Q0V7M1

SS
Gene name
PSKH1
Protein name
Serine/threonine-protein kinase H1
Names
EC 2.7.11.1 , Protein serine kinase H1 , PSK-H1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:509656
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

Serine/threonine-protein kinase H1 (PSKH1) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of PSKH1.

Autoinhibitory domains (AIDs)

Accessory elements

238-262 (Activation loop from InterPro)

Target domain

98-355 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q0V7M1

Entry ID Method Resolution Chain Position Source
AF-Q0V7M1-F1 Predicted AlphaFoldDB

100 variants for Q0V7M1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs470003802 5 T>P No EVA
rs454134547 29 G>S No EVA
rs435339998 48 L>V No EVA
rs441126403 52 F>L No EVA
rs451323140 62 S>T No EVA
rs471371270 63 P>H No EVA
rs443315729 65 T>P No EVA
rs463377457 66 P>R No EVA
rs385631421 67 R>C No EVA
rs480635264 70 H>P No EVA
rs442947933 79 R>S No EVA
rs465422536 108 S>R No EVA
rs450985370 130 E>G No EVA
rs467810469 131 T>A No EVA
rs449129004 133 Y>* No EVA
rs435401604 133 Y>H No EVA
rs465955770 135 E>Q No EVA
rs434718625 137 R>G No EVA
rs451446953 138 E>A No EVA
rs451446953 138 E>G No EVA
rs451446953 138 E>V No EVA
rs471411615 139 V>G No EVA
rs436742821 140 C>G No EVA
rs457042550 140 C>W No EVA
rs442459113 150 V>G No EVA
rs459820763 151 R>G No EVA
rs473404389 158 L>P No EVA
rs439092365 161 V>G No EVA
rs482287321 162 F>C No EVA
rs459142014 162 F>V No EVA
rs450769437 163 E>Q No EVA
rs481555489 169 Y>* No EVA
rs446959478 170 M>R No EVA
rs522928958 173 E>K No EVA
rs465967961 175 A>D No EVA
rs434524010 179 E>* No EVA
rs445141858 179 E>A No EVA
rs465192485 191 T>A No EVA
rs1116014961 195 A>T No EVA
rs437062513 210 H>N No EVA
rs456909015 215 T>K No EVA
rs473596578 218 D>A No EVA
rs436100533 218 D>E No EVA
rs452845565 227 Y>F No EVA
rs452845565 227 Y>S No EVA
rs473415014 232 D>H No EVA
rs438950556 235 I>T No EVA
rs459270541 241 G>D No EVA
rs476134290 249 G>C No EVA
rs444712893 262 E>* No EVA
rs461392360 263 Y>D No EVA
rs481366948 265 A>G No EVA
rs446971804 271 R>H No EVA
rs460602265 273 P>L No EVA
rs479678545 274 Y>D No EVA
rs445019448 279 D>H No EVA
rs451878459 280 M>L No EVA
rs465150917 294 T>P No EVA
rs482214376 301 N>H No EVA
rs450768304 301 N>T No EVA
rs467206932 303 T>S No EVA
rs435912349 318 G>V No EVA
rs452905526 319 E>* No EVA
rs458649052 321 W>R No EVA
rs460893913 326 N>K No EVA
rs444052639 326 N>S No EVA
rs481209837 331 F>L No EVA
rs446462149 332 I>F No EVA
rs467177742 332 I>M No EVA
rs446237996 337 T>A No EVA
rs469707943 339 D>G No EVA
rs438273169 341 G>R No EVA
rs454964103 344 M>L No EVA
rs468497496 345 T>P No EVA
rs41867496 350 L>M No EVA
rs473030592 355 V>G No EVA
rs876552237 356 V>G No EVA
rs444355528 360 A>T No EVA
rs797150147 369 R>H No EVA
rs452177058 377 K>N No EVA
rs475549582 378 R>P No EVA
rs444288832 379 A>T No EVA
rs440105819 382 R>P No EVA
rs477081631 383 C>S No EVA
rs446301059 384 Q>E No EVA
rs469569707 385 S>G No EVA
rs448641890 386 T>I No EVA
rs483316324 386 T>P No EVA
rs468613806 387 K>T No EVA
rs433942784 391 S>P No EVA
rs453956139 392 T>P No EVA
rs452238575 394 S>P No EVA
rs475363617 398 T>P No EVA
rs454711648 405 R>L No EVA
rs470726492 416 L>W No EVA
rs463161028 419 Q>K No EVA
rs483240174 420 Q>P No EVA
rs448787845 421 Q>* No EVA
rs462450248 424 G>A No EVA
rs479343567 425 G>G No EVA

