Q0QWG9
PR
Gene name |
Grid2ip |
Protein name |
Delphilin |
Names |
Glutamate receptor, ionotropic, delta 2-interacting protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:170935 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0QWG9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0QWG9-F1 | Predicted | AlphaFoldDB |
41 variants for Q0QWG9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388809722 | 84 | P>L | No | EVA | |
| rs3388802203 | 118 | V>M | No | EVA | |
| rs3388801562 | 137 | L>W | No | EVA | |
| rs242348281 | 140 | R>Q | No | EVA | |
| rs3388787724 | 141 | L>P | No | EVA | |
| rs3388814756 | 168 | T>S | No | EVA | |
| rs3388806978 | 174 | E>G | No | EVA | |
| rs3388798364 | 231 | L>I | No | EVA | |
| rs3388811813 | 384 | T>A | No | EVA | |
| rs48795872 | 407 | R>S | No | EVA | |
| rs3388792496 | 411 | H>Y | No | EVA | |
| rs212607561 | 497 | R>H | No | EVA | |
| rs3388806022 | 498 | S>N | No | EVA | |
| rs253479844 | 500 | R>H | No | EVA | |
| rs49227859 | 506 | T>A | No | EVA | |
| rs3388802143 | 509 | S>N | No | EVA | |
| rs3388803222 | 516 | P>L | No | EVA | |
| rs3388803296 | 575 | V>L | No | EVA | |
| rs3388806970 | 593 | P>H | No | EVA | |
| rs3388806975 | 595 | D>E | No | EVA | |
| rs3388806083 | 596 | R>G | No | EVA | |
| rs3388803255 | 597 | L>F | No | EVA | |
| rs3388795212 | 613 | S>Y | No | EVA | |
| rs3388802230 | 627 | S>N | No | EVA | |
| rs3395619100 | 746 | L>P | No | EVA | |
| rs3396320155 | 747 | S>T | No | EVA | |
| rs212016997 | 769 | P>S | No | EVA | |
| rs3396341673 | 780 | L>H | No | EVA | |
| rs235210212 | 784 | N>S | No | EVA | |
| rs3388806992 | 845 | S>A | No | EVA | |
| rs3388801548 | 851 | S>N | No | EVA | |
| rs3388801563 | 876 | E>K | No | EVA | |
| rs3388807040 | 893 | Y>F | No | EVA | |
| rs3388808621 | 901 | H>Y | No | EVA | |
| rs259248205 | 918 | P>T | No | EVA | |
| rs219908601 | 996 | R>Q | No | EVA | |
| rs242925180 | 1090 | A>T | No | EVA | |
| rs3388803304 | 1158 | E>D | No | EVA | |
| rs3388801508 | 1171 | I>N | No | EVA | |
| rs3388792494 | 1196 | G>R | No | EVA | |
| rs3388801528 | 1203 | W>S | No | EVA |
No associated diseases with Q0QWG9
1 regional properties for Q0QWG9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | TATA-box binding protein, conserved site | 246 - 295 | IPR030491 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| G protein-coupled glutamate receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| long-term synaptic depression | A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. |
30 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SZK8 | NHERF1 | Na | Bos taurus (Bovine) | SS |
| O46471 | RGS16 | Regulator of G-protein signaling 16 | Bos taurus (Bovine) | PR |
| Q3T0T8 | RGS5 | Regulator of G-protein signaling 5 | Bos taurus (Bovine) | PR |
| A0A1D5P556 | DAAM2 | Disheveled-associated activator of morphogenesis 2 | Gallus gallus (Chicken) | SS |
| Q5ZM14 | NHERF1 | Na | Gallus gallus (Chicken) | SS |
| Q24008 | inaD | Inactivation-no-after-potential D protein | Drosophila melanogaster (Fruit fly) | PR |
| O95466 | FMNL1 | Formin-like protein 1 | Homo sapiens (Human) | SS |
| Q27J81 | INF2 | Inverted formin-2 | Homo sapiens (Human) | EV |
| Q9Y4D1 | DAAM1 | Disheveled-associated activator of morphogenesis 1 | Homo sapiens (Human) | EV |
| Q86T65 | DAAM2 | Disheveled-associated activator of morphogenesis 2 | Homo sapiens (Human) | SS |
| Q9Y6N9 | USH1C | Harmonin | Homo sapiens (Human) | PR |
| O14745 | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Homo sapiens (Human) | EV |
| Q86UT5 | PDZD3 | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 | Homo sapiens (Human) | PR |
| P49802 | RGS7 | Regulator of G-protein signaling 7 | Homo sapiens (Human) | PR |
| O15539 | RGS5 | Regulator of G-protein signaling 5 | Homo sapiens (Human) | PR |
