Q0V8T9
Gene name |
Cntnap5a (Caspr5-1) |
Protein name |
Contactin-associated protein like 5-1 |
Names |
Cell recognition molecule Caspr5-1, Cell recognition molecule Caspr5a, Contactin-associated protein-like 5a |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:636808 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0V8T9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0V8T9-F1 | Predicted | AlphaFoldDB |
55 variants for Q0V8T9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388493535 | 3 | S>P | No | EVA | |
| rs3390493193 | 83 | Q>* | No | EVA | |
| rs3390474904 | 84 | N>H | No | EVA | |
| rs3390497813 | 85 | R>* | No | EVA | |
| rs3390497327 | 85 | R>S | No | EVA | |
| rs3390526961 | 85 | R>T | No | EVA | |
| rs3390430753 | 88 | I>F | No | EVA | |
| rs3390460673 | 89 | T>A | No | EVA | |
| rs3390474913 | 111 | S>R | No | EVA | |
| rs3388492733 | 188 | S>* | No | EVA | |
| rs3388492443 | 222 | E>D | No | EVA | |
| rs3388494040 | 227 | D>Y | No | EVA | |
| rs3388493584 | 254 | T>S | No | EVA | |
| rs3412836058 | 260 | L>Q | No | EVA | |
| rs3388492196 | 262 | S>I | No | EVA | |
| rs3390513722 | 264 | L>Q | No | EVA | |
| rs3388493310 | 298 | T>R | No | EVA | |
| rs3388493583 | 338 | V>L | No | EVA | |
| rs3388495846 | 370 | F>Y | No | EVA | |
| rs3388490904 | 447 | D>G | No | EVA | |
| rs3388494056 | 480 | I>M | No | EVA | |
| rs3388492749 | 486 | K>N | No | EVA | |
| rs3388492658 | 575 | T>S | No | EVA | |
| rs3388492605 | 610 | G>D | No | EVA | |
| rs261413938 | 658 | G>D | No | EVA | |
| rs3388493568 | 676 | Q>* | No | EVA | |
| rs223989601 | 692 | D>G | No | EVA | |
| rs3388492622 | 700 | I>N | No | EVA | |
| rs256306668 | 713 | A>S | No | EVA | |
| rs3388493272 | 720 | C>Y | No | EVA | |
| rs258069736 | 741 | I>T | No | EVA | |
| rs240586379 | 748 | T>S | No | EVA | |
| rs3388493262 | 808 | H>L | No | EVA | |
| rs258096442 | 867 | Y>H | No | EVA | |
| rs243719393 | 871 | D>N | No | EVA | |
| rs3390511060 | 874 | W>C | No | EVA | |
| rs3388495708 | 921 | S>L | No | EVA | |
| rs3388490909 | 1000 | A>G | No | EVA | |
| rs3388493868 | 1000 | A>S | No | EVA | |
| rs30647218 | 1001 | L>I | No | EVA | |
| rs3388490915 | 1029 | I>F | No | EVA | |
| rs30647215 | 1033 | L>S | No | EVA | |
| rs50589008 | 1047 | T>I | No | EVA | |
| rs3388492578 | 1086 | H>L | No | EVA | |
| rs3412795737 | 1104 | K>N | No | EVA | |
| rs3388492457 | 1106 | S>C | No | EVA | |
| rs261713760 | 1110 | P>T | No | EVA | |
| rs212185325 | 1124 | S>N | No | EVA | |
| rs30637657 | 1127 | P>S | No | EVA | |
| rs3388495670 | 1153 | A>V | No | EVA | |
| rs3388494073 | 1185 | A>V | No | EVA | |
| rs3388495809 | 1251 | F>C | No | EVA | |
| rs3388494085 | 1259 | R>L | No | EVA | |
| rs3388494032 | 1260 | F>I | No | EVA | |
| rs233078775 | 1297 | E>D | No | EVA |
No associated diseases with Q0V8T9
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartic-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSVPRLNSV | LTLVLSGLWH | LGLTATNYNC | DDPLSNFLSL | KAFSSSSDIT | GSSSSAQLNW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RMGTGGWSPA | DSNAQQWLQI | DLQNRVEITA | VATQGRYGSS | DWVTSYRLMF | SDTGHNWQPY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NQEDSIWTFV | GNMNSDSVVH | HKLLHSVRAR | FVRFVPLEWN | PNGKIGMRVE | AYGCSYRSDV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ADFDGRSSLL | YRFNQKTMST | LKDVISLKFK | SMQGDGVLFH | GEGQRGDHIT | LELQKGRLAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YLNLDDSKAR | LSSTVPLVIL | GSLLDDQHWH | SVLLERVGKQ | ANFTVDMNTQ | HFRTKGDTDS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LDIDYELSFG | GIPVPSKPGT | FLKKNFHGCI | ENLYYNGVNI | IDLAKRRKHQ | IYSGNVTFSC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SEPQIVPITF | INSRSSYLML | PGTPQIDGLS | VSFQFRTWNE | DGLLLSTELS | EGSGTLLLIL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EGGTLRLLIK | KVARHGTEIL | TGSGLNDGLW | HSVSINARRN | RVTLTLDNDA | ASPAPDTSRI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QIYSGKSYYF | GGCPDNLTDS | QCLNPIKAFQ | GCMRLIFIDN | QPKDLISVQQ | GSLGSFSDLH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IDLCSIKDRC | LPNYCEHGGH | CDQTWTTFYC | NCSGTGYTGA | TCHDSIYEQS | CEVYRHRGHT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AGFFYVDSDG | SGPLGPLQVY | CNITEDKIWM | TVQHNNTELT | RVQGSSPENP | YSMTLNYGGS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MEQLEALIDG | SEYCEQEVIY | HCRRSRLLNT | PDGAPFTWWI | GRSTERHPYW | GGAVPGVQQC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GCGLEESCLD | SRHFCNCDAD | IDEWANDTGL | FSFKDHLPVT | QIIIMDTNRT | NSEAAWRIGP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LRCYGDRHFW | NAVSFSTEAS | YLHFPTFHTE | FSADISFFFK | TTALSGVFLE | NLGIKDFFRL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EMSSPSEVTF | AIDVGNGPIE | LLVQSPYPLN | DNQWHYIRAE | TNLKETSLQV | DNLPQSMREA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SEGGHFRLQL | NSQLFVGGTS | SRQKGFLGCI | RSLLLNGHKV | DLEERAKVTS | GVRPGCPGHC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SSYGSNCHNG | GKCVEKHTGY | SCDCTNSPYE | GPFCRKEISA | LFDSGTSVTY | MFQEPYPVTK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| NTSLSSSAIY | TDLAPFKETI | MLSFMTTQAP | TLLLYLNFSS | QNFLAILLSR | NGSLQVRYRL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| SKDESHVFNM | DTENLANRRV | HQVKISRDGP | ELSIQMDQQL | FSYSFSPEVE | FRTLRSLVLG |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KVTETLDLDP | EVARANTLGF | VGCLSSVQYN | HIAPLKAALR | HASIAPVTVQ | KTLTESSCGS |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| MVDSDVNAVT | TVHSLSDSFG | KTDDHEPLQN | AVRSDSAVIG | GVIAVVTFIT | FCVIGIMTRF |
| 1270 | 1280 | 1290 | 1300 | ||
| LYQHKQSHRT | NQMKKEYPEN | LDNSFRNEID | LQNTATECKR | EYFI |