Q0VC65
Gene name |
ETV6 |
Protein name |
Transcription factor ETV6 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:504512 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
340-420 (ETS domain) |
Relief mechanism |
Partner binding, Others |
Assay |
|
Accessory elements
No accessory elements
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Green SM et al. (2010) "DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association", The Journal of biological chemistry, 285, 18496-504
- Coyne HJ 3rd et al. (2012) "Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain", Journal of molecular biology, 421, 67-84
Autoinhibited structure
Activated structure
1 structures for Q0VC65
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0VC65-F1 | Predicted | AlphaFoldDB |
70 variants for Q0VC65
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs462870232 | 12 | Q>H | No | EVA | |
| rs453954157 | 20 | P>R | No | EVA | |
| rs433746001 | 25 | P>S | No | EVA | |
| rs454815692 | 27 | Y>* | No | EVA | |
| rs474939951 | 27 | Y>S | No | EVA | |
| rs437837928 | 36 | P>S | No | EVA | |
| rs469010344 | 52 | A>S | No | EVA | |
| rs800695167 | 85 | N>S | No | EVA | |
| rs435363868 | 135 | H>N | No | EVA | |
| rs384092928 | 139 | S>T | No | EVA | |
| rs457634680 | 159 | Q>H | No | EVA | |
| rs440780250 | 162 | S>P | No | EVA | |
| rs479876246 | 170 | H>P | No | EVA | |
| rs443127452 | 172 | N>H | No | EVA | |
| rs474395366 | 172 | N>T | No | EVA | |
| rs443127452 | 172 | N>Y | No | EVA | |
| rs457569810 | 177 | E>G | No | EVA | |
| rs443670056 | 178 | L>R | No | EVA | |
| rs471933702 | 180 | H>P | No | EVA | |
| rs471933702 | 180 | H>R | No | EVA | |
| rs451683438 | 189 | N>T | No | EVA | |
| rs434776161 | 190 | H>P | No | EVA | |
| rs472633210 | 193 | S>A | No | EVA | |
| rs449888949 | 195 | D>A | No | EVA | |
| rs469943777 | 195 | D>H | No | EVA | |
| rs447153906 | 201 | L>P | No | EVA | |
| rs478406792 | 203 | S>A | No | EVA | |
| rs478406792 | 203 | S>P | No | EVA | |
| rs461616563 | 205 | L>R | No | EVA | |
| rs480976506 | 208 | M>T | No | EVA | |
| rs463891717 | 209 | I>T | No | EVA | |
| rs443829765 | 212 | L>P | No | EVA | |
| rs458228831 | 233 | Y>S | No | EVA | |
| rs441382717 | 235 | L>Q | No | EVA | |
| rs136851975 | 240 | M>R | No | EVA | |
| rs455756592 | 241 | E>D | No | EVA | |
| rs472571641 | 241 | E>G | No | EVA | |
| rs135750641 | 242 | N>T | No | EVA | |
| rs435450311 | 243 | N>S | No | EVA | |
| rs476559026 | 245 | C>R | No | EVA | |
| rs432969826 | 248 | S>* | No | EVA | |
| rs464238629 | 249 | S>P | No | EVA | |
| rs482583757 | 255 | P>L | No | EVA | |
| rs447291298 | 261 | E>K | No | EVA | |
| rs433683349 | 269 | M>I | No | EVA | |
| rs467980949 | 275 | H>P | No | EVA | |
| rs448082247 | 280 | N>S | No | EVA | |
| rs448082247 | 280 | N>T | No | EVA | |
| rs480938735 | 283 | H>L | No | EVA | |
| rs480938735 | 283 | H>P | No | EVA | |
| rs464067448 | 285 | V>G | No | EVA | |
| rs478444469 | 292 | L>P | No | EVA | |
| rs458365079 | 294 | E>K | No | EVA | |
