Q0V7M0

SS
Gene name
KPNA6 (IPOA7)
Protein name
Importin subunit alpha-7
Names
Karyopherin subunit alpha-6
Species
Bos taurus (Bovine)
KEGG Pathway
bta:531602
EC number
Protein Class

Descriptions

Importin-α is a nuclear import receptor that facilitates the transport of proteins with nuclear localization sequences (NLSs) into the nucleus. It is autoinhibited by its N-terminal region, which occupies the NLS-binding site, preventing unnecessary binding and import activity. Importin-α is autoinhibited in the absence of importin-β and the binding of importin-β alleviates this autoinhibition, which displaces the autoinhibitory sequence.

Autoinhibitory domains (AIDs)

44-54 (N-terminal autoinhibitory sequence) SS

Target domain

147-239 (Major NLS-binding site);316-404 (Minor NLS-binding site)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0V7M0

Entry ID Method Resolution Chain Position Source
AF-Q0V7M0-F1 Predicted AlphaFoldDB

63 variants for Q0V7M0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs516944267 35 G>S No EVA
rs472102020 45 Q>* No EVA
rs436296536 49 K>Q No EVA
rs449173269 49 K>R No EVA
rs437973262 50 R>P No EVA
rs467635928 50 R>W No EVA
rs452056117 185 E>* No EVA
rs451699934 221 S>A No EVA
rs440609005 223 R>P No EVA
rs455927621 224 L>V No EVA
rs443968036 226 M>K No EVA
rs474552936 226 M>V No EVA
rs462590759 227 T>P No EVA
rs477808557 231 V>A No EVA
rs438472931 232 W>R No EVA
rs460258466 236 N>S No EVA
rs465661521 250 V>D No EVA
rs432686362 253 C>F No EVA
rs454430858 261 L>V No EVA
rs436007912 265 D>G No EVA
rs472183573 265 D>Y No EVA
rs454577228 267 D>G No EVA
rs476340118 268 L>F No EVA
rs443360465 287 I>L No EVA
rs458620201 292 D>G No EVA
rs470693093 296 C>S No EVA
rs441023561 297 R>L No EVA
rs479022558 299 L>F No EVA
rs459611802 299 L>V No EVA
rs466439759 316 R>S No EVA
rs454468477 319 G>C No EVA
rs469893410 320 N>Y No EVA
rs436897712 323 T>P No EVA
rs452095625 325 D>V No EVA
rs470578891 329 T>P No EVA
rs450826173 332 I>L No EVA
rs469305385 333 L>F No EVA
rs445298192 340 C>F No EVA
rs434195920 343 H>N No EVA
rs455978104 343 H>P No EVA
rs434195920 343 H>Y No EVA
rs474528623 344 L>V No EVA
rs437590926 347 S>C No EVA
rs456173580 349 K>N No EVA
rs471403181 350 E>D No EVA
rs438437118 351 S>T No EVA
rs460225226 356 A>V No EVA
rs442628082 359 T>P No EVA
rs461058288 359 T>S No EVA
rs482771177 360 I>M No EVA
rs478008424 367 N>S No EVA
rs445297009 368 R>G No EVA
rs467045939 370 Q>E No EVA
rs454480247 380 F>V No EVA
rs476183873 391 E>G No EVA
rs470149872 463 V>G No EVA
rs453730639 481 F>L No EVA
rs461231968 481 F>V No EVA
rs476519594 489 E>G No EVA
rs472211947 504 V>I No EVA
rs43325262 505 E>K No EVA
rs433248477 511 L>M No EVA
rs459012722 522 F>V No EVA

No associated diseases with Q0V7M0

3 regional properties for Q0V7M0

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 260 IPR000719
active_site Serine/threonine-protein kinase, active site 119 - 131 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
nuclear import signal receptor activity Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
nuclear localization sequence binding Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.

1 GO annotations of biological process

Name Definition
NLS-bearing protein import into nucleus The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.

