo sapiens (Human)	SS
P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	Homo sapiens (Human)	SS
P17066	HSPA6	Heat shock 70 kDa protein 6	Homo sapiens (Human)	SS
P34931	HSPA1L	Heat shock 70 kDa protein 1-like	Homo sapiens (Human)	SS
P54652	HSPA2	Heat shock-related 70 kDa protein 2	Homo sapiens (Human)	SS
P38646	HSPA9	Stress-70 protein, mitochondrial	Homo sapiens (Human)	SS
P11021	HSPA5	Endoplasmic reticulum chaperone BiP	Homo sapiens (Human)	SS
P11142	HSPA8	Heat shock cognate 71 kDa protein	Homo sapiens (Human)	EV
P48741	HSPA7	Putative heat shock 70 kDa protein 7	Homo sapiens (Human)	SS
P11143	HSP70	Heat shock 70 kDa protein	Zea mays (Maize)	SS
P16627	Hspa1l	Heat shock 70 kDa protein 1-like	Mus musculus (Mouse)	SS
P63017	Hspa8	Heat shock cognate 71 kDa protein	Mus musculus (Mouse)	SS
Q8K0U4	Hspa12a	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	PR
P17156	Hspa2	Heat shock-related 70 kDa protein 2	Mus musculus (Mouse)	SS
Q61696	Hspa1a	Heat shock 70 kDa protein 1A	Mus musculus (Mouse)	SS
Q9CZJ2	Hspa12b	Heat shock 70 kDa protein 12B	Mus musculus (Mouse)	PR
P17879	Hspa1b	Heat shock 70 kDa protein 1B	Mus musculus (Mouse)	SS
Q99M31	Hspa14	Heat shock 70 kDa protein 14	Mus musculus (Mouse)	SS
Q6S4N2	HSPA1B	Heat shock 70 kDa protein 1B	Sus scrofa (Pig)	SS
P14659	Hspa2	Heat shock-related 70 kDa protein 2	Rattus norvegicus (Rat)	SS
P0DMW1	Hspa1b	Heat shock 70 kDa protein 1B	Rattus norvegicus (Rat)	SS
P0DMW0	Hspa1a	Heat shock 70 kDa protein 1A	Rattus norvegicus (Rat)	SS
P63018	Hspa8	Heat shock cognate 71 kDa protein	Rattus norvegicus (Rat)	SS
P55063	Hspa1l	Heat shock 70 kDa protein 1-like	Rattus norvegicus (Rat)	SS
P09446	hsp-1	Heat shock protein hsp-1	Caenorhabditis elegans	SS
P26413	HSP70	Heat shock 70 kDa protein	Glycine max (Soybean) (Glycine hispida)	SS
Q9S9N1	HSP70-5	Heat shock 70 kDa protein 5	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9C7X7	HSP70-18	Heat shock 70 kDa protein 18	Arabidopsis thaliana (Mouse-ear cress)	SS
O65719	HSP70-3	Heat shock 70 kDa protein 3	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9LHA8	HSP70-4	Heat shock 70 kDa protein 4	Arabidopsis thaliana (Mouse-ear cress)	SS
P22954	HSP70-2	Heat shock 70 kDa protein 2	Arabidopsis thaliana (Mouse-ear cress)	SS
P22953	HSP70-1	Heat shock 70 kDa protein 1	Arabidopsis thaliana (Mouse-ear cress)	SS
P24629	HSC-I	Heat shock cognate 70 kDa protein 1	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	SS
P27322	HSC-2	Heat shock cognate 70 kDa protein 2	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	SS
Q90473	hspa8	Heat shock cognate 71 kDa protein	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q5RGE6	hspa14	Heat shock 70 kDa protein 14	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MAAIGVHLGC	TSACVAVYKD	GRAGVVANDA	GDRVTPAVVA	YSENEEIVGL	AAKQSRIRNI
70	80	90	100	110	120
SNTVMKVKQI	LGRSSSDPQA	QKYIAESKCL	VIEKNGKLRY	EIDTGEETKF	VNPEDVARLI
130	140	150	160	170	180
FSKMKETAHS	VLGSDANDVV	ITVPFDFGEK	QKNALGEAAR	AAGFNVLRLI	HEPSAALLAY
190	200	210	220	230	240
GIGQDSPTGK	SNILVFKLGG	TSLSLSVMEV	NSGIYRVLST	NTDDNIGGAH	FTETLAQYLA
250	260	270	280	290	300
SEFQRSFKHD	VRGNARAMMK	LTNSAEVAKH	SLSTLGSANC	FLDSLYEGQD	FDCNVSRARF
310	320	330	340	350	360
ELLCSPLFNK	CIEAIRGLLD	QNGFTADDIN	KVVLCGGSSR	IPKLQQLIKD	LFPAVELLNS
370	380	390	400	410	420
IPPDEVIPIG	AAIEAGILIG	KENLLVEDSL	MIECSARDIL	VKGVDESGAS	RFTVLFPSGT
430	440	450	460	470	480
PLPARRQHTL	QAPGSISSVC	LELYESDGKN	SAKEETKFAQ	VVLQDLDKKE	NGLRDILAVL
490	500
TMKRDGSLHV	TCTDQETGKC	EAISIEIAS