| rs715755622 | 295 | D>E | No | EVA | |
| rs472708473 | 317 | H>Y | No | EVA | |
| rs462106385 | 321 | S>P | No | EVA | |
| rs442016503 | 322 | V>G | No | EVA | |
| rs476465762 | 326 | E>Q | No | EVA | |
| rs456412120 | 327 | E>G | No | EVA | |
| rs439525462 | 328 | H>P | No | EVA | |
| rs470586778 | 330 | V>G | No | EVA | |
| rs453804151 | 332 | I>L | No | EVA | |
| rs433620017 | 333 | G>R | No | EVA | |
| rs468117909 | 335 | I>T | No | EVA | |
| rs137100088 | 351 | D>A | No | EVA | |
| rs464816339 | 380 | W>R | No | EVA | |
| rs434030559 | 421 | K>N | No | EVA | |
| rs468510442 | 436 | H>P | No | EVA | |
| rs454922437 | 443 | D>E | No | EVA | |
| rs469237855 | 452 | C>G | No | EVA |
No associated diseases with Q0VC65
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| hematopoietic stem cell proliferation | The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58DT0 | ELF5 | ETS-related transcription factor Elf-5 | Bos taurus (Bovine) | SS |
| Q2KIC2 | ETV1 | ETS translocation variant 1 | Bos taurus (Bovine) | SS |
| A1A4L6 | ETS2 | Protein C-ets-2 | Bos taurus (Bovine) | SS |
| P32519 | ELF1 | ETS-related transcription factor Elf-1 | Homo sapiens (Human) | PR |
| Q9UKW6 | ELF5 | ETS-related transcription factor Elf-5 | Homo sapiens (Human) | EV |
| Q99607 | ELF4 | ETS-related transcription factor Elf-4 | Homo sapiens (Human) | PR |
| Q9Y603 | ETV7 | Transcription factor ETV7 | Homo sapiens (Human) | SS |
| P78545 | ELF3 | ETS-related transcription factor Elf-3 | Homo sapiens (Human) | SS |
| P41212 | ETV6 | Transcription factor ETV6 | Homo sapiens (Human) | SS |
| Q8VDK3 | Elf5 | ETS-related transcription factor Elf-5 | Mus musculus (Mouse) | SS |
| Q60775 | Elf1 | ETS-related transcription factor Elf-1 | Mus musculus (Mouse) | PR |
| Q9JHC9 | Elf2 | ETS-related transcription factor Elf-2 | Mus musculus (Mouse) | PR |
| Q9Z2U4 | Elf4 | ETS-related transcription factor Elf-4 | Mus musculus (Mouse) | PR |
| P97360 | Etv6 | Transcription factor ETV6 | Mus musculus (Mouse) | EV |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSETPAQCSI | KQERISYTPP | ESPVPSYASS | TPLHVPVPRA | LRMEEDSIRL | PAHLRLQPMF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WSRDDVAQWL | KWAENEFSLR | PIDSNTFEMN | GKALLLLTKE | DFRYRSPHSG | DVLYELLQHI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKQRKPRILF | SPFFHPGNSI | HTQQEVILHQ | NHEEDNGVQR | TSRPSAENVH | QNPPTIELLH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RSRSPITTNH | RPSPDPEQRP | LRSPLDNMIR | RLSPAERAQG | PRLHQENNHQ | EPYPLSVSPM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ENNHCPPSSE | PHPRPSSPRQ | EGTRVIQLMP | SPIMHPLILN | PRHSVDFKQP | RLSEDGLHRE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKPINLSHRE | DLAYMNHIMV | SVSPPEEHAV | PIGRIADCRL | LWDYVYQLLS | DSRYENFIRW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EDKESKIFRI | VDPNGLARLW | GNHKNRTNMT | YEKMSRALRH | YYKLNIIRKE | PGQRLLFRFM |
| 430 | 440 | 450 | |||
| KTPDEIMSGR | TDRLEHLESQ | ELDEQIYQED | EC |