Q0IIG8
Gene name |
RAB18 |
Protein name |
Ras-related protein Rab-18 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:511160 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0IIG8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0IIG8-F1 | Predicted | AlphaFoldDB |
No variants for Q0IIG8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q0IIG8 | |||||
No associated diseases with Q0IIG8
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| endocytic recycling | The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. |
| eye development | The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6QR46 | RAB6B | Ras-related protein Rab-6B | Bos taurus (Bovine) | PR |
| Q8HZJ5 | RAB27B | Ras-related protein Rab-27B | Bos taurus (Bovine) | PR |
| Q5ZLG1 | RAB18 | Ras-related protein Rab-18 | Gallus gallus (Chicken) | PR |
| Q9NP72 | RAB18 | Ras-related protein Rab-18 | Homo sapiens (Human) | PR |
| P35293 | Rab18 | Ras-related protein Rab-18 | Mus musculus (Mouse) | PR |
| Q5EB77 | Rab18 | Ras-related protein Rab-18 | Rattus norvegicus (Rat) | PR |
| Q6DHC1 | rab18b | Ras-related protein Rab-18-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEDVLTTLK | ILIIGESGVG | KSSLLLRFTD | DTFDPELAAT | IGVDFKVKTI | SVDGNKAKLA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IWDTAGQERF | RTLTPSYYRG | AQGVILVYDV | TRRDTFVKLD | NWLNELETYC | TRNDIVNMLV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GNKIDKENRE | VDRNEGLKFA | RKHSMLFIEA | SAKTCDGVQC | AFEELVEKII | QTPGLWESEN |
| 190 | 200 | ||||
| QNKGVKLTHR | EEGQGGGACG | GYCSVL |