Q0VD48
SS
Gene name |
VPS4B |
Protein name |
Vacuolar protein sorting-associated protein 4B |
Names |
EC 3.6.4.6 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:539357 |
EC number |
3.6.4.6: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
VPS4 proteins are AAA+ ATPases required to form multivesicular bodies, release viral particles, and complete cytokinesis. VPS4 proteins act by disassembling ESCRT-III heteropolymers during or after their proposed function in membrane scission. Deleting the N-terminal MIT domain and adjacent linker from VPS4A increases both basal and liposome-enhanced ATPase activity, indicating that these elements play a role in autoinhibiting VPS4A until it encounters ESCRT-III polymers. The interactions between acidic ESCRT-III residues and sequences in VPS4A, in particular in the linker connecting the MIT and AAA+ domains, are involved in regulating the intrinsic autoinhibition of the enzyme.
Autoinhibitory domains (AIDs)
Target domain |
166-302 (AAA+ domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0VD48
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0VD48-F1 | Predicted | AlphaFoldDB |
54 variants for Q0VD48
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs476001448 | 2 | A>G | No | EVA | |
| rs443283898 | 66 | L>H | No | EVA | |
| rs476242920 | 73 | K>Q | No | EVA | |
| rs451145094 | 76 | L>R | No | EVA | |
| rs523633186 | 134 | S>G | No | EVA | |
| rs482144684 | 138 | G>V | No | EVA | |
| rs42053543 | 150 | V>G | No | EVA | |
| rs1117946508 | 153 | P>S | No | EVA | |
| rs481676829 | 165 | T>K | No | EVA | |
| rs463121323 | 167 | W>C | No | EVA | |
| rs441296867 | 233 | I>S | No | EVA | |
| rs456304020 | 236 | I>N | No | EVA | |
| rs437784129 | 258 | F>L | No | EVA | |
| rs458605943 | 265 | V>F | No | EVA | |
| rs440146012 | 269 | N>T | No | EVA | |
| rs472946963 | 270 | D>G | No | EVA | |
| rs463447597 | 293 | E>K | No | EVA | |
| rs438471187 | 294 | K>* | No | EVA | |
| rs471401038 | 296 | I>S | No | EVA | |
| rs459306624 | 298 | I>N | No | EVA | |
| rs441564820 | 307 | A>E | No | EVA | |
| rs474492640 | 311 | K>T | No | EVA | |
| rs455951494 | 313 | H>N | No | EVA | |
| rs42053545 | 318 | Q>H | No | EVA | |
| rs516864929 | 322 | T>M | No | EVA | |
| rs476784824 | 323 | E>V | No | EVA | |
| rs433203946 | 333 | T>A | No | EVA | |
| rs447569873 | 340 | D>Y | No | EVA | |
| rs449117430 | 356 | V>M | No | EVA | |
| rs482081145 | 364 | K>N | No | EVA | |
| rs469469278 | 365 | V>F | No | EVA | |
| rs450975713 | 372 | D>E | No | EVA | |
| rs458850596 | 374 | N>S | No | EVA | |
| rs439508789 | 375 | N>I | No | EVA | |
| rs478928839 | 378 | D>N | No | EVA | |
| rs460388650 | 380 | L>Q | No | EVA | |
| rs441757995 | 385 | S>A | No | EVA | |
| rs474556379 | 388 | D>V | No | EVA | |
| rs444062629 | 389 | P>L | No | EVA | |
| rs451987256 | 393 | E>A | No | EVA | |
| rs467228138 | 396 | W>* | No | EVA | |
| rs434307834 | 396 | W>G | No | EVA | |
| rs434307834 | 396 | W>R | No | EVA | |
| rs455171438 | 397 | M>L | No | EVA | |
| rs436592684 | 397 | M>R | No | EVA | |
| rs469537087 | 399 | V>F | No | EVA | |
| rs451037069 | 401 | G>A | No | EVA | |
| rs446791328 | 405 | L>F | No | EVA | |
| rs478996110 | 409 | V>A | No | EVA | |
| rs460399344 | 411 | M>L | No | EVA | |
| rs458248767 | 412 | S>A | No | EVA | |
| rs439649903 | 413 | D>G | No | EVA | |
| rs517538651 | 413 | D>N | No | EVA | |
| rs479071640 | 444 | G>D | No | EVA |
No associated diseases with Q0VD48
7 regional properties for Q0VD48
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 166 - 302 | IPR003593 |
| domain | ATPase, AAA-type, core | 170 - 300 | IPR003959 |
| conserved_site | ATPase, AAA-type, conserved site | 272 - 291 | IPR003960 |
| domain | MIT domain | 4 - 82 | IPR007330 |
| domain | Spastin/Vps4, C-terminal | 381 - 441 | IPR015415 |
| domain | AAA ATPase, AAA+ lid domain | 324 - 362 | IPR041569 |
| domain | Vacuolar protein sorting-associated protein 4, MIT domain | 7 - 81 | IPR045253 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.6 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| endosomal transport | The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vacuole organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P52917 | VPS4 | Vacuolar protein sorting-associated protein 4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9UN37 | VPS4A | Vacuolar protein sorting-associated protein 4A | Homo sapiens (Human) | EV |
| O75351 | VPS4B | Vacuolar protein sorting-associated protein 4B | Homo sapiens (Human) | PR |
| Q8VEJ9 | Vps4a | Vacuolar protein sorting-associated protein 4A | Mus musculus (Mouse) | PR |
| P46467 | Vps4b | Vacuolar protein sorting-associated protein 4B | Mus musculus (Mouse) | PR |
| Q793F9 | Vps4a | Vacuolar protein sorting-associated protein 4A | Rattus norvegicus (Rat) | PR |
| D0FH76 | VPS4 | Vacuolar protein sorting-associated protein 4 | Bombyx mori (Silk moth) | SS |
| Q9ZNT0 | SKD1 | Protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASTPTNLQK | AIDLASKAAQ | EDKAGNYEEA | LQLYQHAVQY | FLHVVKYEAQ | GDKAKQSIRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KCTEYLDRAE | KLKEYLKKRE | KKPQKPVKEG | QPAPADEKGN | DSDGEGESDD | PEKKKLQNQL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QGAIVIERPN | VKWSDVAGLE | GAKEALKEAV | ILPIKFPHLF | TGKRTPWRGI | LLFGPPGTGK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SYLAKAVATE | ANNSTFFSIS | SSDLVSKWLG | ESEKLVKNLF | QLARENKPSI | IFIDEIDSLC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GSRSENESEA | ARRIKTEFLV | QMQGVGVDND | GILVLGATNI | PWVLDSAIRR | RFEKRIYIPL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PEAHARAAMF | KLHLGTTQNS | LTEADFRDLG | KKTEGYSGAD | ISIIVRDALM | QPVRKVQSAT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HFKKVRGPSR | ADPNNIVDDL | LTPCSPGDPG | AIEMTWMDVP | GDKLLEPVVC | MSDMLRSLSS |
| 430 | 440 | ||||
| TKPTVNEHDL | LKLKKFTEDF | GQEG |