30 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q02821 SRP1 Importin subunit alpha Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
C1JZ66 KPNA7 Importin subunit alpha-8 Bos taurus (Bovine) PR
A2VE08 KPNA1 Importin subunit alpha-5 Bos taurus (Bovine) SS
Q5ZML1 KPNA1 Importin subunit alpha-5 Gallus gallus (Chicken) SS
P52295 Pen Importin subunit alpha Drosophila melanogaster (Fruit fly) SS
O00505 KPNA3 Importin subunit alpha-4 Homo sapiens (Human) SS
A9QM74 KPNA7 Importin subunit alpha-8 Homo sapiens (Human) EV
O00629 KPNA4 Importin subunit alpha-3 Homo sapiens (Human) SS
P52294 KPNA1 Importin subunit alpha-5 Homo sapiens (Human) SS
O15131 KPNA5 Importin subunit alpha-6 Homo sapiens (Human) SS
P52292 KPNA2 Importin subunit alpha-1 Homo sapiens (Human) EV
O60684 KPNA6 Importin subunit alpha-7 Homo sapiens (Human) SS
Q60960 Kpna1 Importin subunit alpha-5 Mus musculus (Mouse) SS
P52293 Kpna2 Importin subunit alpha-1 Mus musculus (Mouse) EV
O35344 Kpna3 Importin subunit alpha-4 Mus musculus (Mouse) SS
O35343 Kpna4 Importin subunit alpha-3 Mus musculus (Mouse) SS
C0LLJ0 Kpna7 Importin subunit alpha-8 Mus musculus (Mouse) SS
O35345 Kpna6 Importin subunit alpha-7 Mus musculus (Mouse) PR
C6K7I2 KPNA7 Importin subunit alpha-8 Sus scrofa (Pig) SS
P83953 Kpna1 Importin subunit alpha-5 Rattus norvegicus (Rat) SS
Q56R16 Kpna5 Importin subunit alpha-6 Rattus norvegicus (Rat) SS
Q71VM4 Os01g0253300 Importin subunit alpha-1a Oryza sativa subsp. japonica (Rice) SS
P91276 ima-2 Importin subunit alpha-2 Caenorhabditis elegans SS
Q19969 ima-3 Importin subunit alpha-3 Caenorhabditis elegans SS
O04294 IMPA3 Importin subunit alpha-3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M9X7 IMPA7 Importin subunit alpha-7 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FJ09 IMPA5 Importin subunit alpha-5 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FWY7 IMPA6 Importin subunit alpha-6 Arabidopsis thaliana (Mouse-ear cress) SS
O22478 Importin subunit alpha Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
Q503E9 kpna5 Importin subunit alpha-6 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
METMASPGKD NYRMKSYKNN ALNPEEMRRR REEEGIQLRK QKREQQLFKR RNVELINEEA
70 80 90 100 110 120
AMFDSLLMDS YVSSTTGESV ITREMVEMLF SDDPDLQLAT TQKFRKLLSK EPSPPIDEVI
130 140 150 160 170 180
NTPGVVDRFV EFLKRNENCT LQFEAAWALT NIASGTSQQT KIVIEAGAVP IFIELLNSDF
190 200 210 220 230 240
EDVQEQAVWA LGNIAGDSSV CRDYVLNCSI LNPLLTLLTK STRLTMTRNA VWALSNLCRG
250 260 270 280 290 300
KNPPPEFAKV SPCLPVLSRL LFSSDSDLLA DACWALSYLS DGPNEKIQAV IDSGVCRRLV
310 320 330 340 350 360
ELLMHNDNKV ASPALRAVGN IVTGDDIQTQ VILNCSALPC LLHLLSSSKE SIRKEACWTI
370 380 390 400 410 420
SNITAGNRAQ IQAVIDANIF PVLIEILQKA EFRTRKEAAW AITNATSGGT PEQIRYLVSL
430 440 450 460 470 480
GCIKPLCDLL TVMDSKIVQV ALNGLENILR LGEQEGKRSG SGVNPYCGLI EEAYGLDKIE
490 500 510 520 530
FLQSHENQEI YQKAFDLIEH YFGVEDDDSS LAPQVDETQQ QFIFQQPEAP MEGFQL