| Q0GNC1 | Inf2 | Inverted formin-2 | Mus musculus (Mouse) | SS |
| P70441 | Slc9a3r1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Mus musculus (Mouse) | PR |
| Q99MJ6 | Pdzd3 | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 | Mus musculus (Mouse) | PR |
| Q9JIL4 | Pdzk1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 | Mus musculus (Mouse) | PR |
| Q9Z2H1 | Rgs11 | Regulator of G-protein signaling 11 | Mus musculus (Mouse) | PR |
| O54829 | Rgs7 | Regulator of G-protein signaling 7 | Mus musculus (Mouse) | PR |
| Q8BPM0 | Daam1 | Disheveled-associated activator of morphogenesis 1 | Mus musculus (Mouse) | PR |
| Q80U19 | Daam2 | Disheveled-associated activator of morphogenesis 2 | Mus musculus (Mouse) | SS |
| Q9JJ40 | Pdzk1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 | Rattus norvegicus (Rat) | PR |
| Q9JJ19 | Nherf1 | Na | Rattus norvegicus (Rat) | SS |
| Q18312 | rgs-3 | Regulator of G-protein signaling rgs-3 | Caenorhabditis elegans | PR |
| Q9C7S1 | FH12 | Formin-like protein 12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LH02 | FH17 | Formin-like protein 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P0C5K4 | FH21A | Putative formin-like protein 21a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FF14 | FH19 | Formin-like protein 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPATNQGWPE | DFGFQLGGSG | PCFVIEVAEG | SSAHAGGLRP | GDQILEVEGL | AVGGLSRERI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VRLARRCPRV | PPSLGVLPGP | EGGPTALTAA | WLTRRFGRSL | PLSRELLRLA | GGPRPDAVHR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ERRRKAQEFS | CQVDDILGDR | LTAKEQVFTA | LKQFAAEQRV | DELVWTLTLV | LPSEAQGPVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DNLRIFIPKK | HRARFDEVVS | QGLLGKLCRA | RRAQGAQRLR | RSRSEERPER | LLVSTRASAA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PRRPDEPPPR | KATSLLGGRT | GPGGPRRTVR | VYKGNKSFGF | TLRGHGPVWI | ESVLPGSPAE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NASLKSGDRI | LFLNGLDMRN | CSHDKVVSML | QGSGAMPTLV | VEEGPVPFAS | DSDSLDSPTR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ASALTSLQWV | ADILPSSIRV | QGRTFSQQLD | HLLTPPERYG | VCRALERFFQ | HRNIDTLIVD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VYPVLDTPAK | QVLWQFLYQL | LTYEEQELCQ | EKIACFLGYT | AMTEPESSLD | LEPESTPEPT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PEPQPRSSLR | ASSMCRRSLR | SQGLETSLSC | GPGDCPEMPL | PLIPGERQAG | DGTSLPETPN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PKMMSAVYAE | LESRLNSSFK | GKIGTMSKSR | ASPPVPSLVG | TSGPRTLSGV | SWPSDRLLPS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PCYDPLCSGG | LASPSSSESH | PYASLDSSRA | PSPQPGLGSI | HADSPPSPDP | IRPPSRRKLF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AFSRPVRSRD | TDRFLDALSE | QLGPRLSIVD | DFLTPENDYE | EMSFHDDQGS | FVTNERSSAS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ECVSSSEEGS | SLTYSSISDH | IPPPPLSPPP | PPPLPFHDPK | PSSRTSDGPR | GPPQSLTKPL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TQINHPVPPP | PPPPLPPPVP | CAPPMLSRGV | GHRRSETSHM | SVKRLRWEQV | ENSEGTIWGQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LGEDSDYDKL | SDMVKYLDLE | LHFGTQKPPK | PVPGPEPFRK | KEVVEILSHK | KAYNTSILLA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| HLKLTPGELR | QVLMSMEPRR | LEPAHLAQLL | LFAPDADEEQ | RYQAFREAPG | RLSEPDQFVL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| QMLSVPEYKT | RLRSLHFQAT | LQEKTEEIRG | SLECLRQASL | ELKNSRKLAK | ILEFVLAMGN |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| YLNDGQPKTN | KTTGFKINFL | TELNSTKTVD | GKSTFLHILA | KSLSQHFPEL | LGFAQDLPTV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| PLAAKVNQRA | LTGDLADLHD | TVSEIQVACQ | SMAPSSEDRF | AVVMASFLET | AQPALRALDG |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LQREAMEELG | KALAFFGEDS | KATTSEAFFG | IFSEFMSKFE | RALSDLQAGD | GPRSSGMVSP |
| LAW |