No associated diseases with Q0V7M1

3 regional properties for Q0V7M1

Type Name Position InterPro Accession
domain Protein kinase domain 98 - 355 IPR000719
active_site Serine/threonine-protein kinase, active site 214 - 226 IPR008271
binding_site Protein kinase, ATP binding site 104 - 127 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Golgi apparatus
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Nucleus speckle
  • Endoplasmic reticulum membrane ; Lipid-anchor
  • Cell membrane ; Lipid-anchor
  • Cytoplasm
  • Localized in the brefeldin A- sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm
  • Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells
  • The acylation-negative form may be only cytoplasmic and nuclear
  • Acylation seems to allow the sequestering to the intracellular membranes
  • Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes
  • Dual acylation is required to stabilize the interaction with Golgi membranes (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions

3 GO annotations of biological process

Name Definition
determination of left/right symmetry The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

102 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0VD22 STK33 Serine/threonine-protein kinase 33 Bos taurus (Bovine) PR
A4IFM7 MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle Bos taurus (Bovine) SS
Q2KJ16 PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Bos taurus (Bovine) PR
Q3MHJ9 CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta Bos taurus (Bovine) SS
Q2HJF7 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta Bos taurus (Bovine) SS
Q96NX5 CAMK1G Calcium/calmodulin-dependent protein kinase type 1G Homo sapiens (Human) SS
O15075 DCLK1 Serine/threonine-protein kinase DCLK1 Homo sapiens (Human) EV
Q14012 CAMK1 Calcium/calmodulin-dependent protein kinase type 1 Homo sapiens (Human) EV
Q9UIK4 DAPK2 Death-associated protein kinase 2 Homo sapiens (Human) EV
O94768 STK17B Serine/threonine-protein kinase 17B Homo sapiens (Human) PR
Q86YV6 MYLK4 Myosin light chain kinase family member 4 Homo sapiens (Human) SS
Q16566 CAMK4 Calcium/calmodulin-dependent protein kinase type IV Homo sapiens (Human) SS
Q8N568 DCLK2 Serine/threonine-protein kinase DCLK2 Homo sapiens (Human) PR
Q9UEE5 STK17A Serine/threonine-protein kinase 17A Homo sapiens (Human) SS
O75962 TRIO Triple functional domain protein Homo sapiens (Human) EV
Q9H1R3 MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle Homo sapiens (Human) EV
Q32MK0 MYLK3 Myosin light chain kinase 3 Homo sapiens (Human) SS
Q8WWF8 CAPSL Calcyphosin-like protein Homo sapiens (Human) PR
P53355 DAPK1 Death-associated protein kinase 1 Homo sapiens (Human) EV
Q6P2M8 PNCK Calcium/calmodulin-dependent protein kinase type 1B Homo sapiens (Human) SS
Q9BYT3 STK33 Serine/threonine-protein kinase 33 Homo sapiens (Human) PR
Q8NCB2 CAMKV CaM kinase-like vesicle-associated protein Homo sapiens (Human) SS
O43293 DAPK3 Death-associated protein kinase 3 Homo sapiens (Human) PR
Q8IU85 CAMK1D Calcium/calmodulin-dependent protein kinase type 1D Homo sapiens (Human) SS
P11801 PSKH1 Serine/threonine-protein kinase H1 Homo sapiens (Human) SS
Q9QYK9 Pnck Calcium/calmodulin-dependent protein kinase type 1B Mus musculus (Mouse) PR
Q91VB2 Camk1g Calcium/calmodulin-dependent protein kinase type 1G Mus musculus (Mouse) SS
Q8BG48 Stk17b Serine/threonine-protein kinase 17B Mus musculus (Mouse) PR
Q8VCR8 Mylk2 Myosin light chain kinase 2, skeletal/cardiac muscle Mus musculus (Mouse) SS
Q6PGN3 Dclk2 Serine/threonine-protein kinase DCLK2 Mus musculus (Mouse) PR
Q91YS8 Camk1 Calcium/calmodulin-dependent protein kinase type 1 Mus musculus (Mouse) SS
Q3UIZ8 Mylk3 Myosin light chain kinase 3 Mus musculus (Mouse) SS
Q8VDF3 Dapk2 Death-associated protein kinase 2 Mus musculus (Mouse) EV
Q6P8Y1 Capsl Calcyphosin-like protein Mus musculus (Mouse) PR
Q8BW96 Camk1d Calcium/calmodulin-dependent protein kinase type 1D Mus musculus (Mouse) SS
Q3UHL1 Camkv CaM kinase-like vesicle-associated protein Mus musculus (Mouse) SS
P08414 Camk4 Calcium/calmodulin-dependent protein kinase type IV Mus musculus (Mouse) SS
Q9JLM8 Dclk1 Serine/threonine-protein kinase DCLK1 Mus musculus (Mouse) SS
Q80YE7 Dapk1 Death-associated protein kinase 1 Mus musculus (Mouse) SS
Q62407 Speg Striated muscle-specific serine/threonine-protein kinase Mus musculus (Mouse) SS
Q0KL02 Trio Triple functional domain protein Mus musculus (Mouse) SS
Q924X7 Stk33 Serine/threonine-protein kinase 33 Mus musculus (Mouse) PR
O54784 Dapk3 Death-associated protein kinase 3 Mus musculus (Mouse) PR
Q91YA2 Pskh1 Serine/threonine-protein kinase H1 Mus musculus (Mouse) SS
Q7TNJ7 Camk1g Calcium/calmodulin-dependent protein kinase type 1G Rattus norvegicus (Rat) SS
P20689 Mylk2 Myosin light chain kinase 2, skeletal/cardiac muscle Rattus norvegicus (Rat) SS
F1M0Z1 Trio Triple functional domain protein Rattus norvegicus (Rat) SS
Q91XS8 Stk17b Serine/threonine-protein kinase 17B Rattus norvegicus (Rat) PR
O08875 Dclk1 Serine/threonine-protein kinase DCLK1 Rattus norvegicus (Rat) PR
E9PT87 Mylk3 Myosin light chain kinase 3 Rattus norvegicus (Rat) SS
O70150 Pnck Calcium/calmodulin-dependent protein kinase type 1B Rattus norvegicus (Rat) PR
Q63092 Camkv CaM kinase-like vesicle-associated protein Rattus norvegicus (Rat) SS
Q63638 Speg Striated muscle-specific serine/threonine-protein kinase Rattus norvegicus (Rat) SS
O88764 Dapk3 Death-associated protein kinase 3 Rattus norvegicus (Rat) PR
P13234 Camk4 Calcium/calmodulin-dependent protein kinase type IV Rattus norvegicus (Rat) SS
Q63450 Camk1 Calcium/calmodulin-dependent protein kinase type 1 Rattus norvegicus (Rat) EV
P97924 Kalrn Kalirin Rattus norvegicus (Rat) SS
Q5MPA9 Dclk2 Serine/threonine-protein kinase DCLK2 Rattus norvegicus (Rat) PR
Q5VQQ5 CPK2 Calcium-dependent protein kinase 2 Oryza sativa subsp. japonica (Rice) SS
Q8LPZ7 CPK3 Calcium-dependent protein kinase 3 Oryza sativa subsp. japonica (Rice) SS
Q75GE8 CPK8 Calcium-dependent protein kinase 8 Oryza sativa subsp. japonica (Rice) SS
Q6I5I8 CPK16 Calcium-dependent protein kinase 16 Oryza sativa subsp. japonica (Rice) SS
Q6AVM3 CCAMK Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase Oryza sativa subsp japonica (Rice) PR
Q84SL0 CPK20 Calcium-dependent protein kinase 20 Oryza sativa subsp. japonica (Rice) SS
P53682 CPK23 Calcium-dependent protein kinase 23 Oryza sativa subsp japonica (Rice) PR
P53684 CPK7 Calcium-dependent protein kinase 7 Oryza sativa subsp japonica (Rice) PR
Q6K968 CPK6 Calcium-dependent protein kinase 6 Oryza sativa subsp. japonica (Rice) SS
Q9TXJ0 cmk-1 Calcium/calmodulin-dependent protein kinase type 1 Caenorhabditis elegans PR
O44997 dapk-1 Death-associated protein kinase dapk-1 Caenorhabditis elegans SS
Q95QC4 zyg-8 Serine/threonine-protein kinase zyg-8 Caenorhabditis elegans PR
P28583 Calcium-dependent protein kinase SK5 Glycine max (Soybean) (Glycine hispida) PR
Q9M9V8 CPK10 Calcium-dependent protein kinase 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FX86 CRK8 CDPK-related kinase 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SSF8 CPK30 Calcium-dependent protein kinase 30 Arabidopsis thaliana (Mouse-ear cress) PR
Q7XJR9 CPK16 Calcium-dependent protein kinase 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIQ7 CPK24 Calcium-dependent protein kinase 24 Arabidopsis thaliana (Mouse-ear cress) PR
P93759 GK-1 Calcium-dependent protein kinase 14 Arabidopsis thaliana (Mouse-ear cress) PR
Q8S8S2 LPEAT2 Lysophospholipid acyltransferase LPEAT2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LJL9 CRK2 CDPK-related kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SG12 CRK6 CDPK-related kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCS2 CRK5 CDPK-related kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W4I7 CPK13 Calcium-dependent protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NLQ6 CPK32 Calcium-dependent protein kinase 32 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZSA4 CPK27 Calcium-dependent protein kinase 27 Arabidopsis thaliana (Mouse-ear cress) PR
Q42479 CPK3 Calcium-dependent protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q1PE17 CPK18 Calcium-dependent protein kinase 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FMP5 CPK17 Calcium-dependent protein kinase 17 Arabidopsis thaliana (Mouse-ear cress) PR
Q38873 CPK7 Calcium-dependent protein kinase 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E9C0 CPK34 Calcium-dependent protein kinase 34 Arabidopsis thaliana (Mouse-ear cress) PR
Q42438 CPK8 Calcium-dependent protein kinase 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FKW4 CPK28 Calcium-dependent protein kinase 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q06850 CPK1 Calcium-dependent protein kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q38869 CPK4 Calcium-dependent protein kinase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q38870 CPK2 Calcium-dependent protein kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q38872 CPK6 Calcium-dependent protein kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q39016 CPK11 Calcium-dependent protein kinase 11 Arabidopsis thaliana (Mouse-ear cress) SS
Q42396 CPK12 Calcium-dependent protein kinase 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SJ61 CPK25 Calcium-dependent protein kinase 25 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZV15 CPK20 Calcium-dependent protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) PR
Q1LUA6 trio Triple functional domain protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
A8C984 mylk3 Myosin light chain kinase 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q7SY49 camkv CaM kinase-like vesicle-associated protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MGCGTSKVLP EPPKDVQLDL VKKVEPFSGT KSDVYKHFIT EVDSVGPLKG GFPAASQGAN
70 80 90 100 110 120
PSPGTPRTSH TEPPSEPPRR ARVAKYRAKF DPRVTAKYDI KALIGRGSFS RVVRVEHRAT
130 140 150 160 170 180
RQPYAIKMIE TKYREGREVC ESELRVLRRV RHANIIQLVE VFETQERVYM VMELATGGEL
190 200 210 220 230 240
FDRIIAKGSF TERDATRVLQ MVLDGVRYLH ALGITHRDLK PENLLYYHPG TDSKIIITDF
250 260 270 280 290 300
GLASARKKGD DCLMKTTCGT PEYIAPEVLV RKPYTNSVDM WALGVIAYIL LSGTMPFEDD
310 320 330 340 350 360
NRTRLYRQIL RGKYSYSGEP WPSVSNLAKD FIDRLLTVDP GARMTALQAL RHPWVVSMAA
370 380 390 400 410 420
SSSMKNLHRS ISQNLLKRAS SRCQSTKSAQ STRSSRSTRS NKSRRVRERE LRELNLRYQQ
